Neuroimaging in Parkinson's Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson's and related disorders. With new neuroimaging methodologies emerging over the past five years, this book provides a comprehensive overview of new technologies and research. Sections discuss the biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders. Readers will be updated on in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders.
Also discussed is the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's disease and related disorders.
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Table of Contents
Section I. Introduction 1. Parkinson's disease and related disorders: The pursuit for reliable readouts and the role of neuroimaging 2. Advances in magnetic resonance imaging 3. Advances in molecular neuromaging methodology
Section II. Clinical Applications in Parkinson's Disease 4. Dopaminergic molecular imaging in familial and idiopathic Parkinson's disease 5. Serotonergic molecular imaging in familial and idiopathic PD 6.�Molecular imaging beyond dopamine and serotonin�in familial and idiopathic Parkinson's disease 7. Structural MRI in familial and idiopathic PD 8. Functional MRI in familial and idiopathic PD 9. Molecular imaging in prodromal Parkinson's disease
Section III. Clinical Applications in Lewy Body Dementias 10. Molecular imaging evidence in favor or against PDD�and DLB overlap 11. Magnetic resonance imaging in Parkinson's disease with mild cognitive impairment, Parkinson's disease dementia, and dementia with Lewy bodies
Section IV. Clinical Applications in Atypical Parkinsonian Disorders 12. Neuroimaging in multiple system atrophy 13. Neuroimaging in progressive supranuclear palsy 14. Neuroimaging in corticobasal syndrome
Section V. Clinical Applications in Other Movement Disorders 15. Molecular imaging in Huntington's disease 16. Magnetic resonance imaging in Huntington's disease 17. Neuroimaging in essential tremor 18. Neuroimaging in restless legs syndrome 19. Neuroimaging in dystonia 20. Demyelinating syndromes and movement disorders
Authors
Marios Politis University of Exeter, United Kingdom. University of Exeter, United KingdomMarios Politis is a Professor of Neurology, Consultant Neurologist, the Director of Mireille Gillings Neuroimaging Center, and the Director of the Neurodegeneration Imaging Group at University of Exeter. His research involves clinical observation and the use of PET and MR imaging as a method of investigating etiology, pathophysiology, and effects and complications of novel therapies in neurodegenerative disorders such as Parkinson's disease. He has served as a chief investigator in a number of observational and interventional trials. Professor Politis has received a high number of awards and distinctions such as from the Movement Disorder Society, Royal College of Physicians, Society of Nuclear Medicine and Molecular Imaging, and European Academy of Neurology. He is a recipient of the John Stolk Award in Movement Disorders from the American Academy of Neurology. Heather Wilson Neurodegeneration Imaging Group and Mireille Gillings Neuroimaging Centre, University of Exeter, London, United Kingdom. Heather Wilson, MSc. PhD, is a Senior Research Fellow at the Neurodegeneration Imaging Group, and Imaging Methodology Lead at the Mireille Gillings Neuroimaging Centre, University of Exeter. Edoardo Rosario de Natale Neurodegeneration Imaging Group and Mireille Gillings Neuroimaging Centre, University of Exeter, London, United Kingdom. Edoardo Rosario de Natale is a Senior Clinical Research Fellow at the Neurodegeneration Imaging Group at University of Exeter, lead of the clinical applications at the Mireille Gillings Neuroimaging Centre and honorary Consultant at the Royal Devon & Exeter NHS Foundation Trust.
