Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.
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Table of Contents
Preface Swapnil K. Sonkusare 1. TRPV4-dependent signaling mechanisms in systemic and pulmonary vasculature Zdravka Daneva and Maniselvan Kuppusamy 2. Endothelial TRPV4 channels in lung edema and injury Swapnil K. Sonkusare and Victor E. Laubach 3. Cardiac TRPV4 channels Vivian C. Onyali and Timothy L. Domeier 4. Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron Kyrylo Pyrshev, Anna Stavniichuk, Viktor N. Tomilin, Oleg Zaika and Oleh Pochynyuk 5. Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function Megan Elizabeth Perkins and Margaret A. Vizzard 6. The role of TRPV4 channels in cutaneous epithelia Carlene Moore 7. Function and regulation of thermosensitive ion channel TRPV4 in the immune system Tusar Kanta Acharya, Ram Prasad Sahu, Satish Kumar, Shamit Kumar, Tejas Pravin Rokade, Ranabir Chakraborty, Nishant Kumar Dubey, Deep Shikha, Saurabh Chawla and Chandan Goswami 8. TRPV4: Cell type-specific activation, regulation and function across the vertebrate eye Luka Lapajne, Christopher N. Rudzitis, Brenan Cullimore, Daniel Ryskamp, Monika Lakk, Sarah Redmon, Oleg Yarishkin and David Krizaj 9. Role of TRPV4 in skeletal function and its mutant-mediated skeletal disorders Rashmita Das and Chandan Goswami
