Pulmonary Arterial Hypertension (PAH) Treatment Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2022 To 2030

Pulmonary Arterial Hypertension (PAH) Treatment Market to Exhibit Healthy Growth during the Forecast Period between 2022 to 2030

The global "pulmonary arterial hypertension (PAH) treatment market" accounted for a value of US$ 10,174.9 Mn in 2021 and expected to attain US$ 19,093.2 Mn by 2030. Drivers accountable for the market growth are worldwide growing elderly population along with increasing prevalence of pulmonary arterial hypertension due to rising risk factors such as connective tissue disorders, human immunodeficiency virus (HIV) infection, chronic liver diseases, lung diseases, sedentary lifestyle, and other idiopathic conditions. Furthermore, increasing launches of novel drugs treatment therapies, favorable initiatives by various governments, and rising spending on healthcare is expected to foster the market growth over the forecast period. According to the European Respiratory Society (ERS), the global prevalence of PAH is ranging from 10 to 52 cases per million and estimated to be in the range of 100,000-200,000 every year. The Centers for Disease Control and Prevention (CDC) reported that the disease affects 1 to 2 people in every 1.0 Mn over the U.S. and Europe. This medical condition is more common in older women and can affect men as well. A data published by the National Hospital Discharge Survey and National Vital Statistics System (NVSS) revealed that death rates from PAH increased 2.5% per year for women and 0.9% per year for men between 2001 and 2010. The World Health Organization (WHO) reported that global aging population would rise from 841.0 Mn in 2013 to 962.3 Mn in 2017 to cross 2.0 Bn by 2050.

The Endothelin Receptor Antagonists Segment is expected to continue the Dominance over the forecast period from 2018 to 2026

On the basis of drug class, the endothelin receptor antagonists segment dominated the market in 2017 as the endothelin receptor antagonism has emerged as a significant therapeutic strategy which acts as the potential pathogenetic in the development progression of pulmonary vasculopathy during pulmonary arterial hypertension treatment. Few oral (ERAs) are approved by the U.S. Food and Drug Administration (US FDA) for class III and IV patients suffering from pulmonary arterial hypertension. Letairis/Volibris (ambrisentan), Opsumit (macitentan), and Tracleer (bosentan) are the leading drugs for PAH treatment that are supporting the dominance of ERAs.

Pipeline Analysis - the Presence of Promising Drug Candidates in Clinical Pipeline Would be the Game Changers of Market in the Near Future

Lung Biotechnology PBC (a wholly-owned subsidiary of United Therapeutics Corporation) and Toray Industries, Inc. completed a Phase II extension trial for Beraprost Sodium 314d Modified Release (BPS-314d-MR), a reformulated single isomer of beraprost in PAH patients in the U.S., Ireland, and Belgium. Additionally, on 3rd September 2018, Lung Biotechnology PBC planned for a Phase III trial for BPS-314d-MR that would be initiated in December 2018. Moreover, Liquidia Technologies, Inc. and Nuventra, Inc. are recruiting a Phase III clinical trial for LIQ861 (inhaled treprostinil) to evaluate the long-term safety and tolerability of the drug in PAH patients. These pipeline drugs are expected to significantly impact on market by the end of 2020.

North America Holds Dominant Position due to the Presence of Supportive Infrastructure for Development and Distribution of High Quality Therapies

North America held the highest market share in 2021 due to the presence of major market players well-established healthcare infrastructure, rising prevalence of lung disorders coupled with increasing US FDA approvals for drugs early market initiation of the PAH treatment drugs. On the other hand, growing elderly population base along with rising burden of causative diseases including scleroderma, lupus, cirrhosis of the liver, and HIV infection; and improving healthcare system in China, India, and Japan are expected to support the lucrative CAGR of Asia Pacific over the forecast period.

The Presence of International Market Participants Makes Market Penetration Challenging for New Entrants

Major players in this space are GlaxoSmithKline plc; Pfizer Inc.; Gilead Sciences, Inc.; Novartis International AG; Bayer AG; Merck KGaA; Bristol-Myers Squibb Company; United Therapeutics Corporation; Actelion Pharmaceuticals Ltd; Reata Pharmaceuticals, Inc.; Toray Industries, Inc.; Liquidia Technologies, Inc.; and Nuventra Pharma Sciences. Companies are focusing on novel drug approvals launches, mergers acquisitions, partnerships, and collaboration strategies to gain an impetus in the market. For instance, in November 2015, GlaxoSmithKline plc received an approval from European Commission (EC) for Volibris (ambrisentan) in the treatment of pulmonary arterial hypertension in adult patients of WHO functional class (FC) II to III. Pfizer Inc.s REVATIO, the capsules containing sildenafil (phosphodiesterase-5 inhibitor) are used in the treatment of adult patients with PAH.

The current report also incorporates qualitative quantitative analysis of market variables such as key market drivers, restraints, opportunities, and trends which convey better market information of the entire pulmonary arterial hypertension treatment. Additionally, the report also comprises a graphical illustration of the competitive landscape based on their market initiatives strategies, product portfolio, financial information, and key developments. Major market players profiled in this study report are GlaxoSmithKline plc; Pfizer Inc.; Gilead Sciences, Inc.; Novartis International AG; Bayer AG; Merck KGaA; Bristol-Myers Squibb Company; United Therapeutics Corporation; Actelion Pharmaceuticals Ltd; Reata Pharmaceuticals, Inc.; Toray Industries, Inc.; Liquidia Technologies, Inc.; and Nuventra Pharma Sciences

Historical Forecast Period

This study report represents analysis of each segment from 2020 to 2030 considering 2021 as the base year. Compounded Annual Growth Rate (CAGR) for each of the respective segments estimated for the forecast period of 2022 to 2030.

The current report comprises of quantitative market estimations for each micro market for every geographical region and qualitative market analysis such as micro and macro environment analysis, market trends, competitive intelligence, segment analysis, porters five force model, top winning strategies, top investment markets, emerging trends and technological analysis, case studies, strategic conclusions and recommendations and other key market insights.

Research Methodology

The complete research study was conducted in three phases, namely: secondary research, primary research, and expert panel review. key data point that enables the estimation of Pulmonary Arterial Hypertension (PAH) Treatment market are as follows:

• Research and development budgets of manufacturers and government spending
• Revenues of key companies in the market segment
• Number of end users and consumption volume, price and value.
• Geographical revenues generate by countries considered in the report
• Micro and macro environment factors that are currently influencing the Pulmonary Arterial Hypertension (PAH) Treatment market and their expected impact during the forecast period.

Market forecast was performed through proprietary software that analyzes various qualitative and quantitative factors. Growth rate and CAGR were estimated through intensive secondary and primary research. Data triangulation across various data points provides accuracy across various analyzed market segments in the report. Application of both top down and bottom-up approach for validation of market estimation assures logical, methodical and mathematical consistency of the quantitative data.

Market Segmentation

Drug Class

• Endothelin Receptor Antagonists (ERAs)
• Vasodilators
• Phosphodiesterase-5 (PDE-5) Inhibitors
• Soluble Guanylate Cyclase (sGC) Stimulators
• Calcium Channel Blockers (CCBs)
• Others (anticoagulants, diuretics, and cardiac glycosides)

Key questions answered in this report

• What are the key micro and macro environmental factors that are impacting the growth of Pulmonary Arterial Hypertension (PAH) Treatment market?
• What are the key investment pockets with respect to product segments and geographies currently and during the forecast period?
• Estimated forecast and market projections up to 2030.
• Which segment accounts for the fastest CAGR during the forecast period?
• Which market segment holds a larger market share and why?
• Are low and middle-income economies investing in the Pulmonary Arterial Hypertension (PAH) Treatment market?
• Which is the largest regional market for Pulmonary Arterial Hypertension (PAH) Treatment market?
• What are the market trends and dynamics in emerging markets such as Asia Pacific, Latin America, and Middle East Africa?
• Which are the key trends driving Pulmonary Arterial Hypertension (PAH) Treatment market growth?
• Who are the key competitors and what are their key strategies to enhance their market presence in the Pulmonary Arterial Hypertension (PAH) Treatment market worldwide?

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