Digital Human Modeling and Medicine: The Digital Twin explores the body of knowledge and state-of-the-art in Digital Human Modeling (DHM) and its applications in medicine. DHM is the science of representing humans with their physical properties, characteristics and behaviors in computerized, virtual models. These models can be used standalone or integrated with other computerized object design systems to both design or study designs of medical devices or medical device products and their relationship with humans. They serve as fast and cost-efficient computer-based tools for the assessment of human functional systems and human-system interaction.
This book provides an industry first introductory and practitioner focused overview of human simulation tools, with detailed chapters describing body functional elements and organs, organ interactions and fields of application. Thus, DHM tools and a specific scientific/practical problem - functional study of the human body - are linked in a coherent framework. Eventually the book shows how DHM interfaces with common physical devices in medical practice, answering to a gap in literature and a common practitioner question. Case studies provide the applied knowledge for practitioners to make informed decisions.
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Table of Contents
1. Virtual Human Anatomy Atlases2. The Visible Human Project
3. The Virtual Physiological Human
4. Human Modeling Software Systems
5. Human Modeling Hardware Systems
6. Mandibular Biomechanics
7. Corneal Biomechanics
8. Biomechanics and Modeling of the Human Heart
9. Biomechanics and Modeling of the Human Lung
10. Biomechanics and Modeling of the Human Spine
11. Biomechanics and Modeling of the Human Shoulder
12. Prosthetic Modeling of the Leg
13. Bone Tissue Remodeling of the Femur
14. Computational Musculoskeletal Biomechanics of the Knee
15. Biomechanics and Modeling of the Human Foot
16. Multiphasic and Multiscale Modelling of Vascular Tissue
17. Simulation of the Blood Flow in Body Arteries
18. Patient-Specific Predictive Modeling
19. Real-Time Simulation of Virtual Surgery
20. Computational Simulation of the Cell Behavior for Tissue Regeneration
21. Cartilage Regeneration
22. Bone Regeneration
23. Damage, Remodeling, and Growth of Vascular tissue
24. Microfluidics Chips to Mimic the Cellular Microenvironment
25. Nano-Structured Materials as a Scaffold for Tissue Regeneration
26. Smart Materials as a Scaffold for Tissue Regeneration
27. Synthesis of Highly Reactive Polymers for Tissue Adhesiveness
28. Mechanical and Micro-Structural Behavior of Biomaterials and Biological Tissue
29. 3D Remodeling and Printing of Implants