Diabesity: A Multidisciplinary Approach Diabesity refers to the linkageof both diabetes and obesity that results in the coexistence of these 2conditions. Research has identified pathophysiological mechanisms revolvingaround insulin resistance and hyperinsulinemia. Diabesity has importantdiagnostic and therapeutic implications. This book is a multidisciplinaryreview of diabesity. It highlights the various pharmacological methods ofmanaging the condition. The book presents 10 chapterscontributed by more than 40 experts from around the world. The review startswith an overview of diabesity and progressively describes the relationships ofdiabesity with the choice of diets and psychological factors.
The chapters thencover the role of adipokines as therapeutic biomarkers before presentingresearch on medicinal and nutritional approaches to treat the condition.Modern approaches to diabesitytreatment such as the use of new bioactive phytochemicals, mitigatingmeta-inflammation and laboratory techniques are also reviewed in the book.
Diabesity: A MultidisciplinaryApproach is a timelyreference for clinicians (in endocrinology and family medicine subspecialties)and students of pharmacology and medicinal chemistry on the intricaterelationship between diabetes and obesity.
The chapters thencover the role of adipokines as therapeutic biomarkers before presentingresearch on medicinal and nutritional approaches to treat the condition.Modern approaches to diabesitytreatment such as the use of new bioactive phytochemicals, mitigatingmeta-inflammation and laboratory techniques are also reviewed in the book.
Diabesity: A MultidisciplinaryApproach is a timelyreference for clinicians (in endocrinology and family medicine subspecialties)and students of pharmacology and medicinal chemistry on the intricaterelationship between diabetes and obesity.
Table of Contents
PREFACE- i LIST OF CONTRIBUTORS
CHAPTER 1 DIABESITY: OBESITY AND TYPE II DIABETES AS A REAL HEALTH PROBLEM IN DEVELOPED COUNTRIES
- Karina Ramírez-Alarcón, Ana Maria Labraña, Montserrat Victoriano, Lorena Meléndez-Illanes and Miquel Martorell INTRODUCTION
- PHYSIOPATHOLOGY OF OBESITY
- IMPACT OF OBESITY ON HEALTH
- EPIDEMIOLOGY OF OBESITY
- PHYSIOPATHOLOGY OF DIABETES MELLITUS
- IMPACT OF DIABETES MELLITUS ON HEALTH
- EPIDEMIOLOGY OF DIABETES MELLITUS
- FROM OBESITY TO DIABETES
- PREVENTION AND THERAPY
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENT
- REFERENCES
CHAPTER 2 PSYCHOLOGIC FACTORS OF OBESITY: THE RELATIONSHIP BETWEEN OBESITY AND THE CHOICE OF FOODS?
- Jose María Xandri Graupera and Raquel Xandri Martínez INTRODUCTION
- EMOTIONS, PERSONALITY AND OBESITY
- FOOD PREFERENCES AND THEIR RELATIONSHIP TO OBESITY
- Historical Reference
- BIOCHEMICAL FACTORS RELATED TO THE HUNGER SACIEDAD BALANCE
- Related Mechanism in the Hunger/Satiety Balance
- CHRONOLOGICAL EVOLUTION OF FOOD PREFERENCES
- DEVELOPMENT OF PREFERENCES DURING THE PRENATAL PERIOD
- DEVELOPMENT OF PREFERENCES DURING THE POSTNATAL PERIOD
- PRIMARY TRIGGERS OF INTAKE AND APPETITE
- Energy Deficit
- Pleasure
- Stress
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 3 DIETARY RECOMMENDATIONS AND PREVENTION OF DIABESITY- ARE THE CURRENT GUIDELINES ENOUGH?
- Masoodi Hedyeh, Barbour-Tuck Erin and Hassan Vatanparast INTRODUCTION
- DIET AND DISEASE
- DIETARY GUIDELINES AND HEALTHY EATING RESOURCES
- SUSTAINABLE DIETS
- OTHER DIETARY RECOMMENDATIONS
- DIETARY REFERENCE INTAKES
- NUTRIENTS
- Macronutrients
- Minerals and Trace Elements
- Vitamins
- EVIDENCE FOR DIETARY PATTERNS AND NUTRIENT REQUIREMENTS TO PREVENT OR TREAT DIABESITY VIA LAST FIVE YEARS META-ANALYSIS
- Dietary Pattern
- DIET COMPOSITION, GENE EXPRESSION, AND DIABESITY
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 4 ADIPOKINES, POSSIBLE BIOMARKERS AND THERAPEUTIC TARGETS IN OBESITY AND RELATED PATHOLOGIES
- Fabiola Domínguez and Ángel Alonso-Castro INTRODUCTION
- METABOLISM ROLE OF ADIPOSE TISSUE
- OBESITY AND INFLAMMATION
- LEPTIN AND OBESITY
- ADIPONECTIN AND OBESITY
- TNF-Α
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 5 MEDITERRANEAN DIET AND PHYSICAL ACTIVITY FOR REDUCING META-INFLAMMATION IN DIABESITY
- Anna Raguzzini, Luca Massaro, Elisabetta Bernardi, Marco Bernardi and Ilaria Peluso INTRODUCTION
- DIABESITY AND METAINFLAMMATION
- DIETARY APPROACH
- LIFESTYLE: DIET AND PHYSICAL ACTIVITY
- HORMETIC EFFECTS OF MED-DIET AND EXERCISE
- THE ROLE OF DIETARY NITRATE AND ARGININE SUPPLEMENTS
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENT
- REFERENCES
CHAPTER 6 NEW PHYTOCHEMICAL COMPOUNDS FOR PREVENTION OR REDUCTION OF DIABESITY
- Nastasia Belc, Tatiana Onisei, Luminița Catană, Monica Catană, Denisa Duță Gabriel Mustățea, Florica Constantinescu and Claudia Moșoiu INTRODUCTION
- THE IMPORTANCE OF PHENOLIC COMPOUNDS IN THE DIABETIC DIET
- Helianthus Tuberosus
- Chemical Composition of Helianthus Tuberosus
- Momordica Charantia L. (Bitter Cucumber)
- Short History Of Momordica Charantia
- Traditional Uses
- Chemical Composition Of Momordica Charantia
- Systematic Analysis Of The Link Between Momordica Charantia L. And Diabetes
- Mechanisms of Action
- Mechanisms That Justify Hypoglycemic Action
- The Insulinogenic Effect Of Bitter Cucumber
- Studies on the Effect of Bitter Cucumber in the Treatment of Diabetes
- Extracts and Active Ingredients of Momordia Charantica L.
- Uses of Momordica Charantia L. in Alternative Diabetes Therapy
- Uses of Momordica Charantia in Food Supplements and Synergism of the Combined Plants are Taken into Account
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 7 MEDICINAL AND EDIBLE PLANTS AND THEIR BIOACTIVE PHYTOCHEMICALS FOR THE PREVENTION OR REDUCTION OF DIABESITY
- Ignacio Migues and Horacio Heinzen INTRODUCTION
- CULINARY MEDICINE
- FLAVONOIDS
- PHENOLIC AND CHLOROGENIC ACIDS
- OTHER IMPORTANT PHENOLIC COMPOUNDS
- XANTHINES
- SAPONINS/TRITERPENES
- DIETARY FIBER
- ALOE
- PLANT DRUG INTERACTIONS & NEW TRENDS
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 8 MICROBIOTA AND DIABESITY: RELATIONSHIP AND NEW PERSPECTIVES FOR THE TREATMENT OF OBESITY
- Nuria Salazar, Silvia Saturio, David Ríos-Covián, Alicja M. Nogacka, Sergio Ruíz-Saavedra, María Gómez-Martín, Miguel Gueimonde, Sonia González, Silvia Arboleya and Clara G. de los Reyes-Gavilán INTRODUCTION
- FACTORS INVOLVED IN THE DEVELOPMENT OF DIABESITY
- THE GUT MICROBIOTA. HIGH THROUGHPUT MOLECULAR TECHNIQUES FOR THE STUDY OF ITS COMPOSITION
- GUT MICROBIOTA ALTERATIONS (DYSBIOSIS) IN DIABESITY
- THE MICROBIOTA AND THE GUT-BRAIN AXIS IN DIABESITY
- EFFECT OF DIETARY AND MEDICAL INTERVENTIONS ON THE MICROBIOTA
- Probiotics, Prebiotics And Food Bioactive Components As Modulators Of The Microbiota In Diabesity
- Effect Of Medical Treatments On The Microbiota
- Antidiabetic And Antiobesity Drugs
- Bariatric Surgery
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 9 NEW TECHNOLOGIES USED FOR THE STUDY OF DIABESITY AND RELATED PATHOLOGIES. THE MOST RELEVANT ANALYTICAL TECHNIQUES AND LABORATORY EQUIPMENT
- Libia A. García-Flores, Daniel Velázquez-Cortés, Jorge Iván Zurutuza-Lorméndez and Yi Huang INTRODUCTION
- DIABESITY ANALYTICAL TECHNIQUES AND LABORATORY EQUIPMENT
- The Current Diabetes Diagnosis Equipment
- Level Of Glucose On Fluids: Blood Case
- Oral Glucose Tolerance Test
- Glycated Hemoglobin
- PHYSICAL EXAMINATION
- DIABESITY AND OMICS: ANALYTICAL TECHNIQUES AND LABORATORY EQUIPMENT
- Genomics
- Transcriptomics
- Proteomics
- Metabolomics
- Omics Approaches Equipment
- RELATED PATHOLOGIES OF THE DIABESITY: ANALYTICAL TECHNIQUES AND LABORATORY EQUIPMENT
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGMENTS
- REFERENCES
CHAPTER 10 APPROACHING ACTUAL STRATEGIES AND NEW PERSPECTIVES FOR THE PREVENTION AND TREATMENT OF DIABESITY
- Raúl Arcusa, Javier Marhuenda, Cristina García-Viguera and Débora Villaño INTRODUCTION
- NON-PHARMACOLOGICAL TREATMENT OF DIABESITY
- Weight Loss
- Physical Exercise
- Diet
- Microbiota
- Phytochemicals
- PSYCHOLOGICAL APPROACH
Author
- Débora Villaño
- Javier Marhuenda
- Cristina García Viguera
