Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.
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Table of Contents
1. Regulation of Gene Expression in Mammals: An Overview2. Post Transcriptional Gene Regulation: An Overview
3. Methods to Study Post-Transcriptional Regulation of Gene Expression
4. Epigenetic Regulation of Post-Transcriptional Machinery
5. Post-Transcriptional Regulation: A Less Explored Territory in the World of Neurodegenerative Diseases
6. Role of Post-Transcriptional Gene Regulation in Hematological Malignancies
7. Post-Transcriptional Gene Regulation in Solid Tumors
8. A Comprehensive View of the Prostate Cancer Metastasis and Role of Androgen Receptor Splice Variants
9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome
10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their Role in CVDs
11. microRNAs as Critical Regulators in Heart Development and Diseases
12. MicroRNA Regulation in Autoimmune Diseases
13. Post-Transcriptional Regulation of Inflammatory Disorder
14. Post-Transcriptional Gene Regulation in Metabolic Syndrome
15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral and Host Factors
16. Post-Transcriptional Regulation of Gene Expression in Entamoeba histolytica
17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria Parasite Plasmodium falciparum
18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines Anemia of Chronic Diseases
19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder
Authors
Buddhi Prakash Jain Assistant Professor, Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar, India. Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU) New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He is the recipient of several awards including a gold medal in Master Programme (M.Sc.), EMBO travel award, DST (Department of Science and Technology) Govt of India, Young Scientist travel award, and has published several papers in reputed international journals and a number of books and book chapters. Shyamal K Goswami Professor (retired), School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. Shyamal Goswami has a research career spanning 35 years. He has experience teaching in biochemistry, cellular and molecular biology and redox biology at the postgraduate level. He served as Associate Professor and Professor in the School of Life Sciences at Jawaharlal Nehru University, India, from 1998 to 2020. Prior to this he was a Research Assistant Professor in the Department of Anatomy and Cell Biology at the State University of New York-Health Science Centre at Brooklyn, New York, USA.Dr. Goswami has contributed numerous publications across his field and has more than 1500 citations. He also co-authored Protocols in Biochemistry and Clinical Biochemistry and co-edited Post-transcriptional Gene Regulation in Human Disease, both published by Academic Press/Elsevier. His main areas of research are cell signaling and gene expression in the cardiovascular system; redox biology of degenerative diseases; and signal scaffolds and cell functions. Tapan Sharma Postdoctoral Research Scientist, University of Massachusetts Medical School, Worcester, MA, USA. Dr. Tapan Sharma is a Postdoctoral Research Scientist at the University of Massachusetts Medical School, Worcester, MA, USA. His research focuses on understanding the epigenetic mechanisms involved in the regulation of skeletal muscle differentiation, with more than nine years of laboratory experience in the field of ATP-dependent chromatin remodelers. He has worked with mouse models and multiple primary and immortalized cell lines, having led projects independently during Ph.D. and post-doctoral associateships.
