Colorectal Cancer is a complex disease caused by the interaction of hereditary and environmental factors that can be classified based on their importance. Colorectal Cancer Diagnosis and Therapeutic Updates provides comprehensive information about the diagnosis and treatment of colorectal cancer. Chapters first cover the fundamentals of colorectal cancer diagnosis, progressing further towards explaining therapeutic modalities and recent advances in the understanding of the disease.
Key Features
Key Features
- 11 organized, reader-friendly chapters that provide a complete overview of colorectal cancer
- Covers the colorectal cancer diagnosis, screening and histopathology
- Covers multimodal treatment of colorectal cancer, including chemotherapy, radiotherapy and robotic surgery
- Covers the management and surveillance of colorectal cancer
- Explains the key biochemical mechanisms involved in colorectal cancer treatment
- Covers recent information about colorectal cancer theranostics and drug delivery
- Includes references for further reading in every chapter
Table of Contents
Chapter 1 Colorectal Cancer Diagnosis- Introduction
- Invasive Examination
- Non-Invasive Diagnosis Methods
- Fecal Occult Blood Test
- Non-Enzymatic Tumor Markers
- Lysosomal Exoglycosidases as Potential Crc Markers
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Detection of Early Colorectal Carcinoma
- Early Diagnosis of Colorectal Carcinoma
- What is Screening?
- Who Should be Screened?
- Screening People at an Average Risk for Colorectal Carcinoma
- Fecal Occult Blood Test
- Flexible Sigmoidoscopy
- Combination of Fobt and Flexible Sigmoidoscopy
- Colonoscopy
- Screening People at Increased Risk for Colorectal Carcinoma
- Genetic Syndromes
- New Screening Tests
- Ct Colonography
- Faecal Occult Blood Test
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Normal Histology of Colorectal Area
- General Presentation in Colorectal Cancer
- Need for Histopathological Inspection in Colorectal Carcinoma
- Factors Involved in the Histopathological Analysis of Colorectal Carcinoma
- Histopathologic Diagnosis of Colorectal Cancer
- Histologic Variants
- Grading of Colorectal Carcinoma Using Histopathological Analysis
- Process of Grading the Cancers
- Issues with Pdc System and Their Rectification
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Chemotherapy and Colorectal Cancer
- Administration of Chemotherapeutic Agents
- Chemotherapy in Different Stages of Colorectal Cancer
- Components of Chemotherapy
- 5-Fluorouracil (5-Fu)
- Irinotecan
- Oxaliplatin
- Novel Therapies for Colorectal Carcinoma
- Agarose Microbeads
- Anti-Inflammatory Agents
- Probiotics
- Functional Foods
- Targeted Therapies
- Targeting Egfr
- Cetuximab and Panitumumab
- Braf Inhibitors
- Her-2 Inhibitors
- Targeting Vegf
- Bevacizumab
- Novel Anti-Vegfr Agents
- Hgf/C-Met Pathway
- Hgf Inhibitors
- Met Antagonists
- Tkis
- Immune Checkpoint Blockade
- Adjuvant and Neoadjuvant Therapy Using Targeted Medicine
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Total Mesorectal Excision
- Techniques Abdominoperineal Resection
- Coloanal Anastomosis
- Local Excision
- Transanal Excision
- Transcoccygeal Excision
- Transsphincteric Excision
- Transanal Endoscopic Microsurgery
- Disadvantages of Surgical Treatment for Rectal Cancer
- Short Term Effects of Surgery
- Long Term Effects
- Laparoscopic Surgery
- Advantages Over Conventional Surgical Methods
- Short Term Advantages Are:
- Long Term Advantages
- Limitations of Laparoscopic Surgery
- Robotic Surgery for Colorectal Cancer
- Components of the Da Vinci Surgical System
- Operation of the System
- Outcomes of Da Vinci Surgical System
- Short Term Outcomes
- Long Term Outcomes
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Lncrna in Colorectal Cancer
- Hotair
- H19
- Malat 1
- Involvement of Lncrnas in Crc Pathogenesis
- Wnt/Β-Catenin Pathway
- Egfr/Igf-Ir Signaling (Pi3K and Kras Pathways)
- Tgf-Β Signaling Pathway
- P53. Pathway
- Emt Program
- Detail Discussion of Experimental Data Conducted for Colorectal Cancer (Crc)
- Lncrna Overexpression Tgf-Β1 Downregulation by Nlipmt Inhibits Colorectal Cancer Cell Migration and Invasion
- The Activation of Kpna3 By Lncrna Dleu1 Leads to the Advancement of Colorectal Cancer
- Conclusion
- Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Chromosomal Instability Pathway
- Adenomatous Polyposis Coli Gene and Wnt Signaling Pathway
- Tp-53 Mutation
- 18Q Loss of Heterozygosity (Loh)
- Microsatellite Instability Pathway
- Epigenetic Instability and Cpg Methylation
- Pi3K/Akt Pathway, Pten, and Tgfβr2
- Signalling Pathways in Colorectal Cancer
- Egfr/Mapk Signaling Pathway
- Notch Signaling Pathway
- Pi3K Signaling Pathway
- Tgf-Βsignalling Pathway
- Wnt Pathway
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Types of Radiation Therapy
- Clinical Trials or Research Studies of Radiation and Chemoradiation Therapy in Colorectal Cancer
- Neoadjuvant Radiation Therapy
- Probable Side Effects of Radiotherapy
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Colonoscopy
- Flexible Sigmoidoscopy
- Conclusions
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Author
- Sankha Bhattacharya
- Amit Page
- Saurabh Maru
- Shilpa Dawre
