Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish.
All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
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Table of Contents
1. Introduction on neuroimmunology
2. Neuroimmune interactions: from bench to bedside
3. Neuroimmunology: translational lessons from zebrafish
4. COVID-19-related neuroinflammation may reveal the triggers for healthy longevity
5. Role of neural-immune dysregulation in the periphery in the development of immune dysfunctions
6. Pericytes, a cell type contributing to immune tolerance and autoimmunity
7. Immunity and cognition
8. Neuroimmunology and sleep
9. Impact of systemic inflammation on neuroinflammation
10. Rare autoimmune and autoinflammatory neurologic disorders
11. Epstein-Barr virus and neuroinflammation
12. The potential role of dietary intervention for the treatment of neuroinflammation
13. Immune dysregulation and neurodegenerative diseases
14. Immunological Aspects of Glaucomatous Optic Neuropathy Etiology and Treatments
15. Imaging characteristics of neuroimmunological disorders
16. Contribution of neuroimaging studies to understanding of immunology and inflammation in epilepsy
17. Bedside to bench side translation with the targeting of the BAFF/APRIL axis in neurological autoimmune disorders
18. New insights on Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) as potential therapeutic target for immune mediated neurological disorders
19. Inflammasome Elements in Epilepsy and Seizures
20. Treatment Approaches to Neuroimmunological Diseases: Therapeutic Candidates Affecting Neuroinflammation
Authors
Nima Rezaei Professor, Department of Immunology, School of Medicine; Head, Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences; Founding President, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),Universal Scientific Education and Research Network (USERN),Tehran, Iran. Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals. Niloufar Yazdanpanah Managing Director, Network of Immunity in Infection,Malignancy and Autoimmunity (NIIMA)
Universal Scientific Education and Research Network (USERN); and School of Medicine,
Tehran University of MEdical Sciences,
Tehran, Iran.
