This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Edited by Drs. Susan C. Lester and Beth T. Harrison, it is uniquely organized by the questions surgeons pose during intraoperative consultations, such as "Is the bronchial margin positive or negative?� or "Can this liver be used for transplantation?� among many others. This fully updated volume is the most comprehensive and targeted resource available in this time-sensitive area, covering more than 70 questions supported by tables, diagrams, radiographs, and photographs. Concisely written and easy to use, the third edition of Diagnostic Pathology: Intraoperative Consultation is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
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Contains new chapters on the evaluation of margins from cervical resections, the use of ex vivo microscopy to image fresh tissue for the rapid creation of digital microscopic images for intraoperative diagnosis, and on other emerging techniques that may replace frozen section
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Includes a revised Safety Precautions chapter with details on evaluating specimens from patients with COVID-19
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Features updated images and text throughout to align with updated terminology and methods
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Includes videos showing special techniques such as identifying radioactive seeds in breast biopsies and evaluating lung margins containing staples by frozen section
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Provides updated and expanded introductory and methods chapters in addition to more than 70 chapters based on questions posed by surgeons during intraoperative consultations
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Features more than 2,500 print and online images, including carefully annotated histology and gross pathology photos, full-color illustrations, clinical photographs, and radiologic images to help practicing and in-training pathologists reach a confident diagnosis
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Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
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Includes an eBook version?that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
Table of Contents
SECTION 1: OVERVIEW4 Intraoperative Consultation: Introduction
Susan C. Lester, MD, PhD
10 Quality Assurance
David P. Frishberg, MD
20 Safety Precautions
Susan C. Lester, MD, PhD
28 Telepathology
David P. Frishberg, MD
34 Emerging Alternatives to Frozen Section Diagnosis
Susan C. Lester, MD, PhD
38 Ex Vivo Microscopy
Misha Movahed-Ezazi, MD and Matija Snuderl, MD
SECTION 2: METHODS
46 Gross Examination
Susan C. Lester, MD, PhD
54 Cytologic Examination
David P. Frishberg, MD and Kristine Astvatsaturyan, MD
72 Frozen Section
Susan C. Lester, MD, PhD
80 Slide Preparation
Susan C. Lester, MD, PhD
86 Tissue Allocation for Biorepositories and Special
Studies
Deborah A. Dillon, MD
90 Radioactive Seed Localization
Beth T. Harrison, MD
94 Lymph Nodes: Molecular Methods for Evaluation
Beth T. Harrison, MD
SECTION 3: INTRAOPERATIVE CONSULTATIONS
98 Adrenal Medulla and Paraganglia: Diagnosis
Vania Nos?, MD, PhD
104 Adrenal Cortex: Diagnosis
Vania Nos?, MD, PhD
112 Anterior Mediastinal Mass: Diagnosis
Matthew R. Lindberg, MD
118 Appendix: Diagnosis
Amitabh Srivastava, MD
122 Bone Lesion/Tumor: Diagnosis and Margins
Matthew R. Lindberg, MD
132 Breast: Diagnosis
Beth T. Harrison, MD
138 Breast: Parenchymal Margins
Beth T. Harrison, MD
142 Breast: Nipple Margin Evaluation
Beth T. Harrison, MD 146 Bronchus and Trachea: Diagnosis
Matthew R. Lindberg, MD
148 Cerebellum and Brainstem: Diagnosis
Benjamin Liechty, MD, Matija Snuderl, MD, and Rebecca D. Folkerth, MD
158 Cerebral Hemispheres: Diagnosis
Benjamin Liechty, MD, Matija Snuderl, MD, and Rebecca D. Folkerth, MD
170 Cerebral Hemispheres: Evaluation for Epilepsy
Matija Snuderl, MD, Olga Krasnozhen-Ratush, MD, and Rebecca D. Folkerth, MD
176 Cervical Trachelectomy: Margins
Charles Matthew Quick, MD
178 Colon: Diagnosis and Margins
Amitabh Srivastava, MD
182 Colon: Evaluation for Hirschsprung Disease
Karen S. Thompson, MD
188 Esophagus: Diagnosis and Margins
Amitabh Srivastava, MD
194 Fallopian Tube: Diagnosis
Charles Matthew Quick, MD
200 Head and Neck Mucosa: Diagnosis and Margins
Vickie Y. Jo, MD and Jeffrey F. Krane, MD, PhD
204 Kidney, Adult: Diagnosis and Margins
Roni Michelle Cox, MD
216 Kidney: Evaluation of Allograft Prior to
Transplantation
Lynn D. Cornell, MD
222 Kidney Needle Biopsy: Evaluation for Adequacy
Lynn D. Cornell, MD
226 Kidney, Pediatric: Indications and Utility
Karen S. Thompson, MD
234 Larynx: Diagnosis and Margins
Vickie Y. Jo, MD, Stefan Kraft, MD, and Jeffrey F. Krane, MD, PhD
238 Liver, Capsular Mass: Diagnosis
Amitabh Srivastava, MD
240 Liver: Evaluation of Allograft Prior to
Transplantation
Amitabh Srivastava, MD
246 Liver, Intrahepatic Mass: Diagnosis and Margins
Amitabh Srivastava, MD
250 Lung, Ground-Glass Opacities and Small Masses:
Image-Guided Resection
Matthew R. Lindberg, MD and Lucian R. Chirieac, MD
258 Lung: Margins
Matthew R. Lindberg, MD
264 Lung, Nonneoplastic Diffuse Disease: Diagnosis
Matthew R. Lindberg, MD 268 Lung Mass: Diagnosis
Matthew R. Lindberg, MD
276 Lymph Nodes, Axillary: Diagnosis
Beth T. Harrison, MD
284 Lymph Nodes Below Diaphragm: Diagnosis
David P. Frishberg, MD
292 Lymph Nodes: Diagnosis of Suspected
Lymphoproliferative Disease
Emily F. Mason, MD, PhD
302 Lymph Nodes, Head and Neck: Diagnosis
Vickie Y. Jo, MD and Jeffrey F. Krane, MD, PhD
308 Lymph Nodes, Mediastinal: Diagnosis
David P. Frishberg, MD
316 Meninges: Diagnosis
Benjamin Liechty, MD and Matija Snuderl, MD
326 Nasal/Sinus: Diagnosis of Suspected Fungal Rhinosinusitis
Vickie Y. Jo, MD, Stefan Kraft, MD, and Jeffrey F. Krane, MD, PhD
330 Nasal/Sinus: Diagnosis of Suspected Neoplasia
Vickie Y. Jo, MD and Jeffrey F. Krane, MD, PhD
338 Oropharynx and Nasopharynx: Diagnosis and Margins
Vickie Y. Jo, MD, Stefan Kraft, MD, and Jeffrey F. Krane, MD, PhD
342 Ovary, Mass: Diagnosis
Beth T. Harrison, MD and Charles Matthew Quick, MD
358 Pancreas, Biopsy: Diagnosis
Amitabh Srivastava, MD
362 Pancreas Resection: Parenchymal, Retroperitoneal, and Bile Duct Margins
Amitabh Srivastava, MD
370 Parathyroid Gland: Diagnosis and Margins
Vania Nos?, MD, PhD
380 Peripheral Nerve and Skeletal Muscle: Allocation of
Tissue for Special Studies
Matija Snuderl, MD, Rebecca D. Folkerth, MD, and Rolf Pfannl, MD
382 Peritoneal/Omental Mass: Biopsy
Charles Matthew Quick, MD
394 Pituitary: Diagnosis
Vania Nos?, MD, PhD
406 Pleura: Diagnosis
Matthew R. Lindberg, MD
410 Revision Arthroplasty: Evaluation of Infection
Matthew R. Lindberg, MD
412 Salivary Gland: Diagnosis and Margins
Vickie Y. Jo, MD and Jeffrey F. Krane, MD, PhD
420 Skin: Diagnosis and Margins
David Cassarino, MD, PhD
426 Skin: Evaluation for Toxic Epidermal Necrolysis vs. Staphylococcal Scalded Skin Syndrome
David Cassarino, MD, PhD
428 Skin: Mohs Micrographic Surgery
Christine J. Ko, MD and David Cassarino, MD, PhD
434 Soft Tissue: Evaluation for Necrotizing Fasciitis
David Cassarino, MD, PhD
436 Soft Tissue Mass: Diagnosis and Margins
David Cassarino, MD, PhD 440 Spinal Cord: Diagnosis
Matija Snuderl, MD and Benjamin Liechty, MD
446 Stomach: Diagnosis and Margins
Amitabh Srivastava, MD
450 Thyroid: Diagnosis
Vania Nos?, MD, PhD
462 Ureter: Margins
Roni Michelle Cox, MD
470 Uterus, Endometrium: Diagnosis
Charles Matthew Quick, MD
476 Uterus, Endometrium: Diagnosis of Pregnancy
Charles Matthew Quick, MD
480 Uterus, Myometrium: Diagnosis
Charles Matthew Quick, MD
486 Vulva: Diagnosis and Margins
Charles Matthew Quick, MD
