Cardiovascular and Respiratory Bioengineering focuses on computational tools and modeling techniques in cardiovascular and respiratory systems that help develop bioengineered solutions. The book demonstrates how these technologies can be utilized in order to tackle diseases and medical issues. It provides practical guidance on how a bioengineering or medical problem can be modeled, along with which computational models can be used. Topics include computer modeling of Purkinje fibers with different electrical potential applied, modeling of cardiomyopathies caused by sarcomeric gene mutations, altered sarcomere function, perturbations in intracellular ion homeostasis, impaired myocardial energetics at reduced costs, and more.
The book also discusses blood flow through deformable blood vessels in human aorta, abdominal aortic aneurysm, carotid artery, coronary artery and plaque formation, along with content on stent deployment modeling and stent design and optimization techniques.
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Table of Contents
1. Blood flow through arteries2. Computational modeling of plaque progression3. Optimization of stent deployment4. Predictive modelling of Abdominal Aorta Aneurism5. Computer models of Purkinje fibers network with different electrical potential6. Modeling of cardiomyopathies caused by sarcomeric gene mutations7. Design of inhalation drug therapy8. Particles deposition in the respiratory region of the lung9. Transport in the lung airways10. Distribution of inhaled drug particles11. Computational modelling of dry powder inhalers for pulmonary drug delivery
Authors
Nenad Filipovic Faculty of Engineering, Center for Bioengineering, University of Kragujevac; BioIRC, Bioengineering Research and Development Center, Kragujevac, Serbia. Nenad D. Filipovic is Rector of University of Kragujevac, Serbia, full Professor at Faculty of Engineering and Head of Center forBioengineering at University of Kragujevac, Serbia. He was Research Associate at Harvard School of Public Health in Boston,
US. His research interests are in the area of biomedical engineering, cardiovascular disease, fluid-structure interaction,
biomechanics, bioinformatics, biomedical image processing, medical informatics, multi-scale modeling, data mining, software
engineering, parallel computing, computational chemistry and bioprocess modeling. He is author and co-author 16 textbooks and
11 monographies, over 300 publications in peer review journals and over 10 software for modeling with finite element method and discrete methods from biofluid mechanics and multiphysics. He also leads a number of national and international projects in EU and US in area of bioengineering and software development. He is Director of Center for Bioengineering at University of Kragujevac and leads joint research projects with Harvard University and University of Texas in area of bio-nano-medicine computer simulation. He also leads a number of national and international projects in area of bioengineering and bioinformatics. He is a Managing Editor for Journal of Serbian Society for Computational Mechanics and member of European Society of Biomechanics (ESB), European Society for Artificial Organs (ESAO) and IEEE member.
