This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
- Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes-more than 150 diagnoses in all
- Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care
- Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others
- Meticulously edited by Dr. Vania Nos� with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered
- Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
- Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification
- Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Table of Contents
SECTION 1: THYROID NONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL
4 Thyroglossal Duct Cyst Vania Nos�, MD, PhD and Nicole A. Cipriani, MD 8 Ectopic Thyroid Vania Nos�, MD, PhD 12 Solid Cell Nests Vania Nos�, MD, PhD 16 Dyshormonogenetic Goiter Vania Nos�, MD, PhD
INFECTIOUS
22 Acute Thyroiditis Vania Nos�, MD, PhD
AUTOIMMUNE/INFLAMMATORY
26 Subacute/Granulomatous Thyroiditis Vania Nos�, MD, PhD 32 Palpation Thyroiditis Vania Nos�, MD, PhD and Nicole A. Cipriani, MD 34 IgG4-Related Thyroid Disease Vania Nos�, MD, PhD 38 Riedel Thyroiditis Vania Nos�, MD, PhD 44 Hashimoto Thyroiditis Vania Nos�, MD, PhD 52 Graves Disease (Diffuse Hyperplasia) Suzana Leite, MD and Vania Nos�, MD, PhD 60 Amyloid Goiter Vania Nos�, MD, PhD
REACTIVE
66 Pigments and Crystals, Thyroid Nicole A. Cipriani, MD and Vania Nos�, MD, PhD 72 Post-FNA Site Changes, Thyroid Vania Nos�, MD, PhD and Darcy A. Kerr, MD
NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS
74 Thyroid Follicular Nodular Disease Vania Nos�, MD, PhD 80 Adenomatous Nodules Vania Nos�, MD, PhD and Lori A. Erickson, MD 86 Follicular Thyroid Adenoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 94� Follicular Thyroid Adenoma With Papillary� Architecture� Vania Nos�, MD, PhD� 98� Oncocytic Thyroid Adenoma� Vania Nos�, MD, PhD and Lori A. Erickson, MD� 102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features Vania Nos�, MD, PhD and Ying-Hsia Chu, MD 112 Hyalinizing Trabecular Tumor of Thyroid Vania Nos�, MD, PhD and Nicole A. Cipriani, MD 118 Follicular Thyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 128 Oncocytic Thyroid Carcinoma Ying-Hsia Chu, MD and Vania Nos�, MD, PhD 132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 140 Kinase Fusion-Related Thyroid Carcinomas Ying-Hsia Chu, MD and Vania Nos�, MD, PhD 148 Follicular Cell-Derived Thyroid Carcinoma, High Grade Nicole A. Cipriani, MD and Vania Nos�, MD, PhD 158 Anaplastic Thyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 168 Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Ying-Hsia Chu, MD 182 Classic Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC 190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 194 Macrofollicular Papillary Thyroid Carcinoma Vania Nos�, MD, PhD 200 Diffuse Sclerosing Papillary Thyroid Carcinoma Nicole A. Cipriani, MD and Vania Nos�, MD, PhD 206 Oncocytic Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD 210 Tall Cell Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC 218 Columnar Cell Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 222 Clear Cell Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC 224 Solid/Trabecular Papillary Thyroid Carcinoma Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC 228 Hobnail Papillary Thyroid Carcinoma Julie Guilmette, MD, FRCPC and Vania Nos�, MD, PhD 234 Warthin-Like Papillary Thyroid Carcinoma Vania Nos�, MD, PhD
C-CELL-DERIVED TUMORS
240 C-Cell Hyperplasia Vania Nos�, MD, PhD and Adam S. Fisch, MD, PhD 246 Medullary Thyroid Carcinoma Vania Nos�, MD, PhD and Adam S. Fisch, MD, PhD
MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA
256 Mixed Medullary and Follicular Cell-Derived Thyroid Carcinoma Vania Nos�, MD, PhD and Darcy A. Kerr, MD
THYMIC TUMORS WITHIN THYROID
260 Spindle Epithelial Tumor With Thymus-Like Differentiation Vania Nos�, MD, PhD 266 Intrathyroid Thymic Carcinoma Vania Nos�, MD, PhD
SALIVARY GLAND-LIKE THYROID TUMORS
274 Mucoepidermoid Carcinoma of Thyroid Darcy A. Kerr, MD and Vania Nos�, MD, PhD 278 Secretory Carcinoma of Salivary Gland Type Darcy A. Kerr, MD and Vania Nos�, MD, PhD
HEMATOLYMPHOID TUMORS
282 Lymphoma, Thyroid Judith Ferry, MD 288 Follicular Dendritic Cell Sarcoma, Thyroid Vania Nos�, MD, PhD and Darcy A. Kerr, MD 292 Langerhans Cell Histiocytosis, Thyroid Vania Nos�, MD, PhD and Dipti P. Sajed, MD, PhD
GERM CELL ORIGIN
296 Benign Thyroid Teratoma Vania Nos�, MD, PhD 302 Struma Ovarii, Struma Carcinoid, and Malignant Struma Ovarii Vania Nos�, MD, PhD
EMBRYONAL THYROID TUMORS
310 Thyroblastoma Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
MESENCHYMAL AND STROMAL TUMORS
316 Peripheral Nerve Sheath Tumor, Thyroid Vania Nos�, MD, PhD and Darcy A. Kerr, MD 320 Solitary Fibrous Tumor, Thyroid Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD 326 Paraganglioma, Thyroid Lori A. Erickson, MD and Vania Nos�, MD, PhD 332 Leiomyoma and Leiomyosarcoma, Thyroid Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD 336 Angiosarcoma, Thyroid Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD 340 Primary Ewing Sarcoma, Thyroid Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD
SECONDARY TUMORS WITHIN THYROID
344 Metastasis to Thyroid Gland Vania Nos�, MD, PhD and Darcy A. Kerr, MD
TUMORS OF UNCERTAIN HISTOGENESIS
350 Cribriform Morular Thyroid Carcinoma Vania Nos�, MD, PhD 360 Sclerosing Mucoepidermoid Carcinoma With Eosinophilia Darcy A. Kerr, MD and Vania Nos�, MD, PhD
MOLECULAR PATHOLOGY OF THYROID NEOPLASMS
366 Molecular Pathology of Thyroid Neoplasms Vania Nos�, MD, PhD and Ying-Hsia Chu, MD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF THYROID GLAND
372 Thyroid Carcinoma Protocol Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
SECTION 2: PARATHYROID GLAND NONNEOPLASTIC
376 Primary Multiglandular Parathyroid Disease Lori A. Erickson, MD 386 Primary Parathyroid Clear Cell Hyperplasia Lori A. Erickson, MD 390 Secondary Parathyroid Hyperplasia Lori A. Erickson, MD 396 Tertiary Parathyroid Hyperplasia Lori A. Erickson, MD 400 Chronic Parathyroiditis Lori A. Erickson, MD
NEOPLASTIC
404 Parathyroid Adenoma Lori A. Erickson, MD and Vania Nos�, MD, PhD 412 Parathyroid Lipoadenoma Lori A. Erickson, MD 416 Atypical Parathyroid Tumor Vania Nos�, MD, PhD and Lori A. Erickson, MD 422 Parathyroid Carcinoma Vania Nos�, MD, PhD and Lori A. Erickson, MD 432 Metastasis to Parathyroid Gland Lori A. Erickson, MD
SECTION 3: ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC
438 Adrenal Heterotopia Arthur S. Tischler, MD 440 Adrenal Hypoplasia and Malformations Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD 444 Adrenal Cytomegaly Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD 446 Infectious Disorders, Adrenal Glands Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH 450 Autoimmune Adrenalitis Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH 452 Adrenal Amyloidosis Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH 456 Incidental Adrenal Nodules Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD 460 Adrenal Cysts Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
ADRENAL CORTICAL NEOPLASTIC
466 Adrenocortical Hyperplasia and Adrenocortical Nodular Disease Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD 472 Primary Pigmented Nodular Adrenocortical Disease Vania Nos�, MD, PhD 478 Nonfunctioning Adrenal Cortical Adenoma Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD 480 Aldosterone-Producing Adenoma Vania Nos�, MD, PhD and Patricia Nogueira de Sa, MD 486 Cortisol-Secreting Adrenal Cortical Adenoma Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD 492 Sex Hormone-Producing Adrenal Cortical Adenoma Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD 494 Oncocytic Adrenal Cortical Adenoma Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD 498 Adrenal Cortical Carcinoma Vania Nos�, MD, PhD and Ying-Hsia Chu, MD 510 Adrenal Cortical Neoplasms in Children Vania Nos�, MD, PhD
ADRENAL MEDULLA AND PARAGANGLIA 518 Adrenal Medullary Hyperplasia Vania Nos�, MD, PhD 522 Pheochromocytoma and Paraganglioma Vania Nos�, MD, PhD, Arthur S. Tischler, MD, and Ying-Hsia Chu, MD 534 Composite Pheochromocytoma and Composite Paraganglioma Vania Nos�, MD, PhD and Arthur S. Tischler, MD 540 Neuroblastic Tumors of Adrenal Gland Vania Nos�, MD, PhD
ADRENAL MESENCHYMAL AND STROMAL TUMORS 552 Primary Adrenal Myelolipoma Vania Nos�, MD, PhD 556 Primary Adrenal Melanoma Vania Nos�, MD, PhD 560 Primary Adrenal Benign Connective Tissue Tumor Vania Nos�, MD, PhD 562 Primary Adrenal Angiosarcoma Vania Nos�, MD, PhD 566 Primary Adrenal Leiomyosarcoma Vania Nos�, MD, PhD 570 Metastasis to Adrenal Gland Vania Nos�, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ADRENAL GLAND 574 Adrenal Cortical Carcinoma Protocol Vania Nos�, MD, PhD
SECTION 4: PITUITARY GLAND NONNEOPLASTIC 578 Hypophysitis, Pituitary Gland M.Beatriz S. Lopes, MD, PhD 582 Hyperplasia, Pituitary Gland M.Beatriz S. Lopes, MD, PhD 584 Sarcoidosis, Pituitary Gland M.Beatriz S. Lopes, MD, PhD and Vania Nos�, MD, PhD 588 Infarction, Pituitary Gland M.Beatriz S. Lopes, MD, PhD 590 Sheehan Syndrome, Pituitary Gland M.Beatriz S. Lopes, MD, PhD 592 Cystic Lesions of Sellar Region M.Beatriz S. Lopes, MD, PhD 596 Empty Sella Syndrome M.Beatriz S. Lopes, MD, PhD
NEOPLASTIC ANTERIOR NEUROENDOCRINE NEOPLASMS 598 Pituitary Neuroendocrine Tumor/Adenoma M.Beatriz S. Lopes, MD, PhD and Vania Nos�, MD, PhD 604 Somatotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 608 Lactotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 612 Thyrotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 616 Plurihormonal PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 620 Corticotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 624 Gonadotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 628 Null Cell PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 630 Metastatic Pituitary Neuroendocrine Tumor Vania Nos�, MD, PhD and M. Beatriz S. Lopes, MD, PhD
OTHER ANTERIOR PITUITARY TUMORS 634 Adamantinomatous Craniopharyngioma M.Beatriz S. Lopes, MD, PhD 636 Papillary Craniopharyngioma M.Beatriz S. Lopes, MD, PhD 638 Pituitary Blastoma
POSTERIOR PITUITARY NEOPLASMS
642 Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor of Sella M.Beatriz S. Lopes, MD, PhD
NEURONAL TUMORS
646 Gangliocytoma M.Beatriz S. Lopes, MD, PhD 650 Neuronal Cell Tumors, Pituitary M.Beatriz S. Lopes, MD, PhD
OTHER PITUITARY TUMORS
652 Metastasis to Pituitary Gland M.Beatriz S. Lopes, MD, PhD 654 Mesenchymal and Hematopoietic Tumors, Pituitary Gland M.Beatriz S. Lopes, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH PRIMARY PITUITARY TUMORS
658 Protocol for Examination of Specimens From Patients With Primary Pituitary Tumors Vania Nos�, MD, PhD and M. Beatriz S. Lopes, MD, PhD
SECTION 5: ENDOCRINE PANCREAS
664 Pancreatic Neuroendocrine Neoplasms Vania Nos�, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ENDOCRINE PANCREAS
674 Pancreatic Neuroendocrine Carcinoma Protocol Vania Nos�, MD, PhD
SECTION 6: ENDOCRINE SKIN
678 Merkel Cell Carcinoma Lori A. Erickson, MD
SECTION 7: FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTED THYROID GLAND
690 DICER1 Syndrome Vania Nos�, MD, PhD and Michelle Menon Miyake, MD 700 Familial Thyroid Carcinoma Vania Nos�, MD, PhD 706 McCune-Albright Syndrome Vania Nos�, MD, PhD 712 Multiple Endocrine Neoplasia Type 2 (MEN2) Vania Nos�, MD, PhD 720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma Vania Nos�, MD, PhD 726 PTEN Hamartoma Tumor Syndromes Vania Nos�, MD, PhD 734 Syndromic Familial Follicular Cell-Derived Thyroid Carcinoma Vania Nos�, MD, PhD
PARATHYROID GLAND
742 Familial Isolated Hyperparathyroidism Vania Nos�, MD, PhD and Lori A. Erickson, MD 746 Hyperparathyroidism-Jaw Tumor Syndrome Vania Nos�, MD, PhD and Lori A. Erickson, MD 754 Multiple Endocrine Neoplasia Type 1 (MEN1) Vania Nos�, MD, PhD and Michelle Menon Miyake, MD 762 Multiple Endocrine Neoplasia Type 4 (MEN4) Vania Nos�, MD, PhD and Michelle Menon Miyake, MD
ADRENAL GLAND AND PARAGANGLIA
768 Beckwith-Wiedemann Syndrome Patricia Nogueira de Sa, MD and Vania Nos�, MD, PhD 776 Carney Complex Vania Nos�, MD, PhD 784 Hereditary Neuroblastoma Vania Nos�, MD, PhD 788 Hereditary Paraganglioma/Pheochromocytoma Syndromes Vania Nos�, MD, PhD 796 Multiple Endocrine Neoplasia Type 5,MAX-Related Vania Nos�, MD, PhD 798 Neurofibromatosis Type 1 Michelle Menon Miyake, MD and Vania Nos�, MD, PhD 806 von Hippel-Lindau Syndrome Vania Nos�, MD, PhD 814 SDH-Deficient Pheochromocytoma and Paraganglioma Vania Nos�, MD, PhD and Arthur S. Tischler, MD
PANCREAS
820 Glucagon Cell Hyperplasia and Neoplasia Vania Nos�, MD, PhD 824 Hereditary and Familial Pancreatic Cancer Syndrome Daniel C. Chung, MD and Vania Nos�, MD, PhD 828 MAFA-Related Familial Insulinomatosis Vania Nos�, MD, PhD 830 Pancreatic Neuroendocrine Tumor Syndromes 842 Ectopic (Paraneoplastic) Syndromes Lori A. Erickson, MD
