Sensorineural Hearing Loss (SHL) - Pipeline Insight, 2024

This “Sensorineural Hearing Loss (SHL) - Pipeline Insight, 2024” report provides comprehensive insights about 20+ companies and 21+ pipeline drugs in Sensorineural Hearing Loss (SHL) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Sensorineural Hearing Loss (SHL): Understanding

Sensorineural Hearing Loss (SHL): Overview

Sensorineural Hearing Loss (SHL) is caused by damage to the structures in your inner ear or your auditory nerve. It is the cause of more than 90 percent of hearing loss in adults. Common causes of SNHL include exposure to loud noises, genetic factors, or the natural aging process. Individuals with SHL may experience difficulties in understanding speech, hearing faint sounds, or distinguishing between different sounds. Diagnosis typically involves a comprehensive hearing evaluation by an audiologist, which may include a physical examination, hearing tests, and imaging studies.

Sensorineural Hearing Loss (SHL) is characterized by various signs and symptoms that can impact an individual's auditory experience. Common indicators of SHL include difficulty understanding speech, muffled hearing, a sensation of fullness in the ear, and a gradual or sudden loss of hearing. Additionally, individuals with SHL may struggle to follow conversations in noisy environments, experience a ringing or buzzing sound in the ears (tinnitus), find it challenging to differentiate between high-pitched sounds, and perceive voices as mumbled or slurred.

Right now, there’s no surgical option to treat SNHL. The most common options are hearing aids and cochlear implants to help compensate for hearing loss. Gene therapy for hearing loss is an expanding field of research. However, at this time it’s not clinically used for SNHL.

• Hearing aids

Modern hearing aids can match specific hearing loss symptoms. For example, if you have problems hearing high-frequency sounds, a hearing aid can help dial in these sounds without affecting other frequencies.

• Cochlear implants

A cochlear implant is a device that can be surgically implemented to help with severe SNHL. A cochlear implant has two parts, a microphone you wear behind your ear and a receiver inside your ear that sends electrical information to your auditory nerve.

"Sensorineural Hearing Loss (SHL) - Pipeline Insight, 2024" report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Sensorineural Hearing Loss (SHL) pipeline landscape is provided which includes the disease overview and Sensorineural Hearing Loss (SHL) treatment guidelines. The assessment part of the report embraces, in depth Sensorineural Hearing Loss (SHL) commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Sensorineural Hearing Loss (SHL) collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Sensorineural Hearing Loss (SHL) R&D. The therapies under development are focused on novel approaches to treat/improve Sensorineural Hearing Loss (SHL).

Sensorineural Hearing Loss (SHL) Emerging Drugs Chapters

This segment of the Sensorineural Hearing Loss (SHL) report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Sensorineural Hearing Loss (SHL) Emerging Drugs

SENS-401: Sensorion

SENS-401 is a first-in-class drug candidate to treat Sudden Sensorineural Hearing Loss (SSNHL). It is aiming at treating or protecting against inner ear lesions that lead to nerve degeneration and sensory hair cell loss. It is protected by a solid intellectual property with two patent families. The drug is currently being evaluated under Phase II/III clinical trial for the treatment of patients with Sensorineural Hearing Loss.

AC-102: AudioCure Pharma

AC-102 is a disease modifying novel molecule. Preclinical models have demonstrated the unique potential of AC102 to act beneficially upon three cell types of the inner ear which are critical for the hearing process: the sensory inner hair cells, the sensory outer hair cells and the acoustic nerve. The drug is currently being evaluated under Phase II clinical trial for the treatment of patients with Sensorineural Hearing Loss (SHL).

LY 3056480: Audion Therapeutics

Audion’s lead candidate (LY 3056480) has undergone a thorough and extensive preclinical characterization in multiple model systems prior to initiation of the clinical studies. These studies include effects of the drug on damaged inner ear tissue, inner ear PK studies to determine drug exposure using different formulations and formal ototoxicity studies to exclude toxic effects on normal hair cells and inner ear tissues. The drug is currently being evaluated under Phase I/II clinical trial for the treatment of patients with Sensorineural Hearing Loss (SHL).

Sensorineural Hearing Loss (SHL): Therapeutic Assessment

This segment of the report provides insights about the different Sensorineural Hearing Loss (SHL) drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Sensorineural Hearing Loss (SHL)

There are approx. 20+ key companies which are developing the therapies for Sensorineural Hearing Loss (SHL). The companies which have their Sensorineural Hearing Loss (SHL) drug candidates in the most advanced stage, i.e. Phase II/III include, Sensorion.

Phases

The report covers around 21+ products under different phases of clinical development like:

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of:
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Sensorineural Hearing Loss (SHL) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as:

• Intravenous
• Subcutaneous
• Oral
• Intramuscular

Molecule Type

Products have been categorized under various Molecule types such as:

• Monoclonal antibody
• Small molecule
• Peptide

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Sensorineural Hearing Loss (SHL): Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Sensorineural Hearing Loss (SHL) therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Sensorineural Hearing Loss (SHL) drugs.

Sensorineural Hearing Loss (SHL) Report Insights

• Sensorineural Hearing Loss (SHL) Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Sensorineural Hearing Loss (SHL) Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Sensorineural Hearing Loss (SHL) drugs?
• How many Sensorineural Hearing Loss (SHL) drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Sensorineural Hearing Loss (SHL)?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Sensorineural Hearing Loss (SHL) therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Sensorineural Hearing Loss (SHL) and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Sensorion
• AudioCure Pharma
• Audion Therapeutics
• Reyon Pharmaceutical
• Decibel Therapeutics
• Sound Pharmaceuticals
• Otonomy
• Pipeline Therapeutics
• Heyu (Suzhou) Pharmaceutical
• Cilcare

Key Products

• SENS-401
• AC-102
• LY 3056480
• RY-103
• DB-OTO
• Ebselen
• OTO 413
• PIPE 505
• HY-01
• CIL-003

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