Designer Microbial Cell Factories: Metabolic Engineering and Applications, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a detailed overview of the biotechnological approaches and strategies used to generate engineered microbes and to facilitate the acceleration, modulation and diversion of metabolic pathways to get desired output such as production of value-added compound or biodegradation of xenobiotic pollutant. The book also highlights applied aspects of designer microbes in fields as diverse as agriculture, pharmaceuticals and bioremediation.
Designer microbes generated through reprogramming the microbial cell factories (MCFs) provide an edge over their natural counterparts in terms of increased molecular diversity and selective chemistry. These bugs are becoming instrumental in several areas, including agriculture, environment and human health. Engineering microbes through directed evolution not only gives freedom from evolutionary constrains but also allow introduction of regulated and foreseeable functions into MCFs.
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Table of Contents
Section I: Technical Aspects of Metabolic Engineering 1. Metabolic engineering: Tools for rewiring of pathways and creation of value 2. Membrane Transport as Target for Metabolic Engineering 3. Analysis and Modeling Tools of Metabolic Flux 4. Equipped C1 chemical assimilation pathway in Engineering Escherichia coli 5. Microbial Tolerance in Metabolic Engineering 6. Application of proteomics and metabolomics in microbiology research 7. Recent approaches and tools of protein tailoring for metabolic engineering 8. Microbial metabolism of aromatic pollutants: High-throughput OMICS and metabolic engineering for efficient bioremediation 9. Microbial Consortium Engineering for the Improvement of Biochemical Production
Section�II: Translational Aspects of Metabolic Engineering 10. Metabolic Engineering Strategies for Effective Utilization of Cellulosic Sugar(s) to Produce Value-added Products 11. Production of fine chemicals from renewable feedstocks through the engineering of artificial enzyme cascades 12. Metabolic engineering of microorganisms for the production of numerous value-added Products 13. Bioengineering in microbial production of bio-butanol from renewable resources 14. Engineered microorganisms for bioremediation 15. Agricultural applications of Engineered Microbes 16. Rhizosphere microbiome engineering 17. Genetically engineered microbes in micro-remediation of metals from contaminated sites 18. Biofuel production from renewable feedstocks: worldwide scenario and progress through metabolic engineering 19. Synthetic biology and the regulatory roadmap for the commercialization of designer microbes
Authors
Swati Joshi Scientist, ICMR-National Institute of Occupational Health (NIOH), Ahmedabad, Gujarat, India(Previous Affiliation: Assistant Professor, School of Life Sciences, Central University of Gujarat, Gandhinagar, India). Dr Swati Joshi earned PhD in Microbiology from University of Delhi, India. During her Ph.D., she focused on developing industrial strains of methylotrophic yeast Pichia pastoris. Currently she is working as Assistant Professor and BioCARe Women Scientist at School of Life Sciences, Central University of Gujarat (CUG), Gandhinagar, where she is engaged in working in the interdisciplinary field of industrial Microbiology and Biotechnology, employing next gen platforms. She has published many peer reviewed scientific papers, reviews and book chapters. She has been conferred with Dr M. J. Thirumalachar Young Scientist Award by Mycological Society of India (MSI) and Young Scientist Award by Association of Microbiologists of India (AMI). She is life member of BRSI, MSI, AMI and Indian Lichenological Society (ILS). Ashok Pandey Professor Ashok Pandey is currently Distinguished Scientist at the Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, India and Executive Director (Honorary) at the Centre for Energy and Environmental Sustainability - India. Formerly, he was Eminent Scientist at the Center of Innovative and Applied Bioprocessing, Mohali and Chief Scientist & Head of Biotechnology Division and Centre for Biofuels at CSIR's National Institute for Interdisciplinary Science and Technology, Trivandrum. His major research and technological development interests are industrial & environmental biotechnology and energy biosciences, focusing on biomass to biofuels & chemicals, waste to wealth & energy, industrial enzymes, etc. Professor Pandey is Adjunct/Visiting Professor/Scientist in universities in France, Brazil, Canada, China, Korea, South Africa, and Switzerland and also in several universities several in India. He has ~1400 publications/communications, which include 16 patents, 87 books, >700 papers and book chapters, etc with h index of 102 and ~46,300 citations (Goggle scholar). He has transferred several technologies to industries and has done industrial consultancy for about a dozen projects for Indian/international industries. Professor Pandey is the recipient of many national and international awards and honours, which include Distinguished Scientist, VDGOOD Professional Association, India (2020); Distinguished Professor of Eminence with global impact in the area of Biotechnology, Precious Cornerstone University, Nigeria (2020), Highest Cited Researcher (Top 1% in the world), Clarivate Analytics, Web of Science (2019); IconSWM Life-time Achievement Award 2019, International Society for Solid Waste Management, KIIT, Bhubaneshwar, India (2019); Yonsei Outstanding Scholar, Yonsei University, Seoul, Korea (2019), Highest Cited Researcher (Top 1% in the world; Top 10 in India), Clarivate Analytics, Web of Science (2018); Life-Time Achievement Award from the Biotech Research Society, India (2018); Life-Time Achievement Award from Venus International Research Awards (2018), Most Outstanding Researcher Award from Career360 (2018), Life-Time Achievement Award from the International Society for Energy, Environment and Sustainability (2017); Academician of European Academy of Sciences and Arts, Austria (2015); Honorary Doctorate degree from Univesite Blaise Pascal, France (2007); Thomson Scientific India Citation Laureate Award, USA (2006); UNESCO Professor (2000); Raman Research Fellowship Award, CSIR (1995); GBF, Germany and CNRS, France Fellowships (1992) and Young Scientist Award (1989), etc. He is Fellow of various academies, which include Royal Society of Biology, UK (2016); International Society for Energy, Environment and Sustainability (2016); National Academy of Sciences, India (2012); Association of Microbiologists of India (2008), International Organization of Biotechnology and Bioengineering (2007) and the Biotech Research Society, India (2005). Professor Pandey is Founder President of the Biotech Research Society, India (www.brsi.in); Founder & International Coordinator of International Forum on Industrial Bioprocesses, France (www.ifibiop.org), Chairman of the International Society for Energy, Environment & Sustainability (www.isees.in), Editor-in-chief of Bioresource Technology (http://ees.elsevier.com/bite/), Honorary Executive Advisor of Journal of Energy and Environmental Sustainability (www.jees.in), Journal of Systems Microbiology and Biomanufacturing (https://www.springer.com/journal/43393), Journal of Environmental Sciences and Engineering (http://neerijese.org/editorial-board/), Subject Editor, Proceedings of National Academy of Sciences, India (https://www.springer.com/life+sciences/journal/40011) and Associate Editor, Biologia - Section Cellular and Molecular Biology (https://www.springer.com/journal/11756/editors) and editorial board member of several international and Indian journals Ranjna Sirohi Research Professor, Department of Chemical and Biological Engineering, Korea University, Seoul, Republic of Korea. Dr. Ranjna Sirohi is currently working as Research Professor in Korea University, Seoul. She obtained B.Tech. degree in Biochemical Engineering and M.Tech. degree in Agricultural Engineering with specialization in Food Biotechnology Engineering. She has worked as Visiting Researcher at the �cole Polytechnique F�d�rale de Lausanne, Switzerland, as Scientist at Centre for Energy and Environment Sustainability, Lucknow and as Senior Project Associate at CSIR-NEERI, Nagpur. She obtained her Ph.D. degree in Process and Food Engineering from G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand. Her major research interests are in the field of Bioprocess Technology - Food & Food Waste Valorisation-Waste to Wealth - Biofuels. She has 65 publications/communications that include 32 research and review papers, 12 book chapters, 7 popular articles and 14 conference proceedings.
Dr Sirohi has won several awards and honors that include Research Excellent Award in the international conference on New Horizons in Biotechnology, Trivandrum, India (2019), Best Poster award in 8th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2019), Miri; Sarawak, Malaysia (2019) and Research Excellence Award in International Conference on Bio-Innovation for Environmental and Health Sustainable Developments (BEHSD-2018), Lucknow, India (2018). She is the Life member of Indian Society of Agricultural Engineers (ISAE); the Biotech Research Society, India (BRSI); Indian Science Congress Association (ISCA) and Association of Food Scientists & Technologists, India (AFSTI). Sung Hoon Park Professor, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan, South Korea. Dr. Sung Hoon Park is Professor at the School of Energy and Chemical Engineering, UNIST (Ulsan National Institute of Science and Technology; http://bcelab.unist.ac.kr/), Korea. He received a BS (1980) and MS (1982) in Chemical Technology from Seoul National University, Korea and a Ph.D. (1988) in Chemical Engineering from University of California, Davis, USA. Before joining UNIST, he worked at CKD Pharmaceuticals, Korea (1980-82), Lawrence Livermore National Laboratory, CA, USA (1988-91), and Pusan National University (PNU), Korea (1991-2017). Dr. Park is former and now honorary Editor-in-Chief of Biotechnology and Bioprocess Engineering (BBE), and a Senior Editor of Journal of Industrial Microbiology and Biotechnology (JIMB). Major research interest lies in metabolic engineering and synthetic biotechnology for microbial production of biofuels and biochemicals from renewable resources. Dr. Park has educated ~100 graduate students and postdocs, published >200 research papers and holds >30 patents.
