Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies.
In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.
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Table of Contents
1. Understanding Pharmacotoxicology2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development
3. Omics in Mechanistic and Predictive Toxicology
4. Role of Micro RNAs in Toxicology
5. Exosomes as Mediators of Chemical-Induced Toxicity
6. Types of Cellular Responses to Chemical Toxicants
7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury
8. Role Of "Toxicant-Induced Loss of Tolerance� in the Emergence of Disease
9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction
10. Adverse Outcome Pathway for Chemical Toxicity
11. Toxicokinetics and Organ-Specific Toxicity
12. Dose Selection for Toxicity Studies
13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing
14. Medication Error and its Toxicity Connection
15. Idiosyncratic Toxicity
16. Toxicological Risk Assessment
17. Clinical Detoxification of the Body
18. Principles of Management of Acute Poisoning
19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure
20. Toxicity Labels
21. Toxic Potential Indicator
22. Aquatic Toxicology
23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions
24. Psychopharmacology in Late Life: Key Challenges and Opportunities
25. Regulatory Agencies for Toxicity Studies
26. Key Challenges for Toxicologists in the 21st Century
