Chromatography Resins Global Market Report 2024

Chromatography resins play a crucial role in capturing and refining biomolecules like monoclonal antibodies, antibody fragments, vaccines, and other substances using a stationary phase. The purification process is driven by a mobile phase that propels the sample and chromatography resins through the stationary phase.

There are two main types of chromatography resins such as native and synthetic. Native resins are crafted from natural polymers like agarose, cellulose, and dextran. Various technology types, including affinity chromatography, anion exchange chromatography, cation exchange chromatography, size exclusion, and hydrophobic interaction, are employed in diverse applications such as pharmaceuticals, biotechnology, food and beverage, as well as water and environmental analysis.

The chromatography resins market research report is one of a series of new reports that provides chromatography resins market statistics, including chromatography resins industry global market size, regional shares, competitors with a chromatography resins market share, detailed chromatography resins market segments, market trends and opportunities, and any further data you may need to thrive in the chromatography resins industry. This chromatography resins market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The chromatography resins market size has grown strongly in recent years. It will grow from $2.73 billion in 2023 to $2.97 billion in 2024 at a compound annual growth rate (CAGR) of 9.1%. The growth observed in the historical period can be attributed to several factors, including an upsurge in biopharmaceutical production, expansion in analytical and research applications, the overall growth of the pharmaceutical industry, increased activities in academic and clinical research, and the continual expansion of the pharmaceutical sector.

The chromatography resins market size is expected to see strong growth in the next few years. It will grow to $4.32 billion in 2028 at a compound annual growth rate (CAGR) of 9.8%. The growth in the forecast period can be attributed to increasing drug development, precision medicine research, regulatory and quality standards, emerging market growth, growing green chemistry initiatives. Major trends in the forecast period include introduction of separation technologies, technological advancements, customized resin solutions, industrial and biotechnology innovations, and advanced chromatography techniques.

The increasing prevalence of cancer cases globally is expected to contribute significantly to the growth of the chromatography resins market. Chromatography resins play a crucial role in the purification of monoclonal antibodies (mAbs) – targeted therapies widely used in cancer treatment. The rising incidence of cancer, as highlighted by the American Cancer Society's January 2022 report on 1.9 million new cancer diagnoses and 609,360 cancer-related deaths in the United States, is driving the demand for chromatography resins. The four predominant cancer types, constituting 43% of all newly diagnosed cases globally, are lung, prostate, colorectal, and breast cancer. This escalating cancer prevalence is anticipated to boost the demand for cancer therapies, particularly monoclonal antibodies, thereby fueling the chromatography resins market.

The chromatography resin market is poised for growth due to increasing investments in the healthcare sector. Healthcare investments encompass financial resources directed towards medical research, the development of new healthcare technologies, and infrastructure enhancements. The injection of funds into chromatography resins in the healthcare sector facilitates research and development activities, leading to enhanced purification processes and more efficient drug production. A notable example is the data reported by Silicon Valley Bank in 2022, indicating a record $23.4 billion in private investments in the healthcare sector in the first quarter of 2021. This momentum continued into Q2 2021, with total healthcare investment reaching $47 billion in the first half of the year, more than double the pace observed in the same period in 2020. Consequently, the increasing investments in the healthcare sector are instrumental in propelling the growth of the chromatography resin market.

Technological advancements are driving the evolution of the chromatography resins market. In 2021, Purolite, a UK-based manufacturer specializing in resin-based chromatography separation, purification, and extraction technologies, introduced a groundbreaking protein A alkaline stable resin. This innovation addresses the purification challenges of pH-sensitive antibodies and other Fc-containing proteins. Purolite deployed jetting technology to produce agarose beads with a uniform size and a narrow particle size distribution. Results from this advancement showcased a 70% increase in yield compared to conventional protein A resins, coupled with improved clearance of host cell proteins. These technological strides not only enhance efficiency but also alleviate downstream processing burdens, positioning chromatography resins as pivotal players in the evolving landscape of bioseparation technologies.

Prominent companies in the chromatography resin market are strategically intensifying their focus on the introduction of high-performance resins as a means to establish a competitive advantage. These specialized materials play a crucial role in chromatography, a laboratory technique utilized for the separation and analysis of complex substance mixtures. As an illustration, in February 2022, Repligen, a bioprocessing company based in the United States, unveiled three advanced affinity chromatography resins designed for gene therapy purification, namely AVIPure-AAV9, AVIPure-AAV8, and AVIPure-AAV2. Specifically tailored for the major adeno-associated virus (AAV) gene therapy vectors in use today, these resins are integral to the primary platform for gene delivery in treating various human diseases. Notably, they offer capture-step purification of AAV 2, 8, and 9 vectors, featuring potential alkaline clean-in-place regeneration. These resins provide high performance at a competitive price point, surpassing or meeting the performance metrics of resins developed on alternative platforms, along with the added advantage of robust alkaline stability.

In December 2021, Ecolab, a U.S.-based company specializing in water, hygiene, and infection prevention solutions, completed the acquisition of Purolite for $3.7 billion. Through this strategic move, Ecolab aims to achieve substantial global growth by enhancing end-product safety and quality for critical key customers in the life sciences and industrial markets. Purolite, based in the UK, is recognized as a manufacturer of resin-based chromatography separation, purification, and extraction technologies, solidifying its position as a valuable addition to Ecolab's portfolio.

Major companies operating in the chromatography resins market include Merck KGaA, Bio-Rad Laboratories Inc., GE Healthcare Life Sciences, Thermo Fisher Scientific Inc., Purolite Corporation, W. R. Grace and Company, Mitsubishi Chemical Corporation, Tosoh Corporation, Danaher Corporation, Life Technologies Corporation., Repligen Corporation, Pall Corporation a Danaher operating company under the Cytiva brand, Cytiva a Danaher operating company, Bio-Works Technologies AB, E. I. du Pont de Nemours and Company, Agilent Technologies Inc., Avantor Inc., Waters Corporation, Nouryon Holding B.V., ChromaTan Corporation, BIA Separations GmbH, KANEKA Corporation, Sepax Technologies Inc., YMC Co Ltd., Phenomenex Inc., MilliporeSigma, 'Roche Diagnostics International Ltd., Axion BioSystems Inc.

North America was the largest region in the chromatography resins market in 2023. Asia-Pacific is expected to be the fastest-growing region in the market. The regions covered in the chromatography resins market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, the Middle East, and Africa.

The countries covered in the chromatography resins market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA.

The chromatography resins market consists of sales of affinity resins and ion exchange resin. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.


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