Biomarkers in Medicine is a comprehensive guide to understanding the current and future status of biomarkers. The book features 27 chapters focusing on disease biomarkers for diseases such as cancer, neurodegenerative diseases, cardiac diseases, metabolic conditions and much more.
This book supplies readers with the unique insight of experts in multiple specialties in medicine and life sciences who have extensive experience in diagnostics and clinical laboratories. The book includes case studies and practical examples from different classes of biomarkers on different platforms, including new data for biomarkers in different therapeutic indications. In addition to presenting biomarker information, each chapter covers the relevant pathology and also emphasizes on preclinical and clinical manifestation of the disease process.
Clinicians managing patients or clinical trials, clinical researchers, clinical laboratories, diagnostic companies, regulatory agencies, medical school graduate students, academic students, and the general public involved in healthcare delivery will all benefit from information presented in this book.
This book supplies readers with the unique insight of experts in multiple specialties in medicine and life sciences who have extensive experience in diagnostics and clinical laboratories. The book includes case studies and practical examples from different classes of biomarkers on different platforms, including new data for biomarkers in different therapeutic indications. In addition to presenting biomarker information, each chapter covers the relevant pathology and also emphasizes on preclinical and clinical manifestation of the disease process.
Clinicians managing patients or clinical trials, clinical researchers, clinical laboratories, diagnostic companies, regulatory agencies, medical school graduate students, academic students, and the general public involved in healthcare delivery will all benefit from information presented in this book.
Table of Contents
Chapter 1Principles of Cancer İmmunotherapy- Tumor Immunology
- Therapeutic Approaches
- Immune Checkpoint Inhibitors (Ici)
- the Predictive and Prognostic Markers of Immunotherapy
- Immunotherapy Toxicity
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Selim Afsar Introduction
- Ovarian and Fallopian Tube Cancers
- Carbohydrate Antigen 125 (Ca125)
- Screening
- Prediction Models
- Prognosis
- Recurrence
- Human Epididymis Protein 4 (He4)
- Diagnosis
- Prognosis
- Risk of Ovarian Malignancy Algorithm (Roma)
- Circulating Cell-Free Dna (Cfdna)
- Dna Methylation
- Metabolites
- Micrornas
- Carcinoembryonic Antigen (Cea)
- Alpha-Fetoprotein (Afp)
- Inhibin B
- Human Chorionic Gonadotropin (Hcg)
- Kallikreins
- Other Markers
- Uterine Cancer
- Ca125
- He4
- Genomic Classification
- Other Markers
- Cervical Cancer
- Squamous Cell Carcinoma Antigen (Scc-Ag)
- Other Markers
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Biomarkers in Bladder Cancer
- Blood-Based Biomarkers
- Tumor Cells
- Cd8 Count and Immune Cells
- Matrix Metalloproteinase
- Epigenetic Markers
- Tissue-Based Biomarkers
- Cell Cycle-Based Markers
- Transmembrane- and Signaling-Based Markers
- Pdl/Pdl1
- Mtor
- Mdr1
- Human Epidermal Growth Factor Receptor 2 (Her2)
- Apoptosis- and Dna Repair-Based Markers
- Multiplexed Markers
- Twenty-Gene Panel, Genomedx Gene-Expression Assay
- Urine-Based Biomarkers
- Fluorescence in Situ Hybridization (Fish)
- Bladder Tumor Antigen (Bta) Tests
- Nuclear Matrix Protein-22 (Nmp-22) Test
- Immunocyt Test
- Cxbladder Test
- Summary
- Biomarkers in Prostate Cancer
- Blood-Based Biomarkers
- Psa or Hk3
- Free Psa (Fpsa)
- Prostate Health Index (Phi)
- 4Kscore Test
- Circulating Tumor Cells (Ctcs) and Circulating Tumor Dna (Ctdna)
- Prostate-Specific Membrane Antigen (Psma)
- Urine-Based Biomarkers
- Pca3
- Gene Fusion
- Selectmdx
- Annexin A3
- Tissue-Based Biomarkers
- Α-Methylacyl Coenzyme a Racemase (Amacr)
- Epigenetic Modifications
- Genomic Expression Profiles
- Inherited Genetic Markers
- Summary
- Biomarkers in Renal Cell Carcinoma
- Diagnostic Biomarkers
- Carbonic Anhydrase Ix (Caix)
- Gene Expression Profile
- Urine Biomarkers
- Tissue Biomarkers
- Prognostic Biomarkers
- Routine Blood Biomarkers
- Von Hippel-Lindau (Vhl) Gene
- Vegf
- Survivin
- P53
- Ki-67
- Phosphatase and Tensin Homolog (Pten)
- Predictive Biomarkers
- Immune Checkpoint Inhibitors
- Mtor Inhibitors
- Pediatric Renal Tumors:
- Summary
- Biomarkers in Testicular Cancer
- Alfa-Fetoprotein (Afp)
- Human Chorionic Gonodotropin (Hcg)
- Lactate Dehydrogenase (Ldh)
- Potential Biomarkers in Future
- Placental Alkaline Phosphatase (Plap)
- Oct-3/4, Sall 4, and Cd 117
- Mirnas
- Summary
- Next Generation Sequencing
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Introduction
- Thyroid Gland
- Classification of Thyroid Cancer
- Medical Management of Thyroid Cancer
- Differentiated Thyroid Cancer
- Medullary Thyroid Cancer
- Anaplastic Thyroid Cancer
- Serological Biomarkers
- Thyroglobulin
- Anti-Thyroglobulin Antibodies
- Calcitonin and Procalcitonin
- Carcinoembryonic Antigen
- Other Peptides
- Liquid Biopsy
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Introduction
- Dna Methylation and Regulation Mechanism
- Dna Methylation in Cancer
- Regional Hypermethylation
- Global Hypomethylation
- Dna Methylation Biomarkers in Cancer
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Introduction
- Established Biomarkers
- Tissue Based Biomarkers
- Dna Alterations: Polymorphisms
- Gene Expression
- Microrna (Mirna)
- Blood Based Biomarkers
- Cfdna and Ctdna
- Cfmrna and Htert
- Cfmirna
- Circulating Proteins/Peptides
- Other Predictive Biomarkers
- Thymidylate Synthase (Ts)
- Epidermal Growth Factor Receptor (Egfr)
- Cyclooxygenase 2 (Cox-2)
- Bax/Bcl-2
- P21
- Ki-67
- Cea
- Ctdna
- Circulating Tumour Cells (Ctc)
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- Referances
Author
- Pınar Atukeren
- Hafize Uzun
