Exosome Therapeutics Market Industry Trends and Global Forecasts to 2035, by Type of Therapeutic, Target Indication, Therapeutic Area, Route of Administration and Geography

The global exosome therapy is estimated to grow from USD 0.03 billion in 2029 to USD 1.4 billion by 2040, at a CAGR of 41.1% during the forecast period, till 2035.

The market sizing and opportunity analysis has been segmented across the following parameters:

Type of Exosome Therapeutics

• Allogenic
• Autologous

Target Disease Indications

• Degenerative Meniscal Injury
• Dystrophic Epidermolysis Bullosa
• Fistula Perianal
• Retinitis Pigmentosa 

Therapeutic Area

• Dermatological Disorders
• Musculoskeletal Disorders
• Ophthalmic Disorders
• Rectal Disorders

Route of Administration

• Fistula Tract
• Intra-articular
• Intra-ocular

Key Geographical Regions

• North America
• Europe
• Asia-Pacific
• Rest of the World

Exosome Therapy Market: Growth and Trends

Owing to the various benefits, such as enhanced tissue regeneration, reduced inflammation and chronic pain, and target specificity, exosome therapies have garnered significant attention in the recent past. Various studies have demonstrated the high efficacy and therapeutic superiority of exosome therapeutics in disease diagnosis, drug delivery and therapeutic applications. It is worth highlighting that over 120 therapeutic candidates are currently being investigated for treating myriads of disease indications, across the globe. This depicts the extensive development efforts being undertaken by drug developers in this domain. More than 40% of the total number of drugs are in various phases of clinical development. Of the total candidates, seven exosome therapies, including EXOMSC-COV19 (Dermama Biotech Lab), Dex2 (Gustave Roussy Institute), SF-MSC-EX (Osmangazi University), are currently being tested in the advanced clinical stages of development.

At present, around 30% of exosome-based therapeutics are under development for the treatment of various cancers. This innovative approach uses exosomes as a means to deliver drugs specifically to cancer cells, and these therapies are still in the early phases of research. Notable types of cancer being investigated for exosome delivery systems include breast cancer, lung cancer, melanoma, and colon cancer. Considering the ongoing R&D efforts in this domain, promising clinical trial results and anticipated launch of late-stage exosome therapies, the market is anticipated to witness notable growth over the next decade.

Exosome Therapy Market: Key Insights

The report delves into the current state of the exosome therapy market and identifies potential growth opportunities within the industry. Some key findings from the report include:

• Close to 60 players, worldwide, have taken initiatives to develop exosome therapeutics; the market is characterized by the presence of start-ups and small companies.

• The current pipeline features more than 120 exosome therapeutics that are being evaluated across different phases of development; most of these are designed for intravenous administration.
• 3,000+ patients have been recruited / enrolled in clinical trials evaluating exosome related therapies and biomarkers across different geographies.
• More than 530 grants have been awarded for the ongoing R&D efforts for exosome therapeutics; the University of California has been awarded the maximum grant amount of USD 21 million.
• A variety of investors, having realized the benefits and future opportunities in this field, have invested more than USD 570 million across more than 30 instances.
• The rising interest of stakeholders in exosome therapeutics is also reflected by the increasing number of partnerships established by various industry and non-industry players.
• Stakeholders have participated in various global events to discuss the research outcomes, and affiliated challenges as well as opportunities existing in this domain.
• At present, more than 30 start-ups are driving innovation in this domain; a variety of R&D initiatives have been undertaken by these players over the last few years for the development of exosome therapeutics.
• Lack of efficacy, the COVID-19 pandemic, limited patient enrollment, and scarce funding are among the key reasons that have led to the discontinuation of studies sponsored by various industry and non-industry players.
• With the rising demand for therapeutic advances in drug safety, the market for exosome therapeutics is expected to grow at an annualized rate of 41.1% between 2029-2040.

Exosome Therapy Market: Key Segments

Autologous Therapies are Likely to Capture Largest Share of the Exosome Therapy Market

Based on the type of therapy, the market is segmented into allogenic therapy and autologous therapy. It is anticipated that the autologous therapy segment will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that allogeneic therapy is likely to grow at a relatively higher CAGR.

Retinitis Pigmentosa is Likely to be the Fastest Growing Segment of the Exosome Therapy Market During the Forecast Period

Based on the target disease indication, the market is segmented into degenerative meniscal injury, dystrophic epidermolysis bullosa, fistula perianal and retinitis pigmentosa. It is anticipated that fistula perianal will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that the exosome therapy market for retinitis pigmentosa is likely to grow at a relatively higher CAGR.

Rectal Disorders Segment is the Fastest Growing Segment of the Exosome Therapy Market

Based on the therapeutic area, the market is segmented into dermatological disorders, musculoskeletal disorders, ophthalmic disorders and rectal disorders. While the rectal disorders segment is likely to hold a relatively higher market share, it is worth highlighting that the ophthalmic diseases segment is expected to witness substantial market growth in the coming years.

Fistula Tract Segment is Likely to Capture Largest Share of the Exosome Therapy Market in 2029

Based on the route of administration, the market is segmented into fistula tract, intra-articular and intra-ocular. It is anticipated that the fistula tract segment will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that the intraocular segment is likely to grow at a relatively higher CAGR.

Asia-Pacific Accounts for the Largest Share of the Market

Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific and the Rest of the World. The majority share is expected to be captured by drug developers based in Asia-Pacific. It is worth highlighting that, over the years, the market in Europe is expected to grow at a higher CAGR.

Some Key Players in the Exosome Therapy Market include:

• Coya Therapeutics
• Evox Therapeutics
• Curexsys
• EV Therapeutics
• SHIFTBIO

Primary Research Overview

The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:

• Chief Business Officer, Capricor Therapeutics
• R&D and Innovation Manager, Exogenus Therapeutics
• Chief Business Officer, ILIAS Biologics

Exosome Therapy Market: Research Coverage

• Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the exosome therapy market, focusing on key market segments, including [A] type of therapy, [B] target disease indications, [C] therapeutic area, [D] route of administration and [E] key geographical regions.
• Market Landscape: A comprehensive evaluation of exosome therapeutics, considering various parameters, such as [A] phase of development, [B] technology platform, [C] type of payload, [D] target disease indication (s), [E] therapeutic area, [F] biological target, [G] route of administration, [H] type of therapy, [I] combination drug, [J] line of treatment and [K] dosing frequency. Further, it includes details on the exosome therapeutic developers, along with information on their [L] year of establishment, [M] company size and [N] location of headquarters.
• Company Profiles: In-depth profiles of key industry players engaged in the development of exosome therapeutics, focusing on [A] company overviews, [B] financial information (if available), [C] product portfolio, [E] recent developments and [F] an informed future outlook.
• Drug Profiles: In-depth profiles of key exosome therapies, focusing on [A] product portfolio and [B] clinical trial information.
• Clinical Trials Analysis: Examination of completed, ongoing, and planned clinical studies of various exosome therapeutics, based on parameters like [A] trial status, [B] trial registration year, [C] type of sponsor / collaborator, [D] study design, [E] number of patients enrolled, [F] year-wise trend of completed and recruiting trials, [G] age group of the patients enrolled, [H] active industry and non-industry players and [I] location of the trials.
• Academic Grant Analysis: A comprehensive examination of various academic grants that have been awarded to various research institutes for projects related to exosome therapeutics, based on several parameters, such as [A] year of grant awarded, [B] amount awarded, [C] type of funding institute center, [D] popular NIH departments, [E] support period, [F] emerging focus area, [G] purpose of grants, [H] grant activity code, [I] local recipients, [J] type of recipient organization study section, [K] type of grant application and [L] popular recipient organizations, (in terms of number of grants and amount awarded).
• Global Event Analysis: An in-depth analysis of the global events attended by the exosome therapy developers, based on several relevant parameters, such as [A] year of event, [B] type of event platform, [C] location of event, [D] emerging focus areas, [E] active organizers (in terms of number of events), [F] active industry and non-industry participants, [G] designation of participants, [H] affiliated department of participants, and [I] active speakers (in terms of number of events).
• Partnerships and Collaborations: An analysis of partnerships established in this sector, since 2017, covering research agreements, licensing agreements, manufacturing agreements, product development and commercialization agreements, mergers / acquisitions, and other relevant deals.
• Funding and Investment Analysis: A detailed evaluation of the investments made in this domain, encompassing seed financing, venture capital financing, IPOs, secondary offering, debt financing and other equity.
• Start-Up Health Indexing: An analysis of start-ups / small companies engaged in the development of exosome therapeutics, based on parameters, such as [A] pipeline strength, [B] pipeline maturity, [C] financial support, [D] number of investors, [E] partnership activity and [F] start-up health indexing.
• Case Study: A case study highlighting the companies offering development and manufacturing services for exosome therapeutics, along with the information on their [A] year of establishment, [B] company size, [C] location of headquarters, [D] types of service(s) offered, [E] method of isolation, [F] method of purification, [G] method of characterization, [H] method of exosome manufacturing, [I] scale of operation and [J] scalability.
• Drug Failure Analysis: An in-depth analysis, focusing on exosome therapeutics that failed to progress to later stages of clinical development, based on various relevant parameters, such as [A] trial status of discontinuation, [B] target disease indication(s), [C] route of administration and [D] type of sponsor.

Key Questions Answered in this Report

• How many companies are currently engaged in this market?
• Which are the leading companies in this market?
• What kind of partnership models are commonly adopted by industry stakeholders?
• What factors are likely to influence the evolution of this market?
• What is the current and future market size?
• What is the CAGR of this market?
• How is the current and future market opportunity likely to be distributed across key market segments?

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• The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
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