Cell and Gene Therapy Global Market Report 2024

The cell & gene therapy market size has grown exponentially in recent years. It will grow from $13.81 billion in 2023 to $17.31 billion in 2024 at a compound annual growth rate (CAGR) of 25.3%. The historical growth can be attributed to an increase in investments in cell and gene therapies, growth in research and development, advances in cancer drug discovery, a rise in public-private partnerships, strong economic growth in emerging markets, increased healthcare expenditure, and an increase in pharmaceutical R&D expenditure.

The cell & gene therapy market size is expected to see exponential growth in the next few years. It will grow to $39.74 billion in 2028 at a compound annual growth rate (CAGR) of 23.1%. Forecasted growth is fueled by increasing cancer and chronic disease prevalence, a growing geriatric population, heightened focus on cell and gene therapy, and rising healthcare expenditure. Key trends include advanced therapies such as CAR T-cell therapy, research initiatives, strategic collaborations, emphasis on gene editing tools such as CRISPR, partnerships or acquisitions, expanded pipeline studies for cell and gene therapies, and investment in manufacturing facility expansion.

The growth of the cell and gene therapy (CGT) market has been significantly bolstered by consistent investment and consolidation initiatives within the sector. Recognizing the immense potential of the CGT market, 16 of the top 20 largest biopharmaceutical companies, ranked by revenue, have integrated CGT products into their portfolios. An illustrative example is Pfizer, which, in December 2021, allocated a substantial investment of $68.5 million to establish a cutting-edge facility in Durham, North Carolina. This strategic move aimed to further advance the company's gene therapy capabilities. Pfizer's facility expansion in North Carolina, accommodating over 3,600 employees across multiple sites in the state, significantly contributes to enhancing their end-to-end capabilities in gene therapy. The steady influx of investment and consolidation in CGT production capacity has resulted in an augmented production capacity, consequently fueling the market's growth.

The burgeoning number of ongoing clinical trials stands as a driving force propelling the cell and gene therapy market forward. Clinical trials serve as pivotal research studies involving human participants to assess the safety and efficacy of new medical treatments, interventions, or diagnostic procedures. In the realm of cell and gene therapy, these trials play an integral role in advancing these innovative therapies by providing a controlled environment to evaluate their safety and efficacy. As evidenced by data from ClinicalTrials.gov, a division of the National Institutes of Health (NIH), the number of registered studies increased significantly from 437,523 in 2022 to 468,457 across all 50 states of the United States and spanning 221 countries by October 2023. Notably, a considerable portion of these studies - 143,613 (31% of the total) - are conducted solely within the U.S., while 251,159 studies (54% of the total) are conducted in non-U.S. locations. This escalating number of ongoing clinical trials signifies a driving force behind the growth trajectory of the cell and gene therapy market.

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a pivotal driver shaping the landscape of the cell and gene therapy (CGT) market. This innovative therapy combines elements of both cell and gene therapy by utilizing T cells obtained from a patient's blood, which are then genetically modified to produce specialized receptors known as chimeric antigen receptors (CARs) on their surface. These engineered T cells, equipped with modified receptors, are reintroduced into the patient's system. The modified receptors on the T cells enable them to effectively target and bind to specific surface antigens present on cancer cells, ultimately leading to the destruction of tumor cells within patients. A notable example occurred in June 2022 when Bristol-Myers Squibb Company, a US-based pharmaceutical firm, received approval from the United States Food and Drug Administration (US FDA) for Breyanzi, a CAR T cell therapy designed for treating adult patients with large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma. Breyanzi stands out as a distinct CAR T cell therapy engineered from a patient's own T cells, collected and genetically reengineered into CAR T cells, subsequently administered via infusion as a one-time treatment.

Major companies operating within the cell and gene therapy market are intensifying their focus on introducing agnostic systems to gain a competitive edge. Agnostic systems encompass platforms integrated with a diverse array of cell and gene therapy (CGT) software platforms, as well as biopharmaceutical or provider-facing platforms. For instance, in April 2023, AmerisourceBergen, a US-based healthcare company, unveiled the Cell and Gene Therapy Integration Hub - a newly launched platform-agnostic system. This innovative system aims to enhance connectivity throughout the cell and gene therapy treatment journey, elevating the overall patient and provider experience. Powered by the company's customer relationship management system, the hub is designed to expedite the benefits investigation process, offer real-time insights into therapy development and transportation status, and assist in streamlining patient support coordination.

In December 2021, Novartis AG, a Switzerland-based pharmaceutical company, completed the acquisition of Gyroscope Therapeutics Holdings plc for $800 million. This strategic move adds GT005, an experimental one-time gene therapy in Phase 2 for treating geographic atrophy (GA), to Novartis' portfolio. The acquisition enhances gene therapy research capabilities and contributes to global ophthalmic innovation for treating and preventing blindness. Gyroscope Therapeutics Holdings plc is a UK-based clinical-stage biopharmaceutical company specializing in gene therapies for eye-related diseases.

Major companies operating in the cell and gene therapy market report are Biogen Inc., Novartis AG, Gilead Sciences, Ionis Pharmaceuticals Inc., Alnylam Pharmaceuticals Inc., ArrowHead Pharmaceuticals Inc., Spark Therapeutics, Bluebird Bio Inc., RegenexBio, Mesoblast Limited, Biocon, Cipla, Stempeutics Research Pvt. Ltd., EdiGene Inc., Immunochina, Takara Bio, Daiichi Sankyo Company, Ultragenyx Pharmaceutical Inc., Mitsubishi Tanabe Pharma, Oxford Biomedica PLC, Santen Pharmaceutical Co., Therapeutic Innovation Australia, Merck, GenScript, Cellular Biomedicine Group, GE Healthcare, inStem, Lonza, Nikon CeLL innovation Co. Ltd., Bristol-Myers Squibb, Amgen, Pfizer, Kite Pharma, Oxford BioTherapeutics, Freeline Therapeutics, PsiOxus Therapeutics, Herantis Pharma PLC, and AstraZeneca.

North America was the largest region in the cell and gene therapy market in 2023. The regions covered in the cell and gene therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the cell and gene therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Italy, Canada, Spain.

The primary product categories in cell and gene therapies are cell therapy and gene therapy. Gene therapy in medicine focuses on modifying the genetic material of cells for therapeutic effects or disease healing by repairing damaged genetic material. Applications span oncology, dermatology, musculoskeletal treatments, and others, with utilization across sectors such as hospitals, ambulatory surgical centers, cancer care centers, wound care centers, and more.

The cell and gene therapy market research report is one of a series of new reports that provides cell and gene therapy market statistics, including global market size, regional shares, competitors with a cell and gene therapy market share, detailed cell and gene therapy market segments, market trends and opportunities, and any further data you may need to thrive in the cell and gene therapy industry. This cell and gene therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The cell and gene therapy market includes revenues earned by entities treating cancer, cystic fibrosis, heart disease, diabetes, haemophilia, and AIDS. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.


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