Complicated Urinary Tract Infections - Epidemiology Forecast - 2034

Key Highlights

• Urinary tract infections (UTIs) are amongst the most frequent bacterial infections. They can manifest clinically in various ways, from relatively benign, uncomplicated infections to complicated UTIs (cUTIs), pyelonephritis, and severe urosepsis. cUTI is a heterogeneous entity comprising multiple forms.
• The clinical presentation of symptomatic infection in patients with complicated urinary infection varies across a wide spectrum, ranging from mild lower tract irritative symptoms, such as frequency and urgency, to severe systemic manifestations, such as bacteremia and sepsis. Complete urinary obstruction or trauma to the bacteriuric genitourinary tract, especially with hematuria, appears to be associated with more severe clinical presentations.
• The diagnosis of a cUTI is based on three main features: the clinical picture, microbiological tests, and radiological investigations. The most common clinical presentations of UTI include acute cystitis, pyelonephritis, and less commonly acute prostatitis, but patients with abnormal urinary tracts can present more atypically. Ultrasound and CT scans may sometimes be useful or even critical for diagnosing a perinephric abscess, urinary retention, hydronephrosis, and obstructive pyelonephritis from stones in septic patients.
• In the 7MM, the highest cases of age-specific cUTI were observed in the age group of 65-84 years, which were around 4,000,000 cases in 2023.
• As per the analysis, the United States showed the highest number of diagnosed-incident cases of cUTI, accounting for nearly 42% of the diagnosed-incident cases of cUTI in the 7MM in 2023.
• In 2023, approximately 200,000 cUTI incident cases progressed from uUTI in Japan.

The “Complicated Urinary Tract Infection (cUTI) - Epidemiology Forecast - 2034” report delivers an in-depth understanding of cUTI, historical and forecasted epidemiology in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

cUTI Disease Understanding and Diagnostic Algorithm

cUTI Overview

Urinary tract infections (UTIs) are one of the most frequent infectious illnesses in the world, yet they remain understudied. Although uropathogenic E. coli (UPEC) accounts for a high percentage of UTIs, various bacteria, each of which will have its host-pathogen interactions with the bladder environment, can infect the urinary tract.

UTIs come in various clinical morphologies, ranging from relatively benign, uncomplicated infections to complicated UTIs (cUTIs), pyelonephritis, and severe urosepsis. As a result, the stratification of individuals with UTIs is critical. There are several categorization methods for UTIs, with the common reasoning that complicated UTIs have a greater risk of recurrence, chronification, progression, or catastrophic results than uncomplicated UTIs. Host factors, rather than pathogen characteristics, dictate the pathogenesis and management of cUTIs and pyelonephritis. High antibiotic resistance rates among causative microorganisms are linked to cUTIs and pyelonephritis.

cUTI Diagnosis

This diagnosis of a cUTI is based on three main features: the clinical picture, microbiological tests, and radiological investigations. Physicians should always consider atypical microbiology and the potential for urinary tract obstruction (UTO), which may require prompt drainage in this patient group.

The most common clinical presentations of UTI include acute cystitis, pyelonephritis, and less commonly acute prostatitis, but patients with abnormal urinary tracts can present more atypically. A carefully taken history is an essential diagnostic tool, with particular attention to the symptoms of frequency, dysuria, hematuria, suprapubic, and/or loin pain.

Basic laboratory tests may reveal elevated inflammatory markers, and renal function should be recorded. The urine dipstick is a simple and cheap bedside test and is very useful in confirming a diagnosis of UTI.

Radiological investigations are not helpful in the initial diagnosis of most infections limited to the genitourinary tract, as there should be sufficient clues from the history, physical examination, and laboratory results. Ultrasound and CT scans may sometimes be useful or even critical for diagnosing a perinephric abscess, urinary retention, hydronephrosis, and obstructive pyelonephritis from stones in septic patients.

cUTI Epidemiology

The cUTI epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total diagnosed incident cases of cUTI, diagnosed incident cases of cUTI progressed from uUTI, age-specific cases, pathogen-specific cases, and total treated cases of cUTI in the United States, EU4 countries (Germany, France, Italy, Spain) and the United Kingdom, and Japan from 2020 to 2034.

• In the 7MM, nearly 1,000,000 cUTI incident cases progressed from uUTI in the year 2023, which is expected to increase during the forecast period (2024-2034).
• In the US, maximum number of cUTI cases were observed for the age group of 65-84 years, followed by =85 years.
• Among the EU4 and the UK, Germany recorded the highest number of diagnosed-incident cases of cUTI with approximately 26% cases in 2023, which is estimated to rise by 2034, at a CAGR of 0.6%.
• Japan accounted for around 800,000 cases of cUTI in 2023 caused due to Uropathogenic Escherichia coli, followed by 100,000 cases caused by Klebsiella pneumoniae.

Scope of the Report

• The report covers a segment of key events, an executive summary, and a descriptive overview of cUTI, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
• Comprehensive insight into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, and disease progression have been provided.
• A detailed review of current challenges in establishing diagnosis and diagnosis rate is provided.

cUTI Report Insights

• Patient Population
• Total Diagnosed Incident Cases of cUTI, Diagnosed Incident Cases of cUTI Progressed From uUTI, Age-specific Cases, Pathogen-specific Cases, and Total Treated Cases of cUTI
• Country-wise Epidemiology Distribution

cUTI Report Key Strengths

• Eleven-year Forecast
• The 7MM Coverage
• cUTI Epidemiology Segmentation

cUTI Report Assessment

• Epidemiology Segmentation
• Current Diagnostic Practices

Key Questions

Epidemiology Insights

• What are the disease risk, burdens, and unmet needs of cUTI? What will be the growth opportunities across the 7MM with respect to the patient population pertaining to cUTI?
• What is the historical and forecasted cUTI patient pool in the United States, EU4 (Germany, France, Italy, Spain) and the United Kingdom, and Japan?
• What is the diagnostic pattern of cUTI?
• Which clinical factors will affect cUTI?
• Which factors will affect the increase in the diagnosis of cUTI?

Reasons to buy

• Insights on disease burden, details regarding diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the change in cUTI cases in varying geographies over the coming years.
• Detailed overview on total diagnosed incident cases of cUTI, diagnosed incident cases of cUTI progressed from uUTI, age-specific cases, pathogen-specific cases, and total treated cases of cUTI is included.
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the treatment-eligible patient pool.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.