Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations' role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks.
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Table of Contents
SECTION 1 Foundations of Clinical Decision Support and Pharmacogenomic Precision Medicine
1. Overview of Effective Pharmacogenomic Clinical Decision Support
2. Scientific Evidence and Sources of Knowledge for Pharmacogenomics
3. Laboratory Considerations for Pharmacogenomic Clinical Decision Support
4. Ensuring Equity and Access to Pharmacogenomic Clinical Decision Support
SECTION 2 Developing and Building Clinical Decision Support for Pharmacogenomic Precision Medicine
5. Clinical Decision Support Methods and Infrastructure
6. Deep Phenotyping and Machine Learning to Target Drug Therapies
7. Usability and Human-Centered Design
8. Clinical Considerations for Clinical Decision Support
SECTION 3 Adoption and Delivery of Clinical Decision Support for Pharmacogenomic Precision Medicine
9. Patient-Facing Clinical Decision Support for Pharmacogenomic Precision Medicine
10. Role of the Genetic Counselor in Pharmacogenomic Precision Medicine
11. A Learning Health System Approach to Delivery and Adoption of Clinical Decision Support
12. Integration of Clinical Decision Support Infrastructure and Translating into Real-World Applications