Over time, biologics have gained significant popularity owing to their therapeutic efficacy, favorable safety profiles and ability to treat a wide variety of disease indications, which are otherwise hard to treat. The success of these interventions has prompted the stakeholders to upgrade the traditional biologics manufacturing technology. The demand for increasing productivity and flexibility, greater profitability and faster time to market are further driving the replacement of traditional stainless-steel equipment with single-use technologies. These technologies have been well-accepted in relatively shorter period of time and have become an important tool in the development of various biotechnological processes. Moreover, the ongoing COVID-19 pandemic has prompted the biopharmaceutical industry to shift to single-use technology. These technologies not only lower down the footprint requirement but also eliminate the cleaning costs in developmental stage. Additionally, the single-use technologies have the potential to address a number of challenges associated with traditional bioprocessing systems and offer various additional benefits, such as reduced water and energy consumption (by ~45%), lower initial investment cost (by 40%), lesser time for processing of biologics (by 33%), decreased risk of cross-contamination (by 8%) and increased cost saving potential (by 30-40%).
Presently, several companies are engaged in developing and manufacturing single-use upstream bioprocessing technologies and equipment, such as single-use bioreactors, single-use mixers, single-use filters, single-use media bags and containers, single-use sampling systems and single-use connectors. Further, a number of these players are also focusing on incorporating additional features, including provisions for alerts / alarms, built-in system process control sensors, electronic process logs, remote monitoring features, touch screens, and advanced safety provisions, in their proprietary offerings. The adoption of this technology is fraught with some challenges, such as risk of extractables and leachable, single-use technology disposability, sterilization / irradiation issues and potential inconsistency of the resins, however, owing to the ongoing research on sustainability of this technology and other technical advancements, we are led to believe that the opportunity for technology providers engaged in this domain is likely to grow in the foreseen future.
The “Single-Use Upstream Bioprocessing Technology / Equipment Market by Type of Product (Single-use Bioreactors, Single-use Mixers, Single-use Media Bags, Single-use Filters, Single-use Sampling Systems, Single-use Connectors and Others), Scale of Operation (Preclinical / Clinical and Commercial) and Key Geographical Regions (North America, Europe, Asia-Pacific, Latin-America, Middle East and North Africa and Rest of the World): Industry Trends and Global Forecasts, 2022-2035” report features an extensive study of the current landscape and the likely future potential of single-use upstream bioprocessing technology and equipment developers, over the next 15 years. The study also features an in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in this field.
One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of single-use upstream bioprocessing technology / equipment market. Based on multiple parameters, such as overall upstream bioprocessing equipment market, and share of single-use technology, we have provided an informed estimate of the evolution of the market for the period 2022-2035. Our year-wise projections of the current and future opportunity have further been segmented on the basis of [A] scale of operation (preclinical / clinical and commercial), [B] type of product (single-use bioreactors, single-use mixers, single-use media bags, single-use filters, single-use sampling systems, single-use connectors and others), and [C] key geographical regions (North America, Europe, Asia-Pacific, Latin America, MENA and Rest of the World). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.
The opinions and insights presented in this study were also influenced by discussions held with senior stakeholders in the industry.
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
Presently, several companies are engaged in developing and manufacturing single-use upstream bioprocessing technologies and equipment, such as single-use bioreactors, single-use mixers, single-use filters, single-use media bags and containers, single-use sampling systems and single-use connectors. Further, a number of these players are also focusing on incorporating additional features, including provisions for alerts / alarms, built-in system process control sensors, electronic process logs, remote monitoring features, touch screens, and advanced safety provisions, in their proprietary offerings. The adoption of this technology is fraught with some challenges, such as risk of extractables and leachable, single-use technology disposability, sterilization / irradiation issues and potential inconsistency of the resins, however, owing to the ongoing research on sustainability of this technology and other technical advancements, we are led to believe that the opportunity for technology providers engaged in this domain is likely to grow in the foreseen future.
Scope of the Report
The “Single-Use Upstream Bioprocessing Technology / Equipment Market by Type of Product (Single-use Bioreactors, Single-use Mixers, Single-use Media Bags, Single-use Filters, Single-use Sampling Systems, Single-use Connectors and Others), Scale of Operation (Preclinical / Clinical and Commercial) and Key Geographical Regions (North America, Europe, Asia-Pacific, Latin-America, Middle East and North Africa and Rest of the World): Industry Trends and Global Forecasts, 2022-2035” report features an extensive study of the current landscape and the likely future potential of single-use upstream bioprocessing technology and equipment developers, over the next 15 years. The study also features an in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in this field.
In addition to other elements, the study includes:
- A detailed assessment of the overall market landscape of single-use bioreactors based on a number of relevant parameters, such as scale of operation (lab, clinical and commercial), type of cell culture system (2D culture and 3D culture), type of cell culture (mammalian, insect, microbial, viral, plant and others), type of molecule (vaccine, monoclonal antibody, recombinant protein, stem cell, cell therapy, gene therapy and others), key features (touch screen, remote monitoring, build-in system control sensors, electronic log record, alarm system), application area (stem cell research, cancer research, regenerative medicine, drug discovery and others) and end users (pharma / biopharma, contract manufacturing organization, contract research organization and academic institutes). In addition, it presents details of the companies developing single-use bioreactors, highlighting their year of establishment, company size, and geographical presence.
- A detailed assessment of the overall market landscape of single-use mixers based on a number of relevant parameters, such as scale of operation (lab, clinical and commercial), type of mixing system (liquid / liquid, solid / liquid and powder / liquid), type of molecule (vaccines, biologics, biosimilars and monoclonal antibody), key features (visual display / touch screen, ease to use / scalability, build-in system control sensors and process automation) and application area (media preparation, formulation, buffer preparation, viral inactivation and others). In addition, it presents details of the companies developing single-use bioreactors, highlighting their year of establishment, company size, and geographical presence.
- A detailed assessment of the overall market landscape of single-use sensors, based on several relevant parameters, such as type of sensor (conductivity, flow, pH, pressure and temperature), type of bioprocessing, measurement range, operating temperature, sterilization technique, material used) and application area. In addition, the chapter presents details of the companies involved in the development of single-use sensors, including information on their year of establishment, company size, and geographical presence.
- An overview of the overall market landscape of other single-use technologies, such as filters, sampling systems and connectors.
- A detailed competitiveness analysis of single-use bioreactors, single-use mixers and single-use sensors, taking into consideration several relevant parameters. For single-use bioreactors, the parameters taken into account include the product applicability (type of cell culture, type of molecule and application area) and product strength (type of cell culture system, scale of operation and key features). For single-use mixers, the parameters taken into account include the product applicability (type of mixing system, type of molecule and application area) and product strength (scale of operation). For single-use sensors, the parameters taken into account include the product specificity (minimum operating temperature, maximum operating temperature, type of calibration and type of sterilization technique) and product strength (application area and type of bioprocessing).
- Tabulated profiles of the key players providing single-use upstream bioprocessing technologies, which are headquartered in North America, Europe and Asia-Pacific. Each profile includes an overview of the company, information on the financial performance (if available), service portfolio, product portfolio, recent developments, and an informed future outlook.
- An in-depth analysis of various patents that have been filed / granted for single-use upstream bioprocessing technology, till December 2021, highlighting key trends associated with these patents, across type of patents, publication year, application year, issuing authorities involved, type of organizations, emerging focus area, patent age, CPC symbols, leading patent assignees (in terms of number of patents granted / filed), patent characteristics and geography. It also includes a detailed patent benchmarking and an insightful valuation analysis.
- A detailed brand positioning analysis of the key industry players (including single-use bioreactor developers, single-use mixers developers and single-use sensors developers), highlighting the current perceptions regarding their proprietary products by taking into consideration several relevant aspects, such as experience of the manufacturer, number of products offered, product diversity, and number of patents published.
- An insightful analysis of the cost and time saving potential of single-use upstream bioprocessing technology.
- An informed estimate on the current and future demand-supply scenario for single-use upstream bioprocessing technologies, for the period 2022-2035.
One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of single-use upstream bioprocessing technology / equipment market. Based on multiple parameters, such as overall upstream bioprocessing equipment market, and share of single-use technology, we have provided an informed estimate of the evolution of the market for the period 2022-2035. Our year-wise projections of the current and future opportunity have further been segmented on the basis of [A] scale of operation (preclinical / clinical and commercial), [B] type of product (single-use bioreactors, single-use mixers, single-use media bags, single-use filters, single-use sampling systems, single-use connectors and others), and [C] key geographical regions (North America, Europe, Asia-Pacific, Latin America, MENA and Rest of the World). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.
The opinions and insights presented in this study were also influenced by discussions held with senior stakeholders in the industry.
The report features detailed transcripts of interviews held with the following industry players:
- Christopher Brau (R&D Staff Scientist and Engineer, Thermo Fisher Scientific)
- Nico Oosterhuis (Technical Director and Co-Owner, Celltainer Biotech)
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
Key Questions Answered
- Who are the leading players offering single-use upstream bioprocessing technologies?
- What are the different application areas where single-use upstream bioprocessing technologies can be used?
- In which regions majority of the single-use upstream bioprocessing technology providers are located?
- What is the relative competitiveness of different single-use upstream bioprocessing technologies?
- What are the key features of single-use bioreactors?
- How has the intellectual property landscape of single-use upstream bioprocessing technologies, evolved over the years?
- What is the current demand and supply of biologics manufacturing through single-use upstream bioprocessing technology?
- How is the current and future opportunity likely to be distributed across key market segments?
Table of Contents
1. PREFACE
3. INTRODUCTION
4. MARKET LANDSCAPE: SINGLE-USE BIOREACTORS
5. MARKET LANDSCAPE: SINGLE-USE MIXERS
6. MARKET LANDSCAPE: SINGLE-USE SENSORS
7. MARKET LANDSCAPE: OTHER SINGLE-USE UPSTREAM BIOPROCESSING TECHNOLOGIES
8. PRODUCT COMPETITIVENESS ANALYSIS
9. SINGLE-USE UPSTREAM BIOPROCESSING TECHNOLOGY PROVIDERS IN NORTH AMERICA: COMPANY PROFILES
10. SINGLE-USE UPSTREAM BIOPROCESSING TECHNOLOGY PROVIDERS IN EUROPE: COMPANY PROFILES
11. SINGLE-USE UPSTREAM BIOPROCESSING TECHNOLOGY PROVIDERS IN ASIA-PACIFIC: COMPANY PROFILES
12. PATENT ANALYSIS
13. BRAND POSITIONING MATRIX
14. CASE STUDY: COST AND TIME SAVING POTENTIAL OF SINGLE-USE UPSTREAM BIOPROCESSING TECHNOLOGY
15. DEMAND AND SUPPLY ANALYSIS
16. MARKET FORECAST AND OPPORTUNITY ANALYSIS
17. CONCLUSION
18. EXECUTIVE INSIGHTS
List Of Figures
List Of Tables
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 3M
- ABEC
- Acceleron Pharma
- Applied Biosensors
- Applikon Biotechnology
- Avantor
- BIONET
- Bioprocess Engineering Services (BPES)
- Biosan
- Celartia
- Cell Culture Company
- CellBios Healthcare & Lifesciences
- Cellexus
- Celltainer Biotech
- CerCell
- CESCO Bioengineering
- Corning
- Cytiva
- Distek
- DrM Life Science
- Emerson
- Entegris
- Eppendorf
- Equflow
- ErtelAlsop
- Esco Aster
- Finesse Solutions
- FlexBiosys
- High Purity New England
- INTEGRA Biosciences
- LFB Biomanufacturing
- Malema Engineering
- Masterflex
- Meissner Filtration Products
- Merck KGaA
- METTLER TOLEDO
- MicroDigital
- OmniBRx Biotechnologies
- optek-Danulat
- Pall Corporation
- Parker Hannifin
- PBS Biotech
- PerfuseCell
- Polestar Technologies
- PPD
- Premas Biotech
- PreSens Precision Sensing
- ProlifeCell
- RealBio Technology
- Rentschler Biopharma
- REPROCELL
- RIM Bio
- Saint-Gobain
- Sartorius Stedim Biotech
- SATAKE MultiMix
- Scinus Cell Expansion
- Sensirion
- Sentinel Process Systems
- Solaris Biotech
- Solida Biotech
- Strain Measurement Devices
- Synthecon
- Thermo Fisher Scientific
- Univercells
- Venair
Methodology
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