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CD47 Targeting Therapeutics Market by Target Disease Indication, Type of Molecule Key Players and Key Geographical Regions: Industry Trends and Global Forecasts, 2021-2035

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    Report

  • 178 Pages
  • September 2021
  • Region: Global
  • Roots Analysis
  • ID: 5510465

Overview

According to the World Health Organization (WHO), at present, cancer is the second leading cause of death, worldwide. The National Cancer Institute (NCI) has estimated that, by 2030, over 22 million individuals are likely to be diagnosed with various types of cancer, in the US alone. As a result of the growing patient population affected by this disease, there is a rise in the demand for effective treatment modalities. The conventional approaches, such as chemotherapy, surgery and radiation therapy, employed for the treatment of oncological indication(s) are considered to be inadequate, specifically for late-stage cancers. Therefore, in recent years, the focus of the research community has shifted towards the development of novel treatment modalities, such as T- cell immunotherapies, that exhibit high efficacy. However, certain limitations are associated with the aforementioned class of therapies as well; they have been demonstrated to have off-target and toxic side effects, including cytokine release syndrome and neurotoxicity. This has further led to significant research initiatives aimed at identifying target specific drug candidates. Among such initiatives, CD47, owing to its increased expression on the surface of cancer cells, has emerged as a cancer immune checkpoint biomarker. Published literature further indicates that tumor growth and metastasis can be inhibited by blocking the interaction between CD47 and the signal-regulating protein alpha (SIRPα).

Currently, there are no approved therapies based on the inhibition of CD47/SIRPα pathway for advanced stage oncological indication(s), including myelodysplastic syndromes (MDS), non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Drug developers across the world claim to be evaluating several therapeutics, having dual specificities, in order to enhance the efficacy and expand the number of target modalities. In other words, candidates capable of targeting biomarkers, such as HER2, PD-L1, CD-38, CD-40 and CD-20, in addition to CD47, are being investigated across several studies. Even though majority of the drug candidates are currently in preclinical/initial clinical stages, developers are optimistic regarding the therapeutic potential of this emerging class of drugs. Validation of the efficacy of anti-CD47 therapeutics as a promising treatment for oncological indications can be further asserted through the rapidly growing number of research publications, patents and clinical trials focused on this subject. We believe that this niche, but upcoming market, is poised to witness healthy growth over the next decade, with pioneers in the field likely to benefit from the first-to-market advantage. 


Scope of the Report

The “CD47 Targeting Therapeutics Market by Target Disease Indication (Acute Myeloid Leukemias, Non-Hodgkin Lymphoma, Colorectal Cancers, Diffuse Large B-cell Lymphoma, Myelodysplastic Syndromes, Non-Small Cell Lung Cancers, Ovarian Epithelial Cancer, Oral Muscositis, Small Cell Lung Cancers), Type of Molecule (Biologics and Small Molecule) Key Players and Key Geographical Regions (US, France, Germany, Italy, Spain, UK, Australia, China, India and Israel): Industry Trends and Global Forecasts, 2021-2035” report features an extensive study of the current landscape, offering an informed opinion on the likely adoption of CD47 targeting therapeutics in the healthcare industry, over the next 15 years. The report features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain. 


Amongst other elements, the report features:

  • A detailed overview of the current market landscape of CD47 targeting therapeutics, along with information on several relevant parameters, such as phase of development (clinical and preclinical), target disease indication(s), therapeutic area (hematological malignancies, dermatological disorders, solid tumors, unspecified oncological disorders, and other disorders), target molecule, type of molecule (biological and small molecules), type of therapy (monotherapies, and combination therapies), type of biologic (monoclonal antibody, bi-specific antibody, recombinant fusion protein, peptide), route of administration (intravenous, subcutaneous, and intraperitoneal), and special drug designation awarded (if any). In addition, it presents details of the companies engaged in the development of CD47 targeting therapeutics, as well as information on their year of establishment, company size (in terms of employee count), and location of respective headquarters.
  • Elaborate profiles of key players engaged in the development of CD47 targeting therapeutics. Each profile features a brief overview of the company, details on its drug candidates, financial information (if available), recent developments and an informed future outlook.
  • A detailed analysis of completed, ongoing and planned clinical trials of various CD47 targeting therapeutics, based on several relevant parameters, such as trial registration year, number of patients enrolled, gender of patients enrolled, trial phase, recruitment status and study design, leading sponsors/collaborators, most active players (in terms of number of trials conducted), type of organization, popular therapeutic areas, and regional distribution of trials. 
  • A detailed review of close to 600 peer-reviewed, scientific articles related to research on CD47 targeting therapies over the past few years, based on several relevant parameters, such as year of publication, type of publication, therapeutic area, target indication and key journals (in terms of number of articles published).
  • An analysis of the recent partnerships inked between various players engaged in the development of CD47 targeting therapies, during the period 2016-2021, based on several relevant parameters, such as number of partnership instances, type of partnerships, regional distribution (continent and country-wise) and most active players (in terms of number of partnership).
  • A detailed analysis of various investments, such as venture capital financing, debt financing, grants/awards, capital raised from IPOs and subsequent offerings that were undertaken by companies engaged in this domain, during the period 2016-2021.
  • An analysis highlighting the key opinion leaders (KOLs) in this domain. It features a 2×2 matrix assessing the relative experience of KOLs shortlisted based on their contributions (in terms of involvement in various clinical studies) in this domain, and a schematic world map representation, indicating the geographical location of eminent scientists/researchers engaged in the development of CD47-based therapies.
  • An analysis highlighting various social media trends (Twitter), along with information on prominent accounts, popular keywords and hashtags, as well as year and number of tweets added by players engaged in the development of CD47-based therapies.
  • An analysis of the companies engaged within this domain, featuring a 3-D bubble chart analysis of different peer groups (North America, Europe and Asia-Pacific), based on various parameters, such as pipeline strength, portfolio diversity and portfolio strength
  • An analysis of big pharma players engaged in this domain, featuring a wind rose chart based on several relevant parameters, such as number of therapeutics under development, phase of development, line of therapy, number of indications targeted and years of experience.
  • An analysis of the start-ups (established between 2011-2020; less than 200 employees) engaged in the development of CD47 based therapeutics, based on several parameters, such as number of candidates in discovery, preclinical and clinical phases of development, number of indications targeted, amount raised, number of investors, type of funding and number of deals inked.

One of the key objectives of the report was to estimate the existing market size and future growth opportunity associated with CD47 targeting therapeutics developers, over the next 15 years. Further, we have provided an informed estimate of the market’s evolution, during the period 2021-2035, based on several relevant parameters, such as adoption trends, and expected price variations for these products. The report features the likely distribution of the current and forecasted opportunity within the CD47 targeting therapeutics market across [A] target disease indication (acute myeloid leukemias, non-Hodgkin lymphoma, colorectal cancers, diffuse large b-cell lymphoma, myelodysplastic syndromes, non-small cell lung cancers, ovarian epithelial cancer, oral muscositis, small cell lung cancers), [B] type of molecule (biologics and small molecules), [C] key players and [D] key geographical regions (US, France, Germany, Italy, Spain, UK, Australia, China, India and Israel). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth. 

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.


Key Questions Answered

  • Who are the leading players engaged in the development of CD47 targeting therapeutics?
  • Which are the key drugs being developed across early and late stages of development?
  • Which companies are actively involved in conducting clinical trials for their therapeutics? 
  • What is the evolving trend related to the focus of publications related to CD47 targeting therapeutics?
  • What kind of partnership models are commonly adopted by industry stakeholders? 
  • Who are the key investors in this domain? 
  • Who are the key opinion leaders/experts in this field?
  • What are the evolving social media trends related to CD47 targeting therapeutics?
  • What are the different initiatives undertaken by big pharma players for the development of CD47 therapeutics in the recent past? 
  • How is the current and future opportunity likely to be distributed across key market segments?

Table of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines

2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. Key Historical Events related to CD47 Targeting Therapies
3.3. Application Areas
3.4. Mechanism of Action
3.5. Associated Side Effects and Likely Solutions
3.6. Key Features
3.7. Target Indications
3.8. Future Outlook

4. MARKET OVERVIEW
4.1. Chapter Overview
4.2. CD-47 Targeting Therapeutics: Market Landscape
4.2.1. Analysis by Type of Molecule
4.2.2. Analysis by Target Protein
4.2.3. Analysis by Type of Biologic
4.2.4. Analysis by Route of Administration
4.2.5. Analysis by Type of Molecule and Route of Administration
4.2.6. Analysis by Line of Treatment
4.2.7. Analysis by Phase of Development
4.2.8. Analysis by Therapeutic Area
4.2.9. Analysis by Target Indication
4.2.10. Analysis by Type of Therapy
4.3. CD-47 Therapeutics: Developer Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters
4.3.4. Analysis by Number of Pipeline Candidates
4.3.5. Analysis by Phase of Development
4.3.6 Analysis by Regional Strength
4.3.7. Analysis by Company Size and Location of Headquarters
4.3.8. Analysis by Year of Establishment, Company Size and Location of Headquarters

5. COMPANY PROFILES
5.1. Abpro
5.1.1. Company Overview
5.1.2. Financial Information
5.1.3. Product Portfolio
5.1.4. Recent Developments and Future Outlook
5.2. ALX Oncology
5.2.1. Company Overview
5.2.2. Financial Information
5.2.3. Product Portfolio
5.2.4. Recent Developments and Future Outlook
5.3. Apmonia Therapeutics
5.3.1. Company Overview
5.3.2. Financial Information
5.3.3. Product Portfolio
5.3.4. Recent Developments and Future Outlook
5.4. Arch Oncology
5.4.1. Company Overview
5.4.2. Financial Information
5.4.3. Product Portfolio
5.4.4. Recent Developments and Future Outlook
5.5. Aurigene
5.5.1. Company Overview
5.5.2. Financial Information
5.5.3. Product Portfolio
5.5.4. Recent Developments and Future Outlook
5.6. Bristol Myers Squibb
5.6.1. Company Overview
5.6.2. Financial Information
5.6.3. Product Portfolio
5.6.4. Recent Developments and Future Outlook
5.7. EpicentRx
5.7.1. Company Overview
5.7.2. Financial Information
5.7.3. Product Portfolio
5.7.4. Recent Developments and Future Outlook
5.8. Forty Seven
5.8.1. Company Overview
5.8.2. Financial Information
5.8.3. Product Portfolio
5.8.4. Recent Developments and Future Outlook
5.9. ImmuneOncia Therapeutics
5.9.1. Company Overview
5.9.2. Financial Information
5.9.3. Product Portfolio
5.9.4. Recent Developments and Future Outlook
5.10. ImmuneOnco Biopharmaceuticals
5.10.1. Company Overview
5.10.2. Financial Information
5.10.3. Product Portfolio
5.10.4. Recent Developments and Future Outlook
5.11. Innovent Biologics
5.11.1. Company Overview
5.11.2. Financial Information
5.11.3. Product Portfolio
5.11.4. Recent Developments and Future Outlook
5.12. KAHR Medical
5.12.1. Company Overview
5.12.2. Financial Information
5.12.3. Product Portfolio
5.12.4. Recent Developments and Future Outlook
5.13. Light Chain Bioscience
5.13.1. Company Overview
5.13.2. Financial Information
5.13.3. Product Portfolio
5.13.4. Recent Developments and Future Outlook
5.14. Morphiex
5.14.1. Company Overview
5.14.2. Financial Information
5.14.3. Product Portfolio
5.14.4. Recent Developments and Future Outlook
5.15. Trillium Therapeutics
5.15.1. Company Overview
5.15.2. Financial Information
5.15.3. Product Portfolio
5.15.4. Recent Developments and Future Outlook

6. CLINICAL TRIAL ANALYSIS
6.1. Chapter Overview
6.2. Scope and Methodology
6.3. CD-47 Targeting Therapeutics: List of Clinical Trials
6.3.1. Analysis by Trial Status
6.3.2. Analysis by Trial Registration Year
6.3.3. Analysis by Trial Status and Trial Registration Year
6.3.4. Analysis by Number of Patients Enrolled and Phase of Development
6.3.5. Analysis by Type of Sponsor
6.3.6. Analysis by Target Patient Group
6.3.7. Analysis by Study Type
6.3.8. Analysis by Type of Masking
6.3.9. Analysis by Type of Interventional Model
6.3.10. Analysis by Primary Purpose of Trial
6.3.11. Analysis of Enrolled Patient Population by Geography

7. PUBLICATION ANALYSIS
7.1. Chapter Overview
7.2. Scope and Methodology
7.3. CD-47 Therapeutics: List of Publications
7.3.1. Analysis by Year of Publication
7.3.2. Analysis by Type of Publication
7.3.3. Analysis by Therapeutic Area
7.3.4. Analysis by Target Indication
7.3.5. Analysis by Affiliation of First Author
7.3.6. Leading Players: Analysis by Number of Publications
7.3.7. Key Journals: Analysis by Number of Publications

8. PARTNERSHIPS AND COLLABORATIONS
8.1. CD-47 Therapeutics: List of Partnerships and Collaborations
8.1.1 Cumulative Analysis by Year, 2015-2021
8.1.1. Analysis by Type of Partnership
8.1.2. Analysis by Year and Type of Partnership
8.1.3. Analysis by Type of Partner
8.1.4. Analysis by Year by Type of Partner
8.1.5. Analysis by Type of Partner andType of Partnership
8.1.6. Most Active Players: Analysis by Number of Partnerships
8.1.7. Analysis by Region (Continent-wise)
8.1.7.1 Intercontinental and Intracontinental Agreements
8.1.8. Analysis by Region (Country-wise)
8.1.8.1 Local and International Agreements

9. FUNDING AND INVESTMENTS
9.1. CD-47 Therapeutics: List of Funding and Investments
9.1.1. Cumulative Analysis of Funding Instances by Year, 2015-2021
9.1.5. Analysis of Number of Instances by Type of Funding
9.1.2. Analysis of Instances by Year and Type of Funding, 2015-2021
9.1.3. Cumulative Analysis of Amount Invested by Year, 2015-2021
9.1.4. Analysis of Amount Invested by Year and Type of Funding, 2015-2021
9.1.6. Analysis of Amount Invested by Type of Funding
9.1.7. Analysis of Instances by Geography
9.1.8. Analysis of Total Amount Invested by Geography
9.1.9. Most Active Players: Analysis by Number of Instances
9.1.10. Most Active Players: Analysis by Amount Raised
9.1.11. Most Active Investors: Analysis by Number of Funding Instances,

10. KEY OPINION LEADERS
10.1. CD-47 Therapeutics: List of Key Opinion Leaders
10.1.1. Analysis by Type of Current Organization
10.1.2. Analysis by Geography
10.1.2.1. Analysis by Region (Continent-wise Distribution)
10.1.2.2. Analysis by Region (Country-wise Distribution)
10.1.3. Analysis by Number of Investigators and Current Organization
10.1.4. Analysis by Qualification of KOL
10.1.5. Comparison of KOL Activeness v/s Strength (Scatter Plot)
10.1.6. Comparison of Publisher Score v/s Third Party Score
10.1.7. Prominent Players: Comparison of Publisher Score v/s Third Party Score
10.1.8. Analysis by Region
10.1.9. Most Active Key Opinion Leaders: Comparison of Professional Network v/s Academic Strength

11. EMERGING TRENDS ON SOCIAL MEDIA
11.1. Chapter Overview
11.2. CD-47 Therapeutics: Trends on Twitter
11.2.1. Historical Trend in Volume of Tweets
11.2.2. Trending Words / Phrases on Twitter
11.2.3. Most Popular Drugs on Twitter
11.2.4. Most Prolific Authors on Twitter
11.2.5. Most Popular Indications

12. COMPANY COMPETITIVENESS ANALYSIS
12.1. Chapter Overview
12.2. Methodology and Key Parameters
12.3. CD-47 Therapy Developers
12.3.1. Peer Group 1: Players based in North America
12.3.2. Peer Group 2: Players based in Europe
12.3.3. Peer Group 3: Players based in Asia-Pacific

13. BIG PHARMA PLAYERS
13.1. Chapter Overview
13.2. Methodology and Key Parameters
13.2.1. Analysis by Pipeline Strength
13.2.2. Analysis by Funding and Investments
13.2.3. Analysis by Partnerships
13.2.4. Analysis by Clinical Trials
13.2.5. Summary of Big Pharma Activity

14. START-UP HEALTH INDEXING
14.1. Chapter Overview
14.2. Start-ups Focused on CD-47 Targeting Therapeutics
14.3. Methodology and Key Parameters
14.4.1 Analysis by Location of Headquarters
14.2.3. Analysis by Pipeline Maturity
14.2.4. Analysis by Pipeline Strength
14.2.5. Analysis by Indication Diversity
14.2.6. Analysis by Capital Accrued through Investments
14.2.7. Analysis by Number of Investors
14.2.8. Analysis by Partnership Activity
14.2.9. Start-ups Health Indexing: Publisher Perspective

15. MARKET SIZING AND OPPORTUNITY ANALYSIS
15.1. Chapter Overview
15.2. Scope and Limitations
15.3. Key Assumptions and Forecast Methodology
15.4. Global CD-47 Targeting Therapeutics Market, 2021-2035
15.5. CD-47 Targeting Therapeutics Market, 2021-2035: Analysis by Target Indication
15.5.1. CD-47 Targeting Therapeutics Market for Acute Myeloid Leukemia
15.5.2. CD-47 Targeting Therapeutics Market for Colorectal Neoplasms
15.5.3. CD-47 Targeting Therapeutics Market for Diffuse-Large Cell Lymphoma
15.5.4. CD-47 Targeting Therapeutics Market for Myelodysplastic Syndromes
15.5.5. CD-47 Targeting Therapeutics Market for Non-Hodgkin Lymphoma
15.5.6. CD-47 Targeting Therapeutics Market for Non-Small Cell Lung Cancer
15.5.7. CD-47 Targeting Therapeutics Market for Oral Muscositis
15.5.8. CD-47 Targeting Therapeutics Market for Ovarian Epithelial Cancer
15.5.9. CD-47 Targeting Therapeutics Market for Small Cell Lung Cancer
15.6. CD-47 Targeting Therapeutics Market, 2021-2035: Analysis by Type of Molecule
15.6.1. CD-47 Targeting Therapeutics Market for Biologics
15.6.2. CD-47 Targeting Therapeutics Market for Small Molecules
15.7. CD-47 Targeting Therapeutics Market, 2021-2035: Analysis by Geography
15.7.1. CD-47 Targeting Therapeutics Market in the US
15.7.2. CD-47 Targeting Therapeutics Market in France
15.7.3. CD-47 Targeting Therapeutics Market in Germany
15.7.4. CD-47 Targeting Therapeutics Market in Italy
15.7.5. CD-47 Targeting Therapeutics Market in Spain
15.7.6. CD-47 Targeting Therapeutics Market in UK
15.7.7. CD-47 Targeting Therapeutics Market in Australia
15.7.8. CD-47 Targeting Therapeutics Market in China
15.7.9. CD-47 Targeting Therapeutics Market in India
15.7.10. CD-47 Targeting Therapeutics Market in Israel
15.8. Drug-wise Sales Forecast
15.8.1. CPO-127 (Conjupro biotherapeutics)
15.8.1.1. Target Patient Population
15.8.1.2. Value Creation Analysis
15.8.2. DSP-107 (KAHR Medical)
15.8.2.1. Target Patient Population
15.8.2.2. Value Creation Analysis
15.8.3. IBI188 (Innovent Biologics)
15.8.3.1. Target Patient Population
15.8.3.2. Value Creation Analysis
15.8.4. Magrolimab (Forty Seven)
15.8.4.1. Target Patient Population
15.8.4.2. Value Creation Analysis
15.8.5. RRX-001 (EpicentRx)
15.8.5.1. Target Patient Population
15.8.5.2. Value Creation Analysis

16. APPENDIX 1: LIST OF COMPANIES AND ORGANIZATIONS

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • 3×5 Partners
  • 3D Medicines (3DMed)
  • AbbVie
  • Abpro 
  • Acerta Pharma
  • Adage Capital Management
  • Akeso
  • Alector
  • ALX Oncology
  • Apmonia Therapeutics
  • Arch Oncology
  • Ascentage Pharma 
  • Aurigene Discovery Technologies
  • Avego Healthcare Capital
  • Avidity Partners
  • Beijing Institute of Biotechnology
  • BIOCAD
  • Biotech Alliances International
  • Bio-Thera Solutions
  • BliNK Biomedical
  • bluebird bio
  • Boehringer Ingelheim
  • Boxer Capital
  • Bristol-Myers-Squibb
  • BVF Partners
  • California Institute for Regenerative Medicine (CIRM) 
  • Cancer Focus Fund
  • Chia Tai Tianqing Pharmaceutical Group
  • Chinese Academy of Sciences
  • Chinook Therapeutics
  • Clarus Ventures 
  • Conjupro Biotherapeutics
  • Cormorant Asset Management
  • Cowen Healthcare Investments 
  • DAFNA Capital Management
  • EcoR1 Capital
  • Eli Lilly
  • Elpiscience
  • Emerson Collective
  • EMulate Therapeutics
  • EpicentRx
  • Eventide Asset Management
  • Fidelity Management & Research Company
  • Flerie Invest 
  • FMB Research and Broadfin 
  • Foresite Capital
  • Forty Seven
  • Gateway Biologics (A subsidiary of ShangPharma)
  • Genentech
  • Genmab
  • Gilead Sciences
  • GlaxoSmithKline
  • GV 
  • Hadasit Bio Holdings
  • Hanmi Pharmaceuticals
  • Hatteras Venture Partners
  • HBM Healthcare Investments
  • Ichnos Sciences
  • I-Mab Biopharma
  • ImmuneOncia Therapeutics
  • ImmuneOnco Biopharmaceuticals
  • Innovent Biologics
  • ISU ABXIS
  • Janssen
  • Janus Henderson Investors
  • K2 HealthVentures
  • KAHR Medical
  • Leukemia & Lymphoma Society (LLS) 
  • Li Cheng Enterprise
  • Light Chain Bioscience
  • Lightspeed Venture Partners 
  • Lightstone Ventures 
  • Lilly Asia Ventures (LAV)
  • Logos Capital
  • Lonza 
  • LYFE Capital
  • Lynkcell
  • MacroGenics
  • Merck
  • Mirae Asset Venture Investment
  • Morphiex Biotherapeutics
  • Mountain Pacific Venture 
  • Navigen Pharmaceuticals
  • New Enterprise Associates
  • Novartis Institutes for BioMedical Research
  • Novimmune
  • Novo Nordisk
  • Ono Pharmaceutical 
  • Oriella
  • OSE Immunotherapeutics
  • Paradigm Shift Therapeutics
  • Partner Fund Management
  • Pavilion Capital 
  • Peregrine Ventures
  • Pfizer
  • PharmAbcine
  • Piper Sandler 
  • Point72 Asset Management
  • QLSF Biotherapeutics
  • Redmile Group
  • RiverVest Venture Partners
  • Roche
  • Roche Venture Fund
  • Saiyuan
  • Samsung BioLogics
  • Sanquin 
  • SATT Nord
  • SciClone Pharmaceuticals
  • Shanghai Zhangke Lingyi Investment 
  • Shattuck Labs
  • Shavit Capital 
  • Shengzhou Minglang Industrial Development
  • Shijiazhuang High Tech Zone Puen Guoxin 
  • Sorrento Therapeutics
  • Stanford University
  • Sutter Hill Ventures
  • SWISS BIOPHARMA MED 
  • Synthon Biopharmaceuticals
  • Tallac Therapeutics
  • TG Therapeutics
  • Thomas Jefferson University
  • Trillium Therapeutics
  • University Medical Center Groningen
  • venBio 
  • Venrock Healthcare Capital Partners
  • Vivo Capital
  • Vivoryon Therapeutics
  • Washington University School of Medicine
  • Waterstone Hanxbio
  • Xinxiang Medical University
  • Zai Lab
  • Zymeworks

Methodology

 

 

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