Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.
This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.
Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.
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Table of Contents
1. Techniques and Materials for the Fabrication of Microfluidic Chips2. Critical Factors Affecting Cells Behaviour in Microfluidic Chips
3. Cell-Based Assays on Microfluidic Chips
4. Cell Culture Techniques in Microfluidic Chips
5. Skin-On-A-Chip
6. Blood Vessels-On-A-Chip
7. Heart-On-A-Chip
8. Liver-On-A-Chip
9. Lung-On-A-Chip
10. Gut-On-A-Chip
11. Kidney-On-A-Chip
12. Immune Organs-On-Chip
13. Nervous Systems on a Chip
14. Eye-On-A-Chip
15. Endocrine Organs-On-A-Chip
16. Musculoskeletal Tissue-On-a-Chip
17. Tumour-On-A-Chip
18. Multi Organs-On-A-Chip and Personalized Medicine
19. Computational modelling of organ-on-a-chip devices
20. Commercialized Microfabricated Cell Chips
21. Organs-On-A-Chip: Future perspectives
