The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors.
Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders.
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Table of Contents
SECTION I: HYPOTHALAMIC-PITUITARY FUNCTION
1. Pituitary Development
JACQUES DROUIN AND JONATHAN BRIERE
2. Hypothalamic Regulation of Anterior Pituitary Function
ANAT BEN-SHLOMO AND SHLOMO MELMED
3. Adrenocorticotrophin
LINDSEY S. GASTON AND JOSEPH A. MAJZOUB
4. Growth Hormone
VIVIEN S. HERMAN-BONERT AND SHLOMO MELMED
5. Prolactin
ROSA MARIA PARAGLIOLA, NADINE BINART, AND ROBERTO SALVATORI
6. Thyroid-Stimulating Hormone
LAYAL CHAKER AND ROBIN P. PEETERS
7. Gonadotrophin Hormones
ANA PAULA ABREU AND URSULA B. KAISER
8. The Posterior Pituitary
DANIEL G. BICHET
SECTION II: HYPOTHALAMIC-PITUITARY DISORDERS
9. The Hypothalamus
ANDREA GIUSTINA, AGNESE ALLORA, STEFANO FRARA, ALFIO SPINA, AND PIETRO MORTINI
10. Anterior Pituitary Failure
ELENA V. VARLAMOV AND MARIA FLESERIU
11. Pituitary-Immune Interface
MASAAKI YAMAMOTO AND YUTAKA TAKAHASHI
12. Pituitary Dysfunction in Systemic Disorders
PEDRO MARQUES AND MARTA KORBONITS
13. Drugs and Pituitary Function
MONICA R. GADELHA, LUIZ EDUARDO WILDEMBERG, AND LEANDRO KASUKI
14. The Pituitary Gland in Pregnancy
ANDREA GLEZER AND MARCELLO D. BRONSTEIN
SECTION III: PITUITARY ADENOMAS
15. Acromegaly
SHLOMO MELMED
16. Prolactinoma
PHILIPPE CHANSON AND DOMINIQUE MAITER
17. Cushing's Disease
ALBERTO M. PEREIRA AND OLAF M. DEKKERS
18. Nonfunctioning and Gonadotrophin-Secreting Adenomas
NIKI KARAVITAKI AND JOHN A.H. WASS
19. Thyrotrophin-Secreting Pituitary Adenomas
YONA GREENMAN
20. Aggressive Pituitary Adenomas
GERALD RAVEROT
21. Genetics of Pituitary Adenoma Syndromes
ADRIAN F. DALY AND ALBERT BECKERS
22. Nonpituitary Sellar Masses
LUIS V. SYRO, FABIO ROTONDO, OLGA MOSHKIN, AND KALMAN KOVACS
SECTION IV: PITUITARY PROCEDURES
23. Pituitary Imaging
WAIEL A. BASHARI, DANIEL GILLETT, JAMES MACFARLANE, DANIEL SCOFFINGS, AND MARK GURNELL
24. Pituitary Surgery
ADAM N. MAMELAK
25. Radiotherapy in the Management of Pituitary Adenomas
ROMAN O. KOWALCHUK, DANIEL M. TRIFILETTI, PAUL D. BROWN, AND JASON P. SHEEHAN
Authors
Shlomo Melmed Professor of Medicine, Dean of the Medical Faculty, Cedars Sinai Health System, USA. Shlomo Melmed, MB, ChB, FRCP, MACP, is Executive VP and Dean of the Medical Faculty at Cedars-Sinai Medical Center. He leads Cedars-Sinai's research and education programs, recruiting nationally recognized faculty leadership, establishing new educational programs and maintaining the highest academic standards. Dr. Melmed holds the Helene A. and Philip E. Hixon Distinguished Chair in Investigative Medicine. An international authority on pituitary medicine, he has pioneered the discovery and application of novel treatments for endocrine tumors and has authored more than 350 peer-reviewed articles.Dr. Melmed has been a faculty leader at Cedars-Sinai for nearly 40 years and has been the health system's chief academic officer since 1998. Dr. Melmed's laboratory consistently has received competitive grant awards from the National Institutes of Health since 1980, and he has trained over 80 physicians, scientists and graduate students who occupy leading positions in academic endocrinology worldwide. He is on the editorial board of the Journal of Clinical Investigation and is also an Associate Dean of the UCLA School of Medicine.
