Feedback Control for Personalized Medicine provides ideas on ongoing efforts and obstacles by members of the control engineering community in different biological and medical applications. In addition, the book presents key challenges, insights, tools and theoretical developments that arise from personalized medicine, along with medical concepts that are explained by engineers to help non-experts follow research topics. Several clinical trials have tried to find therapeutic approaches to achieve eradication or at least lifelong, therapy-free, host control of the infection. This has been performed integrating clinical observations, empirical knowledge and information from medical tests to treat patients.
As this "trial and error� approach is becoming more challenging and unfeasible by the steep increase in the number of different pieces of information and the complexity of large datasets,� a systematic and tractable approach that integrates a variety of biological and medical research data into mathematical models and computational algorithms is crucial to harness knowledge and to develop new therapies towards personalized medicine.
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Table of Contents
1. Introduction to Control Theory Towards Personalized Medicine2. Control schemes for Personalizing Therapies
3. Input-output approaches for personalized drug dosing of antibiotics
4. Safe glycemia regulation considering parameter variations under the offset-free MPC with pulse inputs scheme
5. Glycemia regulation using Neural Networks
6. Personalizing therapeutic treatments in Influenza Infection
7. Polynomial state estimation in infectious diseases
8. Sliding mode control theory interprets elite control of HIV
9. A stochastic model for Hepatitis C viral infection dynamics with the innate immune response
10. First approach to impulsive nonlinear MPC with application to Oncolytic Virus Therapy
11. Is the isolated heart a relaxation oscillator?
Authors
Esteban A. Hernandez-Vargas Associate Professor, Institute of Mathematics, UNAM, Mexico; Research Fellow, Frankfurt Institute for Advanced Studies, Germany. Esteban Abelardo Hernandez Vargas. Associate Professor, Institute of Mathematics, UNAM, Mexico | Research Fellow, Frankfurt Institute for Advanced Studies, Germany.Esteban moved to Ireland to pursue his PhD in Mathematics at the Hamilton Institute, NUI, Ireland. After completing his doctoral studies in 2011, he continued his research as a postdoctoral fellow (2011-2014) at the Helmholtz Centre for Infection Research, Braunschweig, Germany.
In summer 2014, he founded the research group of Systems Medicine of Infectious Diseases at the Helmholtz Centre for Infection Research. In March 2017, his research group was relocated to the Frankfurt Institute for Advanced Studies in Frankfurt am Main, Germany. Since January 2020, he is also Professor at the National Autonomous University of Mexico (UNAM).
Additionally, he was adjunct lecturer at the Otto-von-Guericke-Universit�t Magdeburg as well as a visiting scholar at Los Alamos National Laboratory, Universidad de Guadalajara and CentraleSupelec.
He has published more than 100 peer-reviewed research articles, and one book in infectious diseases.
