Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.
The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.
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Table of Contents
Basics of Research Methodology1. Reliability and validity in substance abuse and addiction research
2. Animal models
3. Translational research strategies
4. Experimental design in clinical trials Part 1
5. Experimental design in clinical trials Part 2
6. Qualitative and quantitative methods
7. Ethical issues in opioids, alcohol, other drugs and addiction-related research:
8. Informatics
9. Artificial intelligence and machine learning
10. Epidemiology and health services research methods
11. Imaging
12. Systematic review and meta-analysis
Mechanisms of abuse and addiction
13. Abuse and addiction
14. Assessment of addiction/pain and neurobiology
15. Physiological considerations in opioid addiction
16. Basic pharmacology opioid substances
17. Basic pharmacology non-opioid substances
18. Types of addiction
19. Substance use
20. Special study populations
Investigative Therapeutics: Designing studies and measuring outcomes
21. General therapy strategies in substance addiction
22. Alternative Therapy Strategies in Addiction
23. Drug testing and adherence monitoring
24. Pharmacogenetics Genes, genetics, genomics and epigenetics
25. Novel therapeutic strategies effectiveness
26. Methods of psychosocial interventions
27. Principles of vaccine development
28. Drug policy analysis
29. Implementation science: Theories, models and frameworks
30. Designing and testing population-based prevention programs
31. New vistas in research
Authors
Alan David Kaye Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Departments of Anesthesiology and Pharmacology, School of Me. Alan David Kaye, MD, PhD, is the Professor and Chairman of the Department of Anesthesiology at LSU Health Sciences Center in New Orleans since January 2005. He is Board Certified as a Consultant in Anesthesiology and has a special certificate in Pain Management for the American Board of Anesthesiology. He is also a Diplomate of the American Board of Pain Medicine and the American Board of Interventional Pain Physicians. His PhD is in pharmacology, and he was awarded first place in the National Student Research Forum as a resident. He has authored or co-authored over 150 abstracts and 200 manuscripts and book chapters in the fields of pulmonary vascular pharmacology and anesthesiology. He serves on a number of national committees including as a National Board of Directors of ASIPP and ABIPP. He is editor-in-chief of the journal Pain Physicians and is on the FDA Advisory Board on Anesthetics and Analgesics. Richard D. Urman Associate Chair for Dana-Farber Cancer Institute; Associate Professor and Director of the Perioperative Medicine Fellowship in the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Richard D. Urman, MD, MBA, FASA is a staff anesthesiologist at the Brigham and Women's Hospital in Boston, MA and Associate Professor of Anesthesia at Harvard Medical School. He currently serves as Associate Chair for Dana-Farber Cancer Institute, as well as Medical Director of Sedation for Interventional Medicine, Director, Center for Perioperative Research (C.P.R.), and Perioperative Medicine Fellowship Director. He is also the founder of the Incubator for Patient Safety and Outcomes (IPSO).
Dr. Urman received his MD from Harvard Medical School and MBA from Harvard Business School, and completed a residency in anesthesia at Beth Israel Deaconess Medical Center. On the national level, Dr. Urman currently serves on various committees of the American Society of Anesthesiologists (ASA) including as Chair of the subcommittee on Patient Safety and Practice Management, Foundation of Anesthesia Education and Research (FAER), Society for Preoperative Assessment and Quality Improvement, and Enhanced Recovery After Surgery-USA. Elyse M. Cornett Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Anesthesiology, School of Medicine, Louisiana Sta. Amber Edinoff Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, Boston, MA, United States.
