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Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more.�
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Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice.�
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.�
Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.
Table of Contents
Introduction to the Thalassemia Syndromes: Molecular Medicine's Index CaseThe Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation Perspective
Molecular Basis and Genetic Modifiers of Thalassemia
Fetal Hemoglobin Regulation in Beta-Thalassemia
Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia
The Clinical Phenotypes of Alpha Thalassemia
Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability
Pathogenic Mechanisms in Thalassemia II: Iron Overload
Clinical Complications and Their Management
Clinical Challenges with Iron Chelation in Beta Thalassemia
Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia
Hematopoietic Stem Cell Transplantation in Thalassemia
Gene Therapy and Gene Editing for b-Thalassemia
Emerging Therapies in b-Thalassemia
