Attempts to synthetically recreate the biological circuits in human body is a relatively new area of research within synthetic biology. Ever since the 2010s, the use of molecular “toggle” switches to mimic electronic circuits has been prevalent to understand, alter, and recreate molecular circuits within the human body. The evolution of chemistry and synthetic biology has reached an interesting point as these complex processes, including genetic regulation, expression, and replication are being understood at a molecular level. The prominent elements of these exploratory studies are molecular switches, which are responsive to internal or external stimuli and can be manipulated to create a transition between two stable states when exposed to a change in their optical, electrical, or chemical environment. During the past few years, several molecules have been identified and characterized as “switches”, which are now available for the construction of complex synthetic signaling networks with applications in both biology and nanotechnology. Of the different types of molecules, organic molecules, including proteins, nucleic acids, and cyclic organic compounds, such as crown ethers are likely to be the promising candidates in this field due to their diverse structural, electrical, and mechanical properties. In addition, synthetic molecules, such as Rotaxanes and Catenanes have emerged as potential molecular switches, as the binding sites within these mechanically interlocked molecules can be manipulated upon the application of stimuli, resulting in a shift in their structure and chemistry on cue.
One of the most important applications of molecular switches is to combat the challenges associated with anticancer therapies, like system toxicity, multidrug resistance, poor solubility, and membrane permeability. In order to overcome these drawbacks, researchers have undertaken several R&D efforts for identifying and developing effective treatment modalities. Among other alternatives, the use of Nanocarriers has emerged as a viable option. These nanomaterials encapsulate the drug, essentially warding it off from the surrounding physiological conditions and minimizing the side effects. Upon installation of molecular switches in their structure, these nanocarriers can be manipulated to gravitate towards a specific environment within the body and release the drug, when stimulated. The stimulus can further be manipulated to obtain the desired dosage strength and frequency. The extent of modification in these molecules allows for the use of minute differences in the biochemistry of different tissues as stimuli for targeted delivery of drugs. Simultaneously, with constant evolution in biomedical research and other emerging fields, such as optogenetics, molecular switches are being explored to directly switch the genes “on” and “off”, leading to control over genetic regulation and expression. The potential of gaining control over the molecular architecture and consequently, molecular function has led to a steady increase in the research and entrepreneurial activity in this domain. As a result, the intellectual capital around compositions of molecular switches, engineering techniques, and their application in gene regulation and therapeutic use, has also grown. In light of such developments, it is important to keep track of both pockets of innovation and key areas of improvement for stakeholders to remain competitive in this upcoming field of medicine / drugs. This report captures some of the key R&D-related trends and provides competitive intelligence on intellectual property in the field of molecular switches.
Scope of the Report
The “Molecular Switches: Intellectual Property Landscape” report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents), describing the various types of molecular switch interventions intended to treat a growing range of clinical conditions. The insights generated in this report have been presented across two deliverables, namely a MS Excel workbook and a MS PowerPoint deck, summarizing the ongoing activity in this domain.
Key inclusions are briefly described below:
Overall Intellectual Property Landscape
An analytical perspective of the various patents and affiliated IP documents that have been published related to molecular switches, since 1981. An in-depth analysis of published IP documents, representing unique patent families across various global jurisdictions, featuring insightful inferences related to both historical and recent R&D trends within this niche, but rapidly evolving applications in the biotechnology and pharmaceutical industry.
Popular / Relevant Prior Art Search Expressions
An examination of IP literature, shortlisting key words and phrases used to describe molecular switches (and affiliated products) that are either already available in the market, or under development. The analysis also includes details on the historical use of the aforementioned terms across different IP filings, key affiliated terms (which can be used to identify other relevant IP search terms and establish relationships between prior art search expressions), and other related trends.
Patent Valuation Analysis
A competitive benchmarking and valuation analysis of the key members of unique patent families captured in the report, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in value associated with the gross domestic product (GDP) of a particular region).
Patentability and Freedom to Operate
A systematic approach to identifying relevant areas of innovation by analyzing published IP documents (representative of unique patent families), by defining the uniqueness of patented / patent pending innovations, in order to assess the scope of patentability in this domain, and pinpoint jurisdictions wherein new and / or modified claims may be filed without infringing on existing IP.
Analysis of Patent Applications
A detailed summary of the various patent applications (representative of unique patent families) that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis classified the intellectual capital in terms of type of innovation and the innovation (such as a product class, enabling technologies or method of use), thereby, offering the means to identify active arenas of research and assess innovation-specific IP filing trends.
Analysis of Granted Patents
An analysis of the granted patents (representative of unique patent families) across different global jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted IP into relevant categories (namely type of innovation and innovation) to help develop a detailed perspective on the diversity of intellectual capital (having marketing exclusivity) related to molecular switches, and the assessing likelihood for innovators to enter into promising research areas.
Pockets of Innovation and White Spaces
An insightful analysis of the various CPC codes used in published IP literature (representative of unique patent families) and their affiliated families, offering the means to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic IP classification approach, mentioned earlier); the analysis also features a discussion on prevalent white spaces (based on type of innovation and innovation) in this field of research.
Claim Analysis
One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents (representative of unique patent families) in the dataset. Using a systematic segregation approach, we have analyzed trends associated with the preamble, type of patent (product patent or method patent), type of claim (open ended claim or closed ended claim) and key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
Table of Contents
Excel Deliverable
1. Research Notes
2. Summary Dashboard
A. Overall Intellectual Property Landscape
B. Intellectual Property Landscape (Grouped by Simple Families)
C. Key Prior Art Search Expressions
D. Key Trends related to Patent Applications (featuring Patentability and Freedom-to- Operate)
E. Key Trends related to Granted Patents (featuring Patentability and Freedom-to- Operate)
F. Claim Analysis
G. Key CPC Symbols
H. Key Applicants
3. Overall Intellectual Property Landscape Dataset
4. Prior Art Search Expressions (Keyword Analysis)
5. Patent Applications Dataset
6. Granted Patents Dataset
7. Claim Analysis
8. Key Applicants Analysis
9. CPC Analysis
10. Appendix I: Pivot Tables
11. Appendix II: Country / Geography Codes
12. Appendix III: Innovation Categories
PowerPoint Deliverable
1. Context
2. Project Approach
3. Project Objectives
4. Executive Summary
5. Molecular switches
5.1. Overview
5.2. Molecules Acting as Molecular Switches
5.3. Applications of Molecular Switches in Healthcare
5.4. Key Advantages and Limitations
6. Overall Intellectual Property Landscape
6.1. Overview
6.2. Analysis of Simple Patent Families
6.3. Key Innovation Categories
6.4. Insights from Patent Applications
6.5. Insights from Granted Patents
7. Key Prior Art Search Expressions
7.1. Overview
7.2. Analysis of Prior Art Search Expressions
8. Intellectual Property Valuation Analysis
8.1. Valuation Overview
8.2. Analysis of Individual Value Ranks
8.2.1. Rank 1 IP Documents
8.2.2. Rank 2 IP Documents
8.2.3. Rank 3 IP Documents
8.2.4. Rank 4 IP Documents
8.2.5. Rank 5 IP Documents
8.3. Concluding Remarks
8.4. List of Rank 1 IP Documents
9. Analysis of Patent Applications
9.1. Overview
9.2. Relative Valuation of Patent Applications
9.3. Patentability & Freedom-to-Operate
10. Analysis of Granted Patents
10.1. Overview
10.2. Relative Valuation of Grated Patents
10.3. Patentability & Freedom-to-Operate
10.4. Analysis of Patent Claims (Granted Active Patents)
11. Key Applicants
11.1. Overview
11.2. Analysis of Key Applicants
11.2.1. Company A
11.2.2. Company B
11.2.3. Company C
11.2.4. Company D
11.2.5. Company E
11.2.6. Company F
11.2.7. Company G
11.2.8. Company H
11.2.9. Company I
11.2.10. Company J
12. Pockets of Innovation and White Spaces
12.1. Overview
12.2. Pockets of Innovation
12.3. White Spaces
12.4. Concluding Remarks
13. Future Outlook
13.1. Molecular Switches: IP Filing Growth Trends
13.2. Relevance of IP for Business Development and Growth
13.3. Contemporary Sentiments and Predictions
13.4 Anticipated Future Developments and Trends
14. Appendices
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 13therapeutics
- 149 Bio
- 2seventy bio
- 3M
- A2 Biotherapeutics
- Aarhus University
- AB Biosciences
- Ab Studio
- Abbott
- Abbott Laboratories
- AbbVie
- AbbVie
- Abbvie
- Accutar Biotech
- Aclara Biosciences
- Activartis Biotech
- Advanced Microbial
- AdVec
- Advisys
- AdynXX
- Aeomica
- Affigen
- Agency for Science, Technology and Research
- Agensys
- Agensys
- Agilent Technologies
- AIIMS - All India Institute Of Medical Science
- Aix-Marseille University
- Aix-Marseille University
- Alastin Skincare
- Albert Einstein College of Medicine
- Alcatel-Lucent Enterprise
- Alder BioPharmaceuticals
- Alector
- Alize Pharma
- Allergan
- Allinaire Therapeutics
- alliumvitalis
- Alpha Beta Holdings
- Ambion
- Amgen
- Amicus Therapeutics
- Anacor Pharmaceuticals
- Anhui Technology
- Anhui University of Science and Technology
- Antengene Corporation
- Applera
- Applied Genetic Technologies
- Applied Genetics Laboratories
- AptaBharat
- AptaScan
- Araxes Pharma
- Arbor Biotechnologies
- Archemix
- Arena Pharmaceuticals
- ARIAD Pharmaceuticals
- Aridis Pharmaceuticals
- ArQule
- Array BioPharma
- Asahi Kasei
- Ascentage Pharma
- Asklepios BioPharmaceutical
- ASML
- Assistance Publique-Hôpitaux de Paris
- Astellas Pharma
- Asterias Biotherapeutics
- Aston University
- AstraZeneca
- Athenex
- Auburn University
- Augusta University Research Institute
- Autolus
- Aventis Behring
- Aventis Pharma
- AVEO Pharmaceuticals
- Avid Bioservices
- Avigen
- Axaron Bioscience
- Axiogenesis
- Axordia
- Azeria Therapeutics
- Azitra
- Babraham Institute
- Bach Pharma
- Baker Hughes
- Bar-Ilan University
- BASF
- BASF
- Bayer
- Bayer HealthCare
- Bayer Schering Pharma
- Baylor College of Medicine
- Beida Pharmaceutical Industry
- Beijing University of Chemical Technology
- Beijing Xuanyi Pharmasciences
- Bellastem
- Bellicum Pharmaceuticals
- Ben-Gurion University of the Negev
- BERG
- Beth Israel Deaconess Medical Center
- BioActa
- BIOalternatives
- Biogen
- Bio-Gene Technologies
- BioGlow
- BioNTech
- BioNTech
- Bioquest
- BioSante Pharmaceuticals
- Biotheryx
- Biotraces
- BioZyme
- Bluebird bio
- Bond Pet Foods
- Boston Biomedical
- Boston Biomedical Research Institute
- Boston Medical Center
- Boston Probes
- Boston Scientific Scimed
- Boston University
- Brandeis University
- Breast Cancer Now
- Bridge Pharma
- Bridgestone
- Brigham and Women's Hospital
- Brigham and Women's Hospital
- Brilliant Lab
- Bristol Myers Squibb
- Broad Institute
- Brookhaven Science Associates
- Brown University
- Buck Institute for Research on Aging
- Cadus Pharmaceutical
- Cadus Technologies
- California Institute of Technology
- California State University, Northridge
- Caliper Life Sciences
- Cambridge Scientific
- Cambridge University
- Cancer Research Technology
- Canji
- Cara Therapeutics
- Cardax Pharmaceuticals
- Cardiff University
- CareDx
- Caribou Biosciences
- Carmel
- Cartesian Therapeutics
- Cartherics
- CASCADE BIOSYSTEMS
- Case Western Reserve University
- Catalan Institution for Research and Advanced Studies
- Catalyst Therapeutics
- Cathay Biotech
- Cathay Biotech
- Cava Healthcare
- Cedars-Sinai Medical Center
- Celdara Medical
- Celgene
- Cell Genesys
- Cell Signaling Technology
- Cellectis
- Cellex
- Celllular Biomedicine Group
- Cellular Biomedicine Group
- Cellular Therapeutics
- Cemvita Factory
- Center for Human Reproduction
- Centocor
- Centre for Drug Research and Development
- Centre hospitalier de l'Université de Montréal
- Chesapeake Perl
- Children’s Medical Center Dallas
- Children’s Medical Center Dallas
- Children's Healthcare of Atlanta
- Children's Hospital of Philadelphia
- Children's National Hospital
- China Medical University
- China Pharmaceutical University
- Chinese University of Hong Kong
- Chisso
- Chosun University
- ChromaCon
- Chugai Pharmaceutical
- Ciba Corning Diagnostics
- Citranvi Biosciences
- Cleveland State University
- CNIC
- CNRS
- Cochlear
- CODA Biotherapeutics
- Cognosci
- Cognosci
- Cold Spring Harbor Laboratory
- Columbia University
- Columbia University
- Commonwealth System of Higher Education
- Connecticut Children's Medical Center
- Contour Semiconductor
- Cornell University
- Council of Scientific and Industrial Research
- Creative Biomolecules
- CropDesign
- Crossbar
- CrossLife Technologies
- CSPC Dophen
- CuraGen
- Cure Genetics
- Curemark
- Curie Institute
- CZ Biohub
- Dade Behring Marburg
- Daiichi Sankyo
- DAKO
- Dalian Institute of Chemical Physics
- Dana Farber Cancer Institute
- Dana-Farber Cancer Institute
- Dana-Farber Cancer Institute
- Danisco
- Dart NeuroScience
- Dartmouth College
- Dartmouth College
- deCODE genetics
- Dendreon Pharmaceuticals
- Department of Biotechnology
- Detect
- Diabetes Free
- DONGJIN SEMICHEM
- Draper Laboratory
- Drexel University
- Duke University
- DuPont
- East Carolina University
- East China Normal University
- Eastern Michigan University
- Eastern Virginia Medical School
- Ecole Polytechnique Fédérale de Lausanne
- Edge Therapeutics
- Edimer Pharmaceuticals
- eFFECTOR Therapeutics
- Eindhoven University of Technology
- EiRx Therapeutics
- Electrophoretics
- Eleszto Genetika
- EMD Serono
- Emory University
- Empire Dev
- Encyt Technologies
- Environmental Technologies Group
- ESPCI Paris
- Eureka Therapeutics
- European Molecular Biology Laboratory
- Exelixis
- Exelixis
- EXiBONA
- ExxonMobil Chemical
- Fate Therapeutics
- Feinstein Institutes for Medical Research
- Five Prime Therapeutics
- Flagship Pioneering
- Flagship Pioneering
- Flagship Pioneering
- Florida State University
- FormFactor
- Fosun Pharma
- Fovea Pharmaceuticals
- Fox Chase Cancer Center
- Fox Chase Cancer Center
- Frankgen Biotechnologie
- Fred Hutchinson Cancer Research Center
- Fred Hutchinson Cancer Research Center
- French Alternative Energies and Atomic Energy Commission
- French National Centre for Scientific Research
- Fudan University
- Fuji Biomedix
- Fuji Electric
- Fuji Xerox
- Fujian Normal Universit
- Fujifilm
- Fujifilm Cellular Dynamics
- Fujitsu
- Galactica Pharmaceuticals
- GALENAGEN
- GalPharma
- Gamida Cell
- GemVax & KAEL
- Gen-9
- Genagon Therapeutics
- GENEART
- Genelabs Technologies
- GeneMedicine
- Genentech
- General Electric
- Generation Bio
- Genesky Diagnostics
- Geneswitch Innovations
- GeneTAG Technology
- Genethon
- Généthon
- Genetic Therapy
- Genetics Institute
- Geneyus
- GenFleet Therapeutics
- GenFleet Therapeutics
- Geniatech
- Genizon BioSciences
- Genome Therapeutics
- GenPath Pharmaceuticals
- Gen-Probe
- Gen-Probe
- Genzyme
- Georgetown University
- Georgia Regents University
- Geron
- Gevo
- Ghent University
- GigaGen
- Gladstone Institutes
- Gladstone Institutes
- Glaxo Group
- Glaxo Wellcome SA
- Gloriana Therapeutics
- Gorilla Genomics
- GPB Scientific
- GPB Scientific
- GPC Biotech
- Gracell Biotechnologies
- GreenVenus
- Grenoble Alpes University
- GSK
- GSK
- Guangdong Institute of Eco-environmental and Soil Sciences
- Guangzhou Institute of Biomedicine and Health
- Guilin Medical University
- Gwangju Institute of Science and Technology
- H. Lee Moffitt Cancer Center & Research Institute
- Hackensack University Medical Center
- Hackensack University Medical Center
- Hackensack University Medical Center
- Hadasit Medical Research Services & Development
- Hangzhou Clongene Biotech
- Hangzhou Jiuyuan Gene Engineering
- Harbin Veterinary Research Institute
- Harbor Therapeutics
- Harpoon Therapeutics
- Harvard College
- Health Research
- Helix BioPharma
- Henry Ford Health
- HEWLETT PACKARD
- HEWLETT PACKARD
- Hisamitsu Pharmaceutical
- Hokkaido University
- Hong Kong University of Science and Technology
- Hrain Biotechnology
- hsfpharma
- Huaihai Institute of Technology
- Huazhong Agricultural University
- Huazhong University of Science and Technology
- Human Genome Sciences
- Hunan University
- Hunan Essence Biotech
- IBM
- Icahn School of Medicine at Mount Sinai
- iCell Gene Therapeutics
- iCell Gene Therapeutics
- IDEXX Laboratories
- ILIAS Biologics
- IMDEA Nanociencia
- Imiplex
- Immetacyte
- Immune Disease Institute
- ImmuNext
- Immunolight
- Immunolight
- Imperial College London
- Incyte
- Incyte
- Indiana University
- Inhibrx
- Innate Pharma
- InnoCare Pharma
- Innovative Targeting Solutions
- Inovio Pharmaceuticals
- Inserm
- Institut Paoli-Calmettes
- Institut Pasteur of Shanghai, CAS
- Institute Claudius Regaud
- Institute of Biophysics
- Institute of Cancer Research
- Institute of Pharmacology of the Polish Academy of Sciences
- Intelligent Medical Devices
- Intocell
- Intra-Cellular Therapies
- Intrexon
- Invitrogen
- IO Biosciences
- iOmx Therapeutics
- IONTAS
- Ipsen
- IRM
- IrsiCaixa
- Isis Pharmaceuticals
- Jackson Laboratory
- Jacobio Pharmaceuticals
- Janssen Biotech
- Janssen Pharmaceutica
- Japan Science and Technology Agency
- Javelin Oncology
- Jawaharlal Nehru Centre for Advanced Scientific Research
- Jiangnan University
- Jiangsu Police Institute
- Jiangxi University of Science and Technology
- Jilin University
- Jinan University
- Johns Hopkins University
- Johns Hopkins University School of Medicine
- Johnson & Johnson
- Joslin Diabetes Center
- Jubilant Biosys
- Julius Maximilian University of Würzburg
- Juno Therapeutics
- Kagawa University
- Kaiima
- Kansas State University
- Kaunas University of Technology
- Kazusa DNA Research Institute
- Kazusa DNA Research Institute
- Keio University
- Kent State University
- Kindai University
- Kinex Pharmaceuticals
- King Abdulaziz City for Science and Technology
- King Abdulaziz University
- King's College London
- Kingston University
- Kira Pharmaceuticals
- Kiromic
- Kite Pharma
- Knoll
- Knowmtech
- K?chi University
- Konica Minolta
- Korea Institute of Science and Technology
- Korea Research Institute of Bioscience and Biotechnology
- KSQ Therapeutics
- KU Leuven
- Kumho Petrochemical
- Kumquat Biosciences
- Kunming Institute of Botany
- KWS Saat
- Kymab
- Kyowa Hakko Kirin
- La Jolla Institute for Immunology
- LabyRx Immunologic Therapeutics
- Larix Bioscience
- LECTEC
- Leiden University Medical Center
- Leidos Biomedical Research
- Lek Pharmaceuticals
- Lentigen Technology
- LG Chem
- Life Technologies
- London Metropolitan University
- Los Alamos National Security
- Louisiana State University
- Lubris BioPharma
- Lucent
- Lucidicor
- Ludwig Cancer Research
- Ludwig Maximilian University of Munich
- Lund University
- Lundbeck
- Lundbeck
- Lyell Immunopharma
- MacroGenics
- Maine Medical Center Research Institute
- Marquette University
- Martin Luther University of Halle-Wittenberg
- Massachusetts Eye and Ear
- Massachusetts General Hospital
- Massachusetts General Hospital
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Massachusetts Institute of Technology
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Max Planck Society
- Maxim Pharmaceuticals
- Mayo Clinic
- McGill University
- McMaster University
- Medannex
- Medical College of Georgia
- Medical Research Council
- Medigene
- Medigene
- MedImmune
- MediQuest Therapeutics
- Medisix Therapeutics
- Medvet Science
- Memorial Sloan Kettering Cancer Center
- Memorial Sloan Kettering Cancer Center
- Memorial Sloan Kettering Cancer Center
- Merck
- Merck
- Merical
- Meso Scale Discovery
- Michigan State University
- Micron Technology
- Microsoft Technology Licensing
- Millennium Pharmaceuticals
- Miltenyi Biotec
- Miltenyi Biotec
- Miraca Life Sciences
- Mirati Therapeutics
- Mirus Bio
- MitoKor
- MITRE
- Mitsubishi Tanabe Pharma
- MMI - Molecular Machines & Industries
- Monash University
- Monsanto
- Morphochem
- Motorola
- Murdoch Children's Research Institute
- MUSC Foundation for Research Development
- Myogen
- Nagoya University
- Nanjing Agricultural University
- Nanjing Anji Biological Technology
- Nanjing Legend Biotech
- NANJING UNIVERSITY
- Nanjing University of Science and Technology
- Nankai University
- Nano Terra
- Nanofactory
- Nanosys
- Nant Holdings
- NantCell
- Nanyang Technological University
- Nara Institute of Science and Technology (NAIST)
- NASA
- National Agro-Food Biotechnology Institute
- National Brain Research Centre (NBRC)
- National Center for Nanoscience and Technology
- National Dong Hwa University
- National Institute of Advanced Industrial Science and Technology
- National Institute of Biological Sciences
- National Research Council
- National Research Council Canada
- National Taiwan University
- National University of Singapore
- National University of Singapore
- Nationwide Children's Hospital
- NeoNeuro
- NeoStem Oncology
- New Chapter
- New Haven, CT
- New York Blood Center
- Newcastle Innovation
- Newcastle University
- NewSouth Innovations
- NeXstar Pharmaceuticals
- Nissan Chemical
- Nitt? Denk?
- Northern Illinois University
- Northwest Normal University
- Northwestern University
- NOTOX
- Nova Chemicals
- Nova Southeastern University
- Novagenesis Therapeutix
- Novartis
- Novartis
- Novavax
- Novozymes
- Novozymes
- Nps Pharmaceuticals
- NSABP Foundation
- NTT Docomo
- Nuvelo
- Oblique
- Obsidian Therapeutics
- Ocularis Pharma
- Odyssey Thera
- Ohio State Innovation Foundation
- Ohio State University
- Oklahoma Medical Research Foundation
- Oklahoma State University-Stillwater
- Olivia Newton John Cancer Research Institute
- Omega Therapeutics
- Oncalis
- Oncorus
- One Lambda
- Opko Health
- Oragenics
- Oregon Health & Science University
- Oregon State University
- OriMAbs
- Orphazyme
- Ortho-McNeil Pharmaceutical
- Orum Therapeutics
- OSI Pharmaceuticals
- Ottawa Hospital Research Institute
- Oxford University
- Oxitec
- Oy Jurilab
- PANAGENE
- Panomics
- Paris Descartes University
- Paris-Saclay University
- Pennsylvania State University
- Peptinovo
- PerkinElmer
- Perlegen Sciences
- Pfizer
- Pfizer
- Pharmacia & Upjohn
- Pharmacyclics
- Pharmacyclics
- Phenex Pharmaceuticals
- Phio Pharmaceuticals
- Pinteon Therapeutics
- Pioneer Hi Bred International
- Pivot Bio
- Plant Bioscience
- Plasma Antennas
- PolyGene
- Pompeu Fabra University
- Precigen
- Precigen
- Precision BioSciences
- Premium Genetics
- Princeton University
- Promega
- QIMR Berghofer Medical Research Institute
- Qingdao Institute of Bioenergy and Bioprocess Technology
- Qingdao University
- Qingdao University of Science and Technology
- Qtg Development
- Quantum Precision Instruments
- Quantum-Si
- Ramot
- Rational Affinity Devices
- Raytheon BBN
- Regen BioPharma
- Regeneron Pharmaceuticals
- Regenertech
- Regenesis Biomedical
- Regents of the University of Colorado
- REGENXBIO
- Research Center for Eco-Environmental Sciences
- Research Institute of the McGill University Health Centre
- Responsif
- Rhodes University
- Ribozyme Pharmaceuticals
- Rice University
- Rice University
- Rigel Pharmaceuticals
- Roche
- Rochester Institute of Technology
- Rockefeller University
- Rohm and Haas
- Roma Tre University
- Roswell Biotechnologies
- Rubius Therapeutics
- Ruhr University Bochum
- Rush University Medical Center
- Saint Louis University
- Saitama Medical University
- Salk Institute for Biological Studies
- Samaritan Pharmaceuticals
- Samsung
- Samumed
- Sana Biotechnology
- Sandia National Laboratories
- Sandoz
- Sanford Burnham Prebys
- Sanford Burnham Prebys Medical Discovery Institute
- Sangamo Therapeutics
- Sangamo Therapeutics
- Sanofi
- Sanofi
- Santen
- Sapienza University of Rome
- Schering
- Schering-Plough
- Scripps Research Institute
- Seattle Children’s Research Institute
- Senomyx
- Sensei Biotherapeutics
- Senti Bio
- Seoul Electronics & Telecom
- Seoul National University
- Serono Genetics Institute
- Shandong Agricultural University
- Shanghai Cell Therapy Group
- Shanghai Institute of Nutrition and Health
- Shanghai Jiao Tong University
- Shanghai University of Electric Power
- Shanxi Agricultural University
- Shaoyang University
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS
- Shimadzu
- Sibelius
- Sichuan Huiyu Pharmaceutical
- Signase
- Sino Biological
- SIRION Biotech
- SKM PHARMA
- Skolkovo Institute of Science and Technology
- Snap Bio
- SONY
- Soochow University
- South China Agricultural University
- South China Normal University
- South Eastern Sydney Local Health District SESLHD
- Southeast University
- Southern Illinois University
- Southern Methodist University
- SpeeDx
- St. Jude Children's Research Hospital
- St. Jude Children's Research Hospital
- St. Michael’s Hospital
- Staidson Beijing Biopharmaceuticals
- Stanford Research Institute
- Stanford University
- State University of New York
- STMicroelectronics
- STX-Aprilis
- Sulzer
- Sumitomo Pharma Oncology
- Summit
- Sungkyunkwan University
- SunTracker Technologies
- Sure Erasure
- Suzhou University
- SwanBio Therapeutics
- Switch Bio
- SWITCH Materials
- Symphogen
- Syngenta
- Synlogic
- Synpromics
- Syracuse University
- SYZ Cell Therapy
- Taizhou Vocational & Technical College
- Targeted Genetics
- TCR2 Therapeutics
- Technical University of Munich
- Technicon Instruments
- Technion - Israel Institute of Technology
- Temasek Life Sciences Laboratory
- Temple University
- Texas A&M University
- Texas Biomedical Research Institute
- The Institute of Cancer Research
- The Leibniz Institute on Aging - Fritz Lipmann Institute
- The Wistar Institute
- Theodor Kocher Institute
- Theras
- Thomas Jefferson University
- Thsti - Translational Health Science and Technology Institute
- Tianjin Anbisen Biology Technology
- Tianjin Hengda Wenbo Science and Technology
- Tianma Microelectronics
- Tidal Therapeutics
- Tissuemed
- Tmunity Therapeutics
- Tolero Pharmaceuticals
- TOLREMO therapeutics
- Tosk
- Toulouse III - Paul Sabatier University
- Toulouse III - Paul Sabatier University
- Transimmune
- Translate Bio
- Translational Genomics Research Institute
- Transoft Solutions
- TransTech Pharma
- Trinity College Dublin
- Trishula Therapeutics
- TRON Translational Oncology
- TRT Pharma
- Tsinghua University
- Tufts University
- Tularik
- U. S. Genomics
- U.S. Department of Health and Human Services
- UBE
- UCB Biopharma
- UCL Business
- UCLA
- UEA Enterprises
- United Arab Emirates University
- United States Department of Agriculture
- United States Department of Veterans Affairs
- Universal Sequencing Technology
- Universitat Autònoma de Barcelona
- University Clinic Freiburg
- University College Cork
- University Health Network
- University Medical Center Schleswig-Holstein
- University of Aberdeen
- University of Alberta
- University of Angers
- University of Arizona
- University of Arizona
- University of Arkansas
- University of Basel
- University of Bonn
- University of Bordeaux
- University of Bradford
- University of British Columbia
- University of Brussels
- University of California
- University of California San Diego
- University of Cambridge
- University of Central Florida
- University of Chicago
- University of Cologne
- University of Cologne
- University of Colorado
- University of Colorado
- University of Copenhagen
- University of Delaware
- University of Duisburg-Essen
- University of Erlangen-Nuremberg
- University of Florida
- University of Florida
- University of Freiburg
- University of Geneva
- University of Georgia
- University of Heidelberg
- University of Helsinki
- University of Hong Kong
- University of Houston
- University of Illinois
- University of Iowa Research Foundation
- University of Iowa Research Foundation
- University of Jena
- University of Kentucky
- University of Konstanz
- University of Louisville
- University of Magdeburg
- University of Manchester
- University of Manitoba
- University of Maryland
- University of Massachusetts
- University of Miami
- University of Michigan
- University of Michigan
- University of Milano-Bicocca
- University of Minnesota
- University of Missouri
- University of Montpellier
- University of Montreal
- University of Münster
- University of Nantes
- University of Naples Federico II
- University of New York
- University of North Carolina
- University of North Carolina at Chapel Hill
- University of North Carolina at Charlotte
- University of Notre Dame
- University of Oslo
- University of Ottawa
- University of Oxford
- University of Pennsylvania
- University of Pennsylvania
- University of Pennsylvania
- University of Pittsburgh
- University of Pittsburgh
- University of Poitiers
- University of Portsmouth
- University of Puerto Rico
- University of Queensland
- University of Regensburg
- University of Rennes 1
- University of Rochester
- University of Rome Tor Vergata
- University of Saskatchewan
- University of Sheffield
- University of South Carolina
- University of South Dakota
- University of South Florida
- University of Southern California
- University of Southwest
- University of Stanford
- University of Stuttgart
- University of Sussex
- University of Texas
- University of the Witwatersrand
- University of Tokyo
- University of Toyama
- University of Tübingen
- University of Utah
- University of Utah
- University of Vermont
- University of Verona
- University of Virginia
- University of Washington
- University of Washington
- University of Wyoming
- University of York
- University of Zurich
- University Research Corp
- University of Toledo
- UNM Rainforest Innovations
- Upjohn
- URIFER
- Utah State University
- Valentis
- Valio
- Vanderbilt University
- VastCon
- Vegenics
- Ventana Medical Systems
- Verastem
- Verily Life Sciences
- Vernalis
- VEROVACCiNES
- Vestion
- Vgx Pharmaceuticals
- Vgx Pharmaceuticals
- Vidya Herbs
- Virginia Tech
- Virginia Tech Intellectual Properties
- ViroMed
- Vlaams Institute of Biotechnology
- Voronoi
- VORONOI
- Voyager Therapeutics
- Wake Forest University
- Walter and Eliza Hall Institute of Medical Research
- Warner-Lambert
- Wayne State University
- Whitehead Institute
- WindMIL Therapeutics
- Wisconsin Alumni Research Foundation
- WisTa Laboratories
- Wistar Institute
- WiSys
- Wuhan HealthCare Biotechnology
- WuXi Biologics
- Wyeth
- Wyeth
- Xenogen
- Xiamen University
- Xi'an University of Science and Technology
- Xilinx
- Xuanwu Hospital Capital Medical University
- Yale University
- YEDA
- YEDA
- Yeditepe University
- Yissum
- Zeneca
- Zhejiang Academy of Agricultural Sciences
- Zhejiang University
- ZymoGenetics
- ZyngeniaSalix Pharmaceuticals
Methodology
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