Unlike the prophylactic vaccines that are designed and administered as a precautionary measure to prevent the occurrence of a disease, researchers have developed therapeutic vaccines intended to alleviate the suffering of patients already infected with the disease. Therapeutic vaccines are not as efficacious as prophylactic vaccines; however, they demonstrate safety, specificity and a long-lasting response across various clinical conditions. These vaccines help the immune system in recognizing a foreign agent and are primarily being developed for viral infections and different types of cancer. Additionally, individuals who are affected with chronic infections but cannot produce enough efficient antibodies can be administered such vaccines. Currently, six therapeutic vaccines are commercially available, including Imlygic®, Provenge® and Tice® which have recently been approved for treatment of melanoma, prostate cancer and bladder cancer, respectively; in addition, over 350 vaccines are under development for various oncological, infectious, hepatological, neurological and autoimmune disorders.
Extensive research is being conducted to improve the overall stability of these therapeutic formulations and a variety of adjuvants (substances with an innate potential to augment an immune response) have been discovered for the development of more versatile vaccine formulations. Further, researchers are also investigating the potential of these vaccines against other chronic disease conditions, including hypertension and autoimmune disorders. Over the last few years, this segment of industry has witnessed substantial partnership activity and investment from various private and public sector investors/investment funds, which have extended financial support to the organizations engaged in R&D. Driven by encouraging clinical trial results, increasing adoption of therapeutic vaccines for treating various clinical conditions and investment in R&D, the therapeutic vaccines market is poised to witness noteworthy growth in the foreseen future.
One of the key objectives of the report was to estimate the existing market size and future growth opportunity associated with therapeutic vaccines market in the mid to long term. Based on parameters, such as adoption rates and expected prices variations for these products, the publisher has developed informed estimates on the likely evolution of the market for the period 2022-2035.
Our year-wise projections of the current and forecasted opportunity within the therapeutic vaccines market, have further been segmented across different types of vaccines (antigen vaccine, dendritic vaccine, DNA vaccine and peptide vaccine), types of vaccines by method of composition (autologous and allogeneic vaccine), types of therapies (monotherapy and combination), target disease indications, routes of administration (intramuscular, subcutaneous, oral, intranasal, intradermal and others) and key geographical regions (North America, Europe and Asia Pacific).
In order to account for future uncertainties and to add robustness to their model, the publisher has provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.
The opinions and insights presented in the report were influenced by discussions held with senior representatives in the industry. All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD unless otherwise specified.
Extensive research is being conducted to improve the overall stability of these therapeutic formulations and a variety of adjuvants (substances with an innate potential to augment an immune response) have been discovered for the development of more versatile vaccine formulations. Further, researchers are also investigating the potential of these vaccines against other chronic disease conditions, including hypertension and autoimmune disorders. Over the last few years, this segment of industry has witnessed substantial partnership activity and investment from various private and public sector investors/investment funds, which have extended financial support to the organizations engaged in R&D. Driven by encouraging clinical trial results, increasing adoption of therapeutic vaccines for treating various clinical conditions and investment in R&D, the therapeutic vaccines market is poised to witness noteworthy growth in the foreseen future.
Scope of the Report
The “Global Therapeutic Vaccines Market, 2022–2035” report features an extensive study on the current market landscape, offering an informed opinion on the likely evolution and future opportunities associated with the therapeutic vaccines market. The study underlines an in-depth analysis, highlighting the key drivers and the market trends related to this evolving segment of the pharmaceutical industry. Amongst other elements, the report includes:- A detailed assessment of the current market landscape of therapeutic vaccines, based on several relevant parameters, such as phase of development (clinical and preclinical) of lead candidates, type of vaccine (antigen vaccine, dendritic vaccine, DNA vaccine and peptide vaccine), type of vaccine by method of composition (autologous vaccine and allogeneic vaccine), type of therapy (monotherapy and combination therapy), target disease indication and route of administration (intramuscular, intranasal, oral, intradermal, subcutaneous, intravenous and others) and dosing frequency. It also includes a list of players developing therapeutic vaccines along with information on their year of establishment, company size and location of headquarters.
- Elaborate profiles of key players engaged in the development of therapeutic vaccines, based across North America, Europe and Asia Pacific. Each profile features a brief overview of the company, its financial information (if available), details on its clinical-stage vaccine candidates, recent developments and an informed future outlook.
- A detailed analysis of completed, ongoing and planned clinical trials of various therapeutic vaccines, based on important parameters, such as trial registration year, phase of development, trial recruitment status, study design, trial focus area, target disease indication(s), type of sponsor / collaborator, leading industry sponsors / collaborators (in terms of number of trials conducted), number of patients enrolled and regional distribution.
- An in-depth analysis of grants that have been awarded to various research institutes for research related to therapeutic vaccines, during the period, 2016-2022, on the basis of different parameters, such as year of grant award, amount awarded, administering institute center, support period, type of grant application, purpose of grant award, activity code, focus area, study section involved, type of recipient organization and focus area. In addition, it highlights the geographical distribution of recipient organizations, popular NIH departments, prominent program officers, and popular recipient organizations.
- An analysis of the partnerships that have been established in this domain since 2016, covering instances of product development and / or commercialization agreements, R&D collaborations, licensing agreements, mergers and acquisitions, clinical trial agreements, and other relevant deals.
- An analysis of the various start-ups engaged in the field of therapeutic vaccines, based on relevant parameters, such as number of candidates in discovery, preclinical and clinical phases of development, amount raised in different funding instances and number of partnerships established.
- A case study on preventive vaccines, along with information on marketed as well as clinical-stage candidates, based on parameters, such as phase of development, route of administration (intramuscular, subcutaneous, oral, intranasal, intradermal and others), type of vaccine API (live attenuated vaccine, inactivated vaccine, conjugate vaccine, subunit vaccine, toxoid vaccine and others), dosage form (ready to use liquid, lyophilized powder, nasal spray, capsule, and tablet) and target disease indication.
- A case study on contract manufacturing for vaccines, featuring a comprehensive list of active CMOs and analyses based on a number of parameters, such as year of establishment, company size, scale of operation (preclinical, clinical and commercial), geographical location, number of vaccine manufacturing facilities, types of services offered (cell / virus banking, analytical development / testing, formulation, process development, fill / finish and regulatory filings), type of expression systems used for vaccine production (mammalian, microbial and others) and type of vaccine manufactured.
One of the key objectives of the report was to estimate the existing market size and future growth opportunity associated with therapeutic vaccines market in the mid to long term. Based on parameters, such as adoption rates and expected prices variations for these products, the publisher has developed informed estimates on the likely evolution of the market for the period 2022-2035.
Our year-wise projections of the current and forecasted opportunity within the therapeutic vaccines market, have further been segmented across different types of vaccines (antigen vaccine, dendritic vaccine, DNA vaccine and peptide vaccine), types of vaccines by method of composition (autologous and allogeneic vaccine), types of therapies (monotherapy and combination), target disease indications, routes of administration (intramuscular, subcutaneous, oral, intranasal, intradermal and others) and key geographical regions (North America, Europe and Asia Pacific).
In order to account for future uncertainties and to add robustness to their model, the publisher has provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.
The opinions and insights presented in the report were influenced by discussions held with senior representatives in the industry. All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD unless otherwise specified.
Key Questions Answered
- Who are the leading industry players involved in developing therapeutic vaccines?
- What are the key therapeutic areas for which therapeutic vaccines are being / have been developed?
- What are the prevalent trends within competitive landscape of therapeutic vaccines?
- Which geographies are the most active in conducting clinical trials related to therapeutic vaccines?
- Which are the leading funding organizations providing grants for therapeutic vaccines?
- What kind of partnership models are commonly adopted by industry and non-industry stakeholders?
- What are the different initiatives undertaken by start-up players for the development of therapeutic vaccines in the recent past?
- How is the current and future market opportunity likely to be distributed across key market segments?
Please note: This report can be updated on request. Please contact our Customer Experience team using the Ask a Question widget on our website.
Table of Contents
1. PREFACE
3. INTRODUCTION
4. MARKET LANDSCAPE
5. COMPANY PROFILES
6. CLINICAL TRIAL ANALYSIS
7. ACADEMIC GRANT ANALYSIS
8. PARTNERSHIPS AND COLLABORATIONS
9. START-UP HEALTH INDEXING
10. MARKET FORECAST AND OPPORTUNITY ANALYSIS
11. CASE STUDY: GLOBAL PREVENTIVE VACCINES
12. CASE STUDY: VACCINE CONTRACT MANUFACTURING MARKET
List Of Figures
List of Tables
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 3D Medicines
- Abivax
- AC Immune
- Adaptive Biotechnologies
- Aduro Biotech
- Advaxis
- AFFiRiS
- Altimmune
- ApolloBio
- Arbutus Biopharma
- Archivel Farma
- Argos Therapeutics
- Astellas Pharma
- Aston Sci.
- AstraZeneca
- AVAX Technologies
- Axon Neuroscience
- Bavarian Nordic
- Beijing Genomics Institute
- Bellicum Pharmaceuticals
- Bionor Immuno
- BioNTech
- Biosantech
- Brii Biosciences
- Bristol Myers Squibb
- Cancer Insight
- Cancer Vaccines
- Chinook Therapeutics
- Chongqing Jiachen Biotechnology
- Corestem
- CuraVac
- Cure&Sure Biotech
- CureVac
- CYTLIMIC
- Dana-Farber Cancer Institute
- DCPrime
- Dendreon Pharmaceuticals
- Dynavax Technologies
- EMD Serono
- Enterome
- Epimmune
- eTheRNA immunotherapies
- European Oncology Clinical Trial Group
- European Network of Gynaecological Oncological Trial Groups (ENGOT)
- FIT Biotech
- Frame Therapeutics
- Frontier Biotechnologies
- Galena Biopharma
- GeneCure Biotechnologies
- Genentech
- Geneos Therapeutics
- Genexine
- Genocea Biosciences
- Genticel
- Gilead Sciences
- GlaxoSmithKline
- GlobeImmune
- Gradalis
- Gritstone bio
- Hangzhou Neoantigen Therapeutics
- Helocyte
- Ichor Medical Systems
- Immatics Biotechnologies
- Immune Design
- Immune Response BioPharma
- Immunicum
- Immunitor
- ImmunityBio
- ImmunoCellular Therapeutics
- Immunomic Therapeutics
- Immunor
- ImmunoVaccine Technologies
- Immunovative Therapies
- ImmusanT
- Immutep
- Incyte
- InnaVirVax
- Inovio Pharmaceuticals
- Invectys
- iOncologi
- ISA Pharmaceuticals
- Janssen Pharmaceuticals (a subsidiary of Johnson & Johnson)
- Janssen Vaccines & Prevention (a subsidiary of Johnson & Johnson)
- GemVax & KAEL
- Kun Tuo
- Laboratorios Silanes
- LG Life Sciences
- Eli Lilly
- MabVax Therapeutics
- Madison Vaccines
- Marker Therapeutics
- Medigene
- MedImmune
- Memorial Sloan Kettering Cancer Center
- Merck
- Ministry of Health and Family Welfare (MoHFW)
- Moderna
- MOLOGEN
- Morphogenesis
- Mymetics
- NantBioScience (a subsidiary of NantWorks)
- National Heart, Lung, and Blood Institute (NHLBI)
- NEC OncoImmunity
- Nektar Therapeutics
- NewLink Genetics
- Nobelpharma
- Nordic Society of Gynaecological Oncology (NSGO)
- Nouscom
- Novartis Pharmaceuticals
- NovaRx
- NuGenerex Immuno-Oncology
- Nykode Therapeutics
- OncBioMune Pharmaceuticals
- OncoPep
- OncoTherapy Science
- Origimm Biotechnology (acquired by Sanofi)
- OSE Immunotherapeutics
- Oxford Vacmedix
- PapiVax Biotech
- Parker Institute for Cancer Immunotherapy
- PCI Biotech
- PDC*line Pharma
- Peptinov
- Pfizer
- Precision BioSciences
- Precision Life Sciences
- Profectus BioSciences
- QIAGEN
- Quantoom Biosciences
- Regeneron Pharmaceuticals
- ReiThera
- Replicate Bioscience
- RhoVac
- Rigontec (acquired by Merck)
- ROVI Pharmaceuticals
- Sanofi
- SciVac Therapeutics
- Selecta Biosciences
- SELLAS Life Sciences
- Shenzhen BioScien Pharmaceuticals
- Stemirna Therapeutics
- Stemline Therapeutics
- Teva Pharmaceuticals
- Themis Medicare
- Thyas
- Translate Bio (acquired by Sanofi)
- UConn Health
- Ultimovacs
- University of Oxford
- University of Pennsylvania
- Vaccinogen
- Vaccitech
- VaxEquity
- VAXIMM
- Vaxine
- VAXON Biotech
- VBI Vaccines
- Vertex
- Vical
- ViciniVax
- Wistar Institute
- XEME Biopharma
Methodology
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