This reference summarizes information about pharmaceuticals that can target infectious strains of coronaviruses to neutralize infections. Chapters focus on SARS-CoV-2, drug discovery methods and natural methods to combat the virus, which is a causative agent of COVID-19.
The book contents present both conventional drug design and traditional approaches to discovering relevant drugs in an easy-to-read approach, which is supplemented by bibliographic references. It is intended as a reference for students (pharmacology, pharmacy) and researchers (virology) who are seeking information about antiviral drugs that can be used against coronaviruses.
Specifically, the book presents 5 chapters written by expert scholar on the following topics:
- Structure-Based Drug Discovery Approaches Applied to SARS-CoV-2 (the causative agent COVID- 19)
- Potential Antiviral Medicinal Plants against Novel SARS-CoV-2
- Infections Caused by SARS Coronaviruses: Main Characteristics, Targets And Inhibitors
- Natural Sourced Traditional Indian and Chinese Medicines to Combat COVID- 19
- Peptidomimetic and Peptide-Derived Agents Against 3CLpro from Coronaviruses
The book contents present both conventional drug design and traditional approaches to discovering relevant drugs in an easy-to-read approach, which is supplemented by bibliographic references. It is intended as a reference for students (pharmacology, pharmacy) and researchers (virology) who are seeking information about antiviral drugs that can be used against coronaviruses.
Table of Contents
PREFACE- i REFERENCES
- ii LIST OF CONTRIBUTORS
CHAPTER 1 STRUCTURE-BASED DRUG DISCOVERY APPROACHES APPLIED TO SARS-COV-2 (COVID-19)
- Igor José dos Santos Nascimento, Thiago Mendonça de Aquino and Edeildo Ferreira da, Silva-Júnior 1. INTRODUCTION
DRUG DISCOVERY PROCESS
SBDD STRATEGIES AND DISCOVERY OF HITS AGAINST CORONAVIRUSES
1. Homology Modeling
2. Pharmacophore Modeling
3. Molecular Docking and Dynamics Simulations
4. Fragment-Based Drug Discovery
5. De Novo Drug Discovery
5. Virtual Screening (VS) and Virtual High-throughput screening (vHTS)
CHALLENGES IN SBDD FOR SARS-COV-2
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGMENTS
- REFERENCES
CHAPTER 2 POTENTIAL ANTIVIRAL MEDICINAL PLANTS AGAINST NOVEL SARSCOV-2 AND COVID-19 OUTBREAK
- Nazim Sekeroglu and Sevgi Gezici 1. INTRODUCTION
1. Rockrose (Cistus spp.)
2. Lemon balm (Melissa Officinalis L.)
3. Rosemary (Rosmarinus Officinalis L.)
4. Olive leaf (Olea Europea L.)
5. Thyme Species (Origanum, Thymus & Thymbra)
6. Licorice Root (Glycyrrhiza Glabra L.)
7. Other Antiviral Medicinal Plants
- CONCLUSION AND FUTURE DIRECTIONS
- LIST OF ABBREVIATIONS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 3 INFECTIONS CAUSED BY SARS: MAIN CHARACTERISTICS, TARGETS AND INHIBITORS
- Herbert Igor Rodrigues de Medeiros, Gabriela Cristina Soares Rodrigues, Mayara dos, Santos Maia, Marcus Tullius Scotti and Luciana Scotti
ORIGIN AND EPIDEMIOLOGY
SARS PATHOGENESIS
TAXONOMY
MAIN TARGETS OF SARS-COV AND SARS-COV-2
1. Glycoprotein Spike (S)
2. Membrane Protein (M)
3. Envelope Protein (E)
4. Nucleocapsid Protein (N)
5. 3-chymotrypsin-like Cysteine Protease (3CLpro)
6. Angiotensin Converting Enzyme (ACE)-2
DRUGS AND INHIBITORS AGAINST SARS
- CONCLUSION
- LIST OF ABBREVIATIONS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 4 NATURAL SOURCED TRADITIONAL INDIAN AND CHINESE MEDICINES TO COMBAT COVID-19
- Mayank Kumar Khede, Anil Kumar Saxena and Sisir Nandi 1. INTRODUCTION TO INDIAN AND CHINESE TRADITIONAL MEDICINE
1. Traditional Indian Medicines (TIM) to Combat COVID-19
2. Traditional Chinese Medicine (TCM) To Combat COVID-19
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 5 PEPTIDOMIMETIC AND PEPTIDE-DERIVED AGAINST 3CLPRO FROM CORONAVIRUSES
- Paulo Fernando da Silva Santos-Júnior, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior 1. INTRODUCTION
BIOCHEMISTRY ASPECTS AND MOLECULAR HOMOLOGY OF 3CLPRO FROM MERS-COV, SARS-COV, AND SARS-COV-2
1. Structure, Function, and Druggability of 3CLpro from Coronaviruses
2. Catalytic Site of 3CLpro from Coronaviruses
CORONAVIRUSES 3CLPRO AND THEIR INHIBITORS
1. Warhead Groups
2. Peptidomimetics Containing Michael Acceptors as Warhead Groups
3. Peptidomimetics Containing Aldehydes as Warhead Groups
4. Peptidomimetics Containing Keto Groups as Warheads
4.1. Fluoromethyl Ketone Group
4.2. 1,4-Peptidomimetics Containing Phthalazinediones as Warhead Groups
4.3. Peptidomimetics Containing Benzothiazolones/thiazolones as Warhead Groups
4.4.4. Peptidomimetics Containing α-ketoamides as Warhead Groups
4.5. Peptidomimetics Containing Nitroanilides as Warhead Groups
5. Peptidomimetics Containing Nitriles as Warhead Groups
6. Peptidomimetics Containing Aza-epoxides and Aziridines as Warhead Groups
DRUG REPURPOSING FOR PEPTIDOMIMETICS
FINAL CONSIDERATIONS AND FUTURE OUTLOOK
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- SUBJECT INDEX
Author
- Luciana Scotti
- Marcus T. Scotti
