This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery.
Part I covers the following topics:
- Introduction to nanotechnology and herbal-based nanoparticulate systems
- Nucleic acid-based therapeutic drug delivery systems
- Herbal bioactives: a booster dose for advanced pharmaceutical nanoscience
- Pulmonary nano-drug delivery systems
- Application of nano-drug delivery systems in improving the therapeutic efficacy of bioactive natural products
- PEGylated liposomes
- Insulin liposomes
- Aquasomes: a promising novel drug carrier
- Nanoparticle-aided herbal drugs: therapeutic implications on cholinergic dysfunction with relevance to Alzheimer’s disease
- Vitamins based nanomedicine approach
- Recent advances in tumor targeting drug delivery systems: fundamentals of advanced pharmaceutical nanoscience
- Niosomes: a revolutionary progress in the field of pharmaceutical sciences
- Infectious diseases: pharmaceutical nanoscience for targeted drug delivery
Table of Contents
Chapter 1 Introduction to Nanotechnology and Herbal-Based Nanoparticulate Systems- The Principle of Particle Size Reduction to Improve the Solubility and Dissolution Rate of Poorly Water-Soluble Drugs
- Advantages of Nanotechnology in the Pharmaceutical and Medicinal Fields
- Challenges
- Classes of Nanoparticles Drug Delivery System
- Polymeric Nanoparticles
- Metallic Nanoparticles
- Solid Lipid Nanoparticles (Sln) and Solid Lipid Carriers (Slc)
- Solid Solution Type of Sln
- Core-Shell Model with Drug-Enriched Shell
- Core-Shell Model with Drug-Enriched Core
- Liposomes
- According to the Structure
- According to Size
- Carbon Nanotubes (Cnts)
- Api Nanonization Techniques
- Bottom-Up Technologies
- Precipitation with a Compressed Liquid Antisolvent (Pca)
- The Rapid Expansion of Supercritical Solution (Ress)
- Supercritical Fluid (Scf)
- Spray Freezing (Sfl)
- Evaporative Precipitation Anti Solvent (Epas)
- Top-Down Techniques
- Media Milling Techniques
- High-Pressure Homogenization (Hph)
- Combination of Top-Down and Bottom-Up Techniques (Second Generation of Drug Nanocrystals; Smartcrystal®)
- Physical Stability of Nanoparticles
- Aggregation
- Crystal Growth
- Sedimentation in Nanosuspensions
- The Crystalline State
- Stabilization of Nanoparticles
- Mechanism of Stabilization
- Stabilizers for Nanoparticles
- Herbal Based Nanoparticles
- Herbal Active Ingredients
- Herbal Stabilizer
- Marketed Product
- Conclusion
- Nucleic Acid-Based Therapeutic Drug Delivery System
- Nucleic Acid-Based Therapy and Its Principle
- Dna-Based Therapeutics and Their Mechanism
- Rna-Based Therapeutics and Their Mechanism
- Barriers to Nucleic-Acid Based Therapeutics Transfection and Their Delivery Systems
- Transfection of Naked Nucleic-Acid Based Therapeutics and Its Barriers
- Major Delivery Systems Used in Transferring Nucleic-Acids Based Therapy
- Nucleic Acid-Based Therapeutic Drug Delivery System as a Tool of Advanced Pharmaceutical Herbal Nanoscience
- Limitations of Herbal Extracts and Innovations
- Correlation Between Nucleic Acid and Herbal Extract Delivery Systems
- Nano-Carriers Common for the Nucleic Acid and Herbal Extract Delivery System with Their Herbal Loading Mechanisms
- Toxicity of Nano-Carrier After Delivering the Cargo
- Recommendations
- Conclusion
- Consent of Publication
- Conflict of Interest
- Acknowledgements
- References
- Sudarshan Singh and Warangkana Chunglok Introduction
- Advantages of Concentric Bilayer Vesicles
- Advantages of Nanoemulsion as Advanced Nano-Carrier Drug Delivery System
- Formulation Facet of Nanoemulsion
- Spontaneous Nanoemulsion Using Low Energy
- Phase Inversion Temperature (Pit)
- Phase Inversion Composition (Pic)
- Spontaneous Emulsification
- Spontaneous Nanoemulsion by a High-Energy Method
- Characterization of Nanoemulsion
- Nanoemulsion as a Booster for Delivering Herbal Bioactive
- Formulation Facet of Vesicular Drug Delivery Systems
- Characterization of Bioactive Encapsulated Vesicular Drug Delivery System
- Vesicular Drug Delivery System as a Booster for the Delivery of Herbal Bioactive
- Market Potential of Bioactive Encapsulated Advanced Nanoscience
- Potential and Challenges
- Conclusion
- Consent for Publication
- Conflict of Interest
- Consent for Publication
- Conflict of Interest
- $ Acknowledgements
- $ References
- $ Acknowledgements
- Reference
- Abubakar Bishir Daku and Asma Abdullah Nurul Introduction
- Mechanisms of Pulmonary Drug Transport
- Deposition of Particles
- A). Inertial Impaction
- B). Sedimentation
- C). Brownian Diffusion
- D). Interception
- E). Electrostatic Effects
- Absorption of Drugsin Pdd
- A). Transcellular Transport
- B). Paracellular Transport
- C). Transcytosis
- D). Nanoparticles Trafficking
- Methods of Pulmonary Drug Delivery
- A). Nebuliser
- B). Metered Dose Inhaler
- C). Dry Powder Inhaler
- D). Soft-Mist Inhalers (Smi)
- Nanocarriers for Pulmonary Drug Delivery
- Polymers and Polysaccharide-Based Nanocarriers
- A). Cellulose
- B). Chitosan
- C). Hyaluronic Acid
- D). Cyclodextrin
- E). Alginates
- F). Synthetic Polymers
- Lipid-Based Nanocarriers
- A. Liposomes
- B. Micelles
- D. Solid-Lipid Nano
- Other Pdd Nanocarriers
- A. Nano-In-Micro Particles
- B. Liquid Crystalline Nanoparticles (Lcns)
- C. Metal and Metal Oxide Nanoparticles
- Herbal Nanoparticles for Pdd
- Conclusion
- Consent of Publication
- Conflict of Interest
- Acknowledgement
- References
- Archana P Retnakumari and Ruby John Anto Introduction
- Bioactive Principles from Phytochemicals
- Nanotechnology Revolutionized the Biomedical Arena
- An Overview of Nanoparticles for the Delivery of Bioactive Principles from Natural Products
- Challenges of Bioactive Natural Products Through Nano-Drug Delivery
- Future Prospects
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Monika Kaurav, Laxmikant Gautam and Sunita Minz Introduction
- Pegylation
- Pegylated Liposomes
- Properties of Peg
- Peg Linked-Lipids (Peg-Lipids)
- Peg-Phospholipids
- Peg-Non-Phospholipids
- Hyperbranched Polyglycerol (Hbpg)-Lipids
- Modifications in Lipids
- Carboxyl-End Group Peg-Dspe Derivative
- Amino-End Group Peg-Dspe (Amino-Peg-Dspe) Derivative
- Hydrazide-End Group Peg-Dspe (Hz-Peg-Dspe) Derivative
- Maleimide-End Group Peg-Dspe (Mal-Peg-Dspe)
- Methods of Pegylation
- Pre-Insertion Pegylation
- Post-Insertion Pegylation
- Uptake and Clearance of Pegylated Liposomes
- Applications of Pegylated Liposomes
- Applications of Pegylated Liposomes in Herbal Drugs Delivery
- 10. Herbal Nanomedicines of Snedds and Smedds
- Emerging Challenges and Potential Solutions of Pegylated Liposomes
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Deepak Prashar and Jiyauddin Khan Introduction
- Basic Structure of Liposomes
- Types of Liposomes
- Special Liposomes
- Preparation Method for Liposomes
- Methods Employed for the Formulations of Liposomes
- Insulin (Antidiabetic Drug)
- Merits of Liposomes
Author
- Swarnlata Saraf
- Ram Kumar Sahu
- Vivek Dave
