Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.
This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs.
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Table of Contents
1. Biochemical activation of drug metabolizing enzymes: From mechanism of action to functions 2. Computational approaches and drug metabolizing enzymes: Concepts and challenges 3. Biotransformation of drugs by drug metabolizing enzymes: Concepts and challenges 4. Emerging environmental contaminants and drug metabolizing enzymes: Retrospective analysis and prospects 5. Impact of prodrugs on drug metabolizing enzymes: From function to regulation 6. Impact of hormones on drug metabolizing enzymes: From function to regulation 7. Impact of receptors on drug metabolizing enzymes: From function to regulation 8. Biochemistry of cathepsin enzymes and metabolic functions in lysosome 9. Fate of drug metabolizing enzymes in metabolic diseases: Challenges and strategies 10. Fate of drug metabolizing enzymes in cardiovascular diseases: Challenges and strategies 11. Fate of drug metabolizing enzymes in neurological diseases: Challenges and strategies 12. Impact of physiological factors on drug metabolizing enzymes: Challenges and strategies 13. Xenobiotics and drug metabolizing enzymes: Challenges and strategies 14. Drug metabolizing enzymes and inflammatory responses: Mechanism of induction and treatment strategies 15. Polymorphism and drug metabolizing enzymes: Challenges and strategies 16. Modulation of human microbiome and drug metabolism: Current trends and future prospects 17. Bioanalytical techniques for prediction of metabolic activity of drug metabolizing enzymes: Challenges 18. Role of pharmacogenomics for prediction of personalized medicines: Concepts and challenges 19. Dietary sources of drug metabolizing enzymes: From production to regulation 20. Vitamin deficiencies and drug metabolizing enzymes: Challenges and strategies 21. Malnutrition and Drug metabolizing enzymes: Challenges and strategies 22. Drug metabolizing enzymes and oxidative stress: Mechanism of induction and treatment strategies
