Over the last two decades, gene editing concepts and genetic engineering have evolved significantly, with the development of a variety of versatile DNA modulation technologies, including clustered, regularly interspaced short palindromic repeats (CRISPR), zinc finger nucleases and transcription activator-like effector-based nucleases (TALENs). These developments have enabled several medical researchers to perform an array of gene / cell line engineering experiments for a variety of R&D applications. It is worth highlighting that owing to its ease of use, fast, accurate and cost-effective approach, CRISPR / Cas technology is currently considered to be the most popular tool of all available genome manipulation technologies. CRISPRs are the hallmark of a bacterial defense system that forms the basis for CRISPR / Cas genome editing technology. These systems allow researchers to permanently modify genes in living cells and organisms, and in the future, may make it possible to correct mutations at precise locations in the human genome, in order to treat genetic causes of various disease indications. Fundamentally, the CRISPR / Cas system involves specific palindromic DNA sequences which work in tandem with a family of caspase enzymes (Cas9, Cas12), in order to excise gene fragments with high precision. Moreover, the relatively recent discovery / development of novel accompanying nucleases, namely Cas12a, Cas13, Cas14 and dCas9, has further improved the precision of CRISPR technology.
CRISPR / Cas system is a powerful tool with a wide array of applications in the field of disease treatment and diagnosis, and agriculture and biotechnology. It is worth highlighting that this versatile gene editing tool has garnered significant interest in the medical community owing to its ability to act on virtually any physiological target, which has opened up numerous possibilities for precision medicines. Despite its extensive applicability, several challenges limit the use of CRISPR, including complexities associated with delivery of CRISPR components, off-targeting, autoimmune responses and ethical concerns. To address these concerns, a number of researchers across the world are leading the development initiatives in this domain. In fact, over 3,300 patents related to CRISPR and related technologies have been filed / granted till now, highlighting the continuous pace of innovation in this field. Once existing challenges limiting its applicability are addressed, this technology is anticipated to become a mainstream gene editing solution. Currently, there is a lot happening in terms of innovation related to this promising segment of gene editing technology; therefore, it is important to identify key pockets of innovation and areas of improvement in order to truly innovate whilst maintaining a competitive edge. This report attempts to identify key trends that describe the pace and focus of innovation related to CRISPR / Cas technologies, and make key observations / inferences regarding the development of intellectual capital in this domain.
Scope of the Report
The “CRISPR Technologies: Intellectual Property Landscape” report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents) describing CRISPR technologies. The insights generated in this report have been presented across two deliverables, namely a MS Excel sheet and a MS PowerPoint deck, summarizing the ongoing activity in this domain. Key inclusions are briefly described below:
Overall Intellectual Property Landscape
An in-depth review of the various patents and affiliated IP documents that have been published related to the diverse technologies, methods and compositions associated with the use of CRISPR. It features insights on both historical and recent trends in R&D within this domain.
Popular / Relevant Prior Art Search Expressions
An examination of IP literature, shortlisting key words and phrases that have been used to describe CRISPR and associated technologies. The analysis includes information on the historical use of the aforementioned terms across different types of IP filings, key affiliated terms (which can be used to further identify similar innovations) and other related trends.
Patent Valuation Analysis
A competitive benchmarking and valuation analysis of IP documents published in this field of innovation, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in regional GDP).
Patentability and Freedom to Operate
A systematic approach to identify relevant areas of innovation by analyzing published IP documents, defining the uniqueness of patented / patent pending innovations, understanding the scope of patentability in this domain, and pinpointing jurisdictions where new and / or modified claims may be filed without infringing on existing IP.
Analysis of Patent Applications
A detailed summary of the patent applications that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis segregates the intellectual capital, in terms of area of innovation, thereby, offering the means to understand key areas of research and identify innovation-specific IP filing trends.
Analysis of Granted Patents
An elaborate summary of the granted patents across different jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted patents into relevant categories in order to develop a more detailed perspective on the diverse types of innovations in this domain and the feasibility for innovators to enter into promising product markets.
Pockets of Innovation and White Spaces
An insightful analysis of the various CPC codes used in published IP literature and their affiliated families, in order to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic system of classifying IP); the analysis also features a discussion on prevalent white spaces (based on CPC symbols) in this arena of research.
Claims Analysis
One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents in the dataset. Using a systematic segregation approach, we have analyzed trends associated with [A] the preamble, [B] type of patent (technology patent or method patent), [C] type of claim (open ended claim or closed ended claim) and [D] key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
Table of Contents
Excel Deliverable
- Sheet 1 features details regarding how the input data for this project was collated, including the search strings used to query a popular patent database (lens.org), and data segregation notes.
- Sheet 2 is a summary MS Excel dashboard, offering a detailed graphical perspective of the intellectual property landscape of CRISPR technologies. Additionally, it includes pictorial representations of the [A] overall patent landscape, [B] key prior art search expressions, [C] trends related to patent applications (including insights on patentability and freedom to operate), [D] trends related to granted patents (including insights on patentability and freedom to operate), [E] key inferences from a proprietary claim analysis, [F] list of popular CPC symbols (featuring key pockets of innovation), [G] list of popular applicants (shortlisted based on number of published IP documents).
- Sheet 3 is an elaborate tabular representation of the overall IP landscape, featuring information on the various patent application and granted patent-related documents in the domain of CRISPR technologies which have been published since 2013.
- Sheet 4 includes a tabular representation of key words and phrases that are used to describe CRISPR technologies.
- Sheet 5 is a subset of sheet 3, featuring all the patent applications covering innovations related to CRISPR technologies.
- Sheet 6 is a subset of sheet 3, featuring all the granted patents covering innovations related to CRISPR technologies.
- Sheet 7 is an insightful summary of the key inferences from the independent claims mentioned in the granted, active patents in the dataset. We have used a systematic segregation approach in order to analyze trends associated with the preamble, type of patent (technology patent or method patent), type of claim (open ended claim or closed ended claim) and key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
- Sheet 8 provides insights related to some of the key applicants in this field of research featuring company-specific details (such as year of establishment, and location of headquarters), and inputs on their respective IP publication trends.
- Sheet 9 features an analysis of the most popular CPC symbols and CPC families (in terms of frequency of appearance in the dataset) related to the diverse applications of CRISPR technologies.
- Sheet 10 is an appendix which includes pivot tables that drive the charts and interactive elements for the complete IP landscape, in sheet 2.
- Sheet 11 is an appendix, featuring details related to the categorization done in the report, and important abbreviations used in reference to the data categories mentioned in the document.
PowerPoint Deliverable
- Chapter 1 briefly describes the current investment in the development of CRISPR therapeutics, and the key advantages of CRISPR technologies. Further, it provides an overview of the intellectual property landscape related to CRISPR technologies.
- Chapter 2 and 3 features brief (pictorial) summaries of the approach used for data collection and the key objectives of the study.
- Chapter 4 features an executive summary of the key insights generated from analyzing the intellectual property landscape of CRISPR technologies.
- Chapter 5 features a brief description of CRISPR highlighting how this technology is, as compared to other gene editing tools. It provides an impactful summary of the important milestones related to research in this domain and details on mechanism of action of CRISPR. Further, it includes information on various challenges that inhibit the applicability of this tool and ways of overcoming these challenges. It also includes key areas of application of CRISPR technologies.
- Chapter 6 includes a review of the various patents and IP documents that have been published related to technologies and methods associated with CRISPR technologies, featuring insights related to both historical and recent trends.
- Chapter 7 features an insightful examination of IP literature, highlighting key words and phrases that are used to describe CRISPR technologies, including information on historical usage in IP filings, key affiliated terms (which can be used to further identify similar innovations), and other related trends.
- Chapter 8 offers insights from a competitive benchmarking and valuation analysis of the IP documents published related to this field of research, taking into account important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in regional GDP).
- Chapter 9 provides a detailed summary of the patent applications that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis segregates the intellectual capital, in terms of area of innovation, thereby, offering the means to understand key areas of research and identify innovation-specific IP filing trends. Based on a systematic approach, the chapter highlights relevant areas of innovation from a deeper analysis of published IP documents, defining the uniqueness of patent pending innovations, understanding the scope of patentability in this domain, and pinpointing jurisdictions where new and / or modified claims may be filed without infringing on existing IP.
- Chapter 10 is an elaborate summary of the granted patents across different jurisdictions and their relative value in the IP ecosystem. The analysis uses a proprietary segregation criterion, based on type of product / solution; this offers the means to identify unique innovations that presently have marketing exclusivity and explore future opportunities to enter into promising product markets, once their patents expire. Based on a systematic approach, the chapter highlights relevant areas of innovation from a deeper analysis of published IP documents, defining the uniqueness of patented innovations, understanding the scope of patentability in this domain, and pinpointing jurisdictions where new and / or modified claims may be filed without infringing on existing IP.
- Chapter 11 features profiles of some of the most popular applicant companies, which were shortlisted based on patent filing activity. Each profiles includes, a brief overview of the company, information on annual revenues (wherever available), details of its initiatives focused on the healthcare sector, names of key management team members and recent developments.
- Chapter 12 includes an insightful analysis of the various CPC symbols mentioned in the published IP literature and their affiliated families, in order to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic system of classifying IP); the analysis also features a discussion on the prevalent white spaces (based on CPC symbols) in this area of research.
- Chapter 13 concludes the report by providing insights on anticipated developments in this domain (from the perspective of eminent industry representatives of stakeholders in this domain), and trends that are likely to shape the future of the CRISPR market.
- Chapter 14 is a set of appendices.
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 10x Genomics
- 22nd Century Group
- 64x Bio
- 9636137 Canada
- Aadigen
- Aarhus University
- ABclonal
- Abeona Therapeutics
- Academy of Military Medical Sciences
- Acceligen
- Advanced Telecommunications Research Institute International
- Aelian Biotechnology
- Affiliated Hospital of Nantong University
- Agency for Science, Technology and Research
- Agenovir
- AgGenetics
- Agilent Technologies
- Agricultural Genomics Institute
- Air Force Medical University
- Akeagen
- Akouos
- Albert Einstein College of Medicine
- Alexion Pharmaceuticals
- Algentech
- Alia Therapeutics
- All India Council for Technical Education (AICTE)
- Allele Biotechnology & Pharmaceuticals
- Allen Institute for Cell Science
- Alnylam Pharmaceuticals
- Altius Institute for Biomedical Sciences
- Altria Client Services
- Amicus Therapeutics
- Amyris
- Anhui University
- Ann & Robert H. Lurie Children's Hospital of Chicago
- antibodies-online
- Applied StemCell
- Arbor Biotechnologies
- Arbutus Biopharma
- Arc Bio
- Arcturus Therapeutics
- Aridis Pharmaceuticals
- Arizona State University
- Army Medical University
- Artec Biotech
- Artisan Development Labs
- ASC Therapeutics
- Ascend Biopharmaceuticals
- Asclepius Technology
- Asklepios BioPharmaceutical
- Aspen Neuroscience
- Assistance Publique - Hôpitaux de Paris
- Assistance Publique-Hôpitaux de Paris
- Astellas Pharma
- AstraZeneca
- Auburn University
- Austrian Centre of Industrial Biotechnology
- Auxolytic
- Avectas
- Avellino Lab USA
- AVROBIO
- Baoshan Huada Wisdom Agricultural Technology
- Bar-Ilan University
- BASF
- Bayer
- Baylor College of Medicine
- BDgene
- Beam Therapeutics
- Beidahuang Kenfeng Seed
- Beihang University
- Beijing Academy of Agriculture and Forestry Sciences
- Beijing Biotech
- Beijing Chaoyang Hospital
- Beijing Chest Hospital, Capital Medical University
- Beijing Friendship Hospital, Capital Medical University
- Beijing Institute of Technology
- Beijing Linglong Pugongying Technology Development
- Beijing Polytechnic College
- Beijing Sinogene Biotechnology
- Beijing Tongren Hospital
- Beijing Tuberculosis and Thoracic Tumor Research Institute
- Beijing University of Chemical Technology
- Beijing Xingyuan Heji Life Medical Technology
- Beijing Yuji Science & Technology
- Beijing Zhongcheng Huake Bio Technology
- Benaroya Research Institute
- Benson Hill
- Berlin Institute of Health
- Beth Israel Deaconess Medical Center
- BetterSeeds
- BGI
- BGN Technologies
- Bielefeld University
- Bio Spiral
- bio.tools
- BIOCAD
- Biocytogen
- Biogemma
- Biomedrex
- Biomics Biotechnologies
- Bionano Genomics
- BioNTech
- BioPharm
- Bioray Laboratories
- BioSkryb Genomics
- BIOTRONIK
- Bioverativ
- Blackhawk Genomics
- BlueAllele
- bluebird bio
- BlueRock Therapeutics
- BOCO Silicon Valley
- Boehringer Ingelheim
- Bonac
- Boston University
- BRAIN Biotech
- Brandeis University
- Brigham and Women's Hospital
- Brigham Young University
- Bristol Myers Squibb
- BRL Medicine
- Broad Institute
- Buck Institute for Research on Aging
- Cafa Therapeutics
- California Institute of Technology
- Calysta
- Cambridge Enterprise
- CAMP4 Therapeutics
- Campus Science Support Facilities
- CanBreed
- Cancer Research Technology
- Canon Medical Systems
- Canopy Growth
- CanSino Biologics
- Caribou Biosciences
- CARISMA Therapeutics
- Carlos III University of Madrid
- Carnegie Institution for Science
- Carnegie Mellon University
- CARsgen Therapeutics
- Cartherics
- Case Western Reserve University
- Casebia Therapeutics
- Caspr Biotech
- Catalan Institution for Research and Advanced Studies
- CATALOG
- Catholic University of America
- Cedars-Sinai Medical Center
- Cell End Gene Therapy
- Cellectis
- Cellino Biotech
- CELLSCRIPT
- Celularity
- Center for Energy, Environmental and Technological Research (CIEMAT)
- Central South University
- Centre for Eye Research Australia
- Centre for Genomic Regulation
- Centre for Translational Stem Cell Biology
- Ceres
- Cha University
- Chang Chun
- Changzhi Medical College
- Charité - Universitätsmedizin Berlin
- Chengdu Clonorgan Biotechnology
- Chengdu Dayi Precision Tumor New Technology
- Chengdu Huaxi Haiqi Medical Technology
- Chengdu Jin Weike Biotechnology
- Chengdu Meijie Saier Biotechnology
- Chengnuo Regenerative Medicine Technology Zhuhai Hengqin New Area
- Chiba University
- Children’s Healthcare of Atlanta
- Children's Hospital of Soochow University
- Childrens Medical Center
- Children's Medical Center of South Florida
- Children's Minnesota
- Children's National Research & Innovation Campus
- China Agricultural University
- China Jiliang University
- China National Rice Research Institute
- China National Seed Group
- China Pharmaceutical University
- China State Institute of Pharmaceutical Industry
- China Tobacco Yunnan Industrial
- China University of Science and Technology
- Chinagene Tech
- Chinese Academy of Agricultural Sciences
- Chinese Academy of Medical Sciences
- Chinese Academy of Sciences
- Chinese Center for Disease Control and Prevention
- Chinese PLA General Hospital
- Chongqing Medical University
- ChristianaCare
- Chung Ang University Industry Academic Cooperation Foundation
- Chung-Ang University
- Cibus
- Cincinnati Children's Hospital Medical Center
- City of Hope
- City University of Hong Kong
- Clark Atlanta University
- Claude Bernard Lyon 1 University
- CODA Biotherapeutics
- COFCO
- Cold Spring Harbor Laboratory
- Columbia University
- Complutense University of Madrid
- Consortium Biomedical Research Center
- Cornell University
- Corregene Biotechnology
- Council of Scientific & Industrial Research
- CRISPR Therapeutics
- CSIR
- CSL Behring
- CureGenetics
- CureVac
- Cyagen
- CyGenica
- Cyprus Foundation for Muscular Dystrophy Research
- CZ Biohub
- Dairen Chemical
- Dalian University
- Dalian University of Technology
- Dana-Farber Cancer Institute
- Danziger
- Dartmouth College
- Dharmacon
- DiaCarta
- Dicerna Pharmaceuticals
- Distributed Bio
- DNARx
- Donald Danforth Plant Science Center
- Dongtai Deyuan Biological Technology
- Dow
- Draper Laboratory
- Drexel University
- DrinkSavvy
- DSM IP Assets
- Duke University
- DuPont
- DuPont Danisco
- East China Normal University
- East China University of Science and Technology
- EdiGene
- EdiGene
- Editas Medicine
- eGenesis
- eggXYt
- Eligo Bioscience
- Elsoms Seeds
- EMD Millipore
- Emendo Biotherapeutics
- Emory University
- Encoded Therapeutics
- enEvolv (Acquired by Zymergen)
- Engine Biosciences
- Enzene Biosciences
- Erasmus MC
- ETH Zurich
- Ethris
- European Molecular Biology Laboratory
- Evolve BioSystems
- Evox Therapeutics
- Excision BioTherapeutics
- Exeligen Scientific
- Exerkine
- Exonics Therapeutics
- Exosome Therapeutics
- Eye & ENT Hospital of Fudan University
- EZY Biotech
- Factor Bioscience
- Far Eastern New Century
- Fasmac
- Fate Therapeutics
- Federal State Budgetary Institution of Science
- Feldan Therapeutics
- Fertis India
- Firmenich & Cie
- Flagship Pioneering
- Flash Therapeutics
- Florida State University Research Foundation
- Folium Food Science
- Fond Imagine
- Fond Telethon
- Forsyth Institute
- Fortiphyte
- Foshan University
- Foundation for Applied Medical Research
- Foundation for Biomedical Research
- Fred Hutchinson Cancer Research Center
- French Alternative Energies and Atomic Energy Commission
- Freshwater Fisheries Research Center
- Fudan University
- Fujian Agriculture and Forestry University
- Fulcrum Therapeutics
- Function Oncology
- FuturaGene
- G+FLAS Life Sciences
- GE Healthcare Life Sciences
- Gemini Therapeutics
- GemPharmatech
- Gen Hospital
- GeneCker
- GenEdit
- GeneMedicine
- Genentech
- GenePharma
- Generation Bio
- Generulor Wuhan Medical Technology
- Genesis Technologies
- GeneTether Therapeutics
- Genethon
- Genetics Research
- GENEWIZ
- GenKOre
- Genome Research
- Genomic Vision
- Genus
- GenWay Biotech
- Genzyme
- Georgia State University
- Georgia Tech Research Institute
- German Cancer Research Center
- Ginkgo Bioworks
- Gladstone Institutes
- Glycotope
- Goethe University
- Gracell Biotechnologies
- GRAIL
- Green Cross
- GreenVenus
- Guangdong Academy of Medical Sciences
- Guangdong Institute of Microbiology
- Guangdong Kangshen Medical Technology
- Guangdong Medical University
- Guangdong Ocean University
- Guangdong Sanjie Forage Biotechnology
- Guangdong Yaokang Biotechnology
- Guangxi University
- Guangzhou Boshi Nano Biotechnology
- Guangzhou Eighth People's Hospital
- Guangzhou Furong Biotechnology
- Guangzhou Generulor Medical Technology
- Guangzhou Institute of Biomedicine and Health
- Guangzhou Jisai Regenerative Medicine Life Technology
- Guangzhou Juneng Nano Biotechnology
- Guangzhou Pluslife Biotech
- Guangzhou Pushi Lihua Technology
- Guangzhou Regenerative Medicine And Health Guangdong Laboratory
- Guangzhou Ribobio
- Guangzhou University
- Guangzhou Xinyi Biotechnology
- Guilin Medical University
- Gunma University
- Gwangju Institute of Science & Technology
- Gyeongsang National University
- Hamburg University of Technology
- HanBio Therapeutics
- Handong Global University
- Hangzhou Hexinyuan Biotechnology
- Hangzhou Matridx Biotechnology
- Hangzhou Qihan Biotechnology
- Hankyong National University
- Hanyang University
- Harbin Medical University
- Harvard College
- Hebei Agriculture University
- Hebei Youwei Bio-Technology
- Heidelberg University
- Helmholtz Centre for Infection Research
- Helmholtz Zentrum München
- Henan Academy of Agricultural Sciences
- Henan Provincial People's Hospital
- Henan University
- Hiroshima University
- Hoffmann La Roche
- Hokkaido University
- Horizon Discovery
- Hospital de la Santa Creu i Sant Pau
- Hospital Universitario Fundación Jiménez Díaz
- Howard Hughes Medical Institute
- Hrain Biotechnology
- Huaibei Normal University
- Huaiyin Normal University
- Huanan Biology Medicine Research Institute
- Huanong Zhaoqing Biological Industry Technology Research Institute
- Huazhong Argicultural University
- Hubei Academy of Agricultural Sciences
- Hubei Fusheng Biotechnology
- Hubei University
- Hudson Institute of Medical Research
- Humanigen
- Hunan Agricultural University
- Hunan Huisheng Agriculture Technology Development
- Hunan Hybrid Rice Research Center
- Hunan Normal University
- Hunan Pulate Network Technology
- Huzhou Academy of Agricultural Sciences
- i2 Pharmaceuticals
- Icahn School of Medicine at Mount Sinai
- ICM Institute for Brain and Spinal Cord
- IDEAYA Biosciences
- IFP Energies
- Illumina
- Imagine Institute
- Imperial Innovations
- IMRA Japan
- Inari Agriculture
- Indian Council of Medical Research
- Indiana University Bloomington
- Indoor Biotechnologies
- Industrial Technology Research Institute
- Inner Mongolia University
- Innomodels Biotechnology
- Inscripta
- InsideOutBio
- Institut Curie
- Institut de Cancerologie de l'Ouest
- Institut Jules Bordet
- Institut national de la santé et de la recherche médicale
- Institut Pasteur
- Institute Bergonié
- Institute for Basic Science
- Institute For Stem Cell Science and Regenerative Medicine
- Institute for the Study and Prevention of Cancer
- Institute of Animal Health, Guangdong Academy of Agricultural Sciences
- Institute of Fruit Tree Research, Guangdong Academy of Agricultural Sciences
- Institute of Microbial Chemistry
- Institute of Molecular Biotechnology (IMBA)
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Institute of Plant Protection
- Institute of Science And Technology National Health And Health Commission
- Institute of Wolfberry Engineering Technology of Ningxia Academy of Agricultural and Forestry Sciences
- Instituto Carlos Slim de la Salud
- Integrated DNA Technologies
- Intellia Therapeutics
- International Foundations of Medicine
- Intima Bioscience
- Intrexon
- InVivo BioTech
- IO Biosciences
- Ionis Pharmaceuticals
- IONTAS
- Iovance Biotherapeutics
- Istituto Nazionale Genetica Molecolare
- Italian Institute of Technology
- Jackson Laboratory
- Japan Science and Technology Agency
- Jenthera Therapeutics
- Jerome Canady Research Institute for Advanced Biological And Technology Sciences
- JH Biotech
- Jianghan University
- Jiangsu Academy of Agricultural Sciences
- Jiangsu Hengrui Medicine
- Jiangsu Heze Biotechnology
- Jiangsu Kang Huai Biotechnology
- Jiangsu Littoral Agriculture Science Research Institute
- Jiangsu Pracgen Biopharm Technology
- Jiangsu Provincial People's Hospital
- Jiangsu Puzhu Biomedical Technology
- Jiangsu Target Pharma Laboratories
- Jiangsu University
- Jiangxi Agricultural University
- Jiaxing University
- Jichi Medical University
- Jilin Academy of Agricultural Sciences
- Jilin COFCO Bio-chemical
- Jilin University
- Jinan Guoke Yigong Technology Development
- Jinan University
- Jingchu University of Technology
- Johannes Gutenberg University of Mainz
- Johns Hopkins University
- Joslin Diabetes Center
- Jumpcode Genomics
- Juno Therapeutics
- Kangstem Biotech
- Kansas State University
- Kao
- Kewpie
- KeyGene
- KingAgroot
- Kite Pharma
- Klinikum Der University of Muenchen Anstalt Des Oeffentlichen Rechts
- Klogenix
- Kobe University
- Konkuk University
- Korea Advanced Institute of Science & Technology
- Korea Food Research Institute
- Korea Institute of Radiological & Medical Sciences
- Korea Institute of Science and Technology
- Korea Research Institute of Bioscience & Biotechnology
- Korea Research Institute of Chemical Technology
- Korea University
- Kraig Biocraft Laboratories
- KSQ Therapeutics
- KT&G
- KU Leuven
- Kunming University of Science and Technology
- KWS Saat
- Kyoto University
- Kyungpook National University, Industry-Academic Cooperation Foundation (KNU Industry-Academic Cooperation Foundation)
- Kyushu University
- Labcyte
- LanSheng Biotech
- LanzaTech
- Larix Bioscience
- Lausanne University Hospital
- Laval University
- Lawrence Livermore National Laboratory
- Leibniz Research Institute for Environmental Medicine
- Lek Pharmaceuticals
- Leland Stanford Junior University
- Lempo Therapeutics
- LG Chem
- Life Edit Therapeutics
- Life Technologies
- Ligandal
- Liuzhou Municipal Liutie Central Hospital
- Liver Biotechnology (Shenzhen)
- Locanabio
- Locus Biosciences
- Loma Linda University
- Lonza
- Ludwig Institute for Cancer Research
- Luoyang Zhengmu Biotechnology
- M2X2 Therapeutics
- Macquarie University
- Mammoth Biosciences
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Max Delbrück Center for Molecular Medicine
- Max Planck Society
- MaxCyte
- Mayo Foundation for Medical Education and Research
- McGill University
- Mediphage Bioceuticals
- Meiogenix
- Memorial Sloan Kettering Cancer Center
- Meso Scale Discovery
- Mesoblast
- Metagenomi
- Methodist Hospitals
- Mgen Plus
- MGI
- Miami University
- Ministry of Agriculture and Rural Development
- Mirimus
- Mississippi State University
- Modalis Therapeutics
- Moderna
- Mogam Institue for Biomedical Research
- Molecular Transfer
- Momentum Fund
- Monash University
- Monsanto
- Montana State University
- Moogene Medi
- Mount Desert Island Biological Laboratory
- MultiVir
- MyoGene Bio
- Nanjing Genefriend Biotech
- Nanjing IASO Biotherapeutics
- Nanjing Kgene Genetic Engineering
- Nanjing Medical University
- Nanjing Qizhen Gene Eng
- Nanjing University
- Nanjing Xianlin International Hospital
- Nankai University
- Nantes University Hospital
- NantKwest
- Nantong University
- Nanyang Technological University
- NAPIGEN
- National Center for Nanoscience and Technology
- National Cheng Kung University
- National Chiao Tung University
- National Fisheries Research and Development Institute
- National Health and Family Planning Commission
- National Institute for Health and Medical Research
- National Institute of Chemistry
- National Institute of Forest Science
- National Institutes for Food and Drug Control
- National Research Institute of Brewing
- National Scientific and Technical Research Council
- National Tsing Hua University
- National University of Singapore
- National Yang-Ming University
- Nationwide Children’s Hospital
- NEBION
- Neemo
- Neogene Therapeutics
- Netherlands Cancer Institute
- Netherlands Organization for Scientific Research
- New England Biolabs
- New York Blood Center
- New York Genome Center
- New York Stem Cell Foundation
- New York University
- NewSouth Innovations
- Nextbiotics
- Ningbo Academy of Agricultural Sciences
- Ningxia Academy of Agriculture and Forestry Sciences
- Ningxia Medical University
- Nippon Chemical Industrial
- Nkarta
- Noble Research Institute
- Nomad Bioscience
- North Carolina State University
- Northeast Agricultural University
- Northeast Forestry University
- Northwest A&F University
- Northwestern University
- Novartis
- Novozymes
- OBiO Technology
- Obschestvo S Ogranichennoi Otvetstvennostju Proryvnye Innovatsionnye Tekh
- Ocean University of China
- Ohio State Innovation Foundation
- Omega Therapeutics
- Orchard Therapeutics
- Organofab Technologies
- OriCiro Genomics
- Oriengene Biotechnology
- Orig3N
- Ortho Bio
- Osaka University
- Oxford Genetics
- Oxford Nanopore Technologies
- Oxford University Innovation
- PACT Pharma
- Pairwise
- Parkinson's Institute and Clinical Center
- Pebble Labs
- Peking Third Hospital University
- Peking University
- Penn State Research Foundation
- Pennsylvania University
- People's Liberation Army
- Peter MacCallum Cancer Institute
- Philip Morris International
- Pig Improvement
- Pioneer
- Pioneer Hi Bred International
- Pioneer Overseas
- Pirbright Institute
- Pohang University of Science and Technology
- POiRT Systems
- Pompeu Fabra University
- Poseida Therapeutics
- Precision BioSciences
- Promega
- Protalix BioTherapeutics
- Proteineasy Biological Products Research Institute Henan
- Protiva Biotherapeutics
- Provincial Health Services Authority
- Purdue Research Foundation
- QIAGEN Sciences
- Qingdao Agricultural University
- Qingdao Huasaiboman Medical Cell Biology
- Qingdao Vland Biotech
- Recognition Analytix
- Recombinetics
- Reflection Biotechnologies
- Reforgene Medicine
- Refuge Biotechnologies
- Regeneron Pharmaceuticals
- Regents of the University of California
- Regents of the University of Michigan
- Rensselaer Polytechnic Institute
- Research Foundation for the State University of New York
- Research Organization of Information and Systems
- Rice University
- Riken
- Rochester University
- Rockefeller University
- Rocket Pharmaceuticals
- Rodos Biotarget
- Rohm and Haas
- Rongcheng City People's Hospital
- Rowan University
- RPRD Diagnostics
- Rubber Research Institute
- Rutgers University
- Saliogen Therapeutics
- Salk Institute for Biological Studies
- San Raffaele Hospital
- Sana Biotechnology
- Sandia National Laboratories
- Sangamo Therapeutics
- Sanofi
- Schepens Eye Research Institute
- Scribe Therapeutics
- Scripps Research Institute
- Seagate Technology
- Seattle Children's
- Second Affiliated Hospital of Wenzhou Medical University
- Sejong University
- Selecta Biosciences
- Selexis
- Senti Biosciences
- Seoul National University Hospital
- Shaanxi Huikang Biotechnology
- Shaanxi Normal University
- Shaanxi Provincial People's Hospital
- Shandong Academy of Agricultural Sciences
- Shandong Landsee Genetics
- Shandong Lvdu Bio Sicience & Technology
- Shandong Provincial Hospital Affiliated to Shandong First Medical University
- Shandong Shunfeng Biotechnology
- Shandong University
- Shanghai Academy of Agriculture Sciences
- Shanghai Agrobiological Gene Center
- Shanghai Cancer Institute
- Shanghai Changhai Hospital
- Shanghai Children's Hospital
- Shanghai Fan Jing Biological Science & Technology
- Shanghai First Maternity and Infant Hospital
- Shanghai General Hospital
- Shanghai Hengrui Pharmaceutical
- Shanghai Institute of Pharmaceutical Industry
- Shanghai Institute of Quality Inspection and Technical Research
- Shanghai Jiao Tong University
- Shanghai Longyao Biotechnology
- Shanghai Model Organisms Center
- Shanghai Ocean University
- Shanghai Shunho New Materials Technology
- Shanghai Susheng Biotechnology
- Shanghai Technology Center of Animal, Plant and Food Inspection and Quarantine
- Shanghai Tenth People's Hospital
- Shanghai Tongji Hospital
- Shanghai University
- Shanghai Yixin Biological Technology
- ShanghaiTech University
- Shantou University
- Shanxi University
- Shattuck Labs
- Shenzhen Center for Disease Control and Prevention
- Shenzhen People's Hospital
- Shenzhen Rhegen Biotechnology
- Shenzhen Second People's Hospital
- Shenzhen University
- Sherlock Biosciences
- Shoreline Biome
- Sichuan Provincial People's Hospital
- Sichuan University
- Siemens Healthineers
- Sigma-Aldrich
- Silence Therapeutics
- Sinai Health
- SinoBio Biotech
- Sinobioway Group
- Sinopec
- Sinopec Shanghai Engineering
- SiPhox
- Sir Run Run Shaw Hospital
- SiVEC Biotechnologies
- Skolkovo Institute of Science and Technology
- SNIPR Biome
- Solid Biosciences
- Soochow University
- Sorbonne University
- Sorrento Therapeutics
- Sound Agriculture
- South China University of Technology
- Southeast University
- Southern Illinois University
- Southern Medical University
- Southern University of Science and Technology
- Southwest Minzu University
- Southwest University
- Spark Therapeutics
- Specific Biologics
- Sphere Fluidics
- Spiber
- Spotlight Therapeutics
- St. Jude Children's Research Hospital
- Stanford University
- STCube
- Stellate Therapeutics
- Stemgenics
- Stichting Wageningen Research
- Stitch Bio
- Summation Bio
- Sun Yat-sen University
- SunyBiotech
- Superior Council of Scientific Investigations
- Suzhou Aike Ruisi Biotechnology
- Suzhou DiYinAn Biotechnology
- SweTree Technologies
- Swiss Federal Institute of Technology Lausanne
- Syngenta
- Synthego
- Synthekine
- Synthetic Genomics
- Systasy Bioscience
- System Biosciences
- Taipei Veterans General Hospital
- Takara Bio
- Takeda Pharmaceuticals
- TargetGene Biotechnologies
- Tarveda Therapeutics
- Tata Consultancy Services
- TCR2 Therapeutics
- Technical University of Denmark
- Tel Aviv University
- Temple University
- The Administrators of The Tulane Educational Fund
- The Catholic University of Korea
- The Children's Hospital of Philadelphia
- The Chinese University of Hong Kong
- The City University of New York
- The First Affiliated Hospital of Fujian Medical University
- The First Affiliated Hospital of Xi'an Jiaotong University
- The First Hospital Of Hebei Medical University
- The First Hospital of Jiaxing
- The French National Centre for Scientific Research
- The Hospital for Sick Children
- The Industry-University-Research Cooperation Foundation
- The Institute of Cancer Research
- The National Institute of Advanced Industrial Science and Technology
- The Pirbright Institute
- The Second Xiangya Hospital of Central South University
- The Third Affiliated Hospital of Guangzhou Medical University Stomatology
- The University of Alabama
- The University of Hong Kong
- The University of North Texas Health Science Center
- The University of Western Australia
- THEMBA
- Thermo Fisher Scientific
- Thoraxklinik-Heidelberg
- Tianjin Academy of Agricultural Sciences
- Tianjin Genovo Biotechnology
- Tianjin Medical University General Hospital
- Tianjin University
- Tokai National Higher Education and Research System
- Tokai University
- Tokushima University
- Tokyo Medical and Dental University
- Tolo Biotech
- Tongji Hospital
- ToolGen
- Torrey Pines Law Group
- Toshiba
- Translational Genomics Research Institute
- Tropic Biosciences
- Tsinghua Shenzhen International Graduate School
- Tsinghua University
- Tufts University
- TwinStrand Biosciences
- Twist Bioscience
- U.S Department of Commerce
- UAB Research Foundation
- UCL Business
- UK Research and Innovation
- Ulsan National Institute of Science and Technology
- Ultragenyx Pharmaceutical
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- United States Department of Veterans Affairs
- United States Secretary of Health and Human Services
- United States Secretary of the Navy
- UNITY Biotechnology
- Université de Rennes
- University Health Network
- University Hospital of Siena
- University Medical Center Groningen
- University of Alabama
- University of Alberta
- University of Angers
- University of Arkansas
- University of Basel
- University of Bern
- University of Bordeaux
- University of Bristol
- University of California
- University of Colorado
- University of Connecticut
- University of Copenhagen
- University of Edinburgh
- University of Electronic Science and Technology of China
- University of Essex
- University of Évry Val d'Essonne
- University of Florence
- University of Florida
- University of Giessen
- University of Göttingen
- University of Groningen
- University of Helsinki
- University of Illinois Urbana-Champaign
- University of Iowa Research Foundation
- University of Kentucky Research Foundation
- University of Lausanne
- University of Liège
- University of Maryland
- University of Massachusetts
- University of Melbourne
- University of Memphis
- University of Minnesota
- University of Missouri
- University of Montpellier
- University of Nantes
- University of Natural Resources and Life Sciences
- University of Nebraska
- University of Nevada
- University of New Mexico
- University of North Carolina at Chapel Hill
- University of North Texas
- University of Nottingham
- University of Oklahoma
- University of Oregon
- University of Oslo
- University of Ottawa
- University of Paris
- University of Pisa
- University of Pittsburgh
- University of Plymouth
- University of Regensburg
- University of Siena
- University of South Florida
- University of Southern California
- University of Tasmania
- University of Texas
- University of Tokyo
- University of Toronto
- University of Trento
- University of Tübingen
- University of Ulsan
- University of Utah
- University of Veterinary Medicine Vienna
- University of Vienna
- University of Würzburg
- UPSIDE Foods
- Us Health
- UT-Battelle
- Vanderbilt University
- Versiti Blood Research Institute
- Vertex Pharmaceuticals
- Verve Therapeutics
- Vilmorin & Cie
- Vilnius University
- Vland Biotech
- Vnv Newco
- Vor Biopharma
- Voyager Therapeutics
- Vrije Universiteit Brussel
- Wageningen University
- Wake Forest University Health Sciences
- Wanlei Life Sciences Shenyang
- Washington University
- Wave Life Sciences
- Wayne State University
- Weike Biotechnology
- Wenzhou Medical University
- West China Hospital Sichuan University
- Western Ontario University
- Western University
- Western University of Health Sciences
- Westlake University
- Whitehead Institute of Biomedical Research
- Williwaw Biosciences
- Wimi Biotechnology Jiangsu
- Wisconsin Alumni Research Foundation
- WiSys Technology Foundation
- Wright State University
- Wuhan Academy of Agricultural Sciences
- Wuhan Edgene Biotech
- Wuhan Engineering Science & Technology Institute
- Wuhan Kaideweisi Bio Technology
- Wuhan Keqian Biology
- Wuhan University
- Wuhan Yikang Gene Technology
- WuXi Biologics
- Wuxi Shenco Biotechnology
- Wuyi University
- Wuzhong City Hongsibao District Tianyuan Agriculture And Animal Husbandry Technology Development
- Wyoming University
- Xenotherapeutics
- Xi An Jiaotong University
- Xiamen Institute of Rare Earth Materials
- Xian Medical University
- Xian Sunnycell Biomedicine
- Xinjiang Academy Agricultural & Reclamation Sciences
- Xinjiang Academy of Agricultural Sciences
- Xinxiang Medical University
- Xuzhou Medical University
- Yale University
- Yangzhou University
- Yantai Baibo Biological Technology
- Yeasen Biotechnology Shanghai
- Yeda Research & Development
- Yield10 Bioscience
- Yijishan Hospital Wannan Medical College
- Yissum Research Development Of Hebrew University of Jerusalem
- Yonsei University
- Youhealth Biotech
- Yuan Longping High Technology Agriculture
- Yuan Longping High-tech Agriculture
- Yunnan Cancer Hospital
- Yunnan University
- Zhangjiagang Institute of Industrial Technologies.
- Zhaoqing Casgene Biotech
- Zhaoqing South China Normal University of Optoelectronics
- Zhaoqing University
- Zhejiang Academy of Agricultural Sciences
- Zhejiang Academy of Medical Sciences
- Zhejiang Institute of Fresh Water Fisheries
- Zhejiang Saiweisi Biotechnology
- Zhejiang Shance Heqishi Biotechnology
- Zhejiang University
- Zhengzhou University
- Zhongji Zhiyao Nanjing Biotechnology
- Zhuhai Leviregen Medical Technology
- Zhuhai Shutong Medical Technology
- Zoetis
- ZS Genetics
- Zumutor Biologics
- Zymergen
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