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Addresses hematologic conditions including leukemia, lymphoma, and myeloma.�
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Offers guidance on hematopoietic cell transplantation for solid tumors.���
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Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications.�
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Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT.�
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Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference.�
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Offers team-based, clinically-focused coverage from world-renowned leaders in the field.�
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.�
Table of Contents
Part One IntroductionCh 1 Evolution of HCT, past, present, and future
Ch 2 Human leukocyte antigen
Ch 3 Introduction and basic science of chimeric antigen receptor therapies
Ch 4 Statistical methods in HCT and cellular therapies
Part Two Methodology
Ch 5 Hematopoietic cell collection; bone marrow harvesting, apheresis, UCB
Ch 6 Leukapheresis and manufacturing of CAR cells
Part Three General Clinical Aspects
Ch 7 Patient and donor selection and preparing for HCT
Ch 8 General management of patients undergoing HCT
Ch 9 Haploidentical HCT
Ch 10 Umbilical cord blood transplantation
Ch 11 Process and general management of patients undergoing CAR therapies
Part Four Pharmacology and Radiation Therapy
Ch 12 Preparative regimens used in HCT and CAR therapies
Ch 13 Pharmacology of drugs used in HCT and CAR therapies
Ch 14 Role of radiation therapy in HCT and CAR therapies
Part Five Disease-Specific Indications and Results
Ch 15 HCT in AML
Ch 16 CAR therapy in AML
Ch 17 HCT in ALL
Ch 18 CAR therapy in ALL
Ch 19 HCT in chronic leukemias; CML and CLL
Ch 20 HCT in MDS
Ch 21 HCT in myeloproliferative disorders
Ch 22 HCT in aplastic anemia
Ch 23 HCT in multiple myeloma
Ch 24 CAR therapy in multiple myeloma
Ch 25 HCT in light-chain amyloidosis
Ch 26 HCT in NHL
Ch 27 HCT in Hodgkin lymphoma
Ch 28 CAR therapy in lymphoma
Ch 29 HCT in rare malignancies
Ch 30 HCT for hematologic malignancies in HIV patients
Ch 31 HCT in solid tumors
Part Six Prevention and Management of Complications
Ch 32 Infectious complications
Ch 33 Graft failure
Ch 34 Graft-versus-host disease
Ch 35 Miscellaneous complications of HCT
Ch 36 Cytokine release syndrome
Ch 37 Neurologic complications of CAR therapy (ICANS)
Ch 38 Miscellaneous complications of CAR therapy
Ch 39 Symptoms management and palliative care
Ch 40 Survivorship
Authors
Qaiser Bashir Associate Professor of Medicine, Department of Stem Cell Transplantation & Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas. Elizabeth J. Shpall Professor and Chair, at interim, Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer MedicineDirector, Cell Therapy Laboratory, Director, Cord Blood Bank, The University of Texas MD Anderson Cancer Center, Houston, Texas. Richard E. Champlin Professor, Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
