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Degenerative Cervical Myelopathy. From Basic Science to Clinical Practice

  • Book

  • November 2023
  • Elsevier Science and Technology
  • ID: 5694150

Degenerative Cervical Myelopathy: From Basic Science to Clinical Practice lays the foundation for understanding DCM manifestation, pathophysiology, diagnosis and treatment strategies. The book covers the latest basic and clinical research, updates on patient management strategies, and discusses promising neuroprotective therapies for the future of DCM care. Written by international experts across a range of topics related to degenerative cervical myelopathy, the book helps readers understand the challenges and future directions of patient management.

As degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction and one of the most common indications for spinal surgery worldwide, the term DCM encompasses a group of chronic, non-traumatic spinal cord injuries that occur due to degenerative changes in the cervical spine (e.g. disc spondylosis or repetitive dynamic injury from hyper-mobility).

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Table of Contents

1. Overview of DCM
2. Anatomy�and Physiology of Cervical Spine�and Cervical Spinal Cord
3. Epidemiology, Genetics�and Classification of DCM
4. Pathophysiology of DCM
5. Clinical Assessment Tools
6. Imaging of DCM
7. Electrophysiological Assessment of DCM
8. Assessment of Cervical Alignment�and Deformity
9. Patient Trajectory�and Natural History
10. Role of the Primary Care Practitioner in the Assessment�and Management of DCM
11. RECODE Priorities
12. Overview of Management Options for DCM (reference current guidelines)
13. Prehabilitation�and Rehabilitation for DCM
14. Decision Making in Surgical Management of DCM
15. Anterior Surgical Approaches to Treat DCM
16. Posterior Surgical Approaches to Treat DCM Cervical Laminectomy
17. Posterior Surgical Approaches to Treat DCM Cervical Laminoplasty
18. Serological, Genetic�and Imaging Biomarkers
19. Nonoperative Management of DCM (including potential neuroprotective strategies)
20. Neuroregenerative Strategies for DCM
21. State of the Art�and Future Directions of DCM

Authors

Michael G. Fehlings Professor, Vice Chair Research, Department of Surgery, Halbert Chair in Neural Repair and Regeneration, Co-Chairman Spinal Program, University of Toronto; Head Spinal Program, McEwen Centre for Regenerative Medicine, Toronto Western Hospital. Dr. Fehlings is the Vice Chair Research for the Department of Surgery at the University of Toronto and Head of the Spinal Program at Toronto Western Hospital, University Health Network. Dr. Fehlings is a Professor of Neurosurgery at the University of Toronto, holds the Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration, is a Scientist at the McEwen Centre for Regenerative Medicine and a McLaughlin Scholar in Molecular Medicine. In the fall of 2008, Dr. Fehlings was appointed the inaugural Director of the University of Toronto Neuroscience Program (which he held until June 2012) and is currently Co-Director of the University of Toronto Spine Program. Dr. Fehlings combines an active clinical practice in complex spinal surgery with a translationally oriented research program focused on discovering novel treatments to improve functional outcomes following spinal cord injury (SCI).