Multifaceted Role of IL-1 in Cancer and Inflammation

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Book
June 2023
Elsevier Science and Technology
ID: 5755523

Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.

This is a valuable source for cancer researchers, clinicians and other members of the biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

1. Role of IL-1 gene polymorphisms in common solid cancers Ragini D. Singh, Sagar Dholariya, Anusmita Shekher, Avadhesh, Deepak Parchwani and Subash C. Gupta 2. The role of IL-1 in tumor growth and angiogenesis Kinjal Bhadresha, Pradeep K. Shukla and Pratibha Singh 3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer 4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer Abhishek Puthenveetil, Shweta Dubey and Ankita Garg 5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy Shubhi Singh, Smriti Gaur and Manisha Singh 6. IL-1-mediated inflammation in COVID-19 Preeti Jain, Baldeep Singh, Sadhna Aggarwal and Manisha Singh 7. Role of IL-1 in bacterial infections Aishwarya Rani and Devinder Toor

Authors

Manisha Singh Department of Lymphoma/ Myeloma, The University of Texas, MD Anderson Houston, Houston, Texes, United States. Manisha Singh, PhD, is a trained human and mouse immunologist and during the last 10 years, she has specialized in cancer immunology. The main focus of her work has been to increase the efficacy and understand the molecular mechanisms of various cancer immunotherapies. She is serving as the principal investigator on a 2-year grant ($545,486), having been funded by the US Department of Defense. Dr. Singh's current research is focused on understanding the role of inflammation in immune suppression and resistance to immunotherapy in cancer. Recently, she has submitted the NIH-R01 grant in which she proposed to study the role of IL-1a in immunotherapy induced resistance. She has published 24 peer-reviewed articles and many abstracts in prestigious journals such as Nature Communication, Journal of Immunology, and Journal of Clinical Investigator. Her work has been cited by several prestigious, peer-reviewed, international journals.

Table of Contents

Authors

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