The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice.
In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency.
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Table of Contents
1. Introduction to genomic and molecular biology2. Methods in genomic and molecular medicine
3. Structure and function of the cardiovascular system
4. Molecular embryology of the cardiovascular system
5. Molecular mechanisms of cardiac electrical generation, conduction and regulation
6. Ion channel genomics and proteomics
7. Molecular structure and function of the myocardium
8. Molecular correlations of the myocardium with skeletal and smooth muscles
9. Genetic and molecular basis of metabolic and nutritional cardiovascular regulation
10. Genetic and molecular pathophysiology of heart failure
11. Molecular aspects of arterial, venous and lymphatic circulation
12. Molecular mechanisms and pathophysiology of pulmonary arterial and venous hypertension
13. Molecular perspectives of the cardiovascular inflammation
14. Molecular mechanisms of cardiovascular system response to hyperlipidemia and hyperglycemia
15. Molecular pathology of coronary (ischemic) artery disease (CAD)
16. Molecular basis of the adverse drug and toxin response of the cardiovascular system
17. Precision and personalise cardiovascular medicine including Molecular cardiovascular therapeutics
18. Novel cellular and molecular cardiovascular therapeutics
19. Genomic and Molecular basis of cardiovascular phenotype ontology
20. Preventive and public health applications of the genomic and molecular cardiovascular medicine (including social, ethical and legal aspects)
21. Glossary- selection and explanation of pertinent terms & phrases
Authors
Dhavendra Kumar Honorary Clinical Professor, William Harvey Research Institute, Queen Mary University of London, UK. Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature.Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George's Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).
In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George's Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.
Arthur A.M. Wilde Professor in Cardiology, Heart Centre, Department of Clinical and Experimental Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Dr. Arthur A. M. Wilde is a clinical Cardiologist and translational researcher with a focus in electrophysiology, cardiogenetics and inherited arrhythmias. In Amsterdam University Medical Centers (location AMC), his lab is one of the first worldwide to start an outpatient cardiogenetic clinic. Over the years they have seen thousands of patients and families with inherited arrhythmia syndrome. This is the basis of his Academic Research, which is focused on inherited cardiac diseases which are associated with sudden cardiac death. Different aspects, including gene discovery, genotype-phenotype relationships and new treatment modalities have been and are being covered. Dr. Wilde has been the coordinator of the European Reference Network GUARD-Heart (The ERN for rare cardiac diseases) since 2017. Perry Mark Elliott Professor of Cardiovascular Medicine and Director, Centre for Heart Muscle Disease, University College London, London, UK. Perry Elliott) is Professor of Cardiovascular Medicine and director of the Centre for Heart Muscle Disease at University College London (UCL) and a consultant cardiologist in the Centre for Inherited Cardiovascular Disease at St. Bartholomew's Hospital London, UK. He is Chairman of the ESC Heart Academy and the ESC Council on Cardiovascular Genomics. He is past Chairman of the ESC Working Group on Myocardial and Pericardial Diseases (2010-2012), the Executive Committee for the European Outcomes Research Programme (EORP) registry on cardiomyopathies and the ESC Guideline Task Force on Hypertrophic Cardiomyopathy. He is President of Cardiomyopathy UK, Europe's foremost charity for patients with heart muscle disease. Over the past 25 years, Prof. Elliott has established an international reputation in the field of heart muscle disease, authoring more than 500 peer-reviewed papers on the subject. He develops diagnostic standards, risk stratification tools and clinical service models.
