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Bipolar Disorder - Global Drug Forecast and Market Analysis to 2030

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    Report

  • 138 Pages
  • February 2022
  • Region: Global
  • GlobalData
  • ID: 5557740
Bipolar disorder, known originally as manic-depressive illness, is a mental disorder characterized by periods of mania and depression. Manic episodes are the distinguishing feature of this condition and consist of an abnormally elevated, expansive, or irritable mood, as well as persistently increased activity or energy. Conversely, phases of depression involve significantly depressed mood and loss of interest or pleasure. The frequency, severity, and pattern of these episodes can vary considerably over time and among individuals, making bipolar disorder one of the most challenging psychiatric disorders to manage.

The bipolar disorder market is competitive and crowded with a multitude of approved therapies, many of which are available as inexpensive generics. The approved drugs in the bipolar disorder market can be divided into two broad categories: mood stabilizers and antipsychotics. Lithium is widely considered to be the gold standard for bipolar disorder based on its efficacy as a maintenance treatment and its ability to treat acute episodes of both mania and depression.

Key Highlights


  • Moderate growth is expected in the bipolar disorder market from 2020 to 2030.
  • The publisher anticipates that seven late stage pipeline drugs will launch over the forecast period. These are expected to be the main driver of growth in the bipolar disorder market across the 8MM.
  • The publisher expects Intra-Cellular Therapies’ Caplyta to become the top-selling drug in the bipolar disorder market with sales of $800M in 2030.
  • The current key players in the bipolar disorder market are those that market atypical antipsychotic products. However, many products have lost market exclusivity or are facing imminent patent expiry. As such, many of the respective companies are expected to lose their positions in this market over the forecast period due to generic competition.
  • Opportunities remain for pharmaceutical companies to develop drugs with improved safety profiles, as well as novel drugs developed specifically for bipolar disorder.

Key Questions Answered
  • What are the key bipolar disorder treatments in 2020?
  • When will the late stage pipeline products launch, and how will it affect drug sales and the overall bipolar disorder market in the 8MM?
  • Which unmet needs will remain unaddressed in the forecast period and what opportunities remain for pharmaceutical companies?

Scope


  • Overview of bipolar disorder, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and disease management.
  • Annualized bipolar disorder therapeutics market revenue, cost of therapy per patient, and treatment usage patterns in three patient segments ( bipolar I, bipolar II and cyclothymic disorder) forecast from 2020 to 2030.
  • Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the bipolar disorder therapeutics market.
  • Pipeline analysis: comprehensive data assessing emerging trends and mechanisms of action under development for bipolar disorder therapy. The most promising candidates in Phase III and IIb development are profiled.
  • Analysis of the current and future market competition in the global bipolar disorder therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Reasons to Buy


The report will enable you to:

  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
  • Develop business strategies by understanding the trends shaping and driving the global bipolar disorder therapeutics market.
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global bipolar disorder therapeutics market in the future.
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analysing the performance of various competitors.
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.

Table of Contents

1 Bipolar Disorder: Executive Summary
1.1 Modest Growth Expected in the Bipolar Disorder Market from 2020-2030
1.2 In a Market Dominated by Atypical Antipsychotics, Novel Mechanisms of Action Are a Key R&D Strategy for Bipolar Disorder
1.3 Opportunities Remain for Products that Will Fulfill Unmet Needs in the Bipolar Disorder Market
1.4 Novel Late-Stage Pipeline Drugs Will Be a Key Driver of Growth
1.5 What Do Physicians Think?
2 Introduction
2.1 Catalyst
2.2 Related Reports
2.3 Upcoming Reports
3 Disease Overview
3.1 Etiology and Pathophysiology
3.1.1 Etiology
3.1.2 Pathophysiology
3.2 Classification
3.3 Prognosis
4 Epidemiology
4.1 Disease Background
4.2 Risk Factors and Comorbidities
4.3 Global and Historical Trends
4.4 Forecast Methodology
4.4.1 Sources
4.4.2 Forecast Assumptions and Methods
4.4.3 Forecast Assumptions and Methods: 12-Month and Lifetime Prevalent Cases of Bipolar Disorder
4.5 Epidemiological Forecast for Bipolar Disorder (2020-2030)
4.5.1 12-Month Total Prevalent Cases of Bipolar I Disorder
4.5.2 Age-Specific 12-Month Total Prevalent Cases of Bipolar I Disorder
4.5.3 Sex-Specific 12-Month Total Prevalent Cases of Bipolar I Disorder
4.5.4 Lifetime Total Prevalent Cases of Bipolar I Disorder
4.5.5 Age-Specific Lifetime Total Prevalent Cases of Bipolar I Disorder
4.5.6 Sex-Specific Lifetime Total Prevalent Cases of Bipolar I Disorder
4.5.7 12-Month Total Prevalent Cases of Bipolar II Disorder
4.5.8 Age-Specific 12-Month Total Prevalent Cases of Bipolar II Disorder
4.5.9 Sex-Specific 12-Month Total Prevalent Cases of Bipolar II Disorder
4.5.10 Lifetime Total Prevalent Cases of Bipolar II Disorder
4.5.11 Age-Specific Lifetime Total Prevalent Cases of Bipolar II Disorder
4.5.12 Sex-Specific Lifetime Total Prevalent Cases of Bipolar II Disorder
4.5.13 12-Month Total Prevalent Cases of Cyclothymic Disorder
4.5.14 Age-Specific 12-Month Total Prevalent Cases of Cyclothymic Disorder
4.5.15 Sex-Specific 12-Month Total Prevalent Cases of Cyclothymic Disorder
4.5.16 Lifetime Total Prevalent Cases of Cyclothymic Disorder
4.5.17 Age-Specific Lifetime Total Prevalent Cases of Cyclothymic Disorder
4.5.18 Sex-Specific Lifetime Total Prevalent Cases of Cyclothymic Disorder
4.6 Discussion
4.6.1 Epidemiological Forecast Insight
4.6.2 COVID-19 Impact
4.6.3 Limitations of the Analysis
4.6.4 Strengths of the Analysis
5 Disease Management
5.1 Diagnosis and Treatment Overview
5.2 Additional KOL Insights on Disease Management
6 Competitive Assessment
6.1 Overview
7 Unmet Needs and Opportunity Assessment
7.1 Overview
7.2 Effective Treatment Options for Bipolar Depression
7.3 Antipsychotics With a Low Risk of EPS and Metabolic Changes
7.4 Mood Stabilizers With Improved Safety Profiles
7.5 Education for Physicians in Order to Improve Diagnosis Rates
7.6 Novel Drugs Developed Specifically for Bipolar Disorder
8 R&D Strategies
8.1 Overview
8.1.1 Label Expansion
8.1.2 Novel Mechanisms of Action
8.1.3 Reformulations
8.2 Clinical Trials Design
8.2.1 Endpoints
8.2.2 Inclusion/Exclusion Criteria
8.2.3 Trial Duration
9 Pipeline Assessment
9.1 Overview
9.2 Promising Drugs in Clinical Development
10 Pipeline Valuation Analysis
10.1 Overview
10.2 Competitive Assessment
10.2.1 Bipolar Depression
10.2.2 Bipolar Mania
10.2.3 Agitation Associated With Bipolar Disorder
11 Current and Future Players
11.1 Overview
11.2 Deal-Making Trends
12 Market Outlook13 Appendix
List of Tables
Table 1: Bipolar Disorder: Key Metrics in the 8MM
Table 2: Symptom Criteria for Manic, Hypomanic and Major Depressive Episodes
Table 3: DSM-V Classification of Bipolar Disorder
Table 4: Risk Factors and Comorbid Conditions Associated with Bipolar Disorder
Table 5: Treatment Guidelines for Bipolar Disorder
Table 6: Bipolar Disorder Market - Global Drivers and Barriers, 2020-2030
Table 7: Key Events Impacting Sales for Bipolar Disorder in the US, 2020-2030
Table 8: Bipolar Disorder Market - Drivers and Barriers in the US, 2020-2030
Table 9: Key Events Impacting Sales for Bipolar Disorder in the 5EU, 2020-2030
Table 10: Bipolar Disorder Market - Drivers and Barriers in the 5EU, 2020-2030
Table 11: Key Events Impacting Sales for Bipolar Disorder in Japan, 2020-2030
Table 12: Bipolar Disorder Market - Drivers and Barriers in Japan, 2020-2030
Table 13: Key Events Impacting Sales for Bipolar Disorder in Canada, 2020-2030
Table 14: Bipolar Disorder Market - Drivers and Barriers in Canada, 2020-2030
Table 15: High-Prescribing Physicians (non-KOLs) Surveyed, By Country
List of Figures
Figure 1: Global Sales Forecast by Country for Bipolar Disorder in 2020 and 2030
Figure 2: Analysis of the Company Portfolio Gap in Bipolar Disorder During the Forecast Period
Figure 3: Competitive Assessment of the Marketed and Pipeline Drugs for Bipolar Depression Benchmarked Against the Standard of Care, Generic Lithium
Figure 4: Competitive Assessment of the Marketed and Pipeline Drugs for Bipolar Mania Benchmarked Against the Standard of Care, Generic Lithium
Figure 5: Competitive Assessment of the Marketed and Pipeline Drugs for Agitation Associated with Bipolar Disorder Benchmarked Against the Standard of Care, Generic Haloperidol
Figure 6: The Etiology and Pathophysiology of Bipolar Disorder
Figure 7: 8MM, 12-Month and Lifetime Total Prevalence of Bipolar Spectrum Disorder, Men and Women (%), Ages =13 Years, 2020
Figure 8: 8MM, Sources Used and Not Used to Forecast the 12-Month Total Prevalent Cases of Bipolar I Disorder
Figure 9: 8MM, Sources Used and Not Used to Forecast the Lifetime Total Prevalent Cases of Bipolar I Disorder
Figure 10: 8MM, Sources Used to Forecast the 12-Month Total Prevalence of Bipolar II Disorder
Figure 11: 8MM, Sources Used to Forecast the Lifetime Total Prevalent Cases of Bipolar II Disorder
Figure 12: 8MM, Sources Used to Forecast the 12-Month Total Prevalence of Cyclothymic Disorder
Figure 13: 8MM, Sources Used to Forecast the Lifetime Total Prevalence of Cyclothymic Disorder
Figure 14: 8MM, 12-Month Total Prevalent Cases of Bipolar I Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 15: 8MM, 12-Month Total Prevalent Cases of Bipolar I Disorder by Age, N, Both Sexes, 2020
Figure 16: 8MM, 12-Month Total Prevalent Cases of Bipolar I Disorder by Sex, N, Ages =18 Years, 2020
Figure 17: 8MM, Lifetime Total Prevalent Cases of Bipolar I Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 18: 8MM, Lifetime Total Prevalent Cases of Bipolar I Disorder by Age, N, Both Sexes, 2020
Figure 19: 8MM, Lifetime Total Prevalent Cases of Bipolar I Disorder by Sex, N, Ages =18 Years, 2020
Figure 20: 8MM, 12-Month Total Prevalent Cases of Bipolar II Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 21: 8MM, 12-Month Total Prevalent Cases of Bipolar II Disorder by Age, N, Both Sexes, 2020
Figure 22: 8MM, 12-Month Total Prevalent Cases of Bipolar II Disorder by Sex, N, Ages =18 Years, 2020
Figure 23: 8MM, Lifetime Total Prevalent Cases of Bipolar II Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 24: 8MM, Lifetime Total Prevalent Cases of Bipolar II Disorder by Age, N, Both Sexes, 2020
Figure 25: 8MM, Lifetime Total Prevalent Cases of Bipolar II Disorder by Sex, N, Ages =18 Years, 2020
Figure 26: 8MM, 12-Month Total Prevalent Cases of Cyclothymic Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 27: 8MM, 12-Month Total Prevalent Cases of Cyclothymic Disorder by Age, N, Both Sexes, 2020
Figure 28: 8MM, 12-Month Total Prevalent Cases of Cyclothymic Disorder by Sex, N, Ages =18 Years, 2020
Figure 29: 8MM, Lifetime Total Prevalent Cases of Cyclothymic Disorder, N, Both Sexes, Ages =18 Years, 2020
Figure 30: 8MM, Lifetime Total Prevalent Cases of Cyclothymic Disorder by Age, N, Both Sexes, 2020
Figure 31: 8MM, Lifetime Total Prevalent Cases of Cyclothymic Disorder by Sex, N, Ages =18 Years, 2020
Figure 32: Unmet Needs and Opportunities in Bipolar Disorder
Figure 33: Overview of the Development Pipeline in Bipolar Disorder
Figure 34: Key Late-Stage Trials for the Promising Pipeline Agents that GlobalData Expects be Licensed for Bipolar Disorder in the 8MM During the Forecast Period
Figure 35: Competitive Assessment of the Marketed and Pipeline Drugs for Bipolar Depression Benchmarked Against the SOC, Generic Lithium
Figure 36: Competitive Assessment of the Marketed and Pipeline Drugs for Bipolar Mania Benchmarked Against the SOC, Generic Lithium
Figure 37: Competitive Assessment of the Marketed and Pipeline Drugs for Agitation Associated with Bipolar Disorder Benchmarked Against the SOC, Generic Haloperidol
Figure 38: Analysis of the Company Portfolio Gap in Bipolar Disorder During the Forecast Period
Figure 39: Global (8MM) Sales Forecast by Country for Bipolar Disorder in 2020 and 2030
Figure 40: Global (8MM) Sales Forecast by Class for Bipolar Disorder in 2020 and 2030
Figure 41: Sales Forecast by Class for Bipolar Disorder in the US in 2020 and 2030
Figure 42: Sales Forecast by Class for Bipolar Disorder in the 5EU in 2020 and 2030
Figure 43: Sales Forecast by Class for Bipolar Disorder in Japan in 2020 and 2030
Figure 44: Sales Forecast by Class for Bipolar Disorder in Canada in 2020 and 2030

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • AbbVie
  • Actavis
  • Alexza Pharmaceuticals
  • Alkermes
  • Allergan
  • AstraZeneca
  • BioXcel Therapeutics
  • Bristol-Myers Squibb
  • Celon Pharma
  • Eli Lilly
  • Intra-Cellular Therapies
  • Jina Pharmaceuticals
  • Johnson and Johnson
  • Lundbeck
  • Meiji Seika
  • Merck
  • NRX Pharmaceuticals
  • Otsuka Pharmaceutical
  • Pfizer
  • Richter Gedeon
  • Sumitomo Dainippon Pharma
  • Sunovion Pharmaceuticals
  • Vanda Pharmaceuticals