Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications.
Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.
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Table of Contents
1. Synthesis of oxetanes from epoxides2. Synthesis of oxetanes from ketenes
3. Synthesis of oxetanes from carbonyl compounds
4. Synthesis of oxetanes from acid, alcohol, and carbonyl moiety containing compounds
5. Synthesis of oxetanes from alcohols
6. Synthesis of oxetanes from diols and halo alcohols
7. Synthesis of oxetanes under photochemical irradiation
8. Synthesis of fused oxetanes under photochemical irradiation
