This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of cardiovascular pathology, including new cardiac devices, molecular panels and genetics, the latest tumor classifications, up-to-date COVID-19 information, and imaging, this volume incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cardiovascular is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
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Covers all areas of cardiovascular pathology, organizing chapters by how specimens are most often encountered in practice-biopsy, explant and surgical specimens, and autopsy-as well as by anatomic site�
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Contains significantly updated information throughout (text, images, illustrations, and references) including the latest World Health Organization and International Collaboration on Cancer Reporting tumor classifications, as well as new details related to staging and grading of tumors of the heart, and COVID-19 information�
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Evaluates a new generation of cardiac devices in surgical and autopsy specimens in both images and text�
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Includes new material on genetics and sudden cardiac death and cardiomyopathy, and recent recommended amyloid treatment therapies�
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Features nearly 1,500 images, including carefully annotated histology and gross pathology photographs, vivid medical illustrations, photomicrographs, and electron micrographs to help practicing and in-training pathologists reach a confident diagnosis�
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Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care�
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Includes an eBook version?that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud�
Table of Contents
SECTION 1: HEART, ENDOMYOCARDIAL BIOPSYCONGENITAL/GENETIC
4 Endocardial Fibroelastosis Syndrome
Monica P. Revelo, MD, PhD
6 Arrhythmogenic Cardiomyopathy
Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Monica P. Revelo, MD, PhD
12 Fatty Acid Metabolic Disorders
Monica P. Revelo, MD, PhD
14 Mitochondrial Myopathies
Monica P. Revelo, MD, PhD
18 Muscular Dystrophies
Monica P. Revelo, MD, PhD
22 Glycogen Storage Diseases
Monica P. Revelo, MD, PhD
24 Fabry Disease, Heart
Monica P. Revelo, MD, PhD
28 LAMP2 Mutation (Danon Disease)
Jagdish Butany, MBBS, MS, FRCPC, Amar Ibrahim, MB, ChB, MSc, and Monica P. Revelo, MD, PhD
ACQUIRED
30 Amyloid Deposition, Heart
Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD
38 Hemochromatosis, Heart
Philippe Romeo, MD and Monica P. Revelo, MD, PhD
40 Anthracycline Cardiotoxicity
Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD
42 Catecholamine Cardiomyopathy
Monica P. Revelo, MD, PhD
44 Cocaine Cardiotoxicity
Dylan V. Miller, MD and Brian J. Hall, MD
46 Immune Checkpoint Inhibitor Toxicity
Monica P. Revelo, MD, PhD and Dylan V. Miller, MD
INFLAMMATORY
50 Lymphocytic Myocarditis
Monica P. Revelo, MD, PhD
54 Giant Cell Myocarditis
Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD
56 Eosinophilic (L?ffler) Myocarditis
Monica P. Revelo, MD, PhD
60 Sarcoidosis, Heart
Monica P. Revelo, MD, PhD
62 Acute Rheumatic Carditis
Monica P. Revelo, MD, PhD
66 Eosinophilic Granulomatosis With Polyangiitis
Monica P. Revelo, MD, PhD
68 Viral Myocarditis
Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath
70 Toxoplasmosis, Heart
Monica P. Revelo, MD, PhD
72 Chagas Disease, Heart
Dylan V. Miller, MD and Brian J. Hall, MD
76 Lyme Disease and Rickettsial Myocarditis
Dylan V. Miller, MD and Brian J. Hall, MD
80 SARS-CoV-2 (COVID-19)-Related Cardiovascular Disease
Dylan V. Miller, MD and Monica P. Revelo, MD, PhD
84 Lupus Erythematosus, Heart
Monica P. Revelo, MD, PhD
TRANSPLANT REJECTION
90 Acute Cellular Transplant Rejection, Heart
Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD
96 Antibody-Mediated Transplant Rejection, Heart
Elizabeth H. Hammond, MD and Monica P. Revelo, MD, PhD
102 Quilty Lesions
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
106 Previous Biopsy Sites, Heart Transplant
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
108 Posttransplant Lymphoproliferative Disorder, Heart
Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath
110 Harvesting Injury/Acute Ischemia, Heart
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
SECTION 2: HEART, RESECTION
HEART EXPLANT
116 Hypertrophic Cardiomyopathy
Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD
122 Idiopathic Dilated Cardiomyopathy
Dylan V. Miller, MD
126 Ischemic Heart Disease
Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD
130 Overview of Coronary Artery Stents
Dylan V. Miller, MD
134 Cardiac Allograft Vasculopathy
Monica P. Revelo, MD, PhD
140 Radiation Injury, Heart
Dylan V. Miller, MD and Philippe Romeo, MD
142 Cardiac Conduction System Disease
Dylan V. Miller, MD
150 Ventricular Assist Devices
Dylan V. Miller, MD
156 Approach to Cardiomyopathy (Worksheet)
Dylan V. Miller, MD
158 Approach to Cardiomyopathy Diagnosis
Dylan V. Miller, MD
SECTION 3: HEART, TUMORS
BENIGN
166 Cardiac Myxoma
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
172 Papillary Fibroelastoma
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
176 Cardiac Rhabdomyoma
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
180 Cardiac Fibroma
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
184 Ectopic Tissues, Heart
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
186 Lipomatous Hypertrophy of Atrial Septum
Dylan V. Miller, MD and Billie Fyfe, MD
MALIGNANT
188 Cardiac Lymphoma
Dylan V. Miller, MD, Brian J. Hall, MD, and Nikhil Sangle, MD, FRCPath
190 Cardiac Angiosarcoma
Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD
194 Cardiac Sarcoma, Other
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
198 Cardiac Metastases
Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC
SECTION 4: CARDIAC VALVES, NATIVE
AORTIC 206 Unicommissural Aortic Valve
Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC
210 Bicuspid Aortic Valve
Jagdish Butany, MBBS, MS, FRCPC, Amar Ibrahim, MB, ChB, MSc, and Monica P. Revelo, MD, PhD
214 Senile Calcific Aortic Stenosis
Monica P. Revelo, MD, PhD
218 Discrete Membranous Subaortic Stenosis
Dylan V. Miller, MD
MITRAL
220 Myxomatous Mitral Valve Disease
Dylan V. Miller, MD and Philippe Romeo, MD
224 Rheumatic Heart Disease
Dylan V. Miller, MD and Philippe Romeo, MD
TRICUSPID 228 Carcinoid Heart Disease
Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD
232 Ebstein Anomaly
Dylan V. Miller, MD and Philippe Romeo, MD
PULMONARY
234 Congenital Pulmonary Stenosis
Dylan V. Miller, MD and Brian J. Hall, MD
ENDOCARDITIS
236 Endocarditis, Native Valve
Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD
240 Nonbacterial Thrombotic Endocarditis
Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD
SECTION 5: CARDIAC VALVES
PROSTHETIC
246 Leaflet Degeneration, Prosthetic Valves
Jagdish Butany, MBBS, MS, FRCPC and Monica P. Revelo, MD, PhD
250 Thrombosis of Prosthetic Valves
Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Amar Ibrahim, MB, ChB, MSc
252 Endocarditis, Prosthetic Valve
Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC
258 Mechanical Heart Valve Prostheses: Modes of Failure
Dylan V. Miller, MD, Jagdish Butany, MBBS, MS, FRCPC, and Amar Ibrahim, MB, ChB, MSc
260 Catheter-Deployed Valve Therapies
Dylan V. Miller, MD and Monica P. Revelo, MD, PhD
SECTION 6: PERICARDIUM
INFLAMMATORY
268 Acute Pericarditis
Monica P. Revelo, MD, PhD
272 Constrictive Pericarditis
Monica P. Revelo, MD, PhD
274 Tuberculous Pericarditis
Monica P. Revelo, MD, PhD
TUMORS 276 Lymphoma, Pericardium
Dylan V. Miller, MD
278 Metastatic Tumor, Pericardium
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
282 Mesothelioma, Pericardium
Dylan V. Miller, MD and Joseph J. Maleszewski, MD
286 Mesothelial/Monocytic Incidental Cardiac Excrescence
Dylan V. Miller, MD
SECTION 7: VASCULAR DISEASE
ENDARTERECTOMY/ATHERECTOMY/THROMBECTOMY
290 Overview of Peripheral Vascular Specimens
Dylan V. Miller, MD and Billie Fyfe, MD
296 Thromboembolus, Vascular
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
THORACIC AORTA 300 Aortic Degenerative Diseases
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
308 Genetic Diseases of the Aorta
Joseph J. Maleszewski, MD and Monica P. Revelo, MD, PhD
312 Noninfectious Aortitis
Dylan V. Miller, MD
316 Takayasu Arteritis
Dylan V. Miller, MD
320 Aortic Dissection
Dylan V. Miller, MD and Billie Fyfe, MD
324 Aortic Coarctation
Dylan V. Miller, MD and Monica P. Revelo, MD, PhD
ABDOMINAL AORTA 328 Aortic Atherosclerosis and Complications
Billie Fyfe, MD and Monica P. Revelo, MD, PhD
334 Chronic Periaortitis and IgG4-Related Disease
Dylan V. Miller, MD
336 Mycotic Aneurysm
Monica P. Revelo, MD, PhD
CORONARY ARTERIES 340 Atherosclerosis, Coronary
Monica P. Revelo, MD, PhD
344 Coronary Artery Dissection
Monica P. Revelo, MD, PhD
348 Kawasaki Disease
Vidhya Nair, MBBS, MD, FRCPC and Monica P. Revelo, MD, PhD
352 Coronary Artery Emboli
Monica P. Revelo, MD, PhD
TEMPORAL ARTERIES
354 Giant Cell/Temporal Arteritis
Dylan V. Miller, MD and Monica P. Revelo, MD, PhD
PERIPHERAL VESSELS
358 Buerger Disease (Thromboangiitis Obliterans)
Dylan V. Miller, MD and Jagdish Butany, MBBS, MS, FRCPC
362 Fibromuscular Dysplasia
Dylan V. Miller, MD and A. Brad Farris, III, MD
368 Segmental Arterial Mediolysis
Dylan V. Miller, MD
370 M?nckeberg Medial Calcific Sclerosis
Brandon T. Larsen, MD, PhD and Monica P. Revelo, MD, PhD
372 Beh?et Disease
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
376 Infectious Vasculitis
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
382 Lymphocytic Venulitis
Monica P. Revelo, MD, PhD
384 Varicosities
Dylan V. Miller, MD and Billie Fyfe, MD
386 Hypertensive Renovascular Diseases
Dylan V. Miller, MD, A. Brad Farris, III, MD, and Brandon T. Larsen, MD, PhD
VASCULAR TISSUE GRAFTS
390 Vascular Graft Pseudoaneurysm
Jagdish Butany, MBBS, MS, FRCPC, Pooja Gupta, MBBS, DNB, and Monica P. Revelo, MD, PhD
SECTION 8: VASCULAR TUMORS
BENIGN 396 Hemangioma
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
406 Angiomyolipoma
Dylan V. Miller, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD
410 Glomus Tumor
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
418 Cystic Lymphangioma
Monica P. Revelo, MD, PhD
420 Arteriovenous Malformations
Dylan V. Miller, MD
MALIGNANT
424 Epithelioid Hemangioendothelioma
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
428 Kaposi Sarcoma
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
434 Angiosarcoma
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
SECTION 9: AUTOPSY
CARDIAC
442 Coronary Artery Bypass Grafting
Dylan V. Miller, MD
446 Valve Replacement (Including Transcatheter)
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
452 Infective Endocarditis
Dylan V. Miller, MD
458 Ventricular Assist Device Insertion
Dylan V. Miller, MD and Brandon T. Larsen, MD, PhD
462 Heart Transplant
Dylan V. Miller, MD
VASCULAR 468 Thoracic Aortic Aneurysm Repair
Dylan V. Miller, MD, Billie Fyfe, MD, and George P. Batsides, MD
474 Abdominal Aortic Aneurysm
Dylan V. Miller, MD and Billie Fyfe, MD
478 Cerebral Aneurysm and Vascular Malformation
Dylan V. Miller, MD and Roy H. Rhodes, MD, PhD
