5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols.�
This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine.�
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Table of Contents
1. Five-membered N-heterocycles 2. Five-membered N-heterocycles: Cyclization of alkenyl or alkynyl systems 3. Five-membered N,N-, N,N,N-, and N,N,N,N-heterocycles 4. Five-membered O-heterocycles: Cyclization of C=C with OH 5. Five-membered O-heterocycles: Cyclization of alkenyl or alkynyl compounds 6. Five-membered O- and O,O-heterocycles 7. Five-membered O,N-heterocycles 8. Five-membered O,N,N-heterocycles: Hydrazine derivatives 9. Five-membered S-heterocycles 10. Five-membered S,N-heterocycles
