This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
- Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes-more than 150 diagnoses in all
- Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care
- Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others
- Meticulously edited by Dr. Vania Nos� with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered
- Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
- Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification
- Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Table of Contents
SECTION 1: THYROID NONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL
4 Thyroglossal Duct Cyst
Vania Nos�, MD, PhD and Nicole A. Cipriani, MD
8 Ectopic Thyroid
Vania Nos�, MD, PhD
12 Solid Cell Nests
Vania Nos�, MD, PhD
16 Dyshormonogenetic Goiter
Vania Nos�, MD, PhD
INFECTIOUS
22 Acute Thyroiditis
Vania Nos�, MD, PhD
AUTOIMMUNE/INFLAMMATORY
26 Subacute/Granulomatous Thyroiditis
Vania Nos�, MD, PhD
32 Palpation Thyroiditis
Vania Nos�, MD, PhD and Nicole A. Cipriani, MD
34 IgG4-Related Thyroid Disease
Vania Nos�, MD, PhD
38 Riedel Thyroiditis
Vania Nos�, MD, PhD
44 Hashimoto Thyroiditis
Vania Nos�, MD, PhD
52 Graves Disease (Diffuse Hyperplasia)
Suzana Leite, MD and Vania Nos�, MD, PhD
60 Amyloid Goiter
Vania Nos�, MD, PhD
REACTIVE
66 Pigments and Crystals, Thyroid
Nicole A. Cipriani, MD and Vania Nos�, MD, PhD
72 Post-FNA Site Changes, Thyroid
Vania Nos�, MD, PhD and Darcy A. Kerr, MD
NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS
74 Thyroid Follicular Nodular Disease
Vania Nos�, MD, PhD
80 Adenomatous Nodules
Vania Nos�, MD, PhD and Lori A. Erickson, MD
86 Follicular Thyroid Adenoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
94� Follicular Thyroid Adenoma With Papillary�
Architecture�
Vania Nos�, MD, PhD�
98� Oncocytic Thyroid Adenoma�
Vania Nos�, MD, PhD and Lori A. Erickson, MD�
102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
Vania Nos�, MD, PhD and Ying-Hsia Chu, MD
112 Hyalinizing Trabecular Tumor of Thyroid
Vania Nos�, MD, PhD and Nicole A. Cipriani, MD
118 Follicular Thyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
128 Oncocytic Thyroid Carcinoma
Ying-Hsia Chu, MD and Vania Nos�, MD, PhD
132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
140 Kinase Fusion-Related Thyroid Carcinomas
Ying-Hsia Chu, MD and Vania Nos�, MD, PhD
148 Follicular Cell-Derived Thyroid Carcinoma, High Grade
Nicole A. Cipriani, MD and Vania Nos�, MD, PhD
158 Anaplastic Thyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
168 Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Ying-Hsia Chu, MD
182 Classic Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
194 Macrofollicular Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD
200 Diffuse Sclerosing Papillary Thyroid Carcinoma
Nicole A. Cipriani, MD and Vania Nos�, MD, PhD
206 Oncocytic Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD
210 Tall Cell Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
218 Columnar Cell Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
222 Clear Cell Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
224 Solid/Trabecular Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
228 Hobnail Papillary Thyroid Carcinoma
Julie Guilmette, MD, FRCPC and Vania Nos�, MD, PhD
234 Warthin-Like Papillary Thyroid Carcinoma
Vania Nos�, MD, PhD
C-CELL-DERIVED TUMORS
240 C-Cell Hyperplasia
Vania Nos�, MD, PhD and Adam S. Fisch, MD, PhD
246 Medullary Thyroid Carcinoma
Vania Nos�, MD, PhD and Adam S. Fisch, MD, PhD
MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA
256 Mixed Medullary and Follicular Cell-Derived Thyroid Carcinoma
Vania Nos�, MD, PhD and Darcy A. Kerr, MD
THYMIC TUMORS WITHIN THYROID
260 Spindle Epithelial Tumor With Thymus-Like Differentiation
Vania Nos�, MD, PhD
266 Intrathyroid Thymic Carcinoma
Vania Nos�, MD, PhD
SALIVARY GLAND-LIKE THYROID TUMORS
274 Mucoepidermoid Carcinoma of Thyroid
Darcy A. Kerr, MD and Vania Nos�, MD, PhD
278 Secretory Carcinoma of Salivary Gland Type
Darcy A. Kerr, MD and Vania Nos�, MD, PhD
HEMATOLYMPHOID TUMORS
282 Lymphoma, Thyroid
Judith Ferry, MD
288 Follicular Dendritic Cell Sarcoma, Thyroid
Vania Nos�, MD, PhD and Darcy A. Kerr, MD
292 Langerhans Cell Histiocytosis, Thyroid
Vania Nos�, MD, PhD and Dipti P. Sajed, MD, PhD
GERM CELL ORIGIN
296 Benign Thyroid Teratoma
Vania Nos�, MD, PhD
302 Struma Ovarii, Struma Carcinoid, and Malignant Struma Ovarii
Vania Nos�, MD, PhD
EMBRYONAL THYROID TUMORS
310 Thyroblastoma
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
MESENCHYMAL AND STROMAL TUMORS
316 Peripheral Nerve Sheath Tumor, Thyroid
Vania Nos�, MD, PhD and Darcy A. Kerr, MD
320 Solitary Fibrous Tumor, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD
326 Paraganglioma, Thyroid
Lori A. Erickson, MD and Vania Nos�, MD, PhD
332 Leiomyoma and Leiomyosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD
336 Angiosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD
340 Primary Ewing Sarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nos�, MD, PhD
SECONDARY TUMORS WITHIN THYROID
344 Metastasis to Thyroid Gland
Vania Nos�, MD, PhD and Darcy A. Kerr, MD
TUMORS OF UNCERTAIN HISTOGENESIS
350 Cribriform Morular Thyroid Carcinoma
Vania Nos�, MD, PhD
360 Sclerosing Mucoepidermoid Carcinoma With Eosinophilia
Darcy A. Kerr, MD and Vania Nos�, MD, PhD
MOLECULAR PATHOLOGY OF THYROID NEOPLASMS
366 Molecular Pathology of Thyroid Neoplasms
Vania Nos�, MD, PhD and Ying-Hsia Chu, MD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF THYROID GLAND
372 Thyroid Carcinoma Protocol
Vania Nos�, MD, PhD and Julie Guilmette, MD, FRCPC
SECTION 2: PARATHYROID GLAND NONNEOPLASTIC
376 Primary Multiglandular Parathyroid Disease
Lori A. Erickson, MD
386 Primary Parathyroid Clear Cell Hyperplasia
Lori A. Erickson, MD
390 Secondary Parathyroid Hyperplasia
Lori A. Erickson, MD
396 Tertiary Parathyroid Hyperplasia
Lori A. Erickson, MD
400 Chronic Parathyroiditis
Lori A. Erickson, MD
NEOPLASTIC
404 Parathyroid Adenoma
Lori A. Erickson, MD and Vania Nos�, MD, PhD
412 Parathyroid Lipoadenoma
Lori A. Erickson, MD
416 Atypical Parathyroid Tumor
Vania Nos�, MD, PhD and Lori A. Erickson, MD
422 Parathyroid Carcinoma
Vania Nos�, MD, PhD and Lori A. Erickson, MD
432 Metastasis to Parathyroid Gland
Lori A. Erickson, MD
SECTION 3: ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC
438 Adrenal Heterotopia
Arthur S. Tischler, MD
440 Adrenal Hypoplasia and Malformations
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
444 Adrenal Cytomegaly
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
446 Infectious Disorders, Adrenal Glands
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
450 Autoimmune Adrenalitis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
452 Adrenal Amyloidosis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
456 Incidental Adrenal Nodules
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
460 Adrenal Cysts
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
ADRENAL CORTICAL NEOPLASTIC
466 Adrenocortical Hyperplasia and Adrenocortical Nodular Disease
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
472 Primary Pigmented Nodular Adrenocortical Disease
Vania Nos�, MD, PhD
478 Nonfunctioning Adrenal Cortical Adenoma
Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD
480 Aldosterone-Producing Adenoma
Vania Nos�, MD, PhD and Patricia Nogueira de Sa, MD
486 Cortisol-Secreting Adrenal Cortical Adenoma
Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD
492 Sex Hormone-Producing Adrenal Cortical Adenoma
Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD
494 Oncocytic Adrenal Cortical Adenoma
Vania Nos�, MD, PhD and Peter M. Sadow, MD, PhD
498 Adrenal Cortical Carcinoma
Vania Nos�, MD, PhD and Ying-Hsia Chu, MD
510 Adrenal Cortical Neoplasms in Children
Vania Nos�, MD, PhD
ADRENAL MEDULLA AND PARAGANGLIA
518 Adrenal Medullary Hyperplasia
Vania Nos�, MD, PhD
522 Pheochromocytoma and Paraganglioma
Vania Nos�, MD, PhD, Arthur S. Tischler, MD, and Ying-Hsia Chu, MD
534 Composite Pheochromocytoma and Composite Paraganglioma
Vania Nos�, MD, PhD and Arthur S. Tischler, MD
540 Neuroblastic Tumors of Adrenal Gland
Vania Nos�, MD, PhD
ADRENAL MESENCHYMAL AND STROMAL TUMORS
552 Primary Adrenal Myelolipoma
Vania Nos�, MD, PhD
556 Primary Adrenal Melanoma
Vania Nos�, MD, PhD
560 Primary Adrenal Benign Connective Tissue Tumor
Vania Nos�, MD, PhD
562 Primary Adrenal Angiosarcoma
Vania Nos�, MD, PhD
566 Primary Adrenal Leiomyosarcoma
Vania Nos�, MD, PhD
570 Metastasis to Adrenal Gland
Vania Nos�, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ADRENAL GLAND
574 Adrenal Cortical Carcinoma Protocol
Vania Nos�, MD, PhD
SECTION 4: PITUITARY GLAND
NONNEOPLASTIC
578 Hypophysitis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
582 Hyperplasia, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
584 Sarcoidosis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD and Vania Nos�, MD, PhD
588 Infarction, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
590 Sheehan Syndrome, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
592 Cystic Lesions of Sellar Region
M.Beatriz S. Lopes, MD, PhD
596 Empty Sella Syndrome
M.Beatriz S. Lopes, MD, PhD
NEOPLASTIC
ANTERIOR NEUROENDOCRINE NEOPLASMS
598 Pituitary Neuroendocrine Tumor/Adenoma
M.Beatriz S. Lopes, MD, PhD and Vania Nos�, MD, PhD
604 Somatotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
608 Lactotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
612 Thyrotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
616 Plurihormonal PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
620 Corticotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
624 Gonadotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
628 Null Cell PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
630 Metastatic Pituitary Neuroendocrine Tumor
Vania Nos�, MD, PhD and M. Beatriz S. Lopes, MD, PhD
OTHER ANTERIOR PITUITARY TUMORS
634 Adamantinomatous Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD
636 Papillary Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD
638 Pituitary Blastoma
POSTERIOR PITUITARY NEOPLASMS
642 Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor of Sella
M.Beatriz S. Lopes, MD, PhD
NEURONAL TUMORS
646 Gangliocytoma
M.Beatriz S. Lopes, MD, PhD
650 Neuronal Cell Tumors, Pituitary
M.Beatriz S. Lopes, MD, PhD
OTHER PITUITARY TUMORS
652 Metastasis to Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
654 Mesenchymal and Hematopoietic Tumors, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH PRIMARY PITUITARY TUMORS
658 Protocol for Examination of Specimens From Patients With Primary Pituitary Tumors
Vania Nos�, MD, PhD and M. Beatriz S. Lopes, MD, PhD
SECTION 5: ENDOCRINE PANCREAS
664 Pancreatic Neuroendocrine Neoplasms
Vania Nos�, MD, PhD
PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ENDOCRINE PANCREAS
674 Pancreatic Neuroendocrine Carcinoma Protocol
Vania Nos�, MD, PhD
SECTION 6: ENDOCRINE SKIN
678 Merkel Cell Carcinoma
Lori A. Erickson, MD
SECTION 7: FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTED THYROID GLAND
690 DICER1 Syndrome
Vania Nos�, MD, PhD and Michelle Menon Miyake, MD
700 Familial Thyroid Carcinoma
Vania Nos�, MD, PhD
706 McCune-Albright Syndrome
Vania Nos�, MD, PhD
712 Multiple Endocrine Neoplasia Type 2 (MEN2)
Vania Nos�, MD, PhD
720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nos�, MD, PhD
726 PTEN Hamartoma Tumor Syndromes
Vania Nos�, MD, PhD
734 Syndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nos�, MD, PhD
PARATHYROID GLAND
742 Familial Isolated Hyperparathyroidism
Vania Nos�, MD, PhD and Lori A. Erickson, MD
746 Hyperparathyroidism-Jaw Tumor Syndrome
Vania Nos�, MD, PhD and Lori A. Erickson, MD
754 Multiple Endocrine Neoplasia Type 1 (MEN1)
Vania Nos�, MD, PhD and Michelle Menon Miyake, MD
762 Multiple Endocrine Neoplasia Type 4 (MEN4)
Vania Nos�, MD, PhD and Michelle Menon Miyake, MD
ADRENAL GLAND AND PARAGANGLIA
768 Beckwith-Wiedemann Syndrome
Patricia Nogueira de Sa, MD and Vania Nos�, MD, PhD
776 Carney Complex
Vania Nos�, MD, PhD
784 Hereditary Neuroblastoma
Vania Nos�, MD, PhD
788 Hereditary Paraganglioma/Pheochromocytoma Syndromes
Vania Nos�, MD, PhD
796 Multiple Endocrine Neoplasia Type 5,MAX-Related
Vania Nos�, MD, PhD
798 Neurofibromatosis Type 1
Michelle Menon Miyake, MD and Vania Nos�, MD, PhD
806 von Hippel-Lindau Syndrome
Vania Nos�, MD, PhD
814 SDH-Deficient Pheochromocytoma and Paraganglioma
Vania Nos�, MD, PhD and Arthur S. Tischler, MD
PANCREAS
820 Glucagon Cell Hyperplasia and Neoplasia
Vania Nos�, MD, PhD
824 Hereditary and Familial Pancreatic Cancer Syndrome
Daniel C. Chung, MD and Vania Nos�, MD, PhD
828 MAFA-Related Familial Insulinomatosis
Vania Nos�, MD, PhD
830 Pancreatic Neuroendocrine Tumor Syndromes
842 Ectopic (Paraneoplastic) Syndromes
Lori A. Erickson, MD
