Low drug solubility and its corresponding impact on bioavailability have remained a primary cause of concern with several marketed as well as clinical stage drugs. According to the Journal of Analytical and Pharmaceutical Research, 70% of the 50 drugs approved by the USFDA in 2021 were poorly soluble. Moreover, approximately 40% of marketed pharmacological products and close to 90% of drug candidates under development, have been associated with solubility and / or permeability issues, resulting in poor bioavailability. It is worth noting that, every year, a large number of drugs fail to reach the market due to poor bioavailability and issues associated with aqueous solubility. As a result, the industry is actively seeking various tools / methods to mitigate this challenge. Amongst the various approaches for bioavailability enhancement of therapeutic interventions, lipid nanoparticles (LNPs) and other lipidic excipients have gained sufficient attention from drug developers owing to their ability to act as drug carriers for complex, albeit highly promising therapeutics. Many studies have indicated that lipid-based formulations are capable of solving the complex drug delivery challenges currently faced by this industry. This can be attributed to the versatility of such molecules in terms of structure and functionality, as well as their ability to enhance the solubility and bioavailability of poorly water-soluble (hydrophobic) drugs.
It is worth highlighting that, currently, lipid nanoparticles / lipids are the most commonly used drug delivery systems, specifically for mRNA therapeutics and vaccines. In fact, LNPs have been used in several mRNA-based COVID-19 vaccines to encapsulate and deliver genetic material to the target cells. As a result, the demand for lipid nanoparticles as drug delivery systems has grown considerably over the years. Presently, several studies are underway to evaluate the potential of next-generation lipid nanoparticles as effective drug delivery systems, aiming to enable the development of therapies with high efficacy and bioavailability. Given the extensive research activity, the intellectual capital related to the use of LNPs in drug delivery has also grown over time. Therefore, it is important to keep track of both pockets of innovation and key areas of improvement for stakeholders to remain competitive in this upcoming field of the healthcare domain. This report captures some of the key R&D trends and provides competitive intelligence on intellectual property related to lipid nanoparticles and their applications in drug delivery.
Scope of the Report
The Lipid Nanoparticles in Drug Delivery: Intellectual Property Landscape report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents), describing the various applications of lipid nanoparticles in drug delivery. The insights generated in this report have been presented across two deliverables, namely a MS Excel workbook and a MS PowerPoint deck, summarizing the ongoing activity in this domain. Key inclusions are briefly described below:
Overall Intellectual Property Landscape
An analytical perspective of the various patents and affiliated IP documents that have been published related to lipid nanoparticles in drug delivery, since 1977. An in-depth analysis of published IP documents, representing unique patent families across various global jurisdictions, featuring insightful inferences related to both historical and recent R&D trends within this niche, yet rapidly evolving segment of the biotechnology and pharmaceutical industry.
Popular / Relevant Prior Art Search Expressions
An examination of IP literature, shortlisting key words and phrases used to describe lipid nanoparticles in drug delivery. The analysis also includes details on the historical use of the aforementioned terms across different IP filings, key affiliated terms (which can be used to identify other relevant IP search terms and establish relationships between prior art search expressions), and other related trends.
Patent Valuation Analysis
A competitive benchmarking and valuation analysis of the key members of unique patent families captured in the report, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in value associated with the gross domestic product (GDP) of a particular region).
Patentability and Freedom to Operate
A systematic approach to identify relevant areas of innovation by analyzing published IP documents (representative of unique patent families), by defining the uniqueness of patented / patent pending innovations, in order to assess the scope of patentability in this domain, and pinpoint jurisdictions wherein new and / or modified claims may be filed without infringing on existing IP.
Analysis of Patent Applications
A detailed summary of the various patent applications (representative of unique patent families) that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis classified the intellectual capital in terms of type of innovation and the innovation (such as a product class, enabling technologies or method of use), thereby, offering the means to identify active arenas of research and assess innovation-specific IP filing trends.
Analysis of Granted Patents
An analysis of the granted patents (representative of unique patent families) across different global jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted IP into relevant categories (namely type of innovation and innovation) to help develop a detailed perspective on the diversity of intellectual capital (having marketing exclusivity) related to lipid nanoparticles in drug delivery, and the assessing likelihood for innovators to enter into promising research areas.
Pockets of Innovation and White Spaces
An insightful analysis of the various CPC codes used in published IP literature (representative of unique patent families) and their affiliated families, offering the means to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic IP classification approach, mentioned earlier); the analysis also features a discussion on prevalent white spaces (based on type of innovation and innovation) in this field of research.
Claim Analysis
One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents (representative of unique patent families) in the dataset. Using a systematic segregation approach, we have analyzed trends associated with the preamble, type of patent (product patent or method patent), type of claim (open ended claim or closed ended claim) and key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
Table of Contents
Excel Deliverable
1. Research Notes
2. Summary Dashboard
A. Overall Intellectual Property Landscape
B. Intellectual Property Landscape (Grouped by Simple Families)
C. Key Prior Art Search Expressions
D. Key Trends related to Patent Applications (featuring Patentability and Freedom to-Operate)
E. Key Trends related to Granted Patents (featuring Patentability and Freedom-to-Operate)
F. Claims Analysis
G. Key CPC Symbols
H. Key Applicants
3. Overall Intellectual Property Landscape Dataset
4. Prior Art Search Expressions (Keyword Analysis)
5. Patent Applications Dataset
6. Granted Patents Dataset
7. Claims Analysis
8. Key Applicants Analysis
9. CPC Analysis
10. Appendix I: Pivot Tables
11. Appendix II: Country / Geography Codes
12. Appendix III: Innovation Categories
PowerPoint Deliverable
1. Context
2. Project Approach
3. Project Objectives
4. Executive Summary
5. Lipid Nanoparticles in Drug Delivery
5.1. Overview
5.2. Introduction to Lipid Nanoparticles
5.3. Advantages and Applications of Lipid Nanoparticles in Pharmaceutical Industry
5.4. Future Perspectives
6. Overall Intellectual Property Landscape
6.1. Overview
6.2. Analysis of Simple Patent Families
6.3. Key Innovation Categories
6.4. Insights from Patent Applications
6.5. Insights from Granted Patents
7. Key Prior Art Search Expressions
7.1. Overview
7.2. Analysis of Prior Art Search Expressions
8. Intellectual Property Valuation Analysis
8.1. Valuation Overview
8.2. Analysis of Individual Value Ranks
8.2.1. Rank 1 IP Documents
8.2.2. Rank 2 IP Documents
8.2.3. Rank 3 IP Documents
8.2.4. Rank 4 IP Documents
8.2.5. Rank 5 IP Documents
8.3. Concluding Remarks
8.4. List of Rank 1 IP Documents
9. Analysis of Patent Applications
9.1. Overview
9.2. Relative Valuation of Patent Applications
9.3. Patentability and Freedom-to-Operate
10. Analysis of Granted Patents
10.1. Overview
10.2. Relative Valuation of Grated Patents
10.3. Patentability and Freedom-to-Operate
10.4. Analysis of Patent Claims (Granted Active Patents)
11. Key Applicants
11.1. Overview
11.2. Analysis of Key Applicants
12. Pockets of Innovation and White Spaces
12.1. Overview
12.2. Pockets of Innovation
12.3. White Spaces
12.4. Concluding Remarks
13. Future Outlook
13.1. Lipid Nanoparticles in Drug Delivery: IP Filing Growth Trends
13.2. Relevance of IP for Business Development and Growth
13.3. Contemporary Sentiments and Predictions
13.4 Anticipated Future Developments and Trends
14. Appendices
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Aarhus University
- 3M Innovative Properties
- Abbott
- Abcombi Biosciences
- ABIONYX Pharma
- AC BioScience
- AC Immune
- Academia Sinica
- Access Pharma
- ACM Biolabs
- ACT Therapeutics
- Acuitas Therapeutics
- Adjuvantix
- Aduro BioTech
- Advanced BioScience Laboratories (ABL)
- Advanced Cardiovascular Systems
- Advanced Inhalation Research
- Advaxis
- Aegis Therapeutics
- AfGin Pharma
- Agency for Science, Technology and Research (A*STAR)
- AGENE Research Institute
- Agenus
- Agilent Technologies
- AgoneX Biopharmaceuticals
- AgResearch
- AgroSource
- Akagera Medicines
- Albany Medical College
- Albert Einstein College of Medicine
- Albumedix
- Alcon
- Alcyone Therapeutics
- Aleph Therapeutics
- Alexion Pharmaceuticals
- Alloplex Biotherapeutics
- Almac Discovery
- Alnylam Pharmaceuticals
- Alpharma
- ALSATECH
- Altea Therapeutics
- Altus Pharmaceuticals
- ALZA Corporation
- Alzeca Biosciences
- Amorepacific Corporation
- Amur Pharmaceuticals
- Ancora Pharmaceuticals
- Angarus Therapeutics
- Angioslide
- Annexin Pharmaceuticals
- Antex Biologics
- Antipodean Pharmaceuticals
- APA Technologies (APAT)
- Aphton
- Apogee Technology
- Apollo Life Sciences
- Applaud Medical
- Applied Biology
- Aptorum Therapeutics
- Aradigm
- Arbutus Biopharma
- Arcturus Therapeutics
- Ares Trading
- Aridis Pharmaceuticals
- Arsanis Biosciences
- Artizan Biosciences
- Arytha Biosciences
- Asahi India Glass
- Ascendia Pharmaceuticals
- Astellas Pharma
- AstraZeneca
- Asymmetric Therapeutics
- Athena Neurosciences
- Atossa Therapeutics
- Atrium Medical
- Atrix Laboratories
- Auburn University
- Aurelium BioPharma
- Austria Wirtschaftsserv
- Avalon GloboCare
- Avanti Polar Lipids
- AVI BioPharma
- Avidea Technologies
- Axceso Biopharma
- Axolabs
- Axon Neuroscience
- AyuVis Research
- Bangor University
- Bar-Ilan University
- Bausch + Lomb
- Bausch Health
- Baxter
- Bayer
- Bayer Animal Health
- Baylor College Medicine
- Baylor Research Institute
- BC Cancer Agency
- BD
- Beckman Coulter
- Beijing Luzhu Biotechnology
- Beijing WeHand Bio Pharmaceutical
- Beijing Xinde Runxing Technology
- Benebiosis
- Ben-Gurion University
- BetterLife Pharma
- Bharat Biotech
- Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh
- Biocarb
- BioCardia
- Biocompatibles
- BIOINFRA Life Science
- BioLeaders
- Biolitec Pharma
- Biomas
- Biome Environmental Solutions
- Biomedical Research Models
- bioMerieux
- BiondVax Pharmaceuticals
- Bioneer
- Bionor Immuno
- BioNTech
- BioPath Holdings
- Biosource Pharm
- Biotechnology Forschung
- Biotechnology Research Center
- BioXcel
- Boehringer Ingelheim
- BONAC corporation
- Boston Scientific
- Boston University
- Bracco
- BrainsGate
- Brigham and Women's Hospital
- Bristol Myers Squibb
- Bullet Biotechnology
- C3J Therapeutics
- California Institute of Technology
- CAMRIS
- Canadian Blood Services
- Cancer Research Technology
- CanSino Biologics
- Capten Therapeutics
- Carantech BioSciences
- CardioVax
- Carnegie Mellon University
- Catalent
- Catholic University of Louvain
- Cedars-Sinai Medical Center
- Celator Pharmaceuticals
- Cell X Technologies
- Cellectar Biosciences
- Cellectis
- Celsion
- Celsus Therapeutics
- Center for Molecular Immunology
- Center for Molecular Medicine and Immunology
- Centocor
- CeramOptec
- CFD Research
- CHA University
- CHA Vaccine Institute
- Chang Gung University
- Chemo-Sero-Therapeutic Research Institute
- Chengdu Ribocure Pharmatech
- Chiba University
- Children's Medical Center Corporation
- Children's National Hospital
- Chimerix
- China Pharmaceutical University
- Chiron Corporation
- Chongqing Jiachen Bioengineering
- Chonnam National University
- Chugai Pharmaceutical
- CisThera
- CiVi Biopharma
- Clarion Pharmaceuticals
- Claudius Regaud Institute
- Clear Direction
- Cleveland Clinic
- Cleveland State University
- Clonit
- Cocrystal Pharma
- Codiak BioSciences
- Coley Pharm
- Collagen Corporation
- Columbia University
- Combined Therapeutics
- Complutense University of Madrid
- Compugen
- Concept Medical Research
- Connecticut Children's Medical Center
- ConserV Bioscience
- Convergent RnR
- Corixa Corporation
- Cornell Research Foundation
- Cornell University
- Council of Scientific & Industrial Research
- Counterpoint Biomedica
- Creighton University
- Critical Pharmaceuticals
- CRM Therapeutics
- CryoLife
- CSL
- CSL Seqirus
- CTT Cancer Targeting Technologies
- Cuprous Pharmaceuticals
- Curadev Pharma
- CureVac
- CytImmune
- Cytos Biotechnology
- Czech Academy of Sciences
- D4 Labs Interactive Technologies
- Daiichi Sankyo
- Dako Denmark
- Dalhousie University
- Dalian Minzu University
- Dana-Farber Cancer Institute
- Dartmouth College
- Datt Life Sciences
- Dcv Biologics
- Delex Therapeutics
- Dendritic NanoTechnologies
- Denka
- Department for Environment, Food & Rural Affairs
- Department of Chemistry and Chemical Biology at Rutgers University
- DepoTech
- DermaTrends
- Development Center for Biotechnology (DCB)
- Dexcel Pharma
- Diadem Biotherapeutics
- Distributed Bio
- Domantis
- Doosan
- D-Pharm
- DPM Therapeutics
- Dresden University of Technology
- Dsm IP Assets
- Duke University
- Dynavax Technologies
- Dyve Biosciences
- EDH Biotech
- Edison Oncology
- Eisai
- Elan Drug Technologies
- Elanco
- Electrosols
- Elicio Therapeutics
- Elwha
- EMED Technologies
- Emergent Product Development Gaithersburg
- Emory University
- EMV Enhance
- ENB Therapeutics
- Enbio
- Endorex
- Engimata
- EnhancedBio
- EntreMed
- Entropy Solutions
- Envisagenics
- Enzymotec
- EP Technologies
- Epimmune
- EPITARGET
- EpiVax
- Erasmus University Medical Center
- Eriochem
- eTheRNA Immunotherapies
- Ethicon
- EuBiologics
- Eureka Therapeutics
- Euro-Celtique
- Evox Therapeutics
- Ewha University-Industry Collaboration Foundation
- Exicure
- Experimental Pharmacology & Oncology Berlin-Buch
- Exponential Biotherapies
- EyeGene
- Ezaki Glico
- Farnex
- Federal University of Minas Gerais
- First Necessity
- First Time US Generics
- Fish Biotech
- Flagship Pioneering
- FMC BioPolymer
- Fondazione Toscana Life Sciences
- Fonterra
- Forskarpatent
- Fudan University
- Fujifilm
- G Tech Bio
- Galenica
- GC Biopharma
- Gene Tools
- Genelux
- Genentech
- Generex Pharmassist
- Genesis Group
- Genevant Sciences
- Genexine
- Genmab
- GenQuest
- Genus Oncology
- Genzyme
- George Mason Research Foundation
- Georgetown University
- Georgia Tech Research Institute
- Geron
- Ghent University
- Gilead Sciences
- Glactone Pharma
- GlobalAcorn
- GP Medical
- GreenLight Biosciences
- Griffith University
- Grinberg Sarina
- Gritstone bio
- GSK
- Guangzhou Argorna Biopharmaceuticals
- Guangzhou University of Chinese Medicine
- Guy's and St Thomas' NHS Foundation Trust
- H&A PHARMACHEM
- Hadasit Medical Research Services & Development
- Hallym University
- Halo Science
- Hamamatsu University School of Medicine
- Hana Biosciences
- Hangzhou DAC Biotech
- Hangzhou Xingao Biotechnology
- Hangzhou Yuhong Pharmaceutical Science & Technology
- Hanyang University
- Harbor Medical
- Harvard College
- Hawaii Biotech
- Health Protection Agency
- Heidelberg Pharma
- Heidelberg University
- HemoShear
- Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF)
- HERMES Biosciences
- HiberCell
- HIPRA
- Hokkaido University
- HTD Biosystems
- Human BioMolecular Research Institute
- i.com medical
- IBC Pharmaceuticals
- Icahn School of Medicine at Mount Sinai
- ICH Productions
- Icure BNP
- ID Biomedical
- Igeneon Krebs-Immuntherapie
- ImaRx Therapeutics
- Immune Targeting Systems
- ImmunityBio
- Immuno Rx
- ImmunoCellular Therapeutics
- ImmunoFrontier
- Immunolight
- Immunomedics
- IMP Innovations
- Imperial Chemical Industries (ICI)
- Imperial College Innovations
- Imperial College London
- Imugene
- IMV Inc.
- Ind Academic Coop
- Indena
- Indian Institute of Technology Bombay
- Indiana University
- Industrial Cooperation Foundation, Chonbuk National University
- Industrial Technology Research Institute
- Inex Pharmaceuticals
- Infectious Disease Research Institute (IDRI)
- Inimmune
- Inis Biotech
- Inmunotek
- InnoMedica
- InnoPharma
- Innovation Ulster
- InPharma
- Insmed
- Institut Curie
- Institute for Advanced Study-Louis Bamberger and Mrs Felix Fuld Foundation
- Institute for Bioengineering of Catalonia
- Institute for Research in Biomedicine
- Institute for Viral Diseases and Immunoprophylaxis (IVI)
- Institute of Basic Medical Sciences (IBMS)
- Institute of Cellular Biology and Pathology
- Institute of Experimental and Technological Biology (iBET)
- Institute of Immunology
- Institute of Materia Medica
- Institute of Molecular and Cell Biology
- Institute of Molecular Biotechnology (IMBA)
- Institute of Organic Chemistry and Biochemistry
- Institute Voor Dierhouderij
- Integral Technologies
- Integrated Nanotherapeutics
- Intensity Therapeutics
- Intercell
- International AIDS Vaccine Initiative
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- International Health Research Center of Barcelona
- International ImMunoGeneTics information system (IMGT)
- Introgene
- Invectors
- Invent Biotechnologies
- Inventprise
- InvivoGen
- ioGenetics
- Isis Innovation
- Israel Institute for Biological Research
- Israel Oceanographic and Limnological Research
- Istanbul University
- Janssen
- Japan Science and Technology Agency (JST)
- Jenner Biotherapies
- Jenner Technologies
- Jeong Pil
- Jeonnam Bioindustry Foundation
- Jiangsu KeyGEN BioTECH
- Jiangsu Lianhuan Pharma
- Jivana Biotechnology
- Johannes Gutenberg University Mainz
- Johns Hopkins University
- Josai University
- JSR Corporation
- Juvaris BioTherapeutics
- Kagoshima University
- Kansas State University
- Kao Corporation
- KAPAC
- KBP Biosciences
- Keio University
- Kennedy Krieger Institute
- Keraplast Technologies
- Kereos
- Keto Patent Group
- King Abdullah University of Science and Technology
- King's College London
- Kintara Therapeutics
- Kintor Pharmaceuticals
- Kitasato Daiichi Sankyo Vaccine
- Klaria Pharma
- Klinikum Rechts der Isar University Hospital at Technical University of Munich
- Kode Biotech
- Kodiak Sciences
- Korea Advanced Institute of Science & Technology (KAIST)
- Korea Institute of Geoscience and Mineral Resources
- Korea Institute of Science and Technology
- Korea Research Institute of Bioscience and Biotechnology
- Korea University of Research and Business Foundation
- Kumamoto University
- KV Pharmaceutical
- Kyowa Kirin
- Kyungpook National University
- Kyushu University
- L2 Diagnostics
- La Jolla Institute for Immunology
- LabyRx
- Lanco Biosciences
- Large Scale Biology Corporation
- Lawrence Livermore National Security
- Leidos
- Leland Stanford Junior University
- Liem Canet Santos
- Life Science Research Israel
- Life Technologies
- Linear Technologies
- Lipella Pharmaceuticals
- LiPlasome Pharma
- LipoMedix
- Liposoma Technology
- Lipotek
- Lipoxen Technologies
- Locus Agricultural Solutions
- Loewi
- Lohmann Therapie Systeme (LTS)
- London Health Sciences Centre
- Longhorn Vaccines & Diagnostics
- Louisiana State University
- Louisiana State University and Agricultural & Mechanical College
- Lpath Therapeutics
- LTT Bio-Pharma
- Ludwig Cancer Research
- Ludwig Maximilian University of Munich
- Luna Innovations
- Lynntech
- M Bio Technology
- Macfarlane Burnet Institute for Medical Research and Public Health
- MacRegen
- Malvern Instruments
- Marina Biotech
- Mashhad University of Medical Sciences
- Massachusetts Institute of Technology
- Maxim Pharmaceuticals
- Mayo Clinic
- MBC Pharma
- McDonnell Douglas Corporation
- McGill University
- McMaster University
- MD Anderson Cancer Center
- MD Labs
- Mecox Curemed
- Medarex
- Medeva Pharma
- Medical & Biological Laboratories
- Medical College of Wisconsin
- Medical Defense Technologies
- Medical University of Vienna
- MediGene
- MedImmune
- Medluminal Systems
- Megabios Corp
- Merck
- Merck Sharp & Dohme (MSD)
- Merrimack Pharmaceuticals
- Merrion Research
- Methodist Hospital Research Institute
- MetrioPharm
- Microdrug Ag
- Mie University
- Millennium Pharmaceuticals
- Minnow Medical
- Miravant Pharmaceuticals
- Mireca Medicines
- Mitsubishi Tanabe Pharma
- Moderna
- ModPro
- MOGAM Biotechnology Research Institute
- MOGAM Institute for Biomedical Research
- Molecular Express
- Molecular Machines
- Molecular Rebar Design
- Mologen
- Moreinx
- Morria Biopharmaceuticals
- Mucokinetica
- Murray Goulburn Co-operative Company
- MVRIX
- MX Adjuvac
- Myelin Repair Foundation
- Mymetics
- N4 Pharma
- Nagasaki University
- Nammi Therapeutics
- Nanjing CoreTech Biomedical
- Nanomed Devices
- Nanomed Skincare
- Nanoprobes
- Nant Holdings
- Nanyang Technological University
- Nastech Pharmaceutical
- NasVax
- National Cheng Kung University
- National Council for Scientific and Technical Research (CONICET)
- National Federation of Agricultural Cooperative Associations
- National Fisheries Research and Development Institute
- National Health Research Institutes
- National Institute for Materials Science
- National Institute of Advanced Industrial Science and Technology
- National Institute of Agricultural Research and Technology
- National Institute of Agricultural Technology (INTA)
- National Institute of Engineering
- National Institute of Health and Medical Research
- National Institute of Infectious Diseases
- National Institute of Psychiatry Ramon de la Fuente Muniz
- National Institutes of Health
- National Jewish Center for Immunology and Respiratory Medicine
- National Jewish Medical and Research Center
- National Research Council Canada
- National Research Development Corporation
- National Taiwan Ocean University
- National Tsing Hua University
- National University Hospital
- National University of Singapore
- National Yang Ming Chiao Tung University
- National Yang-Ming University
- Nektar Therapeutics
- NeoCura Bio-Medical Technology
- Neon Therapeutics
- Neopharm
- Neuroimmuno Therapeutics Research
- New Mexico Tech University Research Park Corporation
- New York University
- NeXstar Pharmaceuticals
- Nihon Medi-Physics
- NIPPON Genetics
- Nippon Shinyaku
- Nitto Denko
- NKD Pharma
- North American Vaccine
- Northeastern University
- Northern Illinois University
- Northwestern University
- Nostopharma
- Nova Pharm
- Novartis
- Novavax
- Novo Nordisk
- Novosom
- Novus International
- NSVascular
- Nuclisome Ab
- Nutricia
- Nutrimed Biotech
- OBI Pharma
- Ohio State University
- Oncothyreon
- Optime Therapeutics
- Oregon Health & Science University
- Orna Therapeutics
- Osaka University
- Ovid Therapeutics
- Palacky University Olomouc
- Paris Descartes University
- Paris Diderot University
- Partners for Utvecklingsinvesteringar inom Life Sciences
- PDS Biotechnology
- Peking University
- Percans Oncology
- Persephone Biosciences
- Pharma Logic
- PharmaDerm Laboratories
- PharmaExceed
- PHARMAFILM
- Pharmexa
- Phylex Biosciences
- Pierre and Marie Curie University
- Politehnica University of Bucharest
- Potentia Pharmaceuticals
- Prolexys Pharmaceuticals
- ProNAi Therapeutics
- Protiva Biotherapeutics
- Providence Therapeutics
- PX'Therapeutics
- Qantu Therapeutics
- Qingdao Harwars Biomedicine Technology
- QPS Holdings
- Quadrant Holdings Cambridge
- Quadrel
- Qualitas Health
- Quantum Materials
- Queen's University Belfast
- Quratis
- Race Oncology
- Ractigen Therapeutics
- Raven Biotechnologies
- Realinn Life Science
- Regeneron Pharmaceuticals
- Regional Centre for Biotechnology (RCB)
- Regional University Hospital of Lille (CHRU)
- Regulus Therapeutics
- RenovoRx
- Repertoire Immune Medicines
- Replicate Bioscience
- Research Institute for Development (IRD)
- Research Institute for Microbial Diseases of Osaka University
- Research Triangle Pharm
- Rhythm Pharmaceuticals
- Riboxx
- RITA Medical Systems
- RJAN Holding
- Roche
- Roche Diagnostics
- Rockefeller University
- Roehm
- ROVI
- Royal Free Hospital School of Medicine
- Royal Veterinary College
- Royer Biomedical
- Rutgers University
- Sahmyook University
- Saint Louis University
- Saitama Medical University
- Salk Institute for Biological Studies
- Samyang Biopharm
- San Diego State University
- Sandia National Laboratories
- Sandoz
- Sanford Burnham
- Sanofi
- Santen Pharmaceutical
- SANUWAVE Health
- Sapientia Pharmaceuticals
- Sapporo Medical University
- Schering
- SciMed Life System
- ScinoPharm Taiwan
- Scottish Agricultural College
- Scripps Clinic Research
- Scripps Research Institute
- SEARETE
- Seattle Children's Hospital & Regional Medical Center
- Seattle Children's Research Institute
- Second Genome
- Sederma
- Seikagaku Kogyo
- Selecta Biosciences
- Seneca College of Applied Arts and Technology
- Seoul National University R&DB Research Foundation
- Sequus Pharmaceuticals
- Serum Institute of India
- Shanghai Ginposome Pharmatech Company
- Shanghai Jiao Tong University School of Medicine
- Shanghai Second Medical Investment Management
- Shanghai Whittlong Pharmaceutical Institute
- Shenyang Pharmaceutical University
- Shenzhen Institute of Advanced Technology
- Shinshu University
- Sichuan University
- Sidney Kimmel Cancer Center
- Sigmoid Pharma
- Silence Therapeutics
- Singapore Health Services
- Sio2 Medical Products
- SipNose
- Sirna Therapeutics
- SiSaf
- Skyepharma
- Sloan Kettering Cancer Center
- Smart Drug Systems
- Sofia University "St. Kliment Ohridski"
- Sogang University
- SOLVE Research and Consultancy
- Sonus Pharmaceuticals
- Sony
- Sorbonne University
- Southwest Research Institute
- Squared Biotechnologies
- SRI International
- St Vincent's Hospital Sydney
- St. Anna Children's Cancer Research
- State University of Campinas (Unicamp)
- Stemirna Therapeutics
- Strand Therapeutics
- Sumitomo Chemical
- Sumitomo Pharma
- Sungkyunkwan University Research & Business Foundation
- SuperGen
- Superior Council of Scientific Investigations
- Superlab Far East
- Supratek Pharma
- Suzhou Abogen Biosciences
- Suzhou M-Conj Biotech
- Swiss Tropical and Public Health Institute
- Symbicom
- Symphogen
- SynGlyco Pharmaceuticals
- Synlife
- SynPharm
- Synthena
- Synvolux Therapeutics
- Taipei Medical University
- Taiwan Liposome Company
- Taizhou Guokehuawu Biomedical Technology
- Takeda
- Tarsius Pharma
- Tarveda Therapeutics
- Technical University of Denmark
- Technical University of Liberec
- Technical University of Munich
- Technion Research & Development Foundation
- Tehran University of Medical Sciences
- Teikyo University
- Tel Aviv University Future Technology Development
- Tel Hashomer Medical Research, Infrastructure and Services
- Telormedix
- Terumo
- Tessa Therapeutics
- Texas A&M University System
- Texas Children's Hospital
- Texas Tech University
- The Burlington Hc Research Group
- The Chinese University of Hong Kong
- The General Hospital Corporation
- The Giannina Gaslini Children's Hospital
- The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF)
- The Istituto Superiore di Sanità
- The Research Institute at Nationwide Children's Hospital
- The School of Pharmacy, University of London (LSOP)
- Texas Heart Institute
- University of Alabama
- University of Chicago
- Theratechnologies
- ThermoLase
- Thomas Jefferson University
- TianJin Medical University
- TianXinFu (Beijing) Medical Appliance
- Tiba Biotech
- Tidal Therapeutics
- TLC Biopharmaceuticals
- Tokai University
- Tokyo Medical and Dental University
- Tonen Corporation
- Tottori University
- Toulouse III - Paul Sabatier University
- TPCera
- Trained Therapeutix Discovery
- Transave
- Transcend Cytotherapy
- Transdermal Biotechnology
- Transgene Biotek
- Translate Bio
- Translational oncology (TRON)
- Transmed
- Transmedica
- Tufts University
- Tulane University
- UCL Business
- Ultrasonic Technologies (UST)
- Umoja Biopharma
- Universal Preservation Technologies
- University Health Network
- University of Alberta
- University of Amsterdam
- University of Arizona
- University of Arkansas
- University of Artois
- University of Bonn
- University of British Columbia
- University of Bruxelles
- University of Cagliari
- University of California
- University of Central Florida
- University of Chile
- University of Cincinnati
- University of Colorado
- University of Connecticut
- University of Copenhagen
- University of Delaware
- University of Florida
- University of Geneva
- University of Georgia
- University of Glasgow
- University of Granada
- University of Groningen
- University of Guelph
- University of Heidelberg
- University of Houston
- University of Illinois
- University of Iowa Research Foundation
- University of Konstanz
- University of KwaZulu-Natal
- University of Lausanne
- University of Leeds
- University of Lille
- University of Liverpool
- University of London
- University of Louisville Research Foundation
- University of Malaya
- University of Manitoba
- University of Maryland
- University of Maryland Biotechnology Institute
- University of Massachusetts
- University of Medicine and Dentistry of New Jersey
- University of Miami
- University of Michigan
- University of Minnesota
- University of Missouri
- University of Montana
- University of Montreal
- University of Montreal Hospital Center
- University of Nantes
- University of Nebraska
- University of North Carolina
- University of North Texas
- University of Notre Dame
- University of Lowa Research Foundation
- University of Otago
- University of Oklahoma
- University of Orleans
- University of Oxford
- University of Pennsylvania
- University of Pittsburgh
- University of Queensland
- University of Rochester
- University of Salamanca
- University of Sao Paulo
- University of Saskatchewan
- University of Sevilla
- University of Sheffield
- University of South Florida
- University of Southampton
- University of Southern California
- University of Tennessee Research Foundation
- University of Texas
- University of the Basque Country
- University of the Republic of Uruguay
- University of Toledo
- University of Tsukuba
- University of Utah
- University of Virginia
- University of Virginia Patent Foundation
- University of Washington
- University of Western Brittany
- University of Zaragoza
- University of Zurich
- US Department of Agriculture
- US Department of Commerce
- US Department of Health & Human Services
- US Department of Veterans Affairs
- US Government
- US Health
- Utrecht University
- Vaccitech
- ValiRx
- Vanderbilt University
- Vaxess Technologies
- VaxInnate
- VaxThera
- VBL Therapeutics
- VCC Medical Deutschland
- Vectron Therapeutics
- Vensica Medical
- Verseau Therapeutics
- VersiTech
- Vestar
- Vical
- Virun
- Vitruviae
- VIVUS
- VLP Therapeutics
- Vrije University of Amsterdam
- Vrije University of Brussel
- Vyome Therapeutics
- Wake Forest University Health Sciences
- Walter and Eliza Hall Institute of Medical Research
- Wayne State University
- West Pharmaceutical Services
- Willmar Poultry
- Wisconsin Alumni Research Foundation
- Wistar Institute
- Wyeth
- XEME Biopharma
- Xeris Pharmaceuticals
- Xiamen Ginposome Pharmaceutical
- Xiamen Sinopeg Biotech
- Xian Libang Biomedical Technology
- XI'an Libang Pharmaceutical
- Yale University
- Yamaguchi University
- Yamanouchi Pharmaceutical
- Yeda Research and Development Company
- Yissum Research Development Company
- Ziphius Vaccines
- Zoetis
- Zomanex
- ZoneOne Pharma
- Zydus Lifesciences
Methodology
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