Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.
- Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
- Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.
- Provides new genetics content focused on data applications.
- Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
- Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
- Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
- Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Table of Contents
PART I Principles of Immune Response1 The Human Immune Response
2 Organization of the Immune System
3 Innate Immunity
4 Antigen Receptor Genes, Gene Products, and Co-Receptors
5 The Major Histocompatibility Complex
6 Antigens and Antigen Presentation
7 B-Cell Development and Differentiation
8 Immunoglobulin Function
9 T-Cell Development
10 T-Cell Activation and Tolerance
11 Helper T-Cell Subsets and Control of the Inflammatory Response
12 Cytotoxic T Lymphocytes and Natural Killer Cells
13 Regulatory Immune Cells
14 Cytokines and Cytokine Receptors
15 Chemokines and Chemokine Receptors
16 Lymphocyte Adhesion and Trafficking
17 Death Pathways and Immunogenicity
PART II Fundamentals of Host-Environmental Interactions
18 Human Genomics in Immunology
19 Regulatory RNA in Immunologic Diseases
20 Immunometabolism
21 Immune Deficiencies at the Extremes of Age
22 The Microbiota in Immunity and Inflammation
PART III Host Defenses to Infectious Agents
23 Immunology of the Skin
24 Immunology of Mucosal Surfaces
25 Host Defenses to Viruses
26 Host Defenses to Intracellular Bacteria
27 Host Defenses to Extracellular Bacteria, Including Spirochetes
28 Host Defenses to Fungi
29 Host Defenses to Protozoa
30 Host Defenses to Helminth Infection
31 Emerging Pandemic Infectious Disease Threats
PART IV Immune Deficiency and Immune Regulatory Disorders
32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency
33 Primary Antibody Deficiencies
34 Primary T-Cell Immunodeficiencies
35 Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity
36 Hemophagocytic Lymphohistiocytosis
37 Autoinflammatory Syndromes
38 Immune Regulatory Disorders
39 Neutrophils and Neutrophil Disorders
40 Complement and Complement Disorders
41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases
PART V Allergic Diseases
43 Allergic Airway Diseases
44 Mast Cells and Mast Cell Disorders
45 Eosinophils and Eosinophilic Disorders
46 Urticaria, Angioedema, and Anaphylaxis
47 Allergic Reactions to Stinging and Biting Insects
48 Atopic and Contact Dermatitis
49 Food Allergy
50 Drug Hypersensitivity
PART VI Systemic Immune Diseases
51 Mechanisms of Autoimmunity
52 Systemic Lupus Erythematosus
53 Rheumatoid Arthritis
54 Juvenile Idiopathic Arthritis
55 Sj�gren's Syndrome
56 Scleroderma-Systemic Sclerosis
57 Inflammatory Muscle Diseases
58 Spondyloarthritis
59 Small- and Medium-Vessel Primary Vasculitis
60 Large Vessel Vasculitides
61 Antiphospholipid Syndrome
PART VII Organ-Specific Inflammatory Disease
62 Immunohematologic Disorders
63 Bullous Diseases of the Skin and Mucous Membranes
64 Immunology of Psoriasis
65 Myasthenia Gravis
66 Multiple Sclerosis
67 Autoimmune Peripheral Neuropathies
68 Immunologic Renal Diseases
69 Immunologic Mechanisms of Atherosclerosis and Myocarditis
70 Autoimmune Thyroid Diseases
71 Type 1 Diabetes
72 Immunologic Lung Diseases, 919
73 Chronic Obstructive Pulmonary Disease and Emphysema
74 Immunologic Ocular Disease
75 Immunologic Diseases of the Gastrointestinal Tract
76 Inflammatory Hepatobiliary Diseases
PART VIII Immunology and Immunotherapy of Neoplasia
77 Lymphoid Leukemias
78 Lymphomas
79 Monoclonal Gammopathies
80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy
81 CAR T-Cell Therapy
PART IX Medical Management of Immunological Diseases
82 Immunoglobulin Therapy: Replacement and Immunomodulation
83 Glucocorticoids
84 Immunomodulating Drugs
85 Protein Kinase Antagonists
86 Biologic Response Modifiers
87 Vaccines
88 Allergen Immunotherapy for Allergic Diseases
PART X Transplantation
89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance
90 Allogeneic Transplantation for Immunodeficiency
91 Gene Therapy for Primary Immune Deficiency Diseases
92 Hematopoietic Stem Cell Transplantation for Malignant Diseases
PART XI Diagnostic Immunology
93 Flow Cytometry
94 Assessment of Functional Immune Responses in Lymphocytes
95 Assessment of Neutrophil Function
96 Assessment of Human Allergic Diseases
Appendix 1: Selected CD Molecules and Their Characteristics
Appendix 2: Laboratory Reference Values
Index
