The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors.
Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders.
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Table of Contents
SECTION I: HYPOTHALAMIC-PITUITARY FUNCTION 1. Pituitary Development JACQUES DROUIN AND JONATHAN BRIERE 2. Hypothalamic Regulation of Anterior Pituitary Function ANAT BEN-SHLOMO AND SHLOMO MELMED 3. Adrenocorticotrophin LINDSEY S. GASTON AND JOSEPH A. MAJZOUB 4. Growth Hormone VIVIEN S. HERMAN-BONERT AND SHLOMO MELMED 5. Prolactin ROSA MARIA PARAGLIOLA, NADINE BINART, AND ROBERTO SALVATORI 6. Thyroid-Stimulating Hormone LAYAL CHAKER AND ROBIN P. PEETERS 7. Gonadotrophin Hormones ANA PAULA ABREU AND URSULA B. KAISER 8. The Posterior Pituitary DANIEL G. BICHET
SECTION II: HYPOTHALAMIC-PITUITARY DISORDERS 9. The Hypothalamus ANDREA GIUSTINA, AGNESE ALLORA, STEFANO FRARA, ALFIO SPINA, AND PIETRO MORTINI 10. Anterior Pituitary Failure ELENA V. VARLAMOV AND MARIA FLESERIU 11. Pituitary-Immune Interface MASAAKI YAMAMOTO AND YUTAKA TAKAHASHI 12. Pituitary Dysfunction in Systemic Disorders PEDRO MARQUES AND MARTA KORBONITS 13. Drugs and Pituitary Function MONICA R. GADELHA, LUIZ EDUARDO WILDEMBERG, AND LEANDRO KASUKI 14. The Pituitary Gland in Pregnancy ANDREA GLEZER AND MARCELLO D. BRONSTEIN
SECTION III: PITUITARY ADENOMAS 15. Acromegaly SHLOMO MELMED 16. Prolactinoma PHILIPPE CHANSON AND DOMINIQUE MAITER 17. Cushing's Disease ALBERTO M. PEREIRA AND OLAF M. DEKKERS 18. Nonfunctioning and Gonadotrophin-Secreting Adenomas NIKI KARAVITAKI AND JOHN A.H. WASS 19. Thyrotrophin-Secreting Pituitary Adenomas YONA GREENMAN 20. Aggressive Pituitary Adenomas GERALD RAVEROT 21. Genetics of Pituitary Adenoma Syndromes ADRIAN F. DALY AND ALBERT BECKERS 22. Nonpituitary Sellar Masses LUIS V. SYRO, FABIO ROTONDO, OLGA MOSHKIN, AND KALMAN KOVACS
SECTION IV: PITUITARY PROCEDURES 23. Pituitary Imaging WAIEL A. BASHARI, DANIEL GILLETT, JAMES MACFARLANE, DANIEL SCOFFINGS, AND MARK GURNELL 24. Pituitary Surgery ADAM N. MAMELAK 25. Radiotherapy in the Management of Pituitary Adenomas ROMAN O. KOWALCHUK, DANIEL M. TRIFILETTI, PAUL D. BROWN, AND JASON P. SHEEHAN
Authors
Shlomo Melmed Professor of Medicine, Dean of the Medical Faculty, Cedars Sinai Health System, USA. Shlomo Melmed, MB, ChB, FRCP, MACP, is Executive VP and Dean of the Medical Faculty at Cedars-Sinai Medical Center. He leads Cedars-Sinai's research and education programs, recruiting nationally recognized faculty leadership, establishing new educational programs and maintaining the highest academic standards. Dr. Melmed holds the Helene A. and Philip E. Hixon Distinguished Chair in Investigative Medicine. An international authority on pituitary medicine, he has pioneered the discovery and application of novel treatments for endocrine tumors and has authored more than 350 peer-reviewed articles.Dr. Melmed has been a faculty leader at Cedars-Sinai for nearly 40 years and has been the health system's chief academic officer since 1998. Dr. Melmed's laboratory consistently has received competitive grant awards from the National Institutes of Health since 1980, and he has trained over 80 physicians, scientists and graduate students who occupy leading positions in academic endocrinology worldwide. He is on the editorial board of the Journal of Clinical Investigation and is also an Associate Dean of the UCLA School of Medicine.
