The global market for bone graft and substitutes should grow from $8.0 billion in 2021 to $11.5 billion by 2026 with a compound annual growth rate (CAGR) of 7.6% for the period of 2021-2026.
The synthetic bone substitutes market should grow from $3.7 billion in 2021 to $5.3 billion by 2026 with a compound annual growth rate (CAGR) of 7.3% for the period of 2021-2026.
The natural bone grafts market should grow from $4.3 billion in 2021 to $6.2 billion by 2026 with a compound annual growth rate (CAGR) of 7.8% for the period of 2021-2026.
Report Scope
This report will provide details about bone grafts and substitutes used in the treatment of orthopedic disease, facial surgery, dental surgery, and other surgical processes. The report will describe the market impact of COVID-19 and highlight the current and future potential for bone grafts and substitutes with a detailed analysis of the competitive environment. Drivers, restraints, opportunities, pricing analysis, prevalence or orthopedic diseases, orthopedic surgeries and regulatory scenario assessment will be covered. The report offers a market projection for 2026.
The report segments the market for bone grafts and substitutes by product and geography. Product types are synthetic bone substitutes (composite bone substitutes, growth factor substitutes, bone substitutes with living cells) and natural bone grafts (xenograft, autograft, allograft, phytogenic materials).
By geography, the market has been segmented into North America, Europe, Asia Pacific, Latin America and the Middle East and African region. Detailed analysis of major countries such as the U.S., Germany, the U.K., Italy, France, Spain, Japan, China, India, Brazil, Mexico, GCC countries and South Africa are offered. Data will be provided for 2020 as the base year, with estimates for 2021 and forecast value for 2026.
Within each section are discussions of commercialization opportunities. New or emerging devices, techniques and pharmaceuticals are highlighted.
Profiles of leading companies involved with bone grafts and substitutes, tissue transplantation and alternative technologies are included. This report provides information on company placement within the market and strategic analyses of available and emerging products.
This report cites autologous products only in relation to impact on the market for allografts. It does not include blood products, except for peripheral and umbilical cord blood as a source of stem cells.
The Report Includes
- 23 data tables and 26 additional tables
- An overview of the global markets for bone grafts and substitutes used in the treatment of orthopedic disease, facial surgery, dental surgery, and other surgical processes
- Analyses of the global market trends, with historic data from 2019-2020, estimates for 2021, and projections of compound annual growth rates (CAGRs) through 2026
- Evaluation and forecast the overall bone grafts and substitutes market size in dollar value terms, and corresponding market share analysis by product type and geographic region
- Discussion of key market dynamics (DROs), technology advancements, regulatory scenario, pricing analysis, and competitive environment of the vendor companies
- Highlights of the market potential for bone grafts and substitutes, opportunities and gaps estimating current and future demand, and rising incidence and prevalence of orthopedic diseases worldwide
- Country specific data and market value analysis for the U.S., Germany, the U.K., Italy, France, Spain, Japan, China, India, Brazil, Mexico, GCC countries and South Africa
- Impact analysis of COVID-19 pandemic on the progress of bone grafts and substitutes global market
- Insight into the recent industry strategies, merger and acquisition deals, company competitive landscape and value share analysis of the key players operating in the global market
- Profile descriptions of the leading medical device manufacturers and suppliers within the industry, including Johnson & Johnson, Anika Therapeutics Inc., Cook Medical Inc., Patterson Companies, Integra and Zimmer Biomet Holdings
Table of Contents
Chapter 1 Introduction
- Study Goals and Objectives
- Reasons for Doing This Study
- Scope of Report
- Information Sources
- Methodology
- Geographic Breakdown
- Analyst's Credentials
- Custom Research
- Related Reports
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
- Introduction
- Bone Graft and Substitutes: Overview
- Cost of Care
- Solid Organ Preservation
- Ideal Bone Grafting Material
- Natural Bone Graft and Substitute Materials
- Synthetic Bone Substitute Materials
- Composite Bone Substitute Materials
- Bone Substitutes with Infused Living Osteogenic Cells
- Trends in Bone Graft and Substitutes Market
- 3D Tissue Assembly
- Nanotechnology
- Innovation from Small Firms
Chapter 4 Market Dynamics
- Market Drivers
- Rapid Development, Dental Technology
- Elder Population
- Sport Injuries
- Disposable Income
- Market Restraints
- Government Approval
- Lower Outcomes
- Market Opportunities
- Launches, Mergers and Acquisitions (M&A)
- Cosmetic Dentistry
Chapter 5 Market Breakdown, by Product
- Introduction
- Orthopedic Alternatives
- Global Market for Bone Graft and Substitutes
- Synthetic Bone Substitutes
- Market Size and Forecast
- Natural Bone Grafts
- Market Size and Forecast
Chapter 6 Market Breakdown, by Synthetic Bone Substitute
- Composite Bone Substitutes
- Market Size and Forecast
- Growth Factor Substitutes
- Market Size and Forecast
- Bone Substitutes with Living Cells
- Market Size and Forecast
Chapter 7 Market Breakdown, by Natural Bone Graft
- Xenografts
- Market Size and Forecast
- Autograft
- Market Size and Forecast
- Allograft
- Classification of Bone Grafts Based on Material Groups:
- Market Size and Forecast
- Phytogenic Materials
- Market Size and Forecast
Chapter 8 Market Breakdown, by Region
- Global Market for Bone Graft and Substitutes, by Region
- North America
- United States
- Canada
- Mexico
- Europe
- Germany
- France
- U.K.
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- Japan
- China
- India
- Australia and New Zealand
- Rest of Asia-Pacific
- Latin America
- Market Analysis
- Brazil
- Argentina
- Rest of Latin American Countries
- Middle East and Africa
- Market Analysis
- GCC Countries
- South Africa
- Rest of Middle East and African Countries
Chapter 9 Impact of COVID-19
- Introduction
- Minimizing Infection Risk in Recipients
- Donor selection criteria
- Future Perspectives
Chapter 10 Regulations & Reimbursement
- Regulations in the U.S.
- U.S. Federal Regulation of Human Tissue
- History of Regulation in the U.S.
- Regulations Outside the U.S.
- Reimbursement in the U.S.
- Organ Acquisition Costs
- Reimbursement for Hospital Costs
- Reimbursement for Physician Services
- Reimbursement for Immunosuppressants in the U.S.
- Reimbursement Outside the U.S.
- Treatment in EU Countries
Chapter 11 Competitive Landscape
- Global Analysis of Companies
- Mergers and Acquisitions
- Agreements, Launches, Collaborations and Partnerships
Chapter 12 Company Profiles
- Allosource Inc.
- Anika Therapeutics Inc.
- Arthrex Inc.
- Biohorizons Iph
- Biotissue Technologies Gmbh
- Cook Medical Inc.
- Dentsply Sirona
- Globus Medical Inc.
- Integra Lifesciences Corp.
- Johnson & Johnson
- Patterson Companies Inc.
- Seaspine
- Straumann Holding Ag.
- Zimmer Biomet Holdings
Chapter 13 Appendix: Acronyms
List of Tables
Summary Table: Global Market for Bone Graft and Substitutes, by Product, Through 2026
Table 1: Bone Graft Techniques
Table 2: Characteristics of Natural Bone Graft
Table 3: Characteristics of Synthetic Bone Grafts
Table 4: MiMedx: Patent Portfolio
Table 5: Selected Commercial Opportunities for Orthopedic Devices
Table 6: Global Market for Bone Graft and Substitutes, by Product, Through 2026
Table 7: Cartilage and Soft Tissue Biologics and Biomaterials
Table 8: Global Market for Synthetic Bone in Bone Graft and Substitutes, by Region, Through 2026
Table 9: Global Market for Natural Bone-in Bone Graft and Substitutes, by Region, Through 2026
Table 10: Global Market for Composite Bone in Bone Graft and Substitutes, by Region, Through 2026
Table 11: Global Market for Growth Factor Substitutes in Bone Graft and Substitutes, by Region, Through 2026
Table 12: Global Market for Bone Substitutes with Living Cells in Bone Graft and Substitutes, by Region, Through 2026
Table 13: Global Market for Xenograft in Bone Graft and Substitutes, by Region, Through 2026
Table 14: Global Market for Autograft in Bone Graft and Substitutes, by Region, Through 2026
Table 15: Global Market for Allograft in Bone Graft and Substitutes, by Region, Through 2026
Table 16: Global Market for Phytogenic Materials in Bone Graft and Substitutes, by Region, Through 2026
Table 17: Global Market for Bone Graft and Substitutes, by Region, Through 2026
Table 18: North American Market for Bone Graft and Substitutes, by Product, Through 2026
Table 19: North American Market for Bone Graft and Substitutes, by Country, Through 2026
Table 20: European Market for Bone Graft and Substitutes, by Product, Through 2026
Table 21: European Market for Bone Graft and Substitutes, by Country, Through 2026
Table 22: Cost of Bone Damage Repair and Related Disorders, Europe
Table 23: Asia-Pacific Market for Bone Graft and Substitutes, by Product, Through 2026
Table 24: Asia-Pacific Market for Bone Graft and Substitutes, by Country, Through 2026
Table 25: Joint Replacement Procedures, Australia, 2017
Table 26: LATAM Market for Bone Graft and Substitutes, by Product, Through 2026
Table 27: Latin American Market for Bone Graft and Substitutes, by Country, Through 2026
Table 28: MEA Market for Bone Graft and Substitutes, by Product, Through 2026
Table 29: Middle East and African Market for Bone Graft and Substitutes, by Country, Through 2026
Table 30: Immunosuppressive Drugs Currently Covered by Medicare*
Table 31: Overview of Medicare Immunosuppressive Drug Coverage
Table 32: Selected Transplant Industry Acquisitions, 2010-2020
Table 33: AlloSource Inc.: Product Portfolio
Table 34: Anika Therapeutics Inc.: Product Portfolio
Table 35: Arthrex Inc.: Orthopedic Products, by Segment
Table 36: BioHorizons: Products
Table 37: Biotissue Technologies GmbH: Products
Table 38: Cook Medical Inc.: Product Portfolio
Table 39: Dentsply Sirona: Dental Bone Graft and Substitutes Product Portfolio
Table 40: Globus Medical Inc.: Product Portfolio
Table 41: Integra: Product Portfolio
Table 42: Johnson & Johnson: Product Portfolio
Table 43: Patterson Companies: Bone Graft and Substitutes Product Portfolio
Table 44: SeaSpine: Product Portfolio
Table 45: Straumann Holding AG: Product Portfolio
Table 46: Zimmer Biomet Holdings: Product Portfolio
Table 47: Zimmer Biomet Holdings: Products
Table 48: Acronyms Used in This Report
List of Figures
Summary Figure: Global Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 1: Snapshot of Bone Grafts and Substitute Materials
Figure 2: Nanotechnology and Tissue Regeneration
Figure 3: 65+ Population, by Region, 2015 and 2050
Figure 4: Healthcare Expenditures, Select Countries, 2016
Figure 5: National Health Expenditure, U.S., 2016
Figure 6: Average Annual Growth Rate of GDP per Capita vs. Healthcare Spending per Capita, 1970-2016
Figure 7: Global Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 8: Global Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 9: Global Market Share for Natural Bone Grafts, by Product, 2020
Figure 10: Global Market for Synthetic Bone in Bone Graft and Substitutes, 2019-2026
Figure 11: Global Market for Synthetic Bone in Bone Graft and Substitutes, by Region, 2019-2026
Figure 12: Global Market for Natural Bone in Bone Graft and Substitutes, 2019-2026
Figure 13: Global Market for Natural Bone in Bone Graft and Substitutes, by Region, 2019-2026
Figure 14: Global Market for Composite Bone in Bone Graft and Substitutes, 2019-2026
Figure 15: Global Market for Composite Bone in Bone Graft and Substitutes, by Region, 2019-2026
Figure 16: Global Market for Growth Factor Substitutes in Bone Graft and Substitutes, 2019-2026
Figure 17: Global Market for Growth Factor Substitutes in Bone Graft and Substitutes, by Region, 2019-2026
Figure 18: Global Market for Bone Substitutes with Living Cells in Bone Graft and Substitutes, 2019-2026
Figure 19: Global Market for Bone Substitutes with Living Cells in Bone Graft and Substitutes, by Region, 2019-2026
Figure 20: Global Market for Xenograft in Bone Graft and Substitutes, 2019-2026
Figure 21: Global Market for Xenograft in Bone Graft and Substitutes, by Region, 2019-2026
Figure 22: Global Market for Autograft in Bone Graft and Substitutes, 2019-2026
Figure 23: Global Market for Autograft in Bone Graft and Substitutes, by Region, 2019-2026
Figure 24: Global Market for Allograft in Bone Graft and Substitutes, 2019-2026
Figure 25: Number of People Affected, by Common Dental Diseases, 2010
Figure 26: Global Market for Allograft in Bone Graft and Substitutes, by Region, 2019-2026
Figure 27: Global Market for Phytogenic Materials in Bone Graft and Substitutes, 2019-2026
Figure 28: Global Market for Phytogenic Materials in Bone Graft and Substitutes, by Region, 2019-2026
Figure 29: Global Market Share for Bone Graft and Substitutes, by Region, 2020
Figure 30: North American Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 31: North American Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 32: North American Market Share for Natural Bone Grafts, by Product, 2020
Figure 33: North American Market Share for Bone Graft and Substitutes, by Country, 2020
Figure 34: U.S. Market for Bone Graft and Substitutes, 2019-2026
Figure 35: Canadian Market for Bone Graft and Substitutes, 2019-2026
Figure 36: Mexican Market for Bone Graft and Substitutes, 2019-2026
Figure 37: European Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 38: European Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 39: European Market Share for Natural Bone Grafts, by Product, 2020
Figure 40: European Market Share for Bone Graft and Substitutes, by Country, 2020
Figure 41: German Market for Bone Graft and Substitutes, 2019-2026
Figure 42: French Market for Bone Graft and Substitutes, 2019-2026
Figure 43: U.K. Market for Bone Graft and Substitutes, 2019-2026
Figure 44: Italian Market for Bone Graft and Substitutes, 2019-2026
Figure 45: Spanish Market for Bone Graft and Substitutes, 2019-2026
Figure 46: Rest of European Market for Bone Graft and Substitutes, 2019-2026
Figure 47: Asia-Pacific Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 48: Asia-Pacific Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 49: Asia-Pacific Market Share for Natural Bone Grafts, by Product, 2020
Figure 50: Asia-Pacific Market Share for Bone Graft and Substitutes, by Country, 2020
Figure 51: Japanese Market for Bone Graft and Substitutes, 2019-2026
Figure 52: Chinese Market for Soft Tissue Allograft, 2019-2026
Figure 53: Indian Market for Bone Graft and Substitutes, 2019-2026
Figure 54: Australia and New Zealand Market for Bone Graft and Substitutes, 2019-2026
Figure 55: Rest of Asia-Pacific Market for Bone Graft and Substitutes, 2019-2026
Figure 56: LATAM Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 57: LATAM Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 58: LATAM Market Share for Natural Bone Grafts, by Product, 2020
Figure 59: Latin American Market Share for Bone Graft and Substitutes, by Country, 2020
Figure 60: Brazilian Market for Bone Graft and Substitutes, 2019-2026
Figure 61: Argentinian Market for Bone Graft and Substitutes, 2019-2026
Figure 62: Rest of Latin American Market for Bone Graft and Substitutes, 2019-2026
Figure 63: MEA Market Share for Bone Graft and Substitutes, by Product, 2020
Figure 64: MEA Market Share for Synthetic Bone Substitutes, by Product, 2020
Figure 65: MEA Market Share for Natural Bone Grafts, by Product, 2020
Figure 66: Middle East and African Market Share for Bone Graft and Substitutes, by Country, 2020
Figure 67: GCC Countries Market for Bone Graft and Substitutes, 2019-2026
Figure 68: South African Market for Bone Graft and Substitutes, 2019-2026
Figure 69: Rest of Middle East and African Market for Bone Graft and Substitutes, 2019-2026
Figure 70: Organ Transplantation, COVID-19
Figure 71: Medical Insurance, Dental Implants
Figure 72: Global Market Share for Bone Graft and Substitutes, by Company, 2020
Figure 73: AlloSource Inc.: Annual Revenue, 2016-2020
Figure 74: Anika Therapeutics Inc.: Annual Revenue, 2016-2020
Figure 75: Anika Therapeutics Inc.: Revenue Share, by Region/Country, 2020
Figure 76: Anika Therapeutics Inc.: Revenue Share, by Business Unit, 2020
Figure 77: Dentsply Sirona: Annual Revenue, 2017-2020
Figure 78: Dentsply Sirona: Revenue Share, by Region/Country, 202
Figure 79: Dentsply Sirona: Yearly Revenue, by Dental Consumable Product, 2017-2020
Figure 80: Johnson & Johnson: Annual Revenue, 2016-2020
Figure 81: Johnson & Johnson: Revenue Share, by Region/Country, 2019
Figure 82: Johnson & Johnson: Revenue Share, by Business Unit, 2019
Figure 83: Patterson Companies: Annual Revenue, 2018-2020
Figure 84: Patterson Companies: Revenue Share, by Region, 2020
Figure 85: Patterson Companies Inc.: Revenue Share, by Segment, 2020
Figure 86: Straumann Holding AG: Annual Revenue, 2017-2020
Figure 87: Straumann Holding AG: Revenue Share, by Region/Country, 2020
Figure 88: Zimmer Biomet Holdings: Annual Revenue, 2016-2020
Figure 89: Zimmer Biomet Holdings: Revenue Share, by Region, 2020
Figure 90: Zimmer Biomet Holdings: Revenue Share, by Product, 2020
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Executive Summary
The high growth rate of this segment is attributed to factors such as demand for bone graft and substitutes in the U.S., Europe and some Asian countries; a rise in chronic diseases; increased prevalence of anterior cruciate ligament (ACL) reconstruction; increasing bone and musculoskeletal transplants; expansion of sports medicine and spine/neurology and significant use treating prominent or life-threatening disorders caused by accidents.
The key market players include Globus Medical, Integra Lifescience, Patterson Companies Inc., Seaspine, Dentsply Sirona, AlloSource Inc., Zimmer Biomet Holdings, Institut Straumann AG, Johnson & Johnson and Anika Therapeutics.
The high growth rate is attributed to demand for bone allografts for aesthetic surgery in the U.S., Europe and some Asian countries; a rise in dental diseases; increased incidence of mucogingival surgery and aesthetic demand; soft tissue augmentation for implant dentistry and significant use for treatment due to accidents.
Companies Mentioned
- Allosource Inc.
- Anika Therapeutics Inc.
- Arthrex Inc.
- Biohorizons Iph
- Biotissue Technologies Gmbh
- Cook Medical Inc.
- Dentsply Sirona
- Globus Medical Inc.
- Integra Lifesciences Corp.
- Johnson & Johnson
- Patterson Companies Inc.
- Seaspine
- Straumann Holding Ag.
- Zimmer Biomet Holdings
Table Information
| Report Attribute | Details |
|---|---|
| No. of Pages | 181 |
| Published | November 2021 |
| Forecast Period | 2021 - 2026 |
| Estimated Market Value ( USD | $ 8 Billion |
| Forecasted Market Value ( USD | $ 11.5 Billion |
| Compound Annual Growth Rate | 7.6% |
| Regions Covered | Global |
| No. of Companies Mentioned | 14 |
