Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas. Edition No. 3

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Book
January 2023
Elsevier Health Science
ID: 5597261

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of benign and malignant lesions of lymph nodes and extranodal and splenic lymphomas, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas, third edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.

Presents concise, extensive, and up-to-date information on more than 120 benign and malignant lesions of the lymph nodes, and covers extranodal lymphomas to help new and experienced surgical pathologists and hematopathologists alike identify crucial elements of each diagnosis and associated differential diagnoses�
Provides clinical and histologic features, results of relevant ancillary studies, and a differential diagnosis for each entry�
Features extensive updates throughout, reflecting the increasing importance of molecular markers for more precise diagnoses, and covering newly defined disease entities�
Includes new chapters covering EBV(+) T- and NK-cell lymphoproliferative disorders of childhood, Erdheim-Chester disease, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, primary cutaneous acral CD8(+) lymphoma, primary cutaneous CD4(+) small/medium T-cell lymphoproliferative disorder, and primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma; also provides new information on breast implant-associated anaplastic large cell lymphoma�
Contains more than 3,400 high-quality clinical and histological images, gross pathology images, radiologic images, micrographs, flow cytometry histograms, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis�
Includes updated criteria, terminology, and classifications using the WHO Classification of Hematolymphoid Tumors: Lymphoid Neoplasms, 5th edition��
Employs consistently templated chapters, bulleted content, key facts, a variety of test data tables, annotated images, and an extensive index for quick, expert reference at the point of care�
Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud�

SECTION 1: REACTIVE NONSPECIFIC CHANGES

4 Reactive Follicular Hyperplasia

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

10 Reactive Paracortical Hyperplasia

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 2: INFECTIOUS CAUSES OF LYMPHADENITIS

20 Chronic Granulomatous Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

28 Suppurative Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

32 Mycobacterium tuberculosis Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

40 Atypical Mycobacterial Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

48 Mycobacterial Spindle Cell Pseudotumor

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

52 Cat-Scratch Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

58 Bacillary Angiomatosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

64 Lymphogranuloma Venereum Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

68 Whipple Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

72 Syphilitic Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

78 Infectious Mononucleosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

84 Histoplasma Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

90 Cryptococcus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

94 Toxoplasma Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

100 Coccidioides Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

106 Herpes Simplex Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

112 Cytomegalovirus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

120 Human Immunodeficiency Virus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 3: REACTIVE LYMPHADENOPATHIES

132 Inflammatory Pseudotumor of Lymph Node

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

140 Progressive Transformation of Germinal Centers

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

146 Kikuchi-Fujimoto Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

156 Rosai-Dorfman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

166 Kimura Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

174 Unicentric Hyaline-Vascular Variant Castleman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

182 Unicentric Mixed/Plasmacytic Variant Castleman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

188 Multicentric Castleman Disease, Idiopathic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

196 Multicentric Castleman Disease, HHV8 Associated

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

204 Rheumatoid Arthritis-Related Lymphadenopathy

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

212 Sarcoid Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

218 Dermatopathic Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

224 Hemophagocytic Lymphohistiocytosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

234 Lymphadenopathy Associated With Joint Prostheses

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

240 Lipid-Associated Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

244 Lymphadenopathy Secondary to Drug-Induced Hypersensitivity Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

254 IgG4-Related Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

264 Systemic Lupus Erythematosus

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

270 Sinus Histiocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 4: HODGKIN LYMPHOMAS

278 Nodular Lymphocyte-Predominant Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD 290 Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Tables

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

292 Lymphocyte-Rich Classic Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

300 Nodular Sclerosis Hodgkin Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

310 Mixed Cellularity Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

316 Lymphocyte-Depleted Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 5: LEUKEMIA/LYMPHOMAS OF IMMATURE B- OR T-CELL LINEAGE

324 B-Lymphoblastic Leukemia/Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

334 T-Lymphoblastic Lymphoma/Leukemia

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 6: NODAL B-CELL LYMPHOMAS

346 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

356 Richter Transformation

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

364 Lymphoplasmacytic Lymphoma and Waldenstr?m Macroglobulinemia

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

374 Nodal Marginal Zone Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

380 Nodal Follicular Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

392 Pediatric-Type Follicular Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

396 Mantle Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

404 Mantle Cell Lymphoma, Blastoid and Pleomorphic Variants

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

412 Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

422 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

428 ALK(+) Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

434 EBV(+) Diffuse Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

442 HHV8(+) Diffuse Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

450 Burkitt Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

460 High-Grade B-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

468 Mediastinal Gray Zone Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 7: EXTRANODAL B-CELL LYMPHOMAS

480 Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

494 Extranodal Follicular Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

506 Primary Cutaneous Follicle Center Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

516 Primary Mediastinal (Thymic) Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

526 Primary Diffuse Large B-Cell Lymphoma of Central Nervous System

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

536 Pyothorax-Associated Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

542 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

550 Plasmablastic Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

560 Primary Effusion Lymphoma and Solid Variant of Primary Effusion Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

570 Lymphomatoid Granulomatosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

580 Intravascular Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

586 Plasmacytoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

594 EBV-Positive Large B-Cell Lymphoma Associated With Breast Implants

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

600 Primary Diffuse Large B-Cell Lymphoma of Testis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

608 Splenic Marginal Zone Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

616 Hairy Cell Leukemia

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

624 Hairy Cell Leukemia Variant

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

632 Splenic Diffuse Red Pulp B-Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

638 Diffuse Large B-Cell Lymphoma Arising in the Spleen

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 8: NODAL T-CELL LYMPHOMAS

646 Peripheral T-Cell Lymphoma, Not Otherwise Specified

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

656 Angioimmunoblastic T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

666 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+)

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

676 ALK(+) Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

684 ALK(-) Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 9: EXTRANODAL NK-/T-CELL LYMPHOMAS

694 Breast Implant-Associated Anaplastic Large Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

706 Extranodal NK-/T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

716 Hepatosplenic T-Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

726 Enteropathy-Associated T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

734 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

742 Indolent T-Cell Lymphoma of the Gastrointestinal Tract

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

748 Subcutaneous Panniculitis-Like T-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

756 T-Cell Prolymphocytic Leukemia Involving Lymph

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

766 Primary Cutaneous ?/d T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

774 EBV(+) T- and NK-Cell Lymphoid Proliferations and Lymphomas of Childhood

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

784 Mycosis Fungoides

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

798 S?zary Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

810 Primary Cutaneous Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

818 Lymphomatoid Papulosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

826 Primary Cutaneous Acral CD8(+) Lymphoproliferative Disorder

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

832 Primary Cutaneous CD8(+) Aggressive

Epidermotropic Cytotoxic T-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

840 Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative Disorder

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 10: IMMUNODEFICIENCYASSOCIATED LYMPHOPROLIFERATIONS

846 Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

852 Autoimmune Lymphoproliferative Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

864 Immunomodulating Agent-Associated Lymphoproliferative Disorders

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

872 Posttransplant Lymphoproliferative Disorders, Nondestructive Lesions and Polymorphic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

882 Posttransplant Lymphoproliferative Disorder, Monomorphic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

892 EBV(+) Mucocutaneous Ulcer

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 11: GRANULOCYTIC/HISTIOCYTIC TUMORS

898 Myeloid Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

906 Blastic Plasmacytoid Dendritic Cell Neoplasm

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

914 Blastic T/Myeloid Neoplasm With Rearrangements of FGFR1

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

924 Cutaneous Mastocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

928 Systemic Mastocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

940 Histiocytic Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

950 Follicular Dendritic Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

958 Interdigitating Dendritic Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

964 Langerhans Cell Histiocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

976 Langerhans Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

984 Erdheim-Chester Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 12: NONHEMATOPOIETIC PROLIFERATIONS IN LYMPH NODE

990 Epithelial Inclusions in Lymph Node

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

996 Nevus Cell Inclusions in Lymph Node

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

1000 Vascular Transformation of Lymph Node Sinuses

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

1004 Angiomyomatous Hamartoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

1008 Palisaded Myofibroblastoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

1012 Metastatic Kaposi Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

Authors

L. Jeffrey Medeiros Professor and Chair, Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, Texas. L. Jeffrey Medeiros MD is Professor and Chair at the Department of Hematopathology of the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include the diagnosis of lymphomas, including the use of histologic, imunnophenotypic, and molecular methods for diagnosis and prognosis, and most recent research efforts have focused on diffuse aggressive B-cell lymphomas. Dr. Medeiros is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas. Roberto N. Miranda Professor, Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, Texas. Roberto N. Miranda, MD is a Professor at the Department of Hematopathology at the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include T-cell lymphomas and he has developed an expertise in breast implant-associated anaplastic large cell lymphoma, a topic on which he has several landmark publications and book chapters, and on which he has lectured nationally and internationally. Dr. Miranda is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas.

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