The Rose and Mackay Textbook of Autoimmune Diseases. Edition No. 7

Table of Contents

Section 1: Immunologic Basis of Autoimmunity 1. Prelude: Historical introduction to autoimmunity and autoimmune disease 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 3. General Features of Autoimmune Diseases (same title new contributor, new content) 4. Antigen Presentation, Dendritic Cells, and Autoimmunity 5. T cells and their subsets 6. Role of Th1 Th2 Th17 Cells in Autoimmunity 7. Tolerance and Autoimmunity: T Cells 8. Regulatory T Cells 9. B Cells and Autoimmunity 10. Immunological memory T cells 11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens 13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 14. Functional Effects of Autoantibodies 15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes 17. HLA Genetics and Autoimmunity 18. Non HLA Genetics 19. AIRE related Autoimmunity 20. Immune Deficiencies and Autoimmunity 21. Infections and Autoimmunity 22. Noninfectious Environmental Agents and Autoimmunity 23. Sex, Pregnancy and Autoimmunity 24. Animal Models of Autoimmune Disease Section 2: Multisystem Diseases 25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma 27. Antiphospholipid Syndrom 28. Sjogren Syndrome 29. Rheumatoid Arthritis 30. Spondyloarthritis and Chronic Idiopathic Arthropathies 31. Myositis 32. Thyroid Disease 33. Type 1 Diabetes 34. Adrenalitis 35. Polyendocrine Syndromes 36. Gastritis and Pernicious Anemia 37. Hypophysitis 38. Hemolytic Anemia 39. Thrombocytopenic Purpura 40. Neutropenia 41. Aplastic Anemia 42. Clotting Disorders 43. Multiple Sclerosis 44. Peripheral Neuropathy 45. Myasthenia Gravis 46. Ocular Disease 47. Inner Ear Disease 48. Celiac Disease 49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease 50. Chronic Hepatitis 51. Primary Billiary Cirrhosis 52. Primary Sclerosing Cholangitis 53. Pancreatitis 54. Bullous Skin Diseases: Pemphigus and Pemphigoid 55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria 56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 57. Orchitis and Male Infertility 58. Oophoritis 59. Rheumatic Heart Disease 60. Myocarditis and Dilated Cardiomyopathy 61. Necrotizing Arteritis and Small Vessel Vasculitis 62. Large and Medium Vessel Vasculitides 63. Autoimmune Disorders of the Lung 64. Paraneoplastic Diseases 65. Antibody-Associated Neurological Diseases 66. Autoinflammatory and other Related Diseases 67. Autoinflammatory diseases and autoimmune responses to tumors 68. COVID Section 3: Diagnosis, Prevention, and Therapy 69. Autoantibody Assays, Testing, and Standardization 70. Prediction of Autoimmune Disease 71. Emerging Therapies for Autoimmune Diseases 72. Postlude

Authors

M. Eric Gershwin Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine and Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA. M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease. George C. Tsokos Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center.

George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.

Betty Diamond Institute of Molecular Medicine, Feinstein Institutes for Medical Research, New York, NY, USA.

Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.