Degenerative nerve diseases are age-related, progressive and cause irreversible neurological loss that may lead too death. Chronic diseases like amylotrophic lateral sclerosis, Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease are associated with insoluble protein depositions and pose serious health challenges that may intensify in the coming decades.
Current therapies only help to alleviate some of the physical or mental symptoms associated with neurodegenerative diseases, although there is currently no remedy for slow disease progression. In recent years, attempts have been made to discover a mechanism for neurodegenerative diseases and prospective treatment that may help mitigate aging effects and prevent these diseases. Natural products have been a constant source of new approaches for the treatment of neurodegenerative diseases, in particular plant alkaloids and polyphenolic compounds. Indopathy for Neuroprotection: Recent Advances highlights herbal treatments that are preferred over conventional treatments in some regions.
Book chapters focus on the effects of various medicinal plants that have shown promise in reversing pathological symptoms of neurodegenerative disease and highlight the neuroprotective role of medicinal herbal phytochemicals and their mechanism of action. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Current therapies only help to alleviate some of the physical or mental symptoms associated with neurodegenerative diseases, although there is currently no remedy for slow disease progression. In recent years, attempts have been made to discover a mechanism for neurodegenerative diseases and prospective treatment that may help mitigate aging effects and prevent these diseases. Natural products have been a constant source of new approaches for the treatment of neurodegenerative diseases, in particular plant alkaloids and polyphenolic compounds. Indopathy for Neuroprotection: Recent Advances highlights herbal treatments that are preferred over conventional treatments in some regions.
Book chapters focus on the effects of various medicinal plants that have shown promise in reversing pathological symptoms of neurodegenerative disease and highlight the neuroprotective role of medicinal herbal phytochemicals and their mechanism of action. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Table of Contents
Chapter 1 Preface- Ii Abbreviations
- Hagera Dilnashin, Hareram Birla, Chetan Keswani And Surya Pratap Singh Introduction
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Atul Kabra, Kamal Uddin, Rohit Sharma, Ruchika Kabra, Raffaele Capasso, Caridad Ivette Fernandez Verdecia, Christophe Hano, Natália Cruz-Martins And Uttam Singh Baghel Introduction
- Neuroprotective Potential Of Botanicals
- In-Vitro Studies
- In-Vivo Studies
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Archana Dwivedi And Deepika Joshi Introduction
- Classification Of Neuroprotective Phytochemicals Used In Ayurvedic Herbal Formulations
- Polyphenols
- Flavonoids
- Non-Flavonoids
- Terpenes
- Alkaloids
- Other Nitrogen-Containing Phytochemicals
- Mechanistic Action Of Phytochemicals In Neuroprotection
- Reactive Oxygen Species (Ros) Regulation
- Mitochondrial Dysfunction
- Anti-Neuroinflammatory Pathways
- Modulating Cell Signaling Pathways
- Apoptosis
- Autophagy
- Hypoxia Inducible Factor 1 Alpha (Hif-1 Α) Pathway
- Α- Synuclein Aggregation
- Neuroprotective Plants In Ayurveda For Parkinson’S Disease Management
- Bacopa Monnieri (Brahmi)
- Mucuna Pruriens (Velvet Beans)
- Withania Somnifera (Ashwagandha Or Indian Ginseng)
- Curcuma Longa (Turmeric)
- Centella Asiatica (Gotu Kola)
- Camellia Sinensis (Tea Plant)
- Vitis Vinifera (Common Grapevine)
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Nalaka Wijekoon, Yoonus Imran, Darshi Attanayake, Lakmal Gonawala And K. Ranil D. De Silva Introduction
- Nrf2 As A Potential Therapeutic Target
- Nrf2 In Aging/ Neurodegenerative Disorders
- Alzheimer’S Disease (Ad)
- Parkinson’S Disease (Pd)
- Huntington’S Disease (Hd)
- Spinocerebellar Ataxias
- Muscular Dystrophy
- Migraine
- Stroke
- Targeting Nrf2 By Natural Products For Neurological Disorders 82 Targeting Ca 2+ Through Nrf2
- Targeting Inflammation By Nrf2
- Targeting Mitochondria By Nrf2
- Targeting Proteostasis By Nrf2
- Targeting Muscle Regeneration By Nrf2
- Natural Products Based Clinical Trials For Neurological Disorders (Tables 1, 2 And 3)
- Biofunctions Of Sri Lankan Phytochemicals In Modulating The Nrf2/Keap1 System
- Cinnamon
- Emblica Officinalis (Nelli)
- Bacopa Monnieri (Brahmi)
- Annona Muricata (Katu Anoda)
- Centella Asiatica (Gotu Kola)
- Green Tea
- Allium Sativum (Garlic)
- Zingiber Officinale (Ginger)
- Piper Nigrum (Black Pepper)
- The Dark Side Of Nrf2 Activation
- Plant-Based Inhibitors Of Nrf2
- Conclusion And Future Direction
- Consent For Publication
- Conflict Of Interest
- Acknowledgments
- References
- Himanshu Verma, Naveen Shivavedi And Prasanta Kumar Nayak Introduction
- B. Monnieri
- Phytoconstituents Of B. Monnieri
- Neuroprotective Activity Of B. Monnieri
- C. Asiatica
- Phytoconstituents Of C. Asiatica
- Neuroprotective Activity Of C. Asiatica
- C. Longa
- Phytoconstituents Of C. Longa
- Neuroprotective Activity Of C. Longa
- A. Sativum
- Phytoconstituents Of A. Sativum
- Neuroprotective Activity Of A. Sativum
- T. Chebula
- Phytoconstituents Of T. Chebula
- Neuroprotective Activity Of T. Chebula
- C. Paniculatus
- Phytoconstituents Of C. Paniculatus
- Neuroprotective Activity Of C. Paniculatus
- G. Glabra
- Phytoconstituents Of G. Glabra
- Neuroprotective Activity Of G. Glabra
- A. Calamus
- Phytoconstituents Of A. Calamus
- Neuroprotective Activity Of A. Calamus
- Other Important Indian Medicinal Herbs For The Treatment Of Neurodegenerative Disorders
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgments
- References
- Pratibha Thakur Introduction
- Source Structure And Classification Of Alkaloids
- Neurotransmitters
- Cholinergic Signaling And Alkaloids
- Alkaloids Acetylcholinesterase Inhibitor
- Glutamatergic Signaling And Alkaloid
- Gabaergic Signaling And Alkaloid
- Alkaloids As Monoamine Inhibitors
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Pratistha Singh, Ashutosh Kumar And Anil Kumar Singh Introduction
- Neurodegenerative Disease
- Medicinal Plants
- Avicennia Marina Forssk. Vierh
- Azadirachta Indica A. Juss
- Aloe Vera (L.) Burm. F.
- Asparagus Racemosa Willd
- Baccopa Monnieri (L.) Pennell
- Centella Asiatica (L.) Urban
- Curcuma Longa L.
- Desmodium Gangedicum (L.) Dc
- Evolvulus Alsinoides Linn.
- Foeniculum Vulgare Mill
- Ficus Religiosa Linn.
- Garcinia Indica Choisy
- Hippophae Rhamnoides L.
- Moringa Oligofera Lam.
- Morinda Pubescens Sm
- Pedalium Murex Linn
- Punica Granatum L.
- Phyllanthus Amarus Schumah & Thonn
- Portulaca Oleracea L
- Sesbania Grandiflora L.
- Terminalia Chebula Retz.
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgments
- References
- Vartika Gupta And Sukala Prasad Introduction
- The Link Between Neurodegeneration And Ayurvedic Herb
- Pd
- Prevalence Of Pd
- Symptoms Of Pd
- Motor Symptoms
- Non-Motor Symptoms
- Risk Factors: Environmental And Genetic Factors
- Hallmark Of Pd: Α -Syn
- Pathophysiology Of Pd
- B. Monnieri And Its Historical Perspective
- Geographical Distribution, Plant Description, And Classification
- B. Monnieri And Its Biologically Active Components
- Role Of B. Monneiri As Nootropic Drug
- Mechanistic Understanding Of B. Monneiri In The Light Of Pd: Pharmacological Effects
- Anti-Inflammatory And Analgesic Effects
- Antioxidative Effect
- B. Monnieri Reduced Α-Syn Protein Aggregation
- B. Monnieri Enhances Cognition
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Nilay Solanki And Hardik Koria Introduction
- Diabetes Mellitus And Neurological Complications
- Causes Of Diabetes
- Signs And Symptoms
- Diabetic Complications Of The Nervous System
- Diabetic Neuropathy
- Pathophysiology Of Diabetic Neuropathy
- Therapeutics And Management Of Diabetic Neuropathy
- Glycemic Control
- Type 1 Diabetes Mellitus
- Type 2 Diabetes Mellitus
- Symptomatic Treatment Of Peripheral Neuropathy
- Diabetic Polyneuropathy (Dpn)
- Antidepressants
- Tricyclic And Tetracyclic Reagents
- Selective Serotonin Reuptake Inhibitors And Serotonin-Norepinephrine Reuptake Inhibitors
- Anticonvulsants
- Calcium Channel Α2-Δ Ligands.
- Topical Agents.
- Natural Products And Neuroprotection In Diabetes
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
- Singla Rubal, Abhishek Mishra, Rupa Joshi, Phulen Sarma And Bikash Medhi Introduction
- History
Author
- Surya Pratap Singh
- Hagera Dilnashin
- Hareram Birla
- Chetan Keswani
