"Cell niches� are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells' behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites.
Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood-brain/BBB and blood-retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential.
The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.
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Table of Contents
1. Evolution of nanotechnology in medicines2. History and evolution of regenerative medicine
3. Nanotechnologies to deliver drugs through the blood-brain and blood-retinal barriers
4. Thermodynamics of nanoparticle-cell interaction
5. Nanogels for drug delivery: Physicochemical properties, biological behavior and in vivo applications
6. The role of blood brain and blood retinal barriers in drug delivery
7. Nanotechnology and stem cell therapy for combating COVID-19
8. Lipid nanoparticles-based semi-solid formulations for cosmetic applications: focus on cellulite
9. 3D Bioprinting: An innovative technique for biofabrication applied to regenerative medicine and tissue engineering
10. Stem cells, organoids, and cellular therapy
11. Growth factors, cytokines, and platelet-rich plasma
12. The biomaterial niche of platelet-rich plasma and hyaluronic acid matrices for tissue regeneration
13. Biomaterials application in wound healing management from fundamental physiology to advanced technology
14. Nanoscaffolds and role of 3D printed surgical dressings for wound healing application
15. Platelet-rich plasma in pain management
16. Tissue engineering in wound healing
17. Role of neurogenesis in regenerative medicine
18. Gut microbiome interventions in regenerative medicine
19. Applications of nanotechnology in chronic diseases and tissue regeneration
20. Electrically conductive nanomaterials for advanced cardiac tissue regeneration
21. Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster a model of new era
Authors
Maria H. Santana Full Professor, Department of Materials Engineering and Bioprocesses and Coordinator, Laboratory for Development of Biotechnological Processes, School of Chemical Engineering, University of Campinas, Brazil. Maria Helena Andrade Santana is a retired Full Professor in the Department of Materials Engineering at the School of Chemical Engineering, University of Campinas, Brazil. Maria Helena is graduated in Chemical Engineering from the University of Maringa, holds PhD. in Mechanical Engineering from the University of Campinas, Brazil, a postdoctoral in Chemical Engineering from the North Caroline State University, USA, and has a nonmedical degree from the American Academy of Regenerative Medicine (American Board of Regenerative Medicine- South America Chapter) (2016). She has extensive experience in multidisciplinary applications, specifically in fermentation processes, nanotechnology, and regenerative medicine of musculoskeletal systems, and is a member of the National Academy of Engineering, Brazil (2014-present). She received twice (2004 and 2015) the "Zeferino Vaz� award for Scientific Productivity in Chemical Engineering and the Inventors award from the Innovation Agency (2010, 2019), both from the University of Campinas, Brazil. Eliana B. Souto Professor, Department of Pharmaceutical Technology of the Faculty of Pharmacy, University of Porto, Portugal. Eliana B. Souto is Habil. Professor from the Department of Pharmaceutical Technology of the Faculty of Pharmacy of University of Porto. Prof. Souto graduated in Pharmaceutical Sciences from University of Coimbra (2000), is holder of a master's in science degree in Pharmaceutical Technology from University of Porto (2002), and PhD in Pharmaceutical Nanotechnology and Biopharmaceutics from the Institut fuer Pharmazie der Freie Universitaet Berlin, Germany (2005). Her research lines include the design, development, and characterization of new drug delivery systems to overcome biological barriers. Prof. Souto serves as Associate Editor, member of the Editorial Board, and Reviewer of several international scientific journals and has published more than 500 works (original and review papers, books and book chapters) in the field of nanosciences and nanomedicine. Prof. Souto also acts as independent expert for several national, European and international funding agencies, and as consultant for pharmaceutical industry. Ranjita Shegokar Postdoctoral Researcher, Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Free University of Berlin, Germany.Ranjita Shegokar holds a Ph.D. degree in Pharmaceutical Technology from the SNDT University, India, and has been a postdoctoral researcher in the Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics at the Free University of Berlin, Germany. Currently, she serves as Chief Scientific Officer (CSO) at Capnopharm GmbH, Germany. She has authored several research articles, book chapters, and presented her research in many national/international conferences. She has filed multiple patent applications in the area of drug delivery and targeting. Besides that, she has edited many trending books in the area of pharmaceutical nanotechnology and drug delivery aspects. For her research, she has received many prestigious national and international awards among them include recently received prestigious German Innovation Award 2022. Her areas of interest include polymeric nanoparticles, nanocrystals, lipid nanoparticles (SLNs/NLCs), nanoemulsions, cancer drug targeting and the role of excipients in delivery systems. (www.ranjitas.com)
