“Lenvatinib + pembrolizumab Emerging Drug Insight and Market Forecast - 2032” report provides comprehensive insights about Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer (mCRC) in the 7MM. A detailed picture of the Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer in the 7MM, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan, for the study period 2019-2032 is provided in this report along with a detailed description of the Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer. The report provides insight about mechanism of action, dosage and administration, as well as research and development activity including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the Lenvatinib + pembrolizumab market forecast, analysis for Metastatic Colorectal Cancer in the 7MM, descriptive analysis such as SWOT, analyst views, comprehensive overview of market competitors, and brief about other emerging therapies in Metastatic Colorectal Cancer.
In March 2018, Eisai and Merck, known as MSD outside the US and Canada, entered into a strategic collaboration through an affiliate for the worldwide co-development and co-commercialization of Lenvima. Under the agreement, the companies will jointly develop, manufacture, and commercialize Lenvima, both as monotherapy and in combination with Merck's Keytruda. The companies have jointly initiated new clinical studies through the LEAP (Lenvatinib and Pembrolizumab) clinical program and are evaluating the combination in 13 different tumor types including colorectal cancer for the patients who have received two prior lines of therapy.
Lenvatinib + pembrolizumab is currently under investigation in a Phase II LEAP-005 trial (NCT03797326) in previously treated subjects with selected advanced (metastatic and/or unresectable) solid tumors including Colorectal Cancer that are incurable and for which prior standard systemic therapy has failed.
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Drug Summary
Lenvima (lenvatinib), discovered and developed by Eisai, is a kinase inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). However, Keytruda (pembrolizumab) is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. The drug is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands.In March 2018, Eisai and Merck, known as MSD outside the US and Canada, entered into a strategic collaboration through an affiliate for the worldwide co-development and co-commercialization of Lenvima. Under the agreement, the companies will jointly develop, manufacture, and commercialize Lenvima, both as monotherapy and in combination with Merck's Keytruda. The companies have jointly initiated new clinical studies through the LEAP (Lenvatinib and Pembrolizumab) clinical program and are evaluating the combination in 13 different tumor types including colorectal cancer for the patients who have received two prior lines of therapy.
Lenvatinib + pembrolizumab is currently under investigation in a Phase II LEAP-005 trial (NCT03797326) in previously treated subjects with selected advanced (metastatic and/or unresectable) solid tumors including Colorectal Cancer that are incurable and for which prior standard systemic therapy has failed.
Scope of the Report
The report provides insights into:
- A comprehensive product overview including the Lenvatinib + pembrolizumab description, mechanism of action, dosage and administration, research and development activities in Metastatic Colorectal Cancer.
- Elaborated details on Lenvatinib + pembrolizumab regulatory milestones and other development activities have been provided in this report.
- The report also highlights the Lenvatinib + pembrolizumab research and development activity in Metastatic Colorectal Cancer in detail across the United States, Europe and Japan.
- The report also covers the patents information with expiry timeline around lenvatinib + pembrolizumab.
- The report contains forecasted sales of Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer till 2032.
- Comprehensive coverage of the late-stage emerging therapies for Metastatic Colorectal Cancer.
- The report also features the SWOT analysis with analyst views for Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer.
Methodology
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by the research team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.Lenvatinib + pembrolizumab Analytical Perspective
In-depth Lenvatinib + pembrolizumab Market Assessment
This report provides a detailed market assessment of Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer in the 7MM, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. This segment of the report provides forecasted sales data from 2025 to 2032.Lenvatinib + pembrolizumab Clinical Assessment
The report provides the clinical trials information of Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer covering trial interventions, trial conditions, trial status, start and completion dates.Report Highlights
- In the coming years, the market scenario for Metastatic Colorectal Cancer is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
- The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence Lenvatinib + pembrolizumab dominance.
- Other emerging products for Metastatic Colorectal Cancer are expected to give tough market competition to Lenvatinib + pembrolizumab and launch of late-stage emerging therapies in the near future will significantly impact the market.
- A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer.
- This in-depth analysis of the forecasted sales data of Lenvatinib + pembrolizumab from 2025 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer.
Key Questions Answered
- What is the product type, route of administration and mechanism of action of Lenvatinib + pembrolizumab?
- What is the clinical trial status of the study related to Lenvatinib + pembrolizumab in Metastatic Colorectal Cancer and study completion date?
- What are the key collaborations, mergers and acquisitions, licensing and other activities related to the Lenvatinib + pembrolizumab development?
- What are the key designations that have been granted to Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer?
- What is the forecasted market scenario of Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer?
- What are the forecasted sales of Lenvatinib + pembrolizumab in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
- What are the other emerging products available in Metastatic Colorectal Cancer and how are they giving competition to Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer?
- Which are the late-stage emerging therapies under development for the treatment of Metastatic Colorectal Cancer?
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Table of Contents
1 Report Introduction2 Lenvatinib + pembrolizumab Overview
2.1 Product Detail
2.2 Clinical Development
2.2.1 Clinical Studies
2.2.2 Clinical Trials Information
2.2.3 Safety and Efficacy
2.3 Other Developmental Activities
2.4 Product Profile
3 Competitive Landscape (Marketed Therapies)
4 Competitive Landscape (Late-stage Emerging Therapies) *
5 Lenvatinib + pembrolizumab Market Assessment
5.1 Market Outlook of Lenvatinib + pembrolizumab for Metastatic Colorectal Cancer
5.2 7MM Market Analysis
5.2.1 Market Size of Lenvatinib + pembrolizumab in the 7MM for Metastatic Colorectal Cancer
5.3 Country-wise Market Analysis
5.3.1 Market Size of Lenvatinib + pembrolizumab in the United States for Metastatic Colorectal Cancer
5.3.2 Market Size of Lenvatinib + pembrolizumab in Germany for Metastatic Colorectal Cancer
5.3.3 Market Size of Lenvatinib + pembrolizumab in France for Metastatic Colorectal Cancer
5.3.4 Market Size of Lenvatinib + pembrolizumab in Italy for Metastatic Colorectal Cancer
5.3.5 Market Size of Lenvatinib + pembrolizumab in Spain for Metastatic Colorectal Cancer
5.3.6 Market Size of Lenvatinib + pembrolizumab in the United Kingdom for Metastatic Colorectal Cancer
5.3.7 Market Size of Lenvatinib + pembrolizumab in Japan for Metastatic Colorectal Cancer
6 SWOT Analysis
7 Analysts’ Views
8 Appendix
8.1 Bibliography
8.2 Report Methodology
9 Publisher Capabilities
10 Disclaimer
11 About the Publisher
12 Report Purchase Options
List of Tables
Table 1: Lenvatinib + pembrolizumab, Clinical Trial Description, 2022
Table 2: Lenvatinib + pembrolizumab: General Description
Table 3: Competitive Landscape (Marketed Therapies)
Table 4: Competitive Landscape (Late -stage Emerging Therapies)
Table 5: Lenvatinib + pembrolizumab Market Size in the 7MM, in USD million (2019-2032)
Table 6: Lenvatinib + pembrolizumab Market Size in the US, in USD million (2019-2032)
Table 7: Lenvatinib + pembrolizumab Market Size in Germany, in USD million (2019-2032)
Table 8: Lenvatinib + pembrolizumab Market Size in France, in USD million (2019-2032)
Table 9: Lenvatinib + pembrolizumab Market Size in Italy, in USD million (2019-2032)
Table 10: Lenvatinib + pembrolizumab Market Size in Spain, in USD million (2019-2032)
Table 11:Lenvatinib + pembrolizumab Market Size in the UK, in USD million (2019-2032)
Table 12: Lenvatinib + pembrolizumab Market Size in Japan, in USD million (2019-2032)
List of Figures
Figure 1: Lenvatinib + pembrolizumab Market Size in the 7MM, USD million (2019-2032)
Figure 2: Lenvatinib + pembrolizumab Market Size in the United States, USD million (2019-2032)
Figure 3: Lenvatinib + pembrolizumab Market Size in Germany, USD million (2019-2032)
Figure 4: Lenvatinib + pembrolizumab Market Size in France, USD million (2019-2032)
Figure 5: Lenvatinib + pembrolizumab Market Size in Italy, USD million (2019-2032)
Figure 6: Lenvatinib + pembrolizumab Market Size in Spain, USD million (2019-2032)
Figure 7: Lenvatinib + pembrolizumab Market Size in the United Kingdom, USD million (2019-2032)
Figure 8: Lenvatinib + pembrolizumab Market Size in Japan, USD million (2019-2032)