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Recent Advances in Analytical Techniques: Volume 5

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    Book

  • October 2021
  • Bentham Science Publishers Ltd
  • ID: 5546140
Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis.

The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines.

  • Superior Aspects of Liquid Chromatography-Based Mass Spectrometers in Chiral Analysis
  • New Trends in Sample Preparation for Pharmaceutical and Biological Analysis by Chromatographic Methods
  • Qualitative and Quantitative Investigation of Bio Tissues using Microscopy and Data Mining
  • Analytical Techniques For Analysis of Metals and Minerals in The Soil Samples
  • Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach

Table of Contents

PREFACE
LIST OF CONTRIBUTORS

CHAPTER 1 SUPERIOR ASPECTS OF LIQUID CHROMATOGRAPHY-BASED MASS SPECTROMETERS IN CHIRAL ANALYSIS
Aysegul Dogan, Cemil C. Eylem and Nursabah E. Başcı
  • INTRODUCTION
  • MASS SPECTROMETRY IN CHIRAL ANALYSIS
  • Gas Chromatography-Mass Spectrometry
  • Liquid Chromatography-Mass Spectrometry
  • Normal Phase and Reverse Phase Liquid Chromatography-Mass Spectrometry
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES


CHAPTER 2 NEW TRENDS IN SAMPLE PREPARATION FOR PHARMACEUTICAL AND BIOLOGICAL ANALYSIS BY CHROMATOGRAPHIC METHODS
Mario Contin, Cecilia Dobrecky, Sabrina Flor, Manuela Martinefski, Silvia Lucangioli and Valeria Tripodi
  • INTRODUCTION
  • SAMPLE PREPARATION METHODS
  • MONOLITHIC SORBENTS
  • Inorganic Monoliths
  • Organic Monoliths
  • Hybrid Monoliths
  • SPE Related Techniques
  • Solid Phase Microextraction (SPME)
  • MOLECULAR IMPRINTING
  • MAGNETIC NANOPARTICLES
  • Definitions
  • Characterization
  • MSPE
  • METAL ORGANIC FRAMEWORKS: THE NEW KIDS ON THE BLOCK
  • How It All Began
  • Structure, Synthesis and Stability
  • De Novo Strategies
  • Post-Synthetic Strategies
  • Post Synthetic Modification (PSM)
  • Hydrophobic Surface Treatment
  • Post-Synthetic Exchange
  • Post-Synthetic Elimination and Installation
  • Tandem PSM
  • Introduction of Functional Groups
  • Engineering Porosity and Pores
  • Improvement of Structural Stability
  • Surface and Interior Modification
  • Catalytic Activity
  • Multiple Magnetic Regulations
  • Hybrid Materials
  • Applications: Welcome to the Multiverse
  • Future Perspectives: To the Infinite and Beyond
  • SUPRAMOLECULAR SOLVENTS
  • CARBON SORBENTS
  • THE JOURNEY SO FAR
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES


CHAPTER 3 QUALITATIVE AND QUANTITATIVE INVESTIGATION OF BIO TISSUES USING MICROSCOPY AND DATA MINING
Hafeez Ullah, Munir Akhtar and Muhammad Ramzan Khawar
  • INTRODUCTION
  • MARROW OF BONE
  • Hematopoietic Stem Cell
  • White Blood Cells
  • Granulocytes
  • Agranulocytes
  • CANCER
  • General Characteristics of Cancer Cells
  • Classification of Blood Cancer
  • Sugar and its Effect on the Body
  • Role of Sugar in Cancer
  • Effect of Sugar on Cancerous Leukocytes
  • Salt and Immune System
  • Effect of Salt on Cancerous WBCs
  • PLATELETS
  • Morphology of Platelets
  • Platelets Adhesion, TCIPA and Effect of Glucose
  • Effect of Salt on Platelets
  • RED BLOOD CELLS
  • Role of Erythrocytes
  • Rouleaux Formation
  • Effect of Sugar on the Rouleaux Formation
  • Effect of Salt on Rouleaux Formation
  • MICROSCOPY
  • Principle of Optical Microscopy (OM)
  • CCD Technique
  • RESULTS AND DISCUSSIONS
  • Effects of Glucose on the Aggregation of Leukocytes & Erythrocytes in Blood Cancer
  • Method of Sample Preparation
  • Discussions
  • Effect of Glucose on Platelets in Blood Cancer
  • Methodology and Sample Preparation
  • Discussions
  • Effect of Sodium Chloride on WBCs & RBCs in Blood Cancer
  • Methodology & Sample Preparation
  • Effect of Sodium Chloride on Platelets in Blood Cancer
  • Method of Sample Preparation
  • QUANTIFICATION OF SALT AND PURE WATER IN HUMAN WHOLE BLOOD USING LIGHT MICROSCOPE
  • Introduction
  • Materials and Methods
  • Sample Set (1)
  • Sample Set (2)
  • Sample Set (3)
  • Results
  • Effect of Pure Salt on RBCs
  • Effect of Distilled Water on RBCs
  • Discussion
  • CLASSIFICATION OF CHRONIC KIDNEY DISEASES AND LIVER CIRRHOSIS
  • What is a Kidney?
  • Renal Physiologies
  • NEPHRONS
  • FUNCTIONS OF KIDNEY
  • SPECIFIC KIDNEY DISEASES
  • Kidney Stone
  • Nephrotic Syndrome
  • Acute Renal Failure
  • Pyelonephritis
  • IMAGE PROCESSING
  • Analog Image Processing
  • Digital Image Processing
  • Advantages of Digital Image Processing in Medical
  • Steps of Image Processing
  • MEDICAL IMAGING PROCESSING
  • Structural Medical Images
  • Functional Medical Images
  • IMAGE CLASSIFICATION USING DATA MINING TECHNIQUE
  • What will be the Data Mining?
  • Application of Data Mining Technique
  • Use of Data Mining in Field of Health
  • WHAT IS A FEATURE EXTRACTION?
  • Color Features
  • Texture Features
  • Shape Features
  • Features
  • METHODOLOGIES
  • Characterization Software
  • DATA MINING TECHNIQUE USED FOR MEDICAL IMAGES FEATURE EXTRACTION
  • WEKA
  • Advantages of Weka
  • Results
  • Extracted Parameter
  • Abnormal Ultrasonic Kidney Images with Chronic Kidney Diseases
  • Discussions
  • Conclusion
  • CLASSIFICATION OF LIVER CIRRHOSIS
  • Liver Physiology and Diseases
  • Anatomy and Function of Liver
  • Diseases of Liver
  • Causes of Liver Damage
  • Liver Cancer
  • Cirrhosis
  • MEDICAL IMAGE ANALYSIS
  • TEXTURE ANALYSIS TECHNIQUES
  • Geometric and Topological Approach
  • Second or Higher-order Statistics
  • Texture Based on Gradient Information
  • Materials and Methods
  • Sample Preparation
  • Selecting ROI
  • Statistical Technique
  • FIRST-ORDER STATISTICAL TEXTURE ANALYSIS
  • Results
  • Classification of Results
  • Conclusion
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES


CHAPTER 4 ANALYTICAL TECHNIQUES FOR ANALYSIS OF METALS AND MINERALS IN THE SOIL SAMPLES
Snežana Filip, Saša Popov, Saša Šorgić and Saša Đurović
  • INTRODUCTION
  • CLASSIFICATION OF ANALYTICAL TECHNIQUES APPLIED FOR SOIL ANALYSIS 161 Quantitative Analysis
  • Classical Analytical Techniques
  • Instrumental Techniques
  • PRETREATMENT OF THE SAMPLES
  • Acid Digestion
  • Single or Sequential Extraction Procedures
  • Alternative Extraction Techniques
  • INSTRUMENTAL TECHNIQUES
  • Atomic Absorption Spectrometry (AAS)
  • Inductively Coupled Plasma (ICP)
  • Anodic Stripping Voltammetry (ASV)
  • Neutron Activation Analysis (NAA)
  • X-ray Fluorescence (XRF) Spectrometry and Induced X-ray Emission (PIXE)
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES


CHAPTER 5 MONITORING THERAPEUTIC RESPONSE IN CANCERS: A RAMAN SPECTROSCOPY APPROACH
Kshama Pansare and C. Murali Krishna
  • INTRODUCTION
  • Raman Scattering
  • Basic Theory
  • Molecular Vibrations
  • Raman Instrumentation
  • Components of Raman Spectrometers
  • Types of Raman Spectroscopy
  • Resonance Raman Spectroscopy (RRS)
  • Surface-Enhanced Raman Spectroscopy (SERS)
  • Coherent Anti-Stokes Raman Spectroscopy (CARS)
  • Stimulated Raman Spectroscopy (SRS)
  • Spatially offset Raman Spectroscopy (SORS)
  • Confocal Raman Microscopy
  • Spectra Pre-Processing and Data Analysis
  • Applications of Raman Spectroscopy
  • CANCER
  • Aetiology and Epidemiology of Cancer
  • Epidemiology of Cancer
  • Pathogenesis of Cancer
  • Classification, Grading and Staging of Tumours
  • Grading and Staging of Tumours
  • Diagnosis of Cancer
  • Treatment of Cancer
  • Novel Approaches for Cancer Therapy
  • Immunotherapy
  • Cold Atmospheric Plasma (CAP) Therapy
  • THERAPEUTIC MONITORING OF CANCERS
  • Raman Spectroscopy in Therapeutic Monitoring of Cancers
  • Raman Spectroscopy and Surgery
  • Intraoperative Surgical Margin Assessment
  • Malignancy-Associated Changes (MAC)/Cancer Field Effects (CFE)
  • Cancer Recurrence Prediction
  • Raman Spectroscopy and Radiotherapy
  • Ex Vivo Biopsies
  • In Vitro Cell Line and Xenograft Models
  • Raman Spectroscopy and Chemotherapy
  • Therapeutic Drug Monitoring (TDM)
  • Chemoresistance
  • Raman Spectroscopy and Novel Approaches for Cancer Therapy
  • RAMAN SPECTROSCOPY AND ARTIFICIAL INTELLIGENCE (AI)

CONCLUSION
CONSENT FOR PUBLICATION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
SUBJECT INDEX

Author

  • Atta-ur-Rahman
  • Sibel A. Ozkan