The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.
This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.
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Table of Contents
Section 1: Immunologic Basis of Autoimmunity
1. Prelude: Historical introduction to autoimmunity and autoimmune disease
2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity
3. General Features of Autoimmune Diseases (same title new contributor, new content)
4. Antigen Presentation, Dendritic Cells, and Autoimmunity
5. T cells and their subsets
6. Role of Th1 Th2 Th17 Cells in Autoimmunity
7. Tolerance and Autoimmunity: T Cells
8. Regulatory T Cells
9. B Cells and Autoimmunity
10. Immunological memory T cells
11. Immunological memory B cells
12. Apoptotic Cells as a Source of Autoantigens
13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes
14. Functional Effects of Autoantibodies
15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes
17. HLA Genetics and Autoimmunity
18. Non HLA Genetics
19. AIRE related Autoimmunity
20. Immune Deficiencies and Autoimmunity
21. Infections and Autoimmunity
22. Noninfectious Environmental Agents and Autoimmunity
23. Sex, Pregnancy and Autoimmunity
24. Animal Models of Autoimmune Disease
Section 2: Multisystem Diseases
25. Systemic Lupus Erythematosus
26. Systemic Sclerosis, Scleroderma
27. Antiphospholipid Syndrom
28. Sjogren Syndrome
29. Rheumatoid Arthritis
30. Spondyloarthritis and Chronic Idiopathic Arthropathies
31. Myositis
32. Thyroid Disease
33. Type 1 Diabetes
34. Adrenalitis
35. Polyendocrine Syndromes
36. Gastritis and Pernicious Anemia
37. Hypophysitis
38. Hemolytic Anemia
39. Thrombocytopenic Purpura
40. Neutropenia
41. Aplastic Anemia
42. Clotting Disorders
43. Multiple Sclerosis
44. Peripheral Neuropathy
45. Myasthenia Gravis
46. Ocular Disease
47. Inner Ear Disease
48. Celiac Disease
49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease
50. Chronic Hepatitis
51. Primary Billiary Cirrhosis
52. Primary Sclerosing Cholangitis
53. Pancreatitis
54. Bullous Skin Diseases: Pemphigus and Pemphigoid
55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria
56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis
57. Orchitis and Male Infertility
58. Oophoritis
59. Rheumatic Heart Disease
60. Myocarditis and Dilated Cardiomyopathy
61. Necrotizing Arteritis and Small Vessel Vasculitis
62. Large and Medium Vessel Vasculitides
63. Autoimmune Disorders of the Lung
64. Paraneoplastic Diseases
65. Antibody-Associated Neurological Diseases
66. Autoinflammatory and other Related Diseases
67. Autoinflammatory diseases and autoimmune responses to tumors
68. COVID
Section 3: Diagnosis, Prevention, and Therapy
69. Autoantibody Assays, Testing, and Standardization
70. Prediction of Autoimmune Disease
71. Emerging Therapies for Autoimmune Diseases
72. Postlude
Authors
M. Eric Gershwin Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine and Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA. M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease. George C. Tsokos Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center.George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
Betty Diamond Institute of Molecular Medicine, Feinstein Institutes for Medical Research, New York, NY, USA.Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.
